LOCUS HUMKAL 5686 bp DNA linear HUM 23-JUL-1993
DEFINITION Homo sapiens pre-pro-protein for kallikrein gene, complete cds.
ACCESSION L10038
VERSION L10038.1
KEYWORDS kallikrein; serine protease.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5686)
AUTHORS Lin,F.K., Lin,C.H., Chou,C.C., Chen,K., Lu,H.S., Bacheller,W.,
Herrera,C., Jones,T., Chao,J. and Chao,L.
TITLE Molecular cloning and sequence analysis of the monkey and human
tissue kallikrein genes
JOURNAL Biochim. Biophys. Acta 1173 (3), 325-328 (1993)
PUBMED 7916636
COMMENT Original source text: Homo sapiens (library: lambda-65A of T.
Maniatis) fetus liver DNA.
FEATURES Location/Qualifiers
source 1..5686
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/tissue_type="liver"
/dev_stage="fetus"
/tissue_lib="lambda-65A of T. Maniatis"
CDS join(803..848,2678..2837,4308..4396,4515..4651,5200..5355)
/EC_number="3.4.21.35"
/function="serine protease"
/standard_name="kallikrein"
/note="putative"
/codon_start=1
/product="pre-pro-protein for kallikrein"
/protein_id="AAA36135.1"
/translation="MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYH
FSTFQCGGILVHRQWVLTAAHCISDVKVVELPTQEPEVGSTCLASGWGSIEPENFSFP
DDLQCVDLKILPNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGV
TSWGYVPCGTPNKPSVAVRVLSYVKWIEDTIAENS"
exon 803..848
/number=1
intron 849..2677
/number=1
exon 2678..2837
/number=2
intron 2838..4106
/number=2
exon 4107..4396
/number=3
intron 4397..4514
/number=3
exon 4515..4651
/number=4
intron 4652..5199
/number=4
exon 5200..5355
/note="putative"
/number=5
BASE COUNT 1021 a 1981 c 1364 g 1320 t
ORIGIN
1 agatctctgg gactttggag gacaggacgt tgagcaccca taactgggag caagaagtgg
61 gaggctcatt gagaccccag cattgtttgg gagggacact ggattttgta atgctaaaga
121 acttaccctg ggagacccct gaaacttcac attcctggat ctggaggcac taggaatgtg
181 gtgatgtgta ccccaaaatt ttattatgaa aggaacagta gctttgggga cctaggtcct
241 gggtctggga gtgcaagaac cagggcattc tgaaggccaa ggcttatatt tcagggggaa
301 ctggcagctg agatgctagt atcttggctc cgagtggtgc agggaatcag agccctaact
361 gctggtgttt gagggcacca ggtctggggg tgcagggcct taattgagac tgaggtatat
421 ggggctttgt accaggggtc actgattcct ccgtcttcct gtttctgctt cccctcagtc
481 cccccttgcc tcactggctg ctccccagag caaagcccca gagccacagg ccctgcccca
541 cctggcttca accccaggaa tgcgtccagc gtgatccagg gcctgcagaa caggtgctgg
601 ttctccctcc ccgtctacag ctctggggat cggaggcggg ggggcaattg tccagccccc
661 aggcaacagg ggaagggcct tggcaacatc tgggtgccag cagggcaggg gtggggctct
721 gaggggataa gggcttttaa aagcctcccc agggaggttc cccagttcct ccacctgctg
781 gcccctggac acctctgtca ccatgtggtt cctggttctg tgcctcgccc tgtccctggg
841 ggggactggt gagacagtgg ggggatgtgg gagggggaac gggccctgat tctcttgctg
901 gcctcacatc cccccccgat aagaccttcc cctccaacac cccaccctca tccctctggc
961 ccacagtcta tcctagtccg gggtgccccg gctcttatct atcttgcgcg gccccaccct
1021 aaacttccac ccccgctcct ccatgttgtc atagtgctca ctcccacacc agattcctgc
1081 tcctcccagg aagcctcagt actttctcct cttccctagc caacgccctg tcccaccgct
1141 ttaccaaagg ggcagattct gggccatctc tgtctctctc tggaggaccc caaccctccc
1201 atgggcttcc cccaccccac aggactctga tcatcccctc ctgcccccta gttccctgcg
1261 gccacctatt tggctcctga gtctacaaat cccaccacac tccagtgact ttttccatcc
1321 agctgtccgc tctcaactgt gtcctccaga ccctgacatc tggtctcccc agtccttcca
1381 gggtccccca aatttcacca gaaaaccctg cttcccaaac tggcatgtgg gatcccccat
1441 ctggtatggg ggggggtctg caaatgtccc ttcccaccca gcacccccag ctctcccagg
1501 aaaaacacca caccctccca ccacatgctc ctttccttgg ggaagttcca tcccgcccca
1561 ggccccagcc cttctctgcc tgaattgttc ctacacagct ctggttttct ggaaccccac
1621 gccaaggatc ctgaatgcct tctcagccag cgcttctgcc ctggctcccc caagtcagta
1681 tgtgattcta caacctcaca tcaagtgggt cctgcattgc attcccacag ctgcttggcg
1741 cctgttctca ccacttctcc aatcctcttc ctaggattgc ctccaagagg accccatatc
1801 cttccagtac cctcagacca tgaaccccat ccccatgaga aacgaagatc ccatccttca
1861 ccctgtccga gaaggactgc cactcacgcc tccctcctcc tgagccccgt cccagtcctg
1921 accgcaactg tgttctcagg gccccaacct cccctcatat tgccattcct ggttcacagg
1981 aaggacccca aaacctctcg gaagcccacc tctagcctta accatagccc tttcttttac
2041 cctttaacca ggaagccctg aaatctaact gtccagccaa gctggcccct tccaacccca
2101 atgtagggac cccaagtcac ccccaaactc ttcagtcgag atgctcttct ttacctctca
2161 gacctggttc cctaaagctg catcctttcc tgaacctcaa aagcccaacc caggtcctgt
2221 ttccctagcc taggagcccc ttagccctcc agattcttcc tcagtgagcc tctgatcctg
2281 tcccaccctt ggcgccttga tccctggttt ccagaatccc tttccactcc cctaacccac
2341 cacctcccat cccccagccc cagaccccaa atgacctgac gcccagatgc agtgtctgct
2401 ccagacactg tctcctgtct cctaccctga tccctggagg ctgctctact gtcagagcac
2461 aaaatctccc caccaggtcc agccaccact ccaaaagccc agggaacagt ccagagtccc
2521 accccttccc aacacccctt gcccatgtcc ccaacctcca gccctggtcc tctacccgca
2581 atgtcccttc agacccacag cccagctccc tctcctagcc ttgtccctgg cctctcctgc
2641 caaccctgcc cttcctgacc cagcaccgcc tctgcaggtg ctgcgccccc gattcagtcc
2701 cggattgtgg gaggctggga gtgtgagcag cattcccagc cctggcaggc ggctctgtac
2761 catttcagca ctttccagtg tgggggcatc ctggtgcacc gccagtgggt gctcacagct
2821 gctcattgca tcagcgagtg agtaggggcc tggggtctgg gaggagggca tctatgctgc
2881 cacaggattg acaggccagt ggcattcccc ttggataacc tcaggcaaga ctggggggct
2941 gagccagaga ggaaggctct ggcgcaggtc gcctggcagg gcagagctgg gctggacacc
3001 cctctccaag gctgcctggg tctcttggga tctggttctg cttgtgtctc tgtgtgactg
3061 tgttctggtc tctgtcttcc tctctctcct ctgtctcctt gtctctgcat ctcccctgtc
3121 tctgtctgtc tctgagtctc tctgcggcat ctctgtcact gtgtctcacc ctccatctct
3181 ctacccatct ctctctctct gggtctctac ctcaccgctc cctcatccct actaaacaca
3241 cacccagatg gacctaaggg aggccccaga gtaaaggaag ggctttatcc ccaacttgtg
3301 tgcctgggag ggggcgcctc tccctctgtc cagctccccg ccccacagga tatccctcca
3361 ctctggagag acacagggaa gggctggttt cagcgggagc tgggtggggc aactgaggga
3421 ggaggaagga ggaggcgggg cgagaaacgc gcgggagggt gctgggaacc gaagggggcc
3481 tcgaccttgg acttcaggcc aggccacctg cccctgggga gcccgcacca cagccccagc
3541 tgcagctgag ccgctctcag gcctcccctc ctccctacct gcccccaccc tccccacctg
3601 cccccaccct cccccagggc ctccctccct tttctctccc acactcggtc actcctgctt
3661 cctctctgcc tctgtttcta gttctcactc tgacgtcccg cgtccttttt catttgtctg
3721 cttctcgctc ccttccgtgt tctgttccct cttcctccct cttccctggg gcctgtttct
3781 cgctgtccct gtcttttatc cttctcatct gcctcttttt tgctcaccct gtttctcact
3841 gccctcccct ccgcctttct cacccctctg tccttttgag ctcttttttg ctctgtctct
3901 tcatttgcct tttgcactct caaactcttt catcttccca ttcgctgtct gtatttctcc
3961 ataactatat ctttcttcct ctgtctccgc ccacccacat ttttctcttt ccctttctct
4021 ctttggggac cctcccccat gctcccctgc cccatcccct tttccccttc ccgtcttctc
4081 atccctccat tcccatcttt ccccagcaat taccagctct ggctgggtcg ccacaacttg
4141 tttgacgacg aaaacacagc ccagtttgtt catgtcagtg agagcttccc acaccctggc
4201 ttcaacatga gcctcctgga gaaccacacc cgccaagcag acgaggacta cagccacgac
4261 ctcatgctgc tccgcctgac agagcctgct gataccatca cagacgctgt gaaggtcgtg
4321 gagttgccca cccaggaacc cgaagtgggg agcacctgtt tggcttccgg ctggggcagc
4381 atcgaaccag agaattgtat gtgggggcag actgtgtagc ccaaggcggg gatggggact
4441 cctgcgtcca agggagaaag ggccagggaa gcaggtgagg tcgggctgca gccctttttc
4501 tcccgggttc gtagtctcat ttccagatga tctccagtgt gtggacctca aaatcctgcc
4561 taatgatgag tgcaaaaaag cccacgtcca gaaggtgaca gacttcatgc tgtgtgtcgg
4621 acacctggaa ggtggcaaag acacctgtgt ggtgaggcag ccctgccccc agggtctgga
4681 agggctgagg gaggggactc agcctctgaa ctggcttctg agagctaacc aggcatctgc
4741 ttcactgctt cccagctagc tgtagccact cgccccatca gtgccccagc tccccctcct
4801 tccccgccca tccagggaca actgcatctc accccccaca ccagagttca ccgttcctcg
4861 tggtaatgtg ttgttaccgt cgagtcagag agtagtcctg gagaggtggc ctctgcgatg
4921 tgcccgcagg ggcagcgtcc tgcagatggt cctgcccctc ctccccctaa cctgtctgca
4981 ggcactgtcc acctggaccc tgccccatgt gcaggagctg gaccctgagg tcccttcccc
5041 cttggccagg actggagacc ctgtcccctc tgtgggaatc cctgcccacc ttcctctggg
5101 agtgggcact ggaggccctg tctgcgagct ggggctcccc aggcagaact tgggccccgt
5161 agacctttct cactctcccc tcccaccttg tgctcccagg gtgattcagg gggcccgctg
5221 atgtgtgatg gtgtgctcca aggtgtcaca tcatggggct acgtcccttg tggcaccccc
5281 aataagcctt ctgtcgccgt cagagtgctg tcttatgtga agtggatcga ggacaccata
5341 gcggagaact cctgaacgcc cagccctgtc ccctaccccc agtaaaatca aatgtgcatc
5401 caatgtgtgt cacgttctgc catcacctat ctttccagat gtggtgcacc tggacccact
5461 cggctgaggc tggggccacc ccagctgtgt caatctcatg cctggaagtc tgaggtcacc
5521 agcaggtggg gaaaggaagg ggctgtgaca ggtgcagaca aacaggcagg gaaaggctca
5581 gatcccaaag ggcgagtcag ggacgccaga acagttcact cacactagga tggaccctgc
5641 cctggtgggg aggtgggggg caatggaagg tctgaggctg agaggt
//