LOCUS HUMDNPOLCS 6912 bp mRNA linear HUM 08-JUN-1998
DEFINITION Homo sapiens DNA polymerase epsilon, catalytic polypeptide mRNA,
complete cds.
ACCESSION L09561
VERSION L09561.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 248; 331 to 6906)
AUTHORS Kesti,T., Frantti,H. and Syvaoja,J.E.
TITLE Molecular cloning of the cDNA for the catalytic subunit of human
DNA polymerase epsilon
JOURNAL J. Biol. Chem. 268 (14), 10238-10245 (1993)
PUBMED 8486689
REFERENCE 2 (bases 1 to 6912)
AUTHORS Syvaoja,J.
TITLE Direct Submission
JOURNAL Submitted (25-MAY-1993) J. Syvaoja, University of Oulu, Dept. of
Biochemistry, Linnanmaa, Oulu, Finland, Sf-90570
REFERENCE 3 (bases 1 to 6912)
AUTHORS Syvaoja,J.
TITLE Direct Submission
JOURNAL Submitted (08-JUN-1998) J. Syvaoja, University of Oulu, Dept. of
Biochemistry, Linnanmaa, Oulu, Finland, Sf-90570
REMARK Sequence update by submitter
COMMENT On Jun 8, 1998 this sequence version replaced gi:915267.
FEATURES Location/Qualifiers
source 1..6912
/db_xref="H-InvDB:HIT000191980"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="ATCC:TIB161"
/db_xref="taxon:9606"
/cell_line="ATCC TIB 161"
/cell_type="T-cell"
CDS 45..6905
/codon_start=1
/product="DNA polymerase epsilon, catalytic polypeptide"
/protein_id="AAC19148.1"
/translation="MSLRSGGRRRADPGADGEASRDDGATSSVSALKRLERSQWTDKM
DLRFGFERLKEPGEKTGWLINMHPTEILDEDKRLGSAVDYYFIQDDGSRFKVALPYKP
YFYIATRKGCEREVSSFLSKKFQGKIAKVETVPKEDLDLPNHLVGLKRNYIRLSFHTV
EDLVKVRKEISPAVKKNREQDHASDAYTALLSSVLQRGGVITDEEETSKKIADQLDNI
VDMREYDVPYHIRLSIDLKIHVAHWYNVRYRGNAFPVEITRRDDLVERPDPVVLAFDI
ETTKLPLKFPDAETDQIMMISYMIDGQGYLITNREIVSEDIEDFEFTPKPEYEGPFCV
FNEPDEAHLIQRWFEHVQETKPTIMVTYNGDFFDWPFVEARAAVHGLSMQQEIGFQKD
SQGEYKAPQCIHMDCLRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEDMCRMATE
QPQTLATYSVSDAVATYYLYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQ
AFHANIIFPNKQEQEFNKLTDDGHVLDSETYVGGHVEALESGVFRSDIPCRFRMNPAA
FDFLLQRVEKTLRHALEEEEKVPVEQVTNFEEVCDEIKSKLASLKDVPSRIECPLIYH
LDVGAMYPNIILTNRLQPSAMVDEATCAACDFNKPGANCQRKMAWQWRGEFMPASRSE
YHRIQHQLESEKFPPLFPEGPARAFHELSREEQAKYEKRRLADYCRKAYKKIHITKVE
ERLTTICQRENSFYVDTVRAFRDRRYEFKGLHKVWKKKLSAAVEVGDAAEVKRCKNME
VLYDSLQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCFTGANIITQARELIEQIGRP
LELDTDGIWCVLPNSFPENFVFKTTNVKKPKVTISYPGAMLNIMVKEGFTNDQYQELA
EPSSLTYVTRSENSIFFEVDGPYLAMILPASKEEGKKLKKRYAVFNEDGSLAELKGFE
VKRRGELQLIKIFQSSVFEAFLKGSTLEEVYGSVAKVADYWLDVLYSKAANMPDSELF
ELISENRSMSRKLEDYGEQKSTSISTAKRLAEFLGDQMVKDAGLSCRYIISRKPEGSP
VTERAIPLAIFQAEPTVRKHFLRKWLKSSSLQDFDIRAILDWDYYIERLGSAIQKIIT
IPAALQQVKNPVPRVKHPDWLHKKLLEKNDVYKQKKISELFTLEGRRQVTMAEASEDS
PRPSAPDMEDFGLVKLPHPAAPVTVKRKRVLWESQEESQDLTPTVPWQEILGQPPALG
TSQEEWLVWLRFHKKKWQLQARQRLARRKRQRLESAEGVLRPGAIRDGPATGLGSFLR
RTARSILDLPWQIVQISETSQAGLFRLWALVGSDLHCIRLSIPRVFYVNQRVAKAEEG
ASYRKVNRVLPRSNMVYNLYEYSVPEDMYQEHINEINAELSAPDIEGVYETQVPLLFR
ALVHLGCVCVVNKQLVRHLSGWEAETFALEHLEMRSLAQFSYLEPGSIRHIYLYHHAQ
AHKALFGIFIPSQRRASVFVLDTVRSNQMPSLGALYSAEHGLLLEKVGPELLPPPKHT
FEVRAETDLKTICRAIQRFLLAYKEERRGPTLIAVQSSWELKRLASEIPVLEEFPLVP
ICVADKINYGVLDWQRHGARRMIRHYLNLDTCLSQAFEMSRYFHIPIGNLPEDISTFG
SDLFFARHLQRHNHLLWLSPTARPDLGGKEADDNCLVMEFDDQATVEINSSGCYSTVC
VELDLQNLAVNTILQSHHVNDMEGADSMGISFDVIQQASLEDMITGGQAASAPASYDE
TALCSNTFRILKSMVVGWVKEITQYHNIYADNQVMHFYRWLRSPSSLLHDPALHRTLH
NMMKKLFLQLIAEFKRLGSSVIYANFNRIILCTKKRRVEDAIAYVEYITSSIHSKETF
HSLTISFSRCWEFLLWMDPSNYGGIKGKVSSRIHCGLQDSQKAGGAEDEQENEDDEEE
RDGEEEEEAEESNVEDLLENNWNILQFLPQAASCQNYFLMIVSAYIVAVYHCMKDGLR
RSAPGSTPVRRRGASQLSQEAEGAVGALPGMITFSQDYVANELTQSFFTITQKIQKKV
TGSRNSTELSEMFPVLPGSHLLLNNPALEFIKYVCKVLSLDTNITNQVNKLNRDLLRL
VDVGEFSEEAQFRDPCRSYVLPEVICRSCNFCRDLDLCKDSSFSEDGAVLPQWLCSNC
QAPYDSSAIEMTLVEVLQKKLMAFTLQDLVCLKCRGVKETSMPVYCTCAGDFALTIHT
QVFMEQIGIFRNIAQHYGMSYLLETLEWLLQKNPQLGH"
BASE COUNT 1602 a 1940 c 1942 g 1428 t
ORIGIN
1 cgccaaattt ctcccctgaa gcagaggtgg tagccaacgg ctccatgtct ctgaggagcg
61 gcgggcggcg gcgcgcggac ccaggcgcgg atggcgaggc cagcagggat gatggcgcca
121 cttcctcagt ttcggcactc aagcgcctgg aacggagtca gtggacggat aagatggatt
181 tgcggtttgg ttttgagcgg ctgaaggagc ctggtgagaa gacaggctgg ctcattaaca
241 tgcatcctac cgagatttta gatgaagata agcgcttagg cagtgcagtg gattactact
301 ttattcaaga tgacggaagc agatttaagg tggctttgcc ctataaaccg tatttctaca
361 ttgcgaccag aaagggttgt gagcgagaag tttcatcttt tctctccaag aagtttcagg
421 gcaaaattgc aaaagtggag actgtcccca aagaggatct ggacttgcca aatcacttgg
481 tgggtttgaa gcgaaattac atcaggctgt ccttccacac tgtggaggat cttgtcaaag
541 tgaggaagga gatctcccct gccgtgaaga agaacaggga gcaggatcac gccagcgacg
601 cgtacacagc tctgctttcc agtgttctgc agaggggcgg tgtcattact gatgaagagg
661 aaacctctaa gaagatagct gaccagttgg acaacattgt ggacatgcgc gagtacgatg
721 ttccctacca catccgcctc tccattgacc tgaagatcca cgtggctcat tggtacaatg
781 tcagataccg aggaaatgct tttccggtag aaatcacccg ccgagatgac cttgttgaac
841 gacctgaccc tgtggttttg gcatttgaca ttgagacgac caaactgccc ctcaagtttc
901 ctgatgctga gacagaccag attatgatga tttcctacat gatcgatggc cagggctacc
961 tcatcaccaa cagggagatt gtttcagaag atattgaaga ttttgagttc acccccaagc
1021 cagaatatga aggccccttt tgtgtcttca atgaacccga tgaggctcat ctgatccaaa
1081 ggtggtttga acacgtccag gagaccaaac ccaccatcat ggtcacctac aacggggact
1141 tttttgactg gccatttgtg gaggcccggg cagcagtcca cggtctgagc atgcagcagg
1201 agataggctt ccagaaggac agccaggggg agtacaaggc gccccagtgc atccacatgg
1261 actgcctcag gtgggtgaag agggacagtt accttcctgt gggcagtcat aatctcaagg
1321 cggccgccaa ggccaagcta ggctatgatc ccgtggagct agacccggag gacatgtgcc
1381 ggatggccac ggagcagccc cagactctgg ccacgtattc tgtgtcagat gctgtcgcca
1441 cttactacct gtacatgaag tacgtccacc cattcatctt tgctctgtgc accattattc
1501 ccatggagcc cgacgaggtg ctgcggaagg gctctggcac tctgtgtgag gccttgctga
1561 tggtgcaggc cttccacgcc aacatcatct tccccaacaa gcaagagcag gagttcaata
1621 agctgacgga cgacggacac gtgctggact ctgagaccta cgtcgggggc cacgtggagg
1681 ccctcgagtc tggggttttc cgcagcgata tcccttgccg gtttaggatg aatcctgccg
1741 cctttgactt cctgctgcag cgggttgaga agaccttgcg ccacgccctt gaggaagagg
1801 agaaagtgcc tgtggagcaa gtcaccaact ttgaagaggt gtgtgatgag attaagagca
1861 agcttgcctc cctgaaggac gttcccagcc gcatcgagtg tccactcatc taccacctgg
1921 acgtgggggc catgtacccc aacatcatcc tgaccaaccg cctgcagccc tctgccatgg
1981 tggacgaagc cacctgtgct gcctgtgact tcaataagcc tggagcaaac tgccagcgga
2041 agatggcctg gcagtggagg ggcgagttca tgccagccag tcgcagcgaa taccatcgga
2101 tccagcacca gctggagtca gagaagttcc cccccttgtt cccagagggg ccagctcggg
2161 cctttcatga actgtcccgc gaggaacagg cgaaatacga gaagagaagg ctggcggatt
2221 actgccggaa agcctacaag aagatccaca tcaccaaggt ggaagagcgt ctcaccacca
2281 tctgccagcg ggaaaactcc ttctacgtgg acaccgtgcg tgccttccgg gacaggcgtt
2341 acgagttcaa agggctccac aaggtgtgga aaaagaagct ctcggcggcc gtggaggtgg
2401 gcgacgcggc tgaggtgaag cgctgcaaga acatggaggt gctgtatgac tcgctgcagc
2461 tggcccacaa gtgcatcctg aactccttct atggctatgt catgcgcaag ggggctcgct
2521 ggtactccat ggagatggct ggcatcgtct gcttcacagg ggccaacatc atcacccagg
2581 cacgggagct gatcgagcag attgggaggc ccttagagct ggacacagat ggtatatggt
2641 gcgtcctgcc caacagcttc ccagaaaatt ttgtcttcaa gacgaccaat gtgaagaagc
2701 ccaaagtgac catctcctac ccaggcgcca tgttgaacat catggtcaag gaaggcttca
2761 ccaatgacca gtaccaggag ctggctgagc cgtcctcact cacctacgtc acccgctcag
2821 agaacagcat cttttttgag gttgatgggc cctaccttgc catgattctt ccagcctcca
2881 aggaagaagg caagaaattg aagaagaggt atgctgtgtt caatgaagac ggttctctgg
2941 ctgagctcaa gggctttgag gtcaaacgcc gcggggaact gcagctgatt aagatcttcc
3001 aatcctcggt gtttgaggcc ttcctcaagg gcagcacgct ggaagaggtg tatggctctg
3061 tagccaaggt ggctgactac tggctggacg tgctgtacag caaggcagcc aacatgcctg
3121 actctgagct attcgagctc atctctgaga accgttccat gtctcggaag ctggaagatt
3181 acggggagca gaagtctaca tccatcagca cagcaaagcg cctggccgag ttcctgggag
3241 accagatggt caaggatgca gggctgagtt gccgctacat catctcccgc aagcccgagg
3301 gctcccctgt cacggagagg gccatcccac ttgccatttt ccaagcagag cccacggtga
3361 ggaagcactt tctccggaaa tggctcaaga gctcttccct tcaagacttt gatattcgag
3421 caattctgga ttgggactac tacattgagc ggctgggaag cgccatccag aagatcatca
3481 ccatccctgc ggccctgcag caggtaaaga acccagtgcc acgtgtcaaa caccccgact
3541 ggctgcacaa aaaactgctg gagaagaatg atgtctacaa gcagaagaag atcagtgagc
3601 tcttcaccct ggagggcagg agacaggtca cgatggccga ggcctcagaa gacagtccga
3661 ggccaagtgc tcctgacatg gaggacttcg gcctcgtaaa gctgcctcac ccagcagccc
3721 ctgtcactgt gaagaggaag cgagttcttt gggagagcca ggaggagtcc caggacctca
3781 cgccgactgt gccctggcag gaaatcttgg ggcagcctcc cgccctggga accagccagg
3841 aggaatggct tgtctggctc cggttccaca agaagaagtg gcagctgcag gcccggcagc
3901 gcctcgcccg caggaagagg cagcgtctgg agtcggcaga gggtgtgctc aggcccgggg
3961 ccatccggga tggtcctgcc acggggctgg ggagcttctt gcgaagaact gcccgcagca
4021 tcctggacct tccgtggcag attgtgcaga tcagcgagac cagccaggcc ggcctgttca
4081 ggctgtgggc gctcgttggc agtgacttgc actgcatcag gctgagcatc ccccgtgtgt
4141 tctacgtgaa ccagcgagtc gctaaagcgg aggagggtgc ttcgtatcgc aaggtaaatc
4201 gggtccttcc tcgctccaac atggtctaca atctctatga gtattcagtg ccagaggaca
4261 tgtaccagga acacatcaac gagatcaacg ctgagctgtc agcgccagac atcgagggcg
4321 tatatgagac tcaggttccg ttactgttcc gggccctggt gcacctgggc tgtgtgtgtg
4381 tggtcaataa acagctggtg aggcaccttt caggctggga agcagagacc tttgctcttg
4441 agcacctgga gatgcgctct ctggcccagt tcagctacct ggaaccaggg agtatccgcc
4501 atatctacct gtaccaccac gcacaggccc acaaagcgct cttcgggatc ttcatcccct
4561 cacagcgcag ggcatccgtc tttgtgctgg acactgtgcg cagcaaccag atgcccagcc
4621 ttggcgccct gtactcagca gagcacggcc tcctcctgga gaaggtgggc cctgagctcc
4681 tgccaccccc caaacacacc ttcgaagttc gggcagaaac tgacctgaag accatctgca
4741 gagccatcca gcgattcctg ctcgcctaca aggaggagcg ccgggggccc acactcatcg
4801 ctgttcagtc cagctgggag ctgaagaggc tggccagtga aattcctgtc ttggaggaat
4861 tcccactggt gcctatctgt gtggctgaca agatcaacta tggggtcctg gactggcagc
4921 gccatggagc ccggcgcatg atccgtcact acctcaacct ggacacctgc ctgtcgcagg
4981 ccttcgagat gagcaggtac tttcacattc ccattgggaa cctaccagag gacatctcca
5041 cattcggctc cgacctcttc tttgcccgcc acctccagcg ccacaaccac ctgctctggc
5101 tgtcccctac agcccgccct gacctgggtg gaaaggaggc tgatgacaac tgtcttgtca
5161 tggagttcga tgaccaagcc actgttgaga tcaacagttc aggctgttac tccacagtgt
5221 gtgtggagct ggaccttcag aacctggccg tcaacaccat tctccagtct caccatgtca
5281 acgacatgga gggggccgac agcatgggga tcagcttcga cgtgatccag caggcctccc
5341 tggaggacat gatcacgggt ggtcaggctg ccagtgcccc ggccagctac gatgagacag
5401 ccctgtgctc taacaccttc aggatcctga agagcatggt cgtgggctgg gtgaaggaga
5461 tcacccagta ccacaacatc tatgcagaca accaggtgat gcacttctac cgctggcttc
5521 ggtcgccatc ctctctgctt catgaccctg ccctgcaccg cacactccac aacatgatga
5581 agaagctctt cctgcagctc atcgctgagt tcaagcgcct ggggtcatca gtcatctacg
5641 ccaacttcaa ccgcatcatc ctctgtacaa agaagcgccg tgtggaagat gccatcgctt
5701 acgtggagta catcaccagc agcatccatt caaaggagac cttccattct ctgacaattt
5761 ctttctctcg atgctgggaa tttcttctct ggatggatcc atctaactat ggcggaatca
5821 aaggaaaagt ttcatctcgt attcactgtg gactgcaaga ctcccagaaa gcagggggag
5881 cagaggatga gcaggaaaat gaggacgatg aggaggaaag agatggggag gaggaggaag
5941 aggcggagga atccaacgtg gaggatttac tggaaaacaa ctggaacatt ttgcagtttt
6001 tgccacaggc agcctcctgc cagaactact tcctcatgat tgtttcagcg tacatcgtgg
6061 ccgtgtacca ctgcatgaag gacgggctga ggcgcagtgc tccagggagc acccccgtga
6121 ggaggagggg ggccagccag ctctcccagg aggccgaggg ggcggtcgga gcccttcccg
6181 gaatgatcac cttctctcag gattatgtcg caaatgagct cactcagagc ttcttcacca
6241 tcactcagaa gattcagaag aaagtcacag gctctcggaa ctccactgag ctctcagaga
6301 tgtttcctgt cctccccggt tcccacttgc tgctcaataa ccctgccctg gagttcatca
6361 aatacgtgtg caaggtgctg tccctggaca ccaacatcac aaaccaggtg aataagctga
6421 accgagacct gcttcgcctg gtggatgtcg gcgagttctc cgaggaggcc cagttccgag
6481 acccctgccg ctcctacgtg cttcctgagg tcatctgccg cagctgtaac ttctgccgcg
6541 acctggacct gtgtaaagac tcttccttct cagaggatgg ggcggtcctg cctcagtggc
6601 tctgctccaa ctgtcaggcg ccctacgact cctctgccat cgagatgacg ctggtggaag
6661 ttctacagaa gaagctgatg gccttcaccc tgcaggacct ggtctgcctg aagtgccgcg
6721 gggtgaagga gaccagcatg cctgtgtact gcacgtgcgc gggagacttc gccctcacca
6781 tccacaccca ggtcttcatg gaacagatcg gaatattccg gaacattgcc cagcactacg
6841 gcatgtcgta cctcctggag accctggagt ggctgctgca gaagaaccca cagctgggcc
6901 attagccagc cc
//