LOCUS HUMTRHYAL 9551 bp DNA linear HUM 28-APR-1995
DEFINITION Human trichohyalin (TRHY) gene, complete cds.
ACCESSION L09190
VERSION L09190.1
KEYWORDS trichohyalin.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 9551)
AUTHORS Lee,S.C., Kim,I.G., Marekov,L.N., O'Keefe,E.J., Parry,D.A. and
Steinert,P.M.
TITLE The structure of human trichohyalin. Potential multiple roles as a
functional EF-hand-like calcium-binding protein, a cornified cell
envelope precursor, and an intermediate filament-associated
(cross-linking) protein
JOURNAL J. Biol. Chem. 268 (16), 12164-12176 (1993)
PUBMED 7685034
COMMENT Original source text: Homo sapiens placenta DNA.
FEATURES Location/Qualifiers
source 1..9551
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/map="1q21.1"
/tissue_type="placenta"
regulatory 58..61
/regulatory_class="CAAT_signal"
/gene="TRHY"
regulatory 117..123
/regulatory_class="TATA_box"
/gene="TRHY"
mRNA join(138..200,1476..1644,1507..1644,2512..9120)
exon 138..200
/number=1
intron 201..1475
/gene="TRHY"
/number=1
exon 1476..1644
/gene="TRHY"
/number=2
gene join(1507..1644,2512..8070)
/gene="TRHY"
CDS join(1507..1644,2512..8070)
/gene="TRHY"
/codon_start=1
/product="trichohyalin"
/protein_id="AAA65582.1"
/translation="MSPLLRSICDITEIFNQYVSHDCDGAALTKKDLKNLLEREFGAV
LRRPHDPKTVDLILELLDRDSNGRVDFNEFLLFIFKVAQACYYALGQATGLDEEKRAR
CDGKESLLQDRRTEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQER
LEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLEL
RRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEE
QLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEER
REQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQEEERREQQLRR
EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEE
ERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWL
KLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERLE
QLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKRE
EVERLEQEERRDERLKREEPEEERRHELLKSEEQEERRHEQLRREQQERREQRLKREE
EEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVLL
EAPQAGRAEAPQEQEEKRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERG
RQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRGRQRREREKELQFLEEEE
QLQRRERAQQLQEEEDGLQEDQERRRQEQRRDQKWRWQLEEERKRRRHTLYAKPALQE
QLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQE
RERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRR
QEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETR
RRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREERE
KRRRQELERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRE
NEQFRQLEDSQVRDRQSQQDLQHLLGEQQERDREQERRRWQQANRHFPEEEQLEREEQ
KEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLLRQERDRKF
REEELLHQEQGRKFLEEEQRLREERERKFLKEEQQLRLEEREQLRQDRDRKFREEEQQ
LSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHR
QERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQ
QLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERK
FMEDEQQLRRQEGQQQLRQEDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQ
EREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEE
QQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDR
KFREEEQLRQGREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQ
LEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRR
QQKEEQRHRQVGEIQSQEGKGHGRLLEPGTHQFASVPVRSSPLYEYIQEQRSQYRP"
intron 1645..2511
/number=2
exon 2512..9120
/gene="TRHY"
polyA_site 9120
/gene="TRHY"
regulatory 9121
/regulatory_class="polyA_signal_sequence"
/gene="TRHY"
BASE COUNT 2907 a 1975 c 2869 g 1800 t
ORIGIN
1 aacaagccat ttgtggagac agaggtggag ctgggcttgg ttaggaatga atcaggccat
61 tccacagagt gggtgtctcc ttcccaagtt gctttccagg gcacaattaa aacccctata
121 aaaggcccag ctcccagtta cccagtacac ttgcctgtgg tgtcagcaag cactgtcgac
181 ttcttcctct ggtgaagtgg gtaagtccca ttctgtggga tcgtggtctt ctttatgatt
241 ctccattttt atagctattt cagatgttgg gatatggggg gaggttccat gtgccagaag
301 gtatcagtat tgcagggata aataaactat cactaactct atcccatctt cttatggttg
361 gagccatcac ttgaactgaa gcatgaccct tctccttggg ctctgaactc tatacttctg
421 cacatcaagg atgatcatgt gtggctctga tagggttcat cttcctaaaa actgctatct
481 caaaagtttg ccagccttct gttctctttt acattggttc tacctaatat gggccatatt
541 catacagtca cagcatttaa ggtactggag ttgagaagta cataaagaag tcagctagat
601 gaacgactac cttatcccac cagcaaagcc attccatgta ttcttataac attgatctac
661 tgctggctaa tgttttataa aaagccaaga ttccaatgat gcatttgggt ttaacaaaac
721 caatatcatt cacagttttc tggattccgt ttggtttaga aaggacctct cagaagcttt
781 caatacttca atatccgaat atcttactat atctgagttg aggcaggtaa tatacagtct
841 ctgttttctg catttgtgta tctgaatgtt acatgccatc ttttgactag gaagaagtac
901 tatttaatct tagaattgct gacttacaaa ttatattcta taagagttcc taaatccctt
961 tatggactgt aatgttgagg aatcattcat attccctttt cattgttcta ttttctacca
1021 atcgttttgc tgacatggcc tctatccact ttaagatact ctcaagtctt ccttcacctt
1081 ttggctttac ctgtcctctt cgctcaactt taaaggaagg tgtgtagcca tatataaaat
1141 tttaatttct gcactcttct cttaattttc tactctgaaa tacggtggag agctggaaga
1201 aagacagaag aaaagggcat agataatcca cattgggtgg acaatcaaaa gctgacaaca
1261 ggatagtctg aagatgattc cctggcttgg aatttctcag gatcgctctt tctctttctg
1321 atacaatatt caaatattaa agtgctctga aagtccaggt tgaaattacc gctataaatt
1381 caaattattt agggatctgc ctgaaatagt gtgaatgaag ccttcccaaa agcagaaacg
1441 ggattttgat tctggatctt attttattgt tctaggttta cttgaacttg aaggaaagaa
1501 aaaaaaatgt ctccacttct gagaagcatc tgtgacatca ctgaaatttt caatcagtat
1561 gtctctcatg attgtgatgg agcagcatta actaagaaag acctgaagaa cctccttgaa
1621 agggaatttg gagctgtgct tcgggtaaga actaacaaga aaatgagatc tattgacttg
1681 aggctatgag atttattctc agaggagacc agagcaagga atggtggttt tatattcatt
1741 ttacaccaca acaggtctac actacatccc ccattcattt ctgagtcaaa aggtacttac
1801 ttgacattgt agtctgaata ataaagtatt tcatgtactt gatggcatgg catgtgaatg
1861 agctcttcat gggacattac tacaaaagat gtcaaatcac actagacttg gaggaacttg
1921 gaggaactta aatttgtttc caaatttcaa aactgagatc agcctgactc tattaaatgg
1981 tgctacccgt aaatgttttg ttctgttttc taatatggaa tagaaaccaa atcaagaata
2041 ctggctgctt cagacagaaa tggctactgc aaatcctcat aaatttctat tgtatctctc
2101 tcaaggatga gttcattctt tctcaattaa agcgaacttg tgttattctt tcttgatgtt
2161 gagtagcttt gttaatttac acacaagttc acgatgctgt tttgaatctt cacctcaggc
2221 tctgctctaa ggtgcgtagg cttacctgct atctacttgt gtctctcttc ctgcttcctt
2281 aggtttgatc agcactaaat tacgagatgt aaaaatttca aacgaatata tgctttaaag
2341 tgagggttca cattttacat ggggacaaaa cttgatacac actggacatt tttctaattg
2401 ctctgaatgt ctcttgaatg tcagcatagc ataaaatata tcatgtgtga atataatttt
2461 accacctgta aatagtgcat tgtaaaattt ttgtttttca ccattttata gagaccacat
2521 gaccctaaga cggtagatct gatcctggaa cttctggatc gtgacagtaa tgggcgtgtc
2581 gatttcaacg aattcctcct atttattttc aaagtggctc aagcttgtta ctatgctctc
2641 ggccaggcca cgggactgga tgaggagaag cgagcccggt gtgacggaaa ggagagcctg
2701 ttacaagatc gacggacaga agaagaccaa aggagattcg agccccggga cagacaactg
2761 gaagaagaac ctgggcaacg acgcaggcag aagaggcagg aacaggagag ggagctagct
2821 gagggagagg agcaaagtga gaaacaagag cgacttgaac agcgcgacag gcagcgccgc
2881 gacgaggagc tgtggcggca aaggcaagaa tggcaagaac gggaagagcg ccgtgcagag
2941 gaagagcagc tgcagagttg caaaggtcac gaaactgagg agtttccaga cgaagagcaa
3001 ctgcgaaggc gggagctgct ggagctgagg aggaagggcc gcgaggagaa acagcagcaa
3061 aggcgagagc gccaagacag agtgttccag gaggaagaag agaaagagtg gaggaagcgc
3121 gagacagtgc tccggaagga agaagagaag ttgcaggaag aggagccgca gcggcaaaga
3181 gagctccagg aggaagaaga gcagctacgg aagctggagc ggcaagagct gaggagggag
3241 cgccaggagg aagagcagca gcagcaaagg ctgaggcgcg agcagcaact aaggcgcaag
3301 caggaggagg agaggcgcga gcagcaggag gagaggcgcg agcagcagga gaggcgcgag
3361 cagcaggagg agaggcgcga gcagcagctg aggcgcgagc aggaggagag gcgcgagcag
3421 cagctgaggc gcgagcagga ggaggagagg cgcgagcagc agctgaggcg cgagcaggag
3481 gaggagaggc gcgagcagca gctgaggcgc gagcaggagg aggagaggcg cgagcagcag
3541 ctgaggcgcg agcagcagct gaggcgcgag cagcagctga ggcgcgagca gcagctgagg
3601 cgcgagcagc agctgaggcg cgagcagcag ctgaggcgcg agcagcagct gaggcgcgag
3661 cagcagctga ggcgcgagca gcagctgagg cgcgagcagc agctgaggcg cgagcaggag
3721 gaggagaggc acgagcagaa gcacgagcag gagaggcgcg agcagcggct gaagcgcgag
3781 caggaggaga ggcgcgattg gctgaagcgc gaggaggaga cggagaggca cgagcaggag
3841 aggcgcaagc agcagctgaa gcgcgaccag gaggaggaga ggcgcgaacg ttggctgaag
3901 ctcgaggagg aggagaggcg cgagcagcag gagaggcgcg agcagcaact aaggcgggag
3961 caagaggaga ggcgcgagca gcggctgaag cgccaggagg aggaagagag gctccagcag
4021 cggttgagga gcgagcaaca actaagacgc gagcaggagg agaggctcga gcagctgctg
4081 aagcgcgagg aggagaagag gctcgagcag gagaggcgag agcagcggct gaagcgcgag
4141 caggaggaga ggcgcgatca gctgctgaag cgcgaggagg agaggcgcca gcagcggctg
4201 aagcgcgagc aggaagagag gctcgagcag cgactgaagc gcgaggaggt ggagagactc
4261 gagcaggagg agaggcgcga cgagcggctg aagcgcgagg agccggagga agagaggcgc
4321 cacgagctgc tgaagagcga ggagcaggag gagaggcgcc acgagcaact gaggcgcgag
4381 cagcaggaaa ggcgcgagca gcggctgaag cgcgaggagg aggaagagag gctcgagcag
4441 cggctgaagc gcgagcatga ggaagagagg cgcgagcagg agctagctga ggaggagcag
4501 gaacaggccc gggagcggat taagagccgc atcccgaagt ggcagtggca gctagaaagc
4561 gaggccgacg cacggcaaag caaagtctta ctcgaggccc cgcaagcagg aagggcagag
4621 gcgccgcaag agcaggagga aaagaggcgg cgcgagagtg agctgcaatg gcaggaggag
4681 gaacgggctc accggcagca gcaggaagag gagcagcgcc gggacttcac atggcagtgg
4741 caggcggagg aaaagagcga gaggggccgt cagaggctgt cggccaggcc cccattgcgg
4801 gagcagcggg agaggcagct gagggccgag gagcgccagc agcgggaaca acggtttctc
4861 ccggaggagg aggagaagga gcagcgcggc cgccagcgac gcgagaggga gaaagagctg
4921 cagttcctgg aggaagagga gcagctccag cggcgggagc gtgcccaaca gctccaggag
4981 gaggaggacg gcctccagga ggatcaggag aggaggcgac aggagcagcg ccgcgaccaa
5041 aaatggaggt ggcaactaga agaagaaagg aagagacgcc gccacacgct gtacgccaag
5101 ccagccctac aagagcagct gaggaaggaa cagcagctgc tgcaggagga ggaggaggag
5161 ctacagagag aggagcgcga gaagagaagg cgccaagaac aggagagaca ataccgcgag
5221 gaagagcagc tgcagcagga ggaagagcag ctgctgagag aggaacggga gaaaagaaga
5281 cgccaggagc gggaaaggca atatcggaag gataagaagc tgcagcagaa ggaagagcag
5341 ctgctgggag aggaaccgga gaagagaagg cgccaggagc gggagaaaaa ataccgcgag
5401 gaagaggagt tgcagcagga ggaagagcag ctgctgagag aggaacggga gaagagaagg
5461 cgccaggagt gggagaggca gtaccgcaaa aaagacgagc tgcagcagga agaagagcag
5521 ctgctgagag aggaacggga gaaaagaaga ctccaggagc gggagaggca atatcgggag
5581 gaagaggagc tgcagcagga ggaagagcag ctgctgggag aggaacggga gacgagaagg
5641 cgccaggagc tggagaggca atatcggaag gaagaggagc tgcagcagga ggaagagcag
5701 ctgctgagag aggaaccgga gaagagaagg cgccaggagc gggagaggca atgtcgggag
5761 gaagaggagc tgcagcagga ggaagagcag ctgctgagag aggaacggga gaagagaagg
5821 cgccaggagc tggagaggca atatcgggag gaggaagagc ttcagcgcca gaaaaggaaa
5881 cagcgatacc gggatgagga tcagcgcagt gatctgaaat ggcagtggga accagaaaaa
5941 gaaaatgcag ttcgtgataa caaggtttac tgcaaaggca gagagaatga acagttccgg
6001 cagttggaag attcccaggt gcgcgacaga caatcccagc aagatctgca gcacctgctg
6061 ggtgaacagc aagagagaga tcgtgagcaa gagaggaggc gctggcagca ggccaacagg
6121 catttcccag aggaagaaca gctggagcga gaagagcaaa aggaagccaa aaggcgcgac
6181 aggaagtccc aagaggaaaa gcagttgctg agagaggaaa gagaagagaa gagacgccgt
6241 caagagacag acagaaaatt ccgcgaggag gaacagctgc tccaggaaag ggaggaacag
6301 ccgctgctcc gccaagagcg tgacagaaaa ttccgcgaag aggaactgct ccatcaggaa
6361 caagggagaa aattcctcga ggaggaacag cggctgcgcg aggaacggga gagaaaattc
6421 cttaaggagg aacagcagct gcgcctcgag gagcgcgagc aactgcgtca ggaccgcgac
6481 agaaaattcc gcgaggagga acagcagctg agccgccaag agcgtgacag aaaattccgt
6541 gaagaggaac agcaggtgcg ccgccaggaa cgagagagaa aattcctgga ggaggaacag
6601 cagctgcgcc aggagcgtca cagaaaattc cgcgaagagg aacagctgct ccaggaaagg
6661 gaagaacagc agctgcaccg ccaagagcgt gacagaaaat tcctggagga ggaacaacag
6721 ctgcgccgcc aagagcgtga cagaaaattc cgcgaacagg aactgcgcag tcaggaacca
6781 gagagaaaat tcctcgagga ggaacagcag ctgcaccgcc agcaacggca gagaaaattc
6841 ctccaggagg aacagcagct gcgccgccag gagcgcgggc aacagcggcg tcaggaccgt
6901 gacagaaaat tccgcgagga ggaacagctg cgccaggaga gggaggaaca gcagctgagc
6961 cgccaagagc gtgacagaaa attccgttta gaggaacaga aagtgcgccg ccaggaacaa
7021 gagagaaaat tcatggagga cgaacagcag ctgcgccgcc aggagggcca acaacagctg
7081 cgccaggagg acagaaaatt ccgcgaagac gaacagctgc tccaggaaag ggaagaacag
7141 cagctgcacc gccaagagcg tgacagaaaa ttcctcgagg aggaaccgca gctgcgccgc
7201 caggagcgcg aacaacagct gcgtcacgac cgcgacagaa aattccgtga agaggaacag
7261 ctgctccagg aaggggagga acagcagctg cgccgccaag agcgtgacag aaaattccgc
7321 gaagaggaac agcagctccg ccgtcaggaa cgagagagaa aattcctcca ggaggaacag
7381 cagctgcgcc gccaggaact ggagagaaaa ttccgtgagg aggaacagct gcgccaagaa
7441 acggagcaag agcagctgcg ccgccaagaa cgctacagaa aaatcctaga ggaagagcag
7501 ctccgtccgg aaagggaaga acagcagctg cgccgccagg agcgcgacag aaaattccgc
7561 gaggaggaac agctccgcca gggaagggag gaacagcagc tgcgcagcca agagtctgac
7621 agaaaattcc gcgaggagga acagctacgc caggagaggg aagaacagca gctccgcccc
7681 caacagcgtg acggaaagta tcgctgggaa gaagagcagc tccaacttga ggaacaagag
7741 cagaggctgc ggcaggagcg agaccggcag taccgggcgg aggagcagtt tgccacgcag
7801 gagaagagtc gtcgtgagga acaagaacta tggcaagaag aggagcagaa acgtcgccag
7861 gaacgggaaa ggaaattacg ggaagaacac atccgccgcc agcagaagga ggaacagagg
7921 caccgccaag tcggggagat acaatcccaa gaagggaagg gccatgggcg gcttctggag
7981 cccggcactc atcagtttgc cagtgtccca gtgcgctcca gccctctcta tgagtacatc
8041 caagagcaga gatctcaata ccgcccttaa gtgatgttgc caatatcttg acacctgcca
8101 aagcttccag cacgggaaaa tgagaaacac tgggtaccaa gtgataactc agatgtttct
8161 ggttgtggga aaactctctg atattagaat gtcttttctt ccaaaatctt aaactacgct
8221 cattttacgc actttgtact tctgcttttt attcttcctc aagtagttct ttactgcaag
8281 atgtctttct tttgctcttt gatgcagatg tggtgtgcat ttaaaaaaaa tataaatcat
8341 ttaatttgtt taagaaattt tgtttgagga acatgttcat ttattgcttt cagaagtaac
8401 aagagtaata ggatgatttg agattctaaa caatgggtcg gtttgtttaa tgactgaccc
8461 atcttgtgga aagtgcagat acttttaatg ttcaagttgc tatttcttct tgaacctaaa
8521 ttgatcattg cctccaaaca gcatttcatc cttttgtggc atagttagca caaattccag
8581 gtaactaaat ttttataacc cttgaatagt gcagggggag tgacctctgc ataaaaactt
8641 cctgtaaaat cagcccatta ctggaagaaa tatctgttaa gaataggttt agctttgaag
8701 atttagaatt taaattagat tttttttaaa ctcaactcca cttaaacaca taatctcatg
8761 aagaaataat gaggtattta gaatttaaat gagttcaaat tttaaaactg tgtctgttgt
8821 agtctatagt gttcattcta cttccccaag ttttgatgag tttcagaata ttatgaacct
8881 ttgttaattt tagcttgtta gaaggaagct gctcagaatc ccataaacat ctgtcttact
8941 ctagggccaa taagagatca catagagcat gttgggggtg taaaagggaa aaatgtgtga
9001 acataggggc aaatttctag aggccctttg acaagaccca tttgcccaca atcatttgag
9061 gcctattgat aataccttag atatattctt gttgaaataa ttggactgtg aaaaattaat
9121 aataaatgtt tggcaagtaa ctacttttgt ctgttttaac tctgcgtcaa tcataacaag
9181 atctcattgt ctggaaacta acacaagttc ccaatcacat aagggcattt tgttacttat
9241 ctatgtccaa atacgaaaaa agaggggaga gaattctttg tttttcccca accttttttt
9301 tttttttttt tttttttttt tgcagttagg ctgaactcta tttccatccc cacactgaga
9361 ttgccttcca gagtgttttt gttcttgacc cacagctttc tatgccattc ttgcagcgac
9421 tcactggtca tgacaaatac tggtgctccc aatatttgtt aatatttcct ttagagaatg
9481 cagcagcttc ttcgtctctg atgtctgatg agccaatgat agaaaatggc ctgaaacttc
9541 agatcctcga g
//