LOCUS HUMDMKIN 13747 bp DNA linear HUM 26-JUL-2016
DEFINITION Homo sapiens DMR-N9, partial cds; and myotonic dystrophy kinase (DM
kinase) gene, complete cds.
ACCESSION L08835
VERSION L08835.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 13747)
AUTHORS Mahadevan,M.S., Amemiya,C.T., Jansen,G., Sabourin,L., Baird,S.,
Neville,C.E., Wormskamp,N., Segers,B., Lamerdin,J., de Jong,P.,
Wieringa,B. and Korneluk,R.G.
TITLE Structure and genomic sequence of the myotonic dystrophy (DM
kinase) gene
JOURNAL Hum. Mol. Genet. 2 (3), 299-304 (1993)
PUBMED 8499920
FEATURES Location/Qualifiers
source 1..13747
/organism="Homo sapiens"
/mol_type="unassigned DNA"
/db_xref="taxon:9606"
/map="19"
CDS <234..281
/note="putative"
/codon_start=1
/product="DMR-N9"
/protein_id="AAC14447.1"
/translation="GISSQPGNSPSGTVV"
regulatory 720..725
/regulatory_class="polyA_signal_sequence"
/note="two weak, non-consensus signals; putative"
regulatory 767..773
/regulatory_class="polyA_signal_sequence"
/note="two weak, non-consensus signals; putative"
mRNA join(1394..2329,4661..4752,5008..5091,5171..5266,
5889..6037,6311..6404,6658..6864,6941..7204,8527..8612,
10739..10850,11566..11723,11829..11926,12098..12144,
12434..12523,12854..13747)
/gene="DM kinase"
/note="transcript utilizes longer exon 8b"
mRNA join(1394..2329,4661..4752,5008..5091,5171..5266,
5889..6037,6311..6404,6658..6864,6941..7204,8527..8612,
10739..10850,11566..11723,11829..11926,12854..13747)
/gene="DM kinase"
/note="alternative transcipt in heart, lacks exons 13 and
14, utilizes the longer exon 8b"
mRNA join(1394..2329,4661..4752,5008..5091,5171..5266,
5889..6037,6311..6404,6658..6864,6941..7189,8527..8612,
10739..10850,11566..11723,11829..11926,12098..12144,
12434..12523,12854..13747)
/gene="DM kinase"
/note="transcript using shorter exon 8a"
mRNA join(1394..2329,4661..4752,5008..5091,5171..5266,
5889..6037,6311..6404,6658..6864,6941..7189,8527..8612,
10739..10850,11566..11723,11829..11926,12854..13747)
/gene="DM kinase"
/note="alternative transcript in heart, lacks exons 13 and
14, utilizes the shorter exon 8a"
exon 1394..2329
/gene="DM kinase"
/note="putative"
/number=1
5'UTR 1394..2169
/gene="DM kinase"
/note="putative"
gene 2170..13006
/gene="DM kinase"
CDS join(2170..2329,4661..4752,5008..5091,5171..5266,
5889..6037,6311..6404,6658..6864,6941..7204,8527..8612,
10739..10850,11566..11723,11829..11926,12098..12144,
12434..12523,12854..13006)
/gene="DM kinase"
/note="CDS using longer exon 8b"
/codon_start=1
/product="myotonic dystrophy kinase"
/protein_id="AAC14449.1"
/translation="MSAEVRLRRLQQLVLDPGFLGLEPLLDLLLGVHQELGASELAQD
KYVADFLQWAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIM
NKWDMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLL
SKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCL
KLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQT
PFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFR
THPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFDLVEDGLTAMVSGGGETLSDIREGA
PLGVHLPFVGYSYSCMALRDSEVPGPTPMEVEAEQLLEPHVQAPSLEPSVSPQDETAE
VAVPAAVPAAEAEAEVTLRELQEALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEA
RNRDLEAHVRQLQERMELLQAEGATAVTGVPSPRATDPPSHLDGPPAVAVGQCPLVGP
GPMHRRHLLLPARVPRPGLSEALSLLLFAVVLSRAAALGCIGLVAHAGQLTAVWRRPG
AARAP"
CDS join(2170..2329,4661..4752,5008..5091,5171..5266,
5889..6037,6311..6404,6658..6864,6941..7189,8527..8612,
10739..10850,11566..11723,11829..11926,12098..12144,
12434..12523,12854..13006)
/gene="DM kinase"
/note="CDS using shorter exon 8a"
/codon_start=1
/product="myotonic dystrophy kinase"
/protein_id="AAC14448.1"
/translation="MSAEVRLRRLQQLVLDPGFLGLEPLLDLLLGVHQELGASELAQD
KYVADFLQWAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIM
NKWDMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLL
SKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCL
KLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQT
PFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFR
THPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFDLVEDGLTAMETLSDIREGAPLGVH
LPFVGYSYSCMALRDSEVPGPTPMEVEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPA
AVPAAEAEAEVTLRELQEALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDL
EAHVRQLQERMELLQAEGATAVTGVPSPRATDPPSHLDGPPAVAVGQCPLVGPGPMHR
RHLLLPARVPRPGLSEALSLLLFAVVLSRAAALGCIGLVAHAGQLTAVWRRPGAARAP
"
CDS join(2170..2329,4661..4752,5008..5091,5171..5266,
5889..6037,6311..6404,6658..6864,6941..7204,8527..8612,
10739..10850,11566..11723,11829..11926,12854..12861)
/gene="DM kinase"
/note="found in heart cDNA clones, contains exon 8a,
lacking exons 13 and 14 resulting in frameshift and early
translation"
/codon_start=1
/product="myotonic dystrophy kinase"
/protein_id="AAC14451.1"
/translation="MSAEVRLRRLQQLVLDPGFLGLEPLLDLLLGVHQELGASELAQD
KYVADFLQWAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIM
NKWDMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLL
SKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCL
KLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQT
PFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFR
THPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFDLVEDGLTAMVSGGGETLSDIREGA
PLGVHLPFVGYSYSCMALRDSEVPGPTPMEVEAEQLLEPHVQAPSLEPSVSPQDETAE
VAVPAAVPAAEAEAEVTLRELQEALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEA
RNRDLEAHVRQLQERMELLQAEGATGP"
CDS join(2170..2329,4661..4752,5008..5091,5171..5266,
5889..6037,6311..6404,6658..6864,6941..7189,8527..8612,
10739..10850,11566..11723,11829..11926,12854..12861)
/gene="DM kinase"
/note="found in heart cDNA clones, contains exon 8a,
lacking exons 13 and 14 resulting in frameshift and early
translation termination"
/codon_start=1
/product="myotonic dystrophy kinase"
/protein_id="AAC14450.1"
/translation="MSAEVRLRRLQQLVLDPGFLGLEPLLDLLLGVHQELGASELAQD
KYVADFLQWAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIM
NKWDMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLL
SKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCL
KLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQT
PFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFR
THPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFDLVEDGLTAMETLSDIREGAPLGVH
LPFVGYSYSCMALRDSEVPGPTPMEVEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPA
AVPAAEAEAEVTLRELQEALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDL
EAHVRQLQERMELLQAEGATGP"
intron 2330..4660
/gene="DM kinase"
/number=1
exon 4661..4752
/gene="DM kinase"
/note="putative"
/number=2
intron 4753..5007
/gene="DM kinase"
/number=2
exon 5008..5091
/gene="DM kinase"
/note="putative"
/number=3
intron 5092..5170
/gene="DM kinase"
/number=3
exon 5171..5266
/gene="DM kinase"
/note="putative"
/number=4
intron 5267..5888
/gene="DM kinase"
/number=4
variation 5285
/gene="DM kinase"
/note="a G to T polymorphism in intron 4 resulting in a
polymorphic HphI site"
/frequency="0.87"
/replace="t"
exon 5889..6037
/gene="DM kinase"
/note="putative"
/number=5
intron 6038..6310
/gene="DM kinase"
/number=5
variation 6043
/gene="DM kinase"
/note="a C to T change in intron 5 results in a
polymorphic HhaI site"
/frequency="0.45"
/replace="c"
exon 6311..6404
/gene="DM kinase"
/note="putative"
/number=6
intron 6405..6657
/gene="DM kinase"
/number=6
exon 6658..6864
/gene="DM kinase"
/note="putative"
/number=7
intron 6865..6940
/gene="DM kinase"
/number=7
exon 6941..7204
/gene="DM kinase"
/note="longer version of exon 8, including last 15 bp (ie
5 codons); putative"
exon 6941..7189
/gene="DM kinase"
/note="shorter version of exon 8, with last 15 bp deleted
(ie. 5 codons); putative"
intron 7190..8526
/gene="DM kinase"
intron 7205..8526
/gene="DM kinase"
variation 8157
/gene="DM kinase"
/note="submitted sequence is smaller of two alleles (freq.
0.47)resulting from a 1 kb deletion of 3 Alu elements from
larger allele. DM is in total linkage disequilibrium with
this larger allele"
/frequency="0.53"
exon 8527..8612
/gene="DM kinase"
/note="putative"
/number=9
intron 8613..10738
/gene="DM kinase"
/number=9
variation 10693
/gene="DM kinase"
/note="a T to G change in intron 9 results in a
polymorphic HinfI site"
/frequency="0.47"
/replace="t"
exon 10739..10850
/gene="DM kinase"
/note="putative"
/number=10
intron 10851..11565
/gene="DM kinase"
/number=10
exon 11566..11723
/gene="DM kinase"
/note="putative"
/number=11
intron 11724..11828
/gene="DM kinase"
/number=11
variation 11780
/gene="DM kinase"
/note="a G to T change results in a polymorphic Fnu4HI
site"
/frequency="0.55"
/replace="g"
exon 11829..11926
/gene="DM kinase"
/note="putative"
/number=12
intron 11927..12853
/gene="DM kinase"
/note="found in alternate transcripts in heart tissue"
intron 11927..12097
/gene="DM kinase"
/number=12
exon 12098..12144
/gene="DM kinase"
/note="exon 13 along with exon 14 is deleted in some cDNA
clones derived from a human heart cDNA library, resulting
in a frameshift and earlier translational stop codon.;
putative"
/number=13
intron 12143..12433
/gene="DM kinase"
/number=13
exon 12434..12523
/gene="DM kinase"
/note="exon 14 along with exon 13 is deleted from some
cDNA clones derived from a human heart cDNA library. This
results in a frameshift and an earlier translational stop
codon.; putative"
/number=14
intron 12524..12853
/gene="DM kinase"
/number=14
variation 12581
/gene="DM kinase"
/note="a G to T sequence change in intron 14"
/frequency="0.45"
/replace="t"
exon 12854..13747
/gene="DM kinase"
/note="putative"
/number=15
variation 13230
/gene="DM kinase"
/note="Polymorphic trinucleotiderepeat ranging from 5 to
30 in normal population. In DM individuals, repeat is
unstable with copy number ranging from 50 to more than
2000"
/replace="ctg"
regulatory 13725..13730
/regulatory_class="polyA_signal_sequence"
/gene="DM kinase"
/note="putative"
BASE COUNT 2681 a 4012 c 4207 g 2847 t
ORIGIN
1 ggatccgcca aggactttga ttattgcgtg aaagtgctga ctgccaggac aggaagctag
61 ctaagatgca agttcccagc ctagagcagt ggcctctggg gggtctaggg cggacccaag
121 ggcaaggcca gggtggcagc agcttgggga ctctggctgg ctccctcccc tgacactggc
181 tgaagcccag gtggtctcta acccctccca tctctccctc tcatcttccc cagggcatct
241 cctcccaacc aggcaactcc ccgagtggca cagtggtgtg aagccatgga tatcgggccc
301 ccccaacccc atgcccccag cctcctagcc ataaccctcc ctgctgacct cacagatcaa
361 cgtattaaca agactaacca tgatggatgg actgctccag tccccccacc tgcacaaaat
421 ttgggggccc cccagactgg cccggacacg ggcgatgtaa tagcccttgt ggcctcagcc
481 ttgtccccca cccactgcca agtacaatga cctcttcctc tgaaacatca gtgttaccct
541 catccctgtc cccagcatgt gactggtcac tcctggggag acactccccg cccctgccac
601 aagagcccca ggtctgcagt gtgcccctca gttgagtggg cagggccggg ggtggtccag
661 ccctcgcccg gcccccaccc cagctgccct tgctattgtc tgtgcttttg aagagtgtta
721 aattatggaa gcccctcagg ttcctccctg tcccgcagga cctcttattt atactaaagt
781 tccctgtttt ctcagcgggt ctgtcccctt cggaggagat gatgtagagg acctgtgtgt
841 gtactctgtg gttctaggca gtccgctttc cccagaggag gagtgcaggc ctgctcccag
901 cccagcgcct cccacccctt ttcatagcag gaaaagccgg agcccaggga gggaacggac
961 ctgcgagtca cacaactggt gacccacacc agcggctgga gcaggaccct cttggggaga
1021 agagcatcct gcccgcagcc agggcccctc atcaaagtcc tcggtgtttt ttaaattatc
1081 agaactgccc aggaccacgt ttcccaggcc ctgcccagct gggactcctc ggtccttgcc
1141 tcctagtttc tcaggcctgg ccctctcaag gcccaggcac cccaggccgg ttggaggccc
1201 cgacttccac tctggagaac cgtccaccct ggaaagaaga gctcagattc ctcttggctc
1261 tcggagccgc agggagtgtg tcttcccgcg ccaccctcca ccccccgaaa tgtttctgtt
1321 tctaatccca gcctgggcag gaatgtggct ccccggccag gggccaagga gctattttgg
1381 ggtctcgttt gcccagggag ggcttggctc caccactttc ctcccccagc ctttgggcag
1441 caggtcaccc ctgttcaggc tctgagggtg ccccctcctg gtcctgtcct caccacccct
1501 tccccacctc ctgggaaaaa aaaaaaaaaa aaaaaaaaag ctggtttaaa gcagagagcc
1561 tgagggctaa atttaactgt ccgagtcgga atccatctct gagtcaccca agaagctgcc
1621 ctggcctccc gtccccttcc caggcctcaa cccctttctc ccacccagcc ccaaccccca
1681 gccctcaccc cctagccccc agttctggag cttgtcggga gcaagggggt ggttgctact
1741 gggtcactca gcctcaattg gccctgttca gcaatgggca ggttcttctt gaaattcatc
1801 acacctgtgg cttcctctgt gctctacctt tttattgggg tgacagtgtg acagctgaga
1861 ttctccatgc attcccccta ctctagcact gaagggttct gaagggccct ggaaggaggg
1921 agcttggggg gctggcttgt gaggggttaa ggctgggagg cgggaggggg gctggaccaa
1981 ggggtgggga gaaggggagg aggcctcggc cggccgcaga gagaagtggc cagagaggcc
2041 caggggacag ccagggacag gcagacatgc agccagggct ccagggcctg gacaggggct
2101 gccaggccct gtgacaggag gaccccgagc ccccggcccg gggaggggcc atggtgctgc
2161 ctgtccaaca tgtcagccga ggtgcggctg aggcggctcc agcagctggt gttggacccg
2221 ggcttcctgg ggctggagcc cctgctcgac cttctcctgg gcgtccacca ggagctgggc
2281 gcctccgaac tggcccagga caagtacgtg gccgacttct tgcagtgggg tgagtgccta
2341 ccctcggggc tcctgcagat ggggtggggg tggggcagca gacagctctg ggcacagagg
2401 cctggctgtt gggggggggc agcatggcag gatgggcatg gggagatcct cccatcctgg
2461 ggctcagagt gtggacctgg gccctggggc aacatttctc tgtcctatgc caccactctg
2521 gaggggcaga gtaaggtcag cagaggctag ggtggctgtg actcagagcc atggcttagg
2581 agtcacagca ggctaggctg ccaacagcct cccatggcct ctctgcaccc cgcctcaggg
2641 tcagggtcag ggtcatgctg ggagctccct ctcctaggac cctcccccca aaagtgggct
2701 ctatggccct ctcccctggt ttcctgtggc ctggggcaag ccaggagggc cagcatgggg
2761 cagctgccag gggcgcagcc gacaggcagg tgttcggcgc cagcctctcc agctgcccca
2821 acaggtgccc aggcgctggg agggcggtga ctcacgcggg ccctgtggga gaaccagctt
2881 tgcagacagg cgccaccagt gccccctcct ctgcgatcca ggagggacaa ctttgggttc
2941 ttctgggtgt gtctccttct ttagtaggtt ctgcacccac ccccaccccc agccccaaag
3001 tctcggttcc tatgagccgt gtgggtcaga caccattccc gccaccccgg gtccctgcgt
3061 cctttagttc tcctggccca gggcctccaa ccttccagct gtcccacaaa accccttctt
3121 gcaagggctt tccagggcct ggggccaggg ctggaaggag gatgcttccg cttctgccag
3181 ctgccttgtc tgcccaacct cctccccaag cccaggactc gggctcactg gtcactggtt
3241 tctttcattc ccagcaccct gctcctctgg ccctcatatg tctggccctc agtgactggt
3301 gtttggtttt tgggctgtgt gtaacaaact gtgtgtgaca cttgtttcct gtttctccgc
3361 cttcccctgc ttcctcttgt gtccatctct ttctgaccca ggcctggttc ctttccctcc
3421 tcctcccatt tcacagatgg gaaggtggcg gccaagaagg gccaggccat tcagcctctg
3481 gaaaaacctt ctcccaacct cccacagccc ctaatgactc tcctggcctc cctttagtag
3541 aggatgaagt tgggttggca gggtaaactg agaccgggtg gggtaggggt ctggcgctcc
3601 cgggaggagc actccttttg tggcccgagc tgcatctcgc ggcccctccc ctgccaggcc
3661 tggggcgggg gagggggcca gggttcctgc tgccttaaaa gggctcaatg tcttggctct
3721 ctcctccctc ccccgtcctc agccctggct ggttcgtccc tgctggccca ctctcccgga
3781 accccccgga acccctctct ttcctccaga acccactgtc tcctctcctt ccctcccctc
3841 ccatacccaa ccctctctcc atcctgtcct ccacttcttc cacccccggg agagccaggc
3901 ctcccctgtg ccccacagtg ccctgaggcc acaagcctcc accccagctg gtccccaccc
3961 aggctgccca gtttaacatt cctagtcata ggaccttgac ttctgagagg cctgattgtc
4021 atctgtaaat aaggggtagg actaaagcac tcctcctgga ggactgagag atgggctgga
4081 ccggagcact tgagtctggg atatgtgacc atgctacctt tgtctccctg tcctgttcct
4141 tcccccagcc ccaaatccag ggttttccaa agtgtggttc aagaaccacc tgcatctgaa
4201 tctagaggta ctggatacaa ccccacgtct gggccgttac ccaggacatt ctacatgaga
4261 acgtgggggt ggggccctgg ctgcacctga actgtcacct ggagtcaggg tggaaggtgg
4321 aagaactggg tcttatttcc ttctcccctt gttctttagg gtctgtcctt ctgcagactc
4381 cgttacccca ccctaaccat cctgcacacc cttggagccc tctgggccaa tgccctgtcc
4441 cgcaaagggc ttctcaggca tctcacctct atgggagggc atttttggcc cccagaacct
4501 tacacggtgt ttatgtgggg aagcccctgg gaagcagaca gtcctagggt gaagctgaga
4561 ggcagagaga aggggagaca gacagagggt ggggctttcc cccttgtctc cagtgccctt
4621 tctggtgacc ctcggttctt ttcccccacc acccccccag cggagcccat cgtggtgagg
4681 cttaaggagg tccgactgca gagggacgac ttcgagattc tgaaggtgat cggacgcggg
4741 gcgttcagcg aggtaagccg aaccgggcgg gagcctgact tgactcgtgg tgggcggggc
4801 ataggggttg gggcgggccc ttagaaattg atgaatgacc gagccttaga acctagggct
4861 gggctggagg cggggcttgg gaccaatggg cgtggtgtgg caggtggggc ggggccacgg
4921 ctgggtgcag aagcgggtgg agttgggtct gggcgagccc ttttgttttc ccgccgtctc
4981 cactctgtct cactatctcg acctcaggta gcggtagtga agatgaagca gacgggccag
5041 gtgtatgcca tgaagatcat gaacaagtgg gacatgctga agaggggcga ggtgaggggc
5101 tgggcggacg tggggggctt tgaggatccg cgccccgtct ccggctgcag ctcctccggg
5161 tgccctgcag gtgtcgtgct tccgtgagga gagggacgtg ttggtgaatg gggaccggcg
5221 gtggatcacg cagctgcact tcgccttcca ggatgagaac tacctggtga gctccgggcc
5281 ggggggacta ggaagaggga caagagcccg tgctgtcact ggacgaggag gtggggagag
5341 gaagctctag gattgggggt gctgcccgga aacgtctgtg ggaaagtctg tgtgcggtaa
5401 gagggtgtgt caggtggatg aggggccttc cctatctgag acggggatgg tgtccttcac
5461 tgcccgtttc tggggtgatc tgggggactc ttataaagat gtctctgttg cggggggtct
5521 cttacctgga atgggatagg tcttcaggaa ttctaacggg gccactgcct agggaaggag
5581 tgtctgggac ctattctctg ggtgttgggt ggcctctggg ttctctttcc cagaacatct
5641 cagggggagt gaatctgccc agtgacatcc caggaaagtt tttttgtttg tgtttttttt
5701 tgaggggcgg gggcgggggc cgcaggtggt ctctgatttg gcccggcaga tctctatggt
5761 tatctctggg ctggggctgc aggtctctgc ccaaggatgg ggtgtctctg ggaggggttg
5821 tcccagccat ccgtgatgga tcagggcctc aggggactac caaccaccca tgacgaaccc
5881 cttctcagta cctggtcatg gagtattacg tgggcgggga cctgctgaca ctgctgagca
5941 agtttgggga gcggattccg gccgagatgg cgcgcttcta cctggcggag attgtcatgg
6001 ccatagactc ggtgcaccgg cttggctacg tgcacaggtg ggtgcagcat ggccgagggg
6061 atagcaagct tgttccctgg ccgggttctt ggaaggtcag agcccagaga ggccagggcc
6121 tggagaggga ccttcttggt tggggcccac cggggggtgc ctgggagtag gggtcagaac
6181 tgtagaagcc ctacaggggc ggaacccgag gaagtggggt cccaggtggc actgcccgga
6241 ggggcggagc ctggtgggac cacagaaggg aggttcattt atcccaccct tctcttttcc
6301 tcccgtgcag ggacatcaaa cccgacaaca tcctgctgga ccgctgtggc cacatccgcc
6361 tggccgactt cggctcttgc ctcaagctgc gggcagatgg aacggtgagc cagtgccctg
6421 gccacagagc aactggggct gctgatgagg gatggaaggc acagagtgtg ggagcgggac
6481 tggatttgga ggggaaaaga ggtggtgtga cccaggctta agtgtgcatc tgtgtggcgg
6541 agtattagac caggcagagg gaggggctaa gcatttgggg agtggttgga aggagggccc
6601 agagctggtg ggcccagagg ggtgggccca agcctcgctc tgctcctttt ggtccaggtg
6661 cggtcgctgg tggctgtggg caccccagac tacctgtccc ccgagatcct gcaggctgtg
6721 ggcggtgggc ctgggacagg cagctacggg cccgagtgtg actggtgggc gctgggtgta
6781 ttcgcctatg aaatgttcta tgggcagacg cccttctacg cggattccac ggcggagacc
6841 tatggcaaga tcgtccacta caaggtgagc acggccgcag ggagacctgg cctctcccgg
6901 taggcgctcc caggctatcg cctcctctcc ctctgagcag gagcacctct ctctgccgct
6961 ggtggacgaa ggggtccctg aggaggctcg agacttcatt cagcggttgc tgtgtccccc
7021 ggagacacgg ctgggccggg gtggagcagg cgacttccgg acacatccct tcttctttgg
7081 cctcgactgg gatggtctcc gggacagcgt gccccccttt acaccggatt tcgaaggtgc
7141 caccgacaca tgcaacttcg acttggtgga ggacgggctc actgccatgg tgagcggggg
7201 cggggtaggt acctgtggcc cctgctcggc tgcgggaacc tccccatgct ccctccataa
7261 agttggagta aggacagtgc ctaccttctg gggtcctgaa tcactcattc cccagagcac
7321 ctgctctgtg cccatctact actgaggacc cagcagtgac ctagacttac agtccagtgg
7381 gggaacacag agcagtcttc agacagtaag gccccagagt gatcagggct gagacaatgg
7441 agtgcagggg gtgggggact cctgactcag caaggaaggt cctggagggc tttctggagt
7501 ggggagctat ctgagctgag acttggaggg atgagaagca ggagaggact cctcctccct
7561 taggccgtct ctcttcaccg tgtaacaagc tgtcatggca tgcttgctcg gctctgggtg
7621 cccttttgct gaacaatact ggggatccag cacggaccag atgagctctg gtccctgccc
7681 tcatccagtt gcagtctaga gaattagaga attatggaga gtgtggcagg tgccctgaag
7741 ggaagcaaca ggatacaaga aaaaatgatg ggcggcaggc aacgggtggg ctcacgcctg
7801 taacccccag caatttggca ggccgaagtg ggtggattgc ttgagcccag gagttcgaga
7861 ccagcctggg caatgtggtg agacccccgt ctctacaaaa atgttttaaa aattggttgg
7921 gcgtggtggc gcatgcctgt atactcagct actagggtgg ccgacgtggg cttgagccca
7981 ggaggtcaag gctgcagtga gctgtgattg tgccactgca ctccagcctg ggcaacggag
8041 agagactctg tctcaaaaat aagataaact gaaattaaaa aataggctgg gctggccggg
8101 cgtggtggct cacgcctgta atctcagcac tttgggaggc cgaggcgggt ggatcacgag
8161 gtcagaagat ggagaccagc ctggccagcg tggcgaaacc ccgtctctac ccaaaaatat
8221 aaaaaattag ccaggcgtgg tagagggcgc ctgtaatctc agctactcag gacgctgagg
8281 caggagaatc gcctgaacct gggaggcgga ggttgcagtg agctgagatt gcaccactgc
8341 actccagcct gggtaacaga gcgagactcc gtatcaaaga aaaagaaaaa agaaaaaatg
8401 ctggaggggc cactttagat aacccctgag ttggggctgg tttgggggga acatgtaagc
8461 caagatccaa aagcagtgag gggcccgccc tgacgactgc tgctcacatc tgtgtgtctt
8521 gcgcaggaga cactgtcgga cattcgggaa ggtgcgccgc taggggtcca cctgcctttt
8581 gtgggctact cctactcctg catggccctc aggtaagcac tgccctggac ggcctccagg
8641 ggacacgagg ctgcttgagc ttcctgggtc ctgctccttg gcagccaatg gagttgcagg
8701 atcagtcttg gaacctcact gtttggggcc cacagactcc taagaggcca gagttggagg
8761 accttaaatt tctcagatct atgtacttca aatgttagat tgaattttaa aacctcagag
8821 tcacagactg ggcttcccag aatcttgtaa ccattaactt ttacgtctgt agtacacaga
8881 gccacaggac ttcagaactt ggcaaatatg aagtttagac ttttacaatc agttgtaaaa
8941 gaatgcaaat tctttgaatc agccatataa caataaggcc atttaaaagt attaatttag
9001 gcgggccgcg gtggctcacg cctgtaatcc tagcactttg ggaggccaag gcaggtggat
9061 catgaggtca ggagatcgag accatcctgg ctaacacggt gaaaccccgt ctctactaaa
9121 aatacaaaaa aattagccgg gcatggtggc gggcgcttgc ggtcccagct acttgggagg
9181 cgaggcagga gaatggcatg aacccgggag gcggagcttg cagtgagccg agatcatgcc
9241 actgcactcc agcctgggcg acagagcaag actccgtctc aaaaaaaaaa aaaaaaaagt
9301 ttttatttag gccgggtgtg gcggctcacg cctgtaatcc agtgctttgg gaggatgagg
9361 tgggtggatc actgaggtca ggagttcgag accagcctga ccacgtggag aaacctcatc
9421 tctactaaaa aacaaaatta gccaggcgtg gtggcatata cctgtaatcc cagctactca
9481 ggaggctgag gcaggagaat cagaacccag gagggggagg ttgtggtgag ctgagatcgt
9541 gccattgcat tccagcctgg gcaacaagag tgaaacttca tctccaaaaa aaaaaaaaaa
9601 aagtactaaa tttacaggct gggcatggtg gctcacgctt ggaatcccag cactttggga
9661 ggctgaagtg gacggattgc ttcagcccag gagttcaaga ccagcctgag caacataatg
9721 agaccctgtc tctaccaaaa attgaaaaaa tcgtgccagg catggtggtc tgtgcctgca
9781 gtcctagcta ctcaggagtc tgaagtagga gaatcacttg agcctggagt ttgaggcttc
9841 agtgagccat gatagattcc agcctaggca acaaagtgag acctggtctc aacaaaagta
9901 ttaattacac aaataatgca ttgcttatca caagtaaatt agaaaataca gataaggaaa
9961 aggaagttga tatctcgtga gctcaccaga tgggcagtgg tccctggctc acacgtgtac
10021 tgacacatgt ttaaatagtg gagaacaggt gtttttttgg tttgtttttt tccccttcct
10081 catgctactt tgtctaagag aacagttggt tttctagtca gcttttatta ctgggcaaca
10141 ttacacatac tataccttat cattaatgaa ctccagcttg attctgaacc gctgcggggc
10201 ctgaacggtg ggtcaggatt gaacccatcc tctattagaa cccaggcgca tgtccaggat
10261 agctaggtcc tgagccgtgt tcccacagga gggactgctg ggttggaggg gacagccact
10321 tcatacccca gggaggagct gtccccttcc cacagctgag tggggtgtgc tgacctcaag
10381 ttgccatctt ggggtcccat gcccagtctt aggaccacat ctgtggaggt ggccagagcc
10441 aagcagtctc cccatcaggt cggcctccct gtcctgaggc cctgagaaga ggggtctgca
10501 gaaggtttag aaagagcagc tcccaggggc ccaaggccag gagaggggca gggcttttcc
10561 taagcagagg aggggctatt ggcctacctg ggactctgtt ctcttcgctc tgctgctccc
10621 cttcctcaaa tcaggaggtc ttggaagcag ctgcccctac ccacaggcca gaagttctgg
10681 ttctccacca gagaatcagc attctgtctc cctccccact ccctcctcct ctccccaggg
10741 acagtgaggt cccaggcccc acacccatgg aagtggaggc cgagcagctg cttgagccac
10801 acgtgcaagc gcccagcctg gagccctcgg tgtccccaca ggatgaaaca gtaagttggt
10861 ggaggggagg gggtccgtca gggacaattg ggagagaaaa ggtgagggct tcccgggtgg
10921 cgtgcactgt agagccctct agggacttcc tcgaacagaa gcagacagaa accacggaga
10981 gacgaggtta cttcagacat gggacggtct ctgtagttac agtggcgcat taagtaaggg
11041 tgtgtgtgtt gctggcgatc tgagaagtcg atctttgagc tgagcgctgg tgaaggagaa
11101 acaagccatg gaaggaaagg tgccaagtgg tcaggcgaga gcctccaggg caaaggcctt
11161 gggcaggtgg gaatcctgat ttgttcctga aaggtagttt gtctgagtca ctacctgaga
11221 aggctggaga ggccagcagg aaacacaacc cagcacggcc tgttgtcgtg tgggcactag
11281 ggagctggag ggattttgag caccagaggg acatagggtg tgttagtgtg tgagcaccag
11341 ccctctggtg ccctgtgtag atttagagga ccagactcag ggatgggtct gagggaggta
11401 gagaagggag ggggcttgga tcattgcagg agctatgggg attccagaaa tgttgagggg
11461 gcggaggagt aggggataaa caaggattcc tagcctggaa ccagtgtcca agtcctgagt
11521 cttccaggag ccacaggcag ccttaagcct ggtccccaca cacaggctga agtggcagtt
11581 ccagcggctg tccctgcggc agaggctgag gccgaggtga cgctgcggga gctccaggaa
11641 gccctggagg aggaggtgct cacccggcag agcctgagcc gggagatgga ggccatccgc
11701 acggacaacc agaacttcgc caggtcggga tcggggccgg ggccggggcc gggatgcggg
11761 ccggtggcaa cccttggcat cccctctcgt ccggcccgga cggactcacc gtccttacct
11821 ccccacagtc aactacgcga ggcagaggct cggaaccggg acctagaggc acacgtccgg
11881 cagttgcagg agcggatgga gttgctgcag gcagagggag ccacaggtga gtccctcatg
11941 tgtccccttc cccggaggac cgggaggagg tgggccgtct gctccgcggg gcgtgtatag
12001 acacctggag gagggaaggg acccacgctg gggcacgccg cgccaccgcc ctccttcgcc
12061 cctccacgcg ccctatgcct ctttcttctc cttccagctg tcacgggggt ccccagtccc
12121 cgggccacgg atccaccttc ccatgtaaga cccctctctt tcccctgcct cagacctgct
12181 gcccattctg cagatcccct ccctggctcc tggtctcccc gtccagatat agggctcacc
12241 ctacgtcttt gcgactttag agggcagaag ccctttattc agccccagat ctccctccgt
12301 tcaggcctca ccagattccc tccgggatct ccctagataa cctccccaac ctcgattccc
12361 ctcgctgtct ctcgccccac cgctgagggc tgggctgggc tccgatcggg tcacctgtcc
12421 cttctctctc cagctagatg gccccccggc cgtggctgtg ggccagtgcc cgctggtggg
12481 gccaggcccc atgcaccgcc gccacctgct gctccctgcc agggtacgtc cggctgccca
12541 cgcccccctc cgccgtcgcg ccccgcgctc cacccgcccc gtgccacccg cttagctgcg
12601 catttgcggg gctgggccca cggcaggagg gcggatcttc gggcagccaa tcaacacagg
12661 ccgctaggaa gcagccaatg acgagttcgg acgggattcg aggcgtgcga gtggactaac
12721 aacagctgta ggctgttggg gcgggggcgg ggcgcaggga agagtgcggg cccacctatg
12781 ggcgtaggcg gggcgagtcc caggagccaa tcagaggccc atgccgggtg ttgacctcgc
12841 cctctccccg caggtcccta ggcctggcct atcggaggcg ctttccctgc tcctgttcgc
12901 cgttgttctg tctcgtgccg ccgccctggg ctgcattggg ttggtggccc acgccggcca
12961 actcaccgca gtctggcgcc gcccaggagc cgcccgcgct ccctgaaccc tagaactgtc
13021 ttcgactccg gggccccgtt ggaagactga gtgcccgggg cacggcacag aagccgcgcc
13081 caccgcctgc cagttcacaa ccgctccgag cgtgggtctc cgcccagctc cagtcctgtg
13141 taccgggccc gccccctagc ggccggggag ggaggggccg ggtccgcggc cggcgaacgg
13201 ggctcgaagg gtccttgtag ccgggaatgc tgctgctgct gctgctgctg ctgctgctgc
13261 tggggggatc acagaccatt tctttctttc ggccaggctg aggccctgac gtggatgggc
13321 aaactgcagg cctgggaagg cagcaagccg ggccgtccgt gttccatcct ccacgcaccc
13381 ccacctatcg ttggttcgca aagtgcaaag ctttcttgtg catgacgccc tgctctgggg
13441 agcgtctggc gcgatctctg cctgcttact cgggaaattt gcttttgcca aacccgcttt
13501 ttcggggatc ccgcgccccc ctcctcactt gcgctgctct cggagcccca gccggctccg
13561 cccgcttcgg cggtttggat atttattgac ctcgtcctcc gactcgctga caggctacag
13621 gacccccaac aaccccaatc cacgttttgg atgcactgag accccgacat tcctcggtat
13681 ttattgtctg tccccaccta ggacccccac ccccgaccct cgcgaataaa aggccctcca
13741 tctgccc
//