LOCUS HUMRETYKIN 5484 bp mRNA linear HUM 09-JAN-1995
DEFINITION Homo sapiens receptor tyrosine kinase (ERBB4) gene, complete cds.
ACCESSION L07868
VERSION L07868.1
KEYWORDS EGF receptor-related; Her4 tyrosine kinase; receptor
protein-tyrosine kinase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5484)
AUTHORS Plowman,G.D., Culouscou,J.M., Whitney,G.S., Green,J.M.,
Carlton,G.W., Foy,L., Neubauer,M.G. and Shoyab,M.
TITLE Ligand-specific activation of HER4/p180erbB4, a fourth member of
the epidermal growth factor receptor family
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 90 (5), 1746-1750 (1993)
PUBMED 8383326
COMMENT Original source text: Homo sapiens (tissue library: lambda ZAPII)
heart cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..5484
/db_xref="H-InvDB:HIT000191867"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_line="MDA-MB-453"
/tissue_type="heart"
/tissue_lib="lambda ZAPII"
gene 1..5484
/gene="ERBB4"
CDS 34..3960
/gene="ERBB4"
/standard_name="Her4 tyrosine kinase-EGF receptor related"
/note="putative"
/codon_start=1
/product="receptor tyrosine kinase"
/protein_id="AAB59446.1"
/translation="MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQ
QYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENL
RIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADT
IHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCD
GRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLE
HNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKAC
DGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVF
RTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSL
KEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCS
SDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGL
LTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQG
CNGPTSHDCIYYPWTGHSTLPQHARTPLIAAGVIGGLFILVIVGLTFAVYVRRKSIKK
KRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPE
GETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQL
MPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNH
VKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELM
TFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAA
EFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAEEYLVPQAFNI
PPPIYTSRARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFAAEQGVSVPYRAPTSTI
PEAPVAQGATAEIFDDSCCNGTLRKPVAPHVQEDSSTQRYSADPTVFAPERSPRGELD
EEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAEDEYVN
EPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEY
STKYFYKQNGRIRPIVAENPEYLSEFSLKPGTVLPPPPYRHRNTVV"
sig_peptide 34..108
/gene="ERBB4"
mat_peptide 109..3957
/gene="ERBB4"
/product="receptor tyrosine kinase"
/note="putative"
misc_difference 3169
/gene="ERBB4"
/note="sequence diverges in several cDNA clones"
/replace=""
misc_difference 3228
/gene="ERBB4"
/note="1 clone"
/replace="g"
polyA_site 5484
/gene="ERBB4"
BASE COUNT 1588 a 1173 c 1230 g 1493 t
ORIGIN
1 aattgtcagc acgggatctg agacttccaa aaaatgaagc cggcgacagg actttgggtc
61 tgggtgagcc ttctcgtggc ggcggggacc gtccagccca gcgattctca gtcagtgtgt
121 gcaggaacgg agaataaact gagctctctc tctgacctgg aacagcagta ccgagccttg
181 cgcaagtact atgaaaactg tgaggttgtc atgggcaacc tggagataac cagcattgag
241 cacaaccggg acctctcctt cctgcggtct gttcgagaag tcacaggcta cgtgttagtg
301 gctcttaatc agtttcgtta cctgcctctg gagaatttac gcattattcg tgggacaaaa
361 ctttatgagg atcgatatgc cttggcaata tttttaaact acagaaaaga tggaaacttt
421 ggacttcaag aacttggatt aaagaacttg acagaaatcc taaatggtgg agtctatgta
481 gaccagaaca aattcctttg ttatgcagac accattcatt ggcaagatat tgttcggaac
541 ccatggcctt ccaacttgac tcttgtgtca acaaatggta gttcaggatg tggacgttgc
601 cataagtcct gtactggccg ttgctgggga cccacagaaa atcattgcca gactttgaca
661 aggacggtgt gtgcagaaca atgtgacggc agatgctacg gaccttacgt cagtgactgc
721 tgccatcgag aatgtgctgg aggctgctca ggacctaagg acacagactg ctttgcctgc
781 atgaatttca atgacagtgg agcatgtgtt actcagtgtc cccaaacctt tgtctacaat
841 ccaaccacct ttcaactgga gcacaatttc aatgcaaagt acacatatgg agcattctgt
901 gtcaagaaat gtccacataa ctttgtggta gattccagtt cttgtgtgcg tgcctgccct
961 agttccaaga tggaagtaga agaaaatggg attaaaatgt gtaaaccttg cactgacatt
1021 tgcccaaaag cttgtgatgg cattggcaca ggatcattga tgtcagctca gactgtggat
1081 tccagtaaca ttgacaaatt cataaactgt accaagatca atgggaattt gatctttcta
1141 gtcactggta ttcatgggga cccttacaat gcaattgaag ccatagaccc agagaaactg
1201 aacgtctttc ggacagtcag agagataaca ggtttcctga acatacagtc atggccacca
1261 aacatgactg acttcagtgt tttttctaac ctggtgacca ttggtggaag agtactctat
1321 agtggcctgt ccttgcttat cctcaagcaa cagggcatca cctctctaca gttccagtcc
1381 ctgaaggaaa tcagcgcagg aaacatctat attactgaca acagcaacct gtgttattat
1441 cataccatta actggacaac actcttcagc acaatcaacc agagaatagt aatccgggac
1501 aacagaaaag ctgaaaattg tactgctgaa ggaatggtgt gcaaccatct gtgttccagt
1561 gatggctgtt ggggacctgg gccagaccaa tgtctgtcgt gtcgccgctt cagtagagga
1621 aggatctgca tagagtcttg taacctctat gatggtgaat ttcgggagtt tgagaatggc
1681 tccatctgtg tggagtgtga cccccagtgt gagaagatgg aagatggcct cctcacatgc
1741 catggaccgg gtcctgacaa ctgtacaaag tgctctcatt ttaaagatgg cccaaactgt
1801 gtggaaaaat gtccagatgg cttacagggg gcaaacagtt tcattttcaa gtatgctgat
1861 ccagatcggg agtgccaccc atgccatcca aactgcaccc aagggtgtaa cggtcccact
1921 agtcatgact gcatttacta cccatggacg ggccattcca ctttaccaca acatgctaga
1981 actcccctga ttgcagctgg agtaattggt gggctcttca ttctggtcat tgtgggtctg
2041 acatttgctg tttatgttag aaggaagagc atcaaaaaga aaagagcctt gagaagattc
2101 ttggaaacag agttggtgga accattaact cccagtggca cagcacccaa tcaagctcaa
2161 cttcgtattt tgaaagaaac tgagctgaag agggtaaaag tccttggctc aggtgctttt
2221 ggaacggttt ataaaggtat ttgggtacct gaaggagaaa ctgtgaagat tcctgtggct
2281 attaagattc ttaatgagac aactggtccc aaggcaaatg tggagttcat ggatgaagct
2341 ctgatcatgg caagtatgga tcatccacac ctagtccggt tgctgggtgt gtgtctgagc
2401 ccaaccatcc agctggttac tcaacttatg ccccatggct gcctgttgga gtatgtccac
2461 gagcacaagg ataacattgg atcacaactg ctgcttaact ggtgtgtcca gatagctaag
2521 ggaatgatgt acctggaaga aagacgactc gttcatcggg atttggcagc ccgtaatgtc
2581 ttagtgaaat ctccaaacca tgtgaaaatc acagattttg ggctagccag actcttggaa
2641 ggagatgaaa aagagtacaa tgctgatgga ggaaagatgc caattaaatg gatggctctg
2701 gagtgtatac attacaggaa attcacccat cagagtgacg tttggagcta tggagttact
2761 atatgggaac tgatgacctt tggaggaaaa ccctatgatg gaattccaac gcgagaaatc
2821 cctgatttat tagagaaagg agaacgtttg cctcagcctc ccatctgcac tattgacgtt
2881 tacatggtca tggtcaaatg ttggatgatt gatgctgaca gtagacctaa atttaaggaa
2941 ctggctgctg agttttcaag gatggctcga gaccctcaaa gatacctagt tattcagggt
3001 gatgatcgta tgaagcttcc cagtccaaat gacagcaagt tctttcagaa tctcttggat
3061 gaagaggatt tggaagatat gatggatgct gaggagtact tggtccctca ggctttcaac
3121 atcccacctc ccatctatac ttccagagca agaattgact cgaataggag tgaaattgga
3181 cacagccctc ctcctgccta cacccccatg tcaggaaacc agtttgtata ccgagatgga
3241 ggttttgctg ctgaacaagg agtgtctgtg ccctacagag ccccaactag cacaattcca
3301 gaagctcctg tggcacaggg tgctactgct gagatttttg atgactcctg ctgtaatggc
3361 accctacgca agccagtggc accccatgtc caagaggaca gtagcaccca gaggtacagt
3421 gctgacccca ccgtgtttgc cccagaacgg agcccacgag gagagctgga tgaggaaggt
3481 tacatgactc ctatgcgaga caaacccaaa caagaatacc tgaatccagt ggaggagaac
3541 ccttttgttt ctcggagaaa aaatggagac cttcaagcat tggataatcc cgaatatcac
3601 aatgcatcca atggtccacc caaggccgag gatgagtatg tgaatgagcc actgtacctc
3661 aacacctttg ccaacacctt gggaaaagct gagtacctga agaacaacat actgtcaatg
3721 ccagagaagg ccaagaaagc gtttgacaac cctgactact ggaaccacag cctgccacct
3781 cggagcaccc ttcagcaccc agactacctg caggagtaca gcacaaaata tttttataaa
3841 cagaatgggc ggatccggcc tattgtggca gagaatcctg aatacctctc tgagttctcc
3901 ctgaagccag gcactgtgct gccgcctcca ccttacagac accggaatac tgtggtgtaa
3961 gctcagttgt ggttttttag gtggagagac acacctgctc caatttcccc acccccctct
4021 ctttctctgg tggtcttcct tctaccccaa ggccagtagt tttgacactt cccagtggaa
4081 gatacagaga tgcaatgata gttatgtgct tacctaactt gaacattaga gggaaagact
4141 gaaagagaaa gataggagga accacaatgt ttcttcattt ctctgcatgg gttggtcagg
4201 agaatgaaac agctagagaa ggaccagaaa atgtaaggca atgctgccta ctatcaaact
4261 agctgtcact ttttttcttt ttctttttct ttctttgttt ctttcttcct cttctttttt
4321 tttttttttt taaagcagat ggttgaaaca cccatgctat ctgttcctat ctgcaggaac
4381 tgatgtgtgc atatttagca tccctggaaa tcataataaa gtttccatta gaacaaaaga
4441 ataacatttt ctataacata tgatagtgtc tgaaattgag aatccagttt ctttccccag
4501 cagtttctgt cctagcaagt aagaatggcc aactcaactt tcataattta aaaatctcca
4561 ttaaagttat aactagtaat tatgttttca acactttttg gtttttttca ttttgttttg
4621 ctctgaccga ttcctttata tttgctcccc tatttttggc tttaatttct aattgcaaag
4681 atgtttacat caaagcttct tcacagaatt taagcaagaa atattttaat atagtgaaat
4741 ggccactact ttaagtatac aatctttaaa ataagaaagg gaggctaata tttttcatgc
4801 tatcaaatta tcttcaccct catcctttac atttttcaac attttttttt ctccataaat
4861 gacactactt gataggccgt tggttgtctg aagagtagaa gggaaactaa gagacagttc
4921 tctgtggttc aggaaaacta ctgatacttt caggggtggc ccaatgaggg aatccattga
4981 actggaagaa acacactgga ttgggtatgt ctacctggca gatactcaga aatgtagttt
5041 gcacttaagc tgtaatttta tttgttcttt ttctgaactc cattttggat tttgaatcaa
5101 gcaatatgga agcaaccagc aaattaacta atttaagtac atttttaaaa aaagagctaa
5161 gataaagact gtggaaatgc caaaccaagc aaattaggaa ccttgcaacg gtatccaggg
5221 actatgatga gaggccagca cattatcttc atatgtcacc tttgctacgc aaggaaattt
5281 gttcagttcg tatacttcgt aagaaggaat gcgagtaagg attggcttga attccatgga
5341 atttctagta tgagactatt tatatgaagt agaaggtaac tctttgcaca taaattggta
5401 taataaaaag aaaaacacaa acattcaaag cttagggata ggtccttggg tcaaaagttg
5461 taaataaatg tgaaacatct tctc
//