LOCUS HUMCOXYSB 1966 bp mRNA linear HUM 24-FEB-1994
DEFINITION Human carboxylesterase mRNA, complete cds.
ACCESSION L07765
VERSION L07765.1
KEYWORDS carboxylesterase; glycosylation-dependent.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1966)
AUTHORS Kroetz,D.L., McBride,O.W. and Gonzalez,F.J.
TITLE Glycosylation-dependent activity of baculovirus-expressed human
liver carboxylesterases: cDNA cloning and characterization of two
highly similar enzyme forms
JOURNAL Biochemistry 32 (43), 11606-11617 (1993)
PUBMED 8218228
COMMENT Original source text: Homo sapiens (library: K19) liver cDNA to
mRNA.
FEATURES Location/Qualifiers
source 1..1966
/db_xref="H-InvDB:HIT000191858"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="chromosome 16"
/tissue_type="liver"
/tissue_lib="K19"
CDS 68..1768
/note="putative"
/codon_start=1
/product="carboxylesterase"
/protein_id="AAA35711.1"
/translation="MWLRAFILATLSASAAWGHPSSPPVVDTVHGKVLGKFVSLEGFA
QPVAIFLGIPFGKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQLLSELFT
NRKENIPLKLSEDCLYLNIYTPADLTKKNRLPVMVWIHGGGLMVGAASTYDGLALAAH
ENVVVVTIQYRLGIWGFFSTGDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIF
GESAGGESVSVLVLSPLAKNLFHRAISESGVALTSVLVKKGDVKPLAEQIAITAGCKT
TTSAVMVHCLRQKTEEELLETTLKMKFLSLDLQGDPRESQPLLGTVIDGMLLLKTPEE
LQAERNFHTVPYMVGINKQEFGWLIPMLMSYPLSEGQLDQKTAMSLLWKSYPLVCIAK
ELIPEATEKYLGGTDDTVKKKDLFLDLIADVMFGVPSVIVARNHRDAGAPTYMYEFQY
RPSFSSDMKPKTVIGDHGDELFSVFGAPFLKEGASEEEIRLSKMVMKFWANFARNGNP
NGEGLPHWPEYNQKEGYLQIGANTQAGQKLKDKEVAFWTNLFAKKAVEKPPQTEHIEL
"
regulatory 1942..1947
/regulatory_class="polyA_signal_sequence"
BASE COUNT 479 a 491 c 547 g 449 t
ORIGIN
1 tctttcttca tccccgcatt cccaatatac ccaggccaca agagccgaga actgtcgccc
61 ttccacgatg tggctccgtg cctttatcct ggccactctc tctgcttccg cggcttgggg
121 gcatccgtcc tcgccacctg tggtggacac cgtgcatggc aaagtgctgg ggaagttcgt
181 cagcttagaa ggatttgcac agcctgtggc cattttcctg ggaatccctt ttggcaagcc
241 gcctcttgga cccctgaggt ttactccacc gcagcctgca gaaccatgga gctttgtgaa
301 gaatgccacc tcgtaccctc ctatgtgcac ccaagatccc aaggcggggc agttactctc
361 agagctattt acaaaccgaa aggagaacat tcctctcaag ctttctgaag actgtcttta
421 cctcaatatt tacactcctg ctgacttgac caagaaaaac aggctgccgg tgatggtgtg
481 gatccacgga ggggggctga tggtgggtgc ggcatcaacc tatgatgggc tggcccttgc
541 tgcccatgaa aacgtggtgg tggtgaccat tcaatatcgc ctgggcatct ggggattctt
601 cagcacaggg gatgaacaca gccgggggaa ctggggtcac ctggaccagg tggctgccct
661 gcgctgggtc caggacaaca ttgccagctt tggagggaac ccaggctctg tgaccatctt
721 tggagagtca gcgggaggag aaagtgtctc tgttcttgtt ttgtctccat tggccaagaa
781 cctcttccac cgggccattt ctgagagtgg cgtggccctc acttctgttc tggtgaagaa
841 aggtgatgtc aagcccttgg ctgagcaaat tgctatcact gctgggtgca aaaccaccac
901 ctctgctgtc atggttcact gcctgcgaca gaagacggaa gaggagctct tggagacgac
961 attgaaaatg aaattcttat ctctggactt acagggagac cccagagaga gtcaacccct
1021 tctgggcact gtgattgatg ggatgctgct gctgaaaaca cctgaagagc ttcaagctga
1081 aaggaatttc cacactgtcc cctacatggt cggaattaac aagcaggagt ttggctggtt
1141 gattccaatg ttgatgagct atccactctc cgaagggcaa ctggaccaga agacagccat
1201 gtcactcctg tggaagtcct atccccttgt ttgcattgct aaggaactga ttccagaagc
1261 cactgagaaa tacttaggag gaacagacga cactgtcaaa aagaaagacc tgttcctgga
1321 cttgatagca gatgtgatgt ttggtgtccc atctgtgatt gtggcccgga accacagaga
1381 tgctggagca cccacctaca tgtatgagtt tcagtaccgt ccaagcttct catcagacat
1441 gaaacccaag acggtgatag gagaccacgg ggatgagctc ttctccgtct ttggggcccc
1501 atttttaaaa gagggtgcct cagaagagga gatcagactt agcaagatgg tgatgaaatt
1561 ctgggccaac tttgctcgca atggaaaccc caatggggaa gggctgcccc actggccaga
1621 gtacaaccag aaggaagggt atctgcagat tggtgccaac acccaggcgg gccagaagct
1681 gaaggacaaa gaagtagctt tctggaccaa cctctttgcc aagaaggcag tggagaagcc
1741 accccagaca gaacacatag agctgtgaat gaagatccag ccggccttgg gagcctggag
1801 gagcaaagac tggggtcttt tgcgaaaggg attgcaggtt cagaaggcat cttaccatgg
1861 ctggggaatt gtctggtggt ggggggcagg ggacagaggc catgaaggag caagttttgt
1921 atttgtgacc tcagctttgg gaataaagga tcttttgaag gccaca
//