LOCUS HUMTGFB3C 4208 bp mRNA linear HUM 22-MAY-1995
DEFINITION Human transforming growth factor-beta type III receptor (TGF-beta)
mRNA, complete cds.
ACCESSION L07594
VERSION L07594.1
KEYWORDS betaglycan; endoglin; proteoglycan; transforming growth factor-beta
type III receptor; transmembrane protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (sites)
AUTHORS Lopez-Casillas,F., Cheifetz,S., Doody,J., Andres,J.L., Lane,W.S.
and Massague,J.
TITLE Structure and expression of the membrane proteoglycan betaglycan, a
component of the TGF-beta receptor system
JOURNAL Cell 67 (4), 785-795 (1991)
PUBMED 1657406
REFERENCE 2 (sites)
AUTHORS Wang,X.F., Lin,H.Y., Ng-Eaton,E., Downward,J., Lodish,H.F. and
Weinberg,R.A.
TITLE Expression cloning and characterization of the TGF-beta type III
receptor
JOURNAL Cell 67 (4), 797-805 (1991)
PUBMED 1657407
REFERENCE 3 (bases 1 to 4208)
AUTHORS Moren,A., Ichijo,H. and Miyazono,K.
TITLE Molecular cloning and characterization of the human and porcine
transforming growth factor-beta type III receptors
JOURNAL Biochem. Biophys. Res. Commun. 189 (1), 356-362 (1992)
PUBMED 1333192
COMMENT On May 22, 1995 this sequence version replaced gi:818000.
Original source text: Homo sapiens (tissue library: ZAPII) placenta
cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..4208
/db_xref="H-InvDB:HIT000191844"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="placenta"
/tissue_lib="ZAPII"
gene 1..4208
/gene="TGFB type III receptor"
CDS 349..2898
/gene="TGFB type III receptor"
/codon_start=1
/product="transforming growth factor-beta type III
receptor"
/protein_id="AAA67061.1"
/translation="MTSHYVIAIFALMSFCLATAGPEPGALCELSPVSASHPVQALME
SFTVLSGCASRGTTGLPQEVHVLNLALRQGPGQLQREVTLHLNPISSVHIHHKSVVFL
LNSPHPLVWHLKTERLATGVSRLFLVSEGSVVQFSSANFSLTAETEERNFPHGNEHLL
NWARKEYGAVTSFTELKIARNIYIKVGEDQVFPPKCNIGKNFLSLNYLAEYLQPKAAE
GCVMSSQPQNEEVHIIELITPNSNPYSAFQVDITIDIRPSQEDLEVVKNLILILKCKK
SVNWVIKSFDVKGSLKIIAPNSIGFGKESERSMTMTKSIRDDIPSTQGNLVKWALDNG
YSPITSYTMAPVAIVFHLRLENNEEMGDEEVHTIPPELRILLDPGALPALQNPPIRGG
EGQNGGLPFPFPDISRRVWNEEGEDGLPRPKDPVIPSIQLFPGLREPEEVQGSVDIAL
SVKCDNEKMIVAVEKDSFQASGYSGMDVTLLDPTCKAKMNGTHFVLESPLNGCGTRPR
WSALDGVVYYNSIVIQVPALGDSSGWPDGYEDLESGDNGFPGDMDEGDASLFTRPEIV
VFNCSLQQVRNPSSFQEQPHGNITFNMELYNTDLFLVPSQGVFSVPENGHVYVEVSVT
KAEQELGFAIQTCFISPYSNPDRMSHYTIIENICPKDESVKFYSPKRVHFPIPQADMD
KKRFSFVFKPVFNTSLLFLQCELTLCTKMEKHPQKLPKCVPPDEACTSLDASIIWAMM
QNKKTFTKPLAVIHHEAESKEKGPSMKEPNPISPPIFHGLDTLTVMGIAFAAFVIGAL
LTGALWYIYSHTGETAGRQQVPTSPPASENSSAAHSIGSTQSTPCSSSSTA"
sig_peptide 364..411
/gene="TGFB type III receptor"
mat_peptide 412..2895
/gene="TGFB type III receptor"
/product="transforming growth factor-beta type III
receptor"
misc_binding 1942..1947
/gene="TGFB type III receptor"
/note="putative"
/bound_moiety="glycosaminoglycan"
misc_binding 1975..1980
/gene="TGFB type III receptor"
/note="putative"
/bound_moiety="glycosaminoglycan"
BASE COUNT 1150 a 1003 c 981 g 1074 t
ORIGIN
1 tctttaagat ttgtagctac taagaaagaa aggagctttt tttccttggg ccttcaaact
61 gaaagaaccg catgagcctg acggcgcatg gtcttaacat caggctgtgc aggaagaagc
121 tatctgcaga tggatgccag cacacacaag gaagcagagc tctggcaaca ttgagtcaaa
181 gcaaggacac aacatcagag ggacggcaga gaatccttgt gtgtagtctt tggtggcagt
241 ttgaaaattg caaggaggga ctttaagact acttctgatt tgcaaagatg gtctgtgctc
301 cgagcaggct aaagtgactg gacgagacgc actgttggag aaataaaaat gacttcccat
361 tatgtgattg ccatctttgc cctgatgagc ttctgtttag ccactgcagg tccagagcct
421 ggtgcactgt gtgaactgtc acctgtcagt gcctcccatc ctgtccaggc cttgatggag
481 agcttcactg ttttgtcagg ctgtgccagc agaggcacaa ctgggctgcc acaggaggtg
541 catgtcctga atctcgcact gcgccagggg cctggccagc tacagagaga ggtcacactt
601 cacctgaatc ccatctcctc agtccacatc caccacaagt ctgttgtgtt cctgctcaac
661 tccccacacc ccctggtgtg gcatctgaag acagagagac ttgccactgg ggtctccaga
721 ctgtttttgg tgtctgaggg ttctgtggtc cagttttcat cagcaaactt ctccttgaca
781 gcagaaacag aagaaaggaa cttcccccat ggaaatgaac atctgttaaa ttgggcccga
841 aaagagtatg gagcagttac ttcattcacc gaactcaaga tagcaagaaa catttatatt
901 aaagtggggg aagatcaagt gttccctcca aagtgcaaca tagggaagaa ttttctctca
961 ctcaattacc ttgctgagta ccttcaaccc aaagcagcag aagggtgtgt gatgtccagc
1021 cagccccaga atgaggaagt acacatcatc gagctaatca cccccaactc taacccctac
1081 agtgctttcc aggtggatat aacaattgat ataagacctt ctcaagagga tcttgaagtg
1141 gtcaaaaatc tcatcctgat cttgaagtgc aaaaagtctg tcaactgggt gatcaaatct
1201 tttgatgtta agggaagcct gaaaattatt gctcctaaca gtattggctt tggaaaagag
1261 agtgaaagat ctatgacaat gaccaaatca ataagagatg acattccttc aacccaaggg
1321 aatctggtga agtgggcttt ggacaatggc tatagtccaa taacttcata cacaatggct
1381 cctgtggcaa tagtatttca tcttcggctt gaaaataatg aggagatggg agatgaggaa
1441 gtccacacta ttcctcctga gctacggatc ctgctggacc ctggtgccct gcctgccctg
1501 cagaacccgc ccatccgggg aggggaaggc caaaatggag gccttccgtt tcctttccca
1561 gatatttcca ggagagtctg gaatgaagag ggagaagatg ggctccctcg gccaaaggac
1621 cctgtcattc ccagcataca actgtttcct ggtctcagag agccagaaga ggtgcaaggg
1681 agcgtggata ttgccctgtc tgtcaaatgt gacaatgaga agatgatcgt ggctgtagaa
1741 aaagattctt ttcaggccag tggctactcg gggatggacg tcaccctgtt ggatcctacc
1801 tgcaaggcca agatgaatgg cacacacttt gttttggagt ctcctctgaa tggctgcggt
1861 actcggcccc ggtggtcagc ccttgatggt gtggtctact ataactccat tgtgatacag
1921 gttccagccc ttggggacag tagtggttgg ccagatggtt atgaagatct ggagtcaggt
1981 gataatggat ttccgggaga tatggatgaa ggagatgctt ccctgttcac ccgacctgaa
2041 atcgtggtgt ttaattgcag ccttcagcag gtgaggaacc ccagcagctt ccaggaacag
2101 ccccacggaa acatcacctt caacatggag ctatacaaca ctgacctctt tttggtgccc
2161 tcccagggcg tcttctctgt gccagagaat ggacacgttt atgttgaggt atctgttact
2221 aaggctgaac aagaactggg atttgccatc caaacgtgct ttatctctcc atattcgaac
2281 cctgatagga tgtctcatta caccattatt gagaatattt gtcctaaaga tgaatctgtg
2341 aaattctaca gtcccaagag agtgcacttc cctatcccgc aagctgacat ggataagaag
2401 cgattcagct ttgtcttcaa gcctgtcttc aacacctcac tgctctttct acagtgtgag
2461 ctgacgctgt gtacgaagat ggagaagcac ccccagaagt tgcctaagtg tgtgcctcct
2521 gacgaagcct gcacctcgct ggacgcctcg ataatctggg ccatgatgca gaataagaag
2581 acgttcacca agccccttgc tgtgatccac catgaagcag aatctaaaga aaaaggtcca
2641 agcatgaagg aaccaaatcc aatttctcca ccaattttcc atggtctgga caccctaacc
2701 gtgatgggca ttgcgtttgc agcctttgtg atcggagcac tcctgacggg ggccttgtgg
2761 tacatctatt ctcacacagg ggagacagca ggaaggcagc aagtccccac ctccccgcca
2821 gcctcggaaa acagcagtgc tgcccacagc atcggcagca cgcagagcac gccttgctcc
2881 agcagcagca cggcctagcc caacccaggc ccaacccggc ccaacccagc ccagcccagc
2941 tcagctcagc tactccaagg gcaggaccaa tggctgagcc tcgtgtccag actcagaggg
3001 ctggattttg gttcccttgt aaagacagag tgaatttcag tataaagatc acccgttgta
3061 ttcaccccac acccagggct agtataaaca tgaccctggg cttctgtacc acactagaat
3121 tcatgtgaga aagctaaaat ggtggtcttc tccaccagcc cctcacaggc ttgggggttt
3181 tctatgtgaa acacatgcca gtttttaaaa tgctgctttg tccaggtgag aacatccata
3241 atttggggcc ctgagtttta cccagactca aggagttggt aaagggttaa tagccagata
3301 gtagaaccag tgaggagatg cggccaaaga ttctttatat ctgaaccaag atgtaaaaca
3361 agaaatgctt tgaggctttc taagcgatcc tcctgtctaa tttgcacctt tgtctggatg
3421 cactcttctg accttgctgc cacaacctgt ggggtctgat gtgtcccaag atgggtgctg
3481 ccctcaggga ctgcaccctg acaagtgtta aggcaacatt ccttgcttgt gccctgggcc
3541 aaaaccaatg ctgatgacct tatcagcttc ctgtttcttc ccatactgca tacaccactg
3601 caaaatgtct taatgcaaat tttgtatttc ttacaggcct acagaaattg aaaatgacca
3661 aaatcaggaa ccacagattt gtgcccattc ctaatatttt gttctgcaaa ttaatgtata
3721 atttgaggtg aaattcagtt ataaagtcaa ggacgaattt gcacagtgat atatttctat
3781 gtgtatgcaa gtacaagtat ataatatgtc acctggcaca ttcattttct cagttgaaga
3841 agagaaaatt tgaaaatgtc cttatgcttt tagagttgca acttaagtat atttggtagg
3901 gtgagtgttt ccactcaaaa tatgtcaact taaaaaaaaa taggcccttt cataaaaacc
3961 aaactgtagc aagatgcaaa tgcatggcaa atctgtcggt ctccagttgg ttatctgaat
4021 agtgtcacca attccaccaa gacagtgctg agattggaaa gggcactcat ttggattgcc
4081 ttacttctct tgccttaaat atatcccata tatttaatat gtcaaaaagg gcttgaggtg
4141 aatttcatta aatggaataa tatgatgcca ctttgcagct aaaataagct cagtgatacc
4201 tccttgtt
//