LOCUS HUMPP2A130 5217 bp mRNA linear HUM 18-JUN-1996
DEFINITION Human protein phosphatase 2A 130 kDa regulatory subunit mRNA,
complete cds.
ACCESSION L07590
VERSION L07590.1
KEYWORDS phosphoprotein phosphohydrolase; protein phosphatase 2A; protein
phosphatase 2A 130 kDa regulatory subunit; regulatory subunit.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5217)
AUTHORS Hendrix,P., Mayer-Jackel,R.E., Cron,P., Goris,J., Hofsteenge,J.,
Merlevede,W. and Hemmings,B.A.
TITLE Structure and expression of a 72-kDa regulatory subunit of protein
phosphatase 2A. Evidence for different size forms produced by
alternative splicing
JOURNAL J. Biol. Chem. 268 (20), 15267-15276 (1993)
PUBMED 8392071
COMMENT Original source text: Homo sapiens (library: lambda ZAP;
Stratagene/lambda gt10; Clonetech) fetal brain cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..5217
/db_xref="H-InvDB:HIT000191842"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
5'UTR 1..504
CDS 505..3957
/EC_number="3.1.3.16"
/codon_start=1
/product="protein phosphatase 2A 130 kDa regulatory
subunit"
/protein_id="AAB02613.1"
/translation="MAATYRLVVSTVNHYSSVVIDRRFEQAIHYCTGTCHTFTHGIDC
IVVHHSVCADLLHIPVSQFKDADLNSMFLPHENGLSSAEGDYPQQAFTGIPRVKRGST
FQNTYNLKDIAGEAISFASGKIKEFSFEKLKNSNHAAYRKGRKVKSDSFNRRSVDLDL
LCGHYNNDGNAPSFGLLRSSSVEEKPLSHRNSLDTNLTSMFLQNFSEEDLVTQILEKH
KIDNFSSGTDIKMCLDILLKCSEDLKKCTDIIKQCIKKKSGSSISEGSGNDTISSSET
VYMNVMTRLASYLKKLPFEFMQSGNNEALDLTELISNMPSLQLTPFSPVFGTEQPPKY
EDVVQLSASDSGRFQTIELQNDKPNSRKMDTVQSIPNNSTNSLYNLEVNDPRTLKAVQ
VQSQSLTMNPLENVSSDDLMETLYIEEESDGKKALDKGQKTENGPSHELLKVNEHRAE
FPEHATHLKKCPTPMQNEIGKIFEKSFVNLPKEDCKSKVSKFEEGDQRDFTNSSSQEE
IDKLLMDLESFSQKMETSLREPLAKGKNSNFLNSHSQLTGQTLVDLEPKSKVSSPIEK
VSPSCLTRIIETNGHKIEEEDRALLLRILESIEDFAQELVECKSSRGSLSQEKEMMQI
LQETLTTSSQANLSVCRSPVGDKAKDTTSAVLIQQTPEVIKIQNKPEKKPGTPLPPPA
TSPSSPRPLSPVPHVNNVVNAPLSINIPRFYFPEGLPDTCSNHEQTLSRIETAFMDIE
EQKADIYEMGKIAKVCGCPLYWKAPMFRAAGGEKTGFVTAQSFIAMWRKLLNNHHDDA
SKFICLLAKPNCSSLEQEDFIPLLQDVVDTHPGLTFLKDAPEFHSRYITTVIQRIFYT
VNRSWSGKITSTEIRKSNFLQTLALLEEEEDINQITDYFSYEHFYVIYCKFWELDTDH
DLYISQADLSRYNDQASSSRIIERIFSGAVTRGKTIQKEGRMSYADFVWFLISEEDKR
NPTSIEYWFRCMDVDGDGVLSMYELEYFYEEQCERMEAMGIEPLPFHDLLCQMLDLVK
PAVDGKITLRDLKRCRMAHIFYDTFFNLEKYLDHEQRDPFAVQKDVENDGPEPSDWDR
FAAEEYETLVAEESAQAQFQEGFEDYETDEPASPSEFGNKSNKILSASLPEKCGKLQS
VDEE"
misc_feature 2449..4438
/note="region homologous with PR72 gene alternatively
spliced form"
3'UTR 3955..5217
regulatory 4424..4429
/regulatory_class="polyA_signal_sequence"
BASE COUNT 1697 a 1061 c 1010 g 1449 t
ORIGIN
1 gaattcctgg aggcaagcgc tgcccgcgag ctgagccgcc ggaggaggag ccgcgggcaa
61 cgaggtttct ctgtcattca cagaaaaatg aatcatttaa acctttggag gactcagtta
121 tcacaatact tctctactac caactaagat ttatgatagt aaatttatga gagcaaattt
181 ccatgttata gaactgttga agaactaaaa gaggatattc tttcatcaaa ataattctgc
241 agtatcataa tattactaaa taaaattaaa aagcacaatt attaaattat taaatttgcc
301 acacatgtgc agcagctact gtatcctgat agtgaccaaa cctcaaatat aaatggtttc
361 ccttcatggg aaaagccatt atatttggaa gaaaccactg aacattgtta ttaaatatat
421 tttcagctaa ctgtcattta ggagaatttt catgaaacaa gttctagaaa gttccaagtc
481 ccaccagtaa gtggatttga tattatggca gcaacttaca gacttgtggt tagtactgtg
541 aaccactaca gcagcgtggt gatagaccgg cgttttgaac aagctataca ttattgcact
601 ggaacctgcc acaccttcac acatggaatt gactgcattg tggtacacca tagtgtttgt
661 gcagacctct tgcacatccc tgtgtctcag ttcaaagatg cagatctgaa ctctatgttt
721 ctaccccatg aaaatgggct ttcttcggct gaaggagact atccccaaca ggccttcaca
781 ggcataccca gggtcaagag aggatctaca tttcagaata cctacaactt aaaggatatt
841 gcaggagaag caatcagttt tgccagtggg aaaataaaag aattttcctt tgaaaaactc
901 aaaaactcta accatgcagc ttacagaaag ggaaggaaag ttaagtctga ctcatttaat
961 aggaggtcag ttgatttgga cttgctttgt ggccattata acaacgatgg gaacgcccca
1021 tcctttggtt tactgcggag ttcctcagtt gaggaaaaac ctttgtctca tagaaactca
1081 ctggatacga acctgacttc catgtttctt caaaactttt ctgaagaaga cttggttact
1141 cagattttgg aaaaacataa aatagataat ttttcttctg ggacagacat aaagatgtgc
1201 ttggacatct tattgaaatg ctccgaggat ttaaaaaaat gcacagacat cataaaacaa
1261 tgcataaaga aaaaatcagg gagtagcatc agtgaaggaa gtggtaatga tacaatttct
1321 agctctgaaa ctgtctatat gaatgtaatg accaggttag catcctatct gaaaaagtta
1381 ccatttgaat tcatgcagtc tgggaataat gaggctctag atttaacaga actgatcagt
1441 aatatgccta gcttacaact gactcccttc tccccagtgt ttggcactga acaaccccct
1501 aaatatgaag atgttgtcca gctctcagct tctgactctg gacgatttca aactattgaa
1561 ttgcaaaatg acaagcctaa ttctaggaag atggacactg tacaatccat tccaaacaac
1621 tccacaaatt ccttatataa cttagaggta aatgatccta gaactctaaa agctgtccag
1681 gtccaatcac agtcattaac catgaatcct ttagaaaatg tttcttctga cgacttaatg
1741 gaaactcttt atattgaaga agagtcagat ggaaagaaag cattagataa aggacaaaag
1801 acagagaatg gacctagtca tgagttatta aaggtaaatg aacatagagc agaatttcca
1861 gaacatgcta ctcatcttaa aaaatgcccc accccaatgc aaaatgaaat tggtaagata
1921 tttgagaaat catttgttaa tctacctaag gaagactgta aatcaaaagt ttctaaattt
1981 gaagagggag accagagaga ttttacaaat tccagtagcc aggaagagat agataaattg
2041 ttaatggatt tggaatcttt ttcacagaag atggagacct ctctaagaga gccacttgcg
2101 aagggtaaaa actctaattt tttaaatagt cacagtcagt tgaccggtca gacccttgta
2161 gatcttgagc ctaaatctaa agtctcttca cccatagaaa aagtctcacc ttcctgtcta
2221 acaaggatta ttgaaaccaa tggacacaaa atagaggaag aggatcgagc cctcttactg
2281 cgaatcctgg aaagcattga agactttgct caagaactag ttgaatgcaa atcaagcaga
2341 gggagcctat cacaagaaaa ggaaatgatg caaattctac aggaaacctt gacaacttcc
2401 tcccaggcca atttatcagt ctgtagaagt cctgttggtg ataaagccaa agatactact
2461 tcagcagttt tgattcagca gactccagag gtgatcaaga ttcaaaataa accagaaaag
2521 aaacctggaa caccactccc acctccagcc acctctccaa gtagtccccg acctctctcc
2581 ccggttcccc atgtgaataa tgttgtgaat gcgccattgt ccataaacat tccacggttc
2641 tactttcctg aaggactccc agatacctgt agtaatcatg aacaaactct aagcagaatt
2701 gaaactgctt tcatggatat tgaagaacag aaagcagaca tttatgaaat ggggaaaatt
2761 gcaaaggtct gtggctgtcc tctctattgg aaagccccca tgttcagggc tgcaggggga
2821 gagaagacag gatttgtgac agcacagtca ttcattgcca tgtggagaaa gttgctgaat
2881 aaccatcatg atgatgcctc taaattcatc tgtcttctag caaagcccaa ctgcagctct
2941 ctagaacagg aggatttcat ccctctactt caggatgtgg tggataccca ccctggtctc
3001 acgttcctga aagatgctcc agaattccac tcccgctaca tcaccacggt tattcagaga
3061 atattctaca cagtcaacag atcttggagt ggaaaaatta cttcgacaga gataagaaaa
3121 agcaactttt tgcaaaccct agcacttttg gaagaagagg aagatataaa ccaaattaca
3181 gattacttct cctatgaaca tttctatgtt atttattgta aattctggga actagatact
3241 gatcacgacc tctacatcag ccaggccgat ctgtctcgat acaatgacca ggcttcatca
3301 agcaggatta ttgaaaggat attctctggt gcagtaacaa ggggaaaaac aatacagaaa
3361 gagggaagaa tgagctatgc agattttgtt tggtttttga tctctgaaga agacaaaagg
3421 aatcctacca gcattgagta ttggttccgc tgcatggatg tggatggaga cggtgtactc
3481 tccatgtatg agctggagta cttctatgag gagcagtgtg aacggatgga agccatggga
3541 attgagccct tgccattcca tgatttactg tgccagatgc ttgacctagt gaagccagct
3601 gttgatggca aaataactct aagagatctg aagaggtgca gaatggctca catcttctat
3661 gacactttct ttaatctgga gaaatactta gaccatgaac agagagatcc ctttgcggtc
3721 cagaaggatg ttgagaacga tgggcctgag ccctcagact gggaccggtt tgccgctgag
3781 gagtatgaga cgcttgttgc agaggaatct gcccaagcac aattccagga aggctttgaa
3841 gattatgaaa cagatgaacc tgcctctccc tctgaatttg gaaacaaaag caataaaata
3901 ttaagtgcaa gccttccaga gaaatgtgga aagcttcaat cagtggatga agaatagctg
3961 ccggtgtcta caatgaaacg aagatgtgta ttttaaatgt ttctttcttg tgaagagatg
4021 ttctcgtttg catactgctt tttaaagact ttgatttctc caagtgtgta tcatctgcac
4081 taggaacttt gtttttaagc aataggtctg gatacacatt taacttagga ggctcctcca
4141 atttgcctca aacctcttac ggagcttctc ctcagaagtg gtaccatcgc cttccaaagt
4201 cagcactcta cactcttgaa tgtaccaagg atctcttggc gacagtacca agcacggttc
4261 tctacacagg tgactgaagt tgcctctgtg ttggctggca tccctgagtc ccctccggct
4321 cctatggagc ctagaagaaa ccttcacttg cagaaaactt gagtcagaaa attctggaac
4381 ttgaaaaagt agtaagggcc tccagaattg acttagccct agtaataaaa gcactgccaa
4441 aacatctcag agacttcttt tatgtatact ggagttcaaa gatctttaac ttacctggct
4501 tatgtaattt cacagttacc tgccaaacta ctagtcactt tacatcctca ggtattgtaa
4561 ccactgggcc ttccaacttt gctggcaagc tctggtaacc tccctgactg tggatcttat
4621 ataaaatctc aagataaaaa aacacttctt aaatgaagta tagaatttga ctcatacttg
4681 gaaaaagccc ttttaacttt tatcttttat tcattgaact attgaatgat gtatttaata
4741 tccaaattag ttgataactg ttttcacttc ctatcagaag gcctgcttga agacataaag
4801 gaataatgat acattaaaat tcttactaga tagatatatt ccttcctccc aggagtatta
4861 gactagctaa tagtaaaggc ctcaacgtta ttctttactt catgttgaaa acaattacta
4921 cagatatttc atccacctca gtatttatca aggaaatgga aaatgataca gctataaaag
4981 aaagctgtta tttactgtag ttgtagatgt attcactaca gaatcctaca tttttcagca
5041 ggccacagtc cagccaaatc ctataatatc cttgaaaaga aactattaaa aaggatagac
5101 atttctgatg taagtaaaac ccccaagcaa cttaatatcc atctgtcagt catcaacttt
5161 tcccctagat ttttttttta actagttctg aaagtgtcaa gaatagcttc ggaattc
//