LOCUS HUMVDAC2X 1404 bp mRNA linear HUM 14-JAN-1995
DEFINITION Human voltage-dependent anion channel isoform 2 (VDAC) mRNA,
complete cds.
ACCESSION L06328
VERSION L06328.1
KEYWORDS isoform 2; outer membrane channel; voltage-dependent anion channel.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1404)
AUTHORS Blachly-Dyson,E., Zambronicz,E.B., Yu,W.H., Adams,V., McCabe,E.R.,
Adelman,J., Colombini,M. and Forte,M.
TITLE Cloning and functional expression in yeast of two human isoforms of
the outer mitochondrial membrane channel, the voltage-dependent
anion channel
JOURNAL J. Biol. Chem. 268 (3), 1835-1841 (1993)
PUBMED 8420959
COMMENT Original source text: Homo sapiens liver cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..1404
/db_xref="H-InvDB:HIT000191709"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="liver"
gene 1..1404
/gene="VDAC"
CDS 63..947
/gene="VDAC"
/codon_start=1
/product="voltage-dependent anion channel"
/protein_id="AAB59457.1"
/translation="MATHGQTCARPMCIPPSYADLGKVARDIFNKGFGFGLVKLDVKT
KSCSGVEFSTSGSSNTDTGKVTGTLETKYKWCEYGLTFTEKWNTDNTLGTEIAIEDQI
CQGLKLTFDTTFSPNTGKKSGKIKSSYKRECINLGCDVDFDFAGPAIHGSAVFGYEGW
LAGYQMTFDSAKSKLTRNNFAVGYRTGDFQLHTNVNDGTEFGGSIYQKVCEDLDTSVN
LAWTSGTNCTRFGIAAKYQLDPTASISAKVNNSSLIGVGYTQTLRPGVKLTLSALVDG
KSINAGGHKVGLALELEA"
variation 133
/gene="VDAC"
/note="in 2 of 5 cDNA clones"
/replace="c"
variation 286..288
/gene="VDAC"
/note="in clone 4-1"
/replace="gt"
polyA_site 1234
/gene="VDAC"
/note="in 4 of 5 cDNA clones"
regulatory 1387..1392
/regulatory_class="polyA_signal_sequence"
/gene="VDAC"
polyA_site 1404
/gene="VDAC"
/note="in clone 4-1"
BASE COUNT 406 a 270 c 324 g 404 t
ORIGIN
1 gctgcagctg cagcagctgg agggcgaagt gaaggagaca ccgttccgcc cgcggcctcg
61 ccatggcgac ccacggacag acttgcgcgc gtccaatgtg tattcctcca tcatatgctg
121 accttggcaa agttgccaga gatattttca acaaaggatt tggttttggg ttggtgaaac
181 tggatgtgaa aacaaagtct tgcagtggcg tggaattttc aacgtccggt tcatctaata
241 cagacactgg taaagttact gggaccttgg agaccaaata caagtggtgt gagtatggtc
301 tgactttcac agaaaagtgg aacactgata acactctggg aacagaaatc gcaattgaag
361 accagatttg tcaaggtttg aaactgacat ttgatactac cttctcacca aacacaggaa
421 agaaaagtgg taaaatcaag tcttcttaca agagggagtg tataaacctt ggttgtgatg
481 ttgactttga ttttgctgga cctgcaatcc atggttcagc tgtctttggt tatgagggct
541 ggcttgctgg ctaccagatg acctttgaca gtgccaaatc aaagctgaca aggaataact
601 ttgcagtggg ctacaggact ggggacttcc agctacacac taatgtcaat gatgggacag
661 aatttggagg atcaatttat cagaaagttt gtgaagatct tgacacttca gtaaaccttg
721 cttggacatc aggtaccaac tgcactcgtt ttggcattgc agctaaatat cagttggatc
781 ccactgcttc catttctgca aaagtcaaca actctagctt aattggagta ggctatactc
841 agactctgag gcctggtgtg aagcttacac tctctgctct ggtagatggg aagagcatta
901 atgctggagg ccacaaggtt gggctcgccc tggagttgga ggcttaatcc agctgaaaga
961 aacctttggg aatggatatc agaagatttg gccttaatat atttccattg tgaccagcag
1021 caggcttttt tcccccaaga agatgatcaa aacaaaggat gatctcaaca agagctgtat
1081 tttaagtatt tagacagttc tttgttagct ggtttctagt tggttatcta gttaccaatg
1141 ctgcagtcct gcagtcacct atacattatt taaatgtatt taactgttaa atgcgctacc
1201 caccaataat gaaatagacc tttatgaaaa ctgtgcaatt gtgtgcatgt ttgtttttat
1261 gttcctttag aaaacattga ctgttaccat tgaatgagat ggatcagtgg atattaagat
1321 gaggttacaa attttgttaa gttcagccat tattactttt ggtatcccag aacatgacaa
1381 attatgaata aaacaagtat acat
//