LOCUS HUMTEKRPTK 4138 bp mRNA linear HUM 14-JAN-1995
DEFINITION Homo sapiens receptor protein-tyrosine kinase (TEK) mRNA, complete
cds.
ACCESSION L06139
VERSION L06139.1
KEYWORDS receptor protein-tyrosine kinase; transmembrane protein; tyrosine
kinase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4138)
AUTHORS Ziegler,S.F., Bird,T.A., Schneringer,J.A., Schooley,K.A. and
Baum,P.R.
TITLE Molecular cloning and characterization of a novel receptor protein
tyrosine kinase from human placenta
JOURNAL Oncogene 8 (3), 663-670 (1993)
PUBMED 8382358
COMMENT Original source text: Homo sapiens placenta cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..4138
/db_xref="H-InvDB:HIT000191703"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="placenta"
gene 1..4138
/gene="TEK"
CDS 149..3523
/gene="TEK"
/codon_start=1
/product="receptor protein-tyrosine kinase"
/protein_id="AAA61139.1"
/translation="MDSLASLVLCGVSLLLSGTVEGAMDLILINSLPLVSDAETSLTC
IASGWRPHEPITIGRDFEALMNQHQDPLEVTQDVTREWAKKVVWKREKASKINGAYFC
EGRVRGEAIRIRTMKMRQQASFLPATLTMTVDKGDNVNISFKKVLIKEEDAVIYKNGS
FIHSVPRHEVPDILEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGP
ECNHLCTACMNNGVCHEDTGECICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKS
YVFCLPDPYGCSCATGWKGLQCNEACHPGFYGPDCKLRCSCNNGEMCDRFQGCLCSPG
WQGLQCEREGIPRMTPKIVDLPDHIEVNSGKFNPICKASGWPLPTNEEMTLVKPDGTV
LHPKDFNHTDHFSVAIFTIHRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPKPLNA
PNVIDTGHNFAVINISSEPYFGDGPIKSKKLLYKPVNHYEAWQHIQVTNEIVTLNYLE
PRTEYELCVQLVRRGEGGEGHPGPVRRFTTASIGLPPPRGLNLLPKSQTTLNLTWQPI
FPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSVLLNNLHPREQYVVRARVNTKAQGE
WSEDLTAWTLSDILPPQPENIKISNITHSSAVISWTILDGYSISSITIRYKVQGKNED
QHVDVKIKNATIIQYQLKGLEPETAYQVDIFAENNIGSSNPAFSHELVTLPESQAPAD
LGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRRMAQAFQNVREEPAVQFNS
GTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKR
MKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFL
RKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILV
GENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWE
IVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQI
LVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA"
sig_peptide 149..202
/gene="TEK"
mat_peptide 203..3520
/gene="TEK"
/product="receptor protein-tyrosine kinase"
/note="a.a. domains: 746..742, transmembrane; 211..340,
EGF-like repeats; 440..733, fibronectin type 3 repeats"
BASE COUNT 1170 a 910 c 988 g 1070 t
ORIGIN
1 cttctgtgct gttccttctt gcctctaact tgtaaacaag acgtactagg acgatgctaa
61 tggaaagtca caaaccgctg ggtttttgaa aggatccttg ggacctcatg cacatttgtg
121 gaaactggat ggagagattt ggggaagcat ggactcttta gccagcttag ttctctgtgg
181 agtcagcttg ctcctttctg gaactgtgga aggtgccatg gacttgatct tgatcaattc
241 cctacctctt gtatctgatg ctgaaacatc tctcacctgc attgcctctg ggtggcgccc
301 ccatgagccc atcaccatag gaagggactt tgaagcctta atgaaccagc accaggatcc
361 gctggaagtt actcaagatg tgaccagaga atgggctaaa aaagttgttt ggaagagaga
421 aaaggctagt aagatcaatg gtgcttattt ctgtgaaggg cgagttcgag gagaggcaat
481 caggatacga accatgaaga tgcgtcaaca agcttccttc ctaccagcta ctttaactat
541 gactgtggac aagggagata acgtgaacat atctttcaaa aaggtattga ttaaagaaga
601 agatgcagtg atttacaaaa atggttcctt catccattca gtgccccggc atgaagtacc
661 tgatattcta gaagtacacc tgcctcatgc tcagccccag gatgctggag tgtactcggc
721 caggtatata ggaggaaacc tcttcacctc ggccttcacc aggctgatag tccggagatg
781 tgaagcccag aagtggggac ctgaatgcaa ccatctctgt actgcttgta tgaacaatgg
841 tgtctgccat gaagatactg gagaatgcat ttgccctcct gggtttatgg gaaggacgtg
901 tgagaaggct tgtgaactgc acacgtttgg cagaacttgt aaagaaaggt gcagtggaca
961 agagggatgc aagtcttatg tgttctgtct ccctgacccc tatgggtgtt cctgtgccac
1021 aggctggaag ggtctgcagt gcaatgaagc atgccaccct ggtttttacg ggccagattg
1081 taagcttagg tgcagctgca acaatgggga gatgtgtgat cgcttccaag gatgtctctg
1141 ctctccagga tggcaggggc tccagtgtga gagagaaggc ataccgagga tgaccccaaa
1201 gatagtggat ttgccagatc atatagaagt aaacagtggt aaatttaatc ccatttgcaa
1261 agcttctggc tggccgctac ctactaatga agaaatgacc ctggtgaagc cggatgggac
1321 agtgctccat ccaaaagact ttaaccatac ggatcatttc tcagtagcca tattcaccat
1381 ccaccggatc ctcccccctg actcaggagt ttgggtctgc agtgtgaaca cagtggctgg
1441 gatggtggaa aagcccttca acatttctgt taaagttctt ccaaagcccc tgaatgcccc
1501 aaacgtgatt gacactggac ataactttgc tgtcatcaac atcagctctg agccttactt
1561 tggggatgga ccaatcaaat ccaagaagct tctatacaaa cccgttaatc actatgaggc
1621 ttggcaacat attcaagtga caaatgagat tgttacactc aactatttgg aacctcggac
1681 agaatatgaa ctctgtgtgc aactggtccg tcgtggagag ggtggggaag ggcatcctgg
1741 acctgtgaga cgcttcacaa cagcttctat cggactccct cctccaagag gtctaaatct
1801 cctgcctaaa agtcagacca ctctaaattt gacctggcaa ccaatatttc caagctcgga
1861 agatgacttt tatgttgaag tggagagaag gtctgtgcaa aaaagtgatc agcagaatat
1921 taaagttcca ggcaacttga cttcggtgct acttaacaac ttacatccca gggagcagta
1981 cgtggtccga gctagagtca acaccaaggc ccagggggaa tggagtgaag atctcactgc
2041 ttggaccctt agtgacattc ttcctcctca accagaaaac atcaagattt ccaacattac
2101 acactcctcg gctgtgattt cttggacaat attggatggc tattctattt cttctattac
2161 tatccgttac aaggttcaag gcaagaatga agaccagcac gttgatgtga agataaagaa
2221 tgccaccatc attcagtatc agctcaaggg cctagagcct gaaacagcat accaggtgga
2281 catttttgca gagaacaaca tagggtcaag caacccagcc ttttctcatg aactggtgac
2341 cctcccagaa tctcaagcac cagcggacct cggagggggg aagatgctgc ttatagccat
2401 ccttggctct gctggaatga cctgcctgac tgtgctgttg gcctttctga tcatattgca
2461 attgaagagg gcaaatgtgc aaaggagaat ggcccaagcc ttccaaaacg tgagggaaga
2521 accagctgtg cagttcaact cagggactct ggccctaaac aggaaggtca aaaacaaccc
2581 agatcctaca atttatccag tgcttgactg gaatgacatc aaatttcaag atgtgattgg
2641 ggagggcaat tttggccaag ttcttaaggc gcgcatcaag aaggatgggt tacggatgga
2701 tgctgccatc aaaagaatga aagaatatgc ctccaaagat gatcacaggg actttgcagg
2761 agaactggaa gttctttgta aacttggaca ccatccaaac atcatcaatc tcttaggagc
2821 atgtgaacat cgaggctact tgtacctggc cattgagtac gcgccccatg gaaaccttct
2881 ggacttcctt cgcaagagcc gtgtgctgga gacggaccca gcatttgcca ttgccaatag
2941 caccgcgtcc acactgtcct cccagcagct ccttcacttc gctgccgacg tggcccgggg
3001 catggactac ttgagccaaa aacagtttat ccacagggat ctggctgcca gaaacatttt
3061 agttggtgaa aactatgtgg caaaaatagc agattttgga ttgtcccgag gtcaagaggt
3121 gtacgtgaaa aagacaatgg gaaggctccc agtgcgctgg atggccatcg agtcactgaa
3181 ttacagtgtg tacacaacca acagtgatgt atggtcctat ggtgtgttac tatgggagat
3241 tgttagctta ggaggcacac cctactgcgg gatgacttgt gcagaactct acgagaagct
3301 gccccagggc tacagactgg agaagcccct gaactgtgat gatgaggtgt atgatctaat
3361 gagacaatgc tggcgggaga agccttatga gaggccatca tttgcccaga tattggtgtc
3421 cttaaacaga atgttagagg agcgaaagac ctacgtgaat accacgcttt atgagaagtt
3481 tacttatgca ggaattgact gttctgctga agaagcggcc taggacagaa catctgtata
3541 ccctctgttt ccctttcact ggcatgggag acccttgaca actgctgaga aaacatgcct
3601 ctgccaaagg atgtgatata taagtgtaca tatgtgctgg aattctaaca agtcataggt
3661 taatatttaa gacactgaaa aatctaagtg atataaatca gattcttctc tctcatttta
3721 tccctcacct gtagcatgcc agtcccgttt catttagtca tgtgaccact ctgtcttgtg
3781 tttccacagc ctgcaagttc agtccaggat gctaacatct aaaaatagac ttaaatctca
3841 ttgcttacaa gcctaagaat ctttagagaa gtatacataa gtttaggata aaataatggg
3901 attttctttt cttttctctg gtaatattga cttgtatatt ttaagaaata acagaaagcc
3961 tgggtgacat ttgggagaca tgtgacattt atatattgaa ttaatatccc tacatgtatt
4021 gcacattgta aaaagtttta gttttgatga gttgtgagtt taccttgtat actgtaggca
4081 cactttgcac tgatatatca tgagtgaata aatgtcttgc ctactcaaaa aaaaaaaa
//