LOCUS HUMATPCU 8478 bp mRNA linear HUM 07-MAY-1993
DEFINITION Human putative Cu++-transporting P-type ATPase mRNA, complete cds.
ACCESSION L06133
VERSION L06133.1
KEYWORDS Cu++-transporting ATPase; P-type ATPase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 8478)
AUTHORS Vulpe,C., Levinson,B., Whitney,S., Packman,S. and Gitschier,J.
TITLE Isolation of a candidate gene for Menkes disease and evidence that
it encodes a copper-transporting ATPase
JOURNAL Nat. Genet. 3 (1), 7-13 (1993)
PUBMED 8490659
COMMENT Original source text: Homo sapiens (library: cDNA libraries from J.
Ellison and J. Edmund) fibroblast cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..8478
/db_xref="H-InvDB:HIT000191702"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="Xq13.3"
/cell_type="fibroblast"
/tissue_type="fibroblast"
/tissue_lib="cDNA libraries from J. Ellison and J. Edmund"
CDS 146..4648
/note="putative"
/codon_start=1
/product="Cu++-transporting P-type ATPase"
/protein_id="AAA35580.1"
/translation="MDPSMGVNSVTISVEGMTCNSCVWTIEQQIGKVNGVHHIKVSLE
EKNATIIYDPKLQTPKTLQEAIDDMGFDAVIHNPDPLPVLTDTLFLTVTASLTLPWDH
IQSTLLKTKGVTDIKIYPQKRTVAVTIIPSIVNANQIKELVPELSLDTGTLEKKSGAC
EDHSMAQAGEVVLKMKVEGMTCHSCTSTIEGKIGKLQGVQRIKVSLDNQEATIVYQPH
LISVEEMKKQIEAMGFPAFVKKQPKYLKLGAIDVERLKNTPVKSSEGSQQRSPSYTND
STATFIIDGMHCKSCVSNIESTLSALQYVSSIVVSLENRSAIVKYNASSVTPESLRKA
IVAVSPGLYRVSITSEVESTSNSPSSSSLQKIPLNVVSQPLTQETVINIDGMTCNSCV
QSIEGVISKKPGVKSIRVSLANSNGTVEYDPLLTSPETLRGAIEDMGFDATLSDTNEP
LVVIAQPSSEMPLLTSTNEFYTKGMTPVQDKEEGKNSSKCYIQVTGMTCASCVANIER
NLRREEGIYSILVALMAGKAEVRYNPAVIQPPMIAEFIRELGFGATVIENADEGDGVL
ELVVRGMTCASCVHKIESSLTKHRGILYCSVALATNKAHIKYDPEIIGPRDIIHTIES
LGFEASLVKKDRSASHLDHKREIRQWRRSFLVSLFFCIPVMGLMTYMMVMDHHFATLH
HNQNMSKEEMINLHSSMFLERQILPGLSVMNLLSFLLCVPVQFFGGWYFYIQAYKALK
HKTANMDVLIVLATTIAFAYSLIILLVAMYERAKVNPITFFDTPPMLFVFIALGRWLE
HIAKGKTSEALAKLISLQATEATIVTLDSDNILLSEEQVDVELVQRGDIIKVVPGGKF
PVDGRVIEGHSMVDESLITGEAMPVAKKPGSTVIAGSINQNGSLLICATHVGADTTLS
QIVKLVEEAQTSKAPIQQFADKLSGYFVPFIVFVSIATLLVWIVIGFLNFEIVETYFP
GYNRSISRTETIIRFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQNGILIKGGE
PLEMAHKVKVVVFDKTGTITHGTPVVNQVKVLTESNRISHHKILAIVGTAESNSEHPL
GTAITKYCKQELDTETLGTCIDFQVVPGCGISCKVTNIEGLLHKNNWNIEDNNIKNAS
LVQIDASNEQSSTSSSMIIDAQISNALNAQQHKVLIGNREWMIRNGLVINNDVNDFMT
EHERKGRTAVLVAVDDELCGLIAIADTVKPEAELAIHILKSMGLEVVLMTGDNSKTAR
SIASQVGITKVFAEVLPSHKVAKVKQLQEEGKRVAMVGDGINDSPALAMANVGIAIGT
GTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNLVGIPIAAGVFM
PIGLVLQPWMGSAAMAASSVSVVLSSLFLKLYRKPTYESYELPARSQIGQKSPSEISV
HVGIDDTSRNSPKLGLLDRIVNYSRASINSLLSDKRSLNSVVTSEPDKHSLLVGDFRE
DDDTAL"
repeat_region 5655..5951
polyA_site 8478
BASE COUNT 2520 a 1595 c 1701 g 2662 t
ORIGIN
1 gccgcagccg cagctactgt gacttctccg attgtgtgag ctttgttgga gcctgcgtac
61 gtggatttat cgctgccacg gtctgcgtag ttccagaggt ttaaccatag gatagagaaa
121 ccaggaatgt aatgaggaaa tcaaaatgga tccaagtatg ggtgtgaatt ctgttaccat
181 ttctgttgag ggtatgactt gcaattcctg tgtttggacc attgagcagc agattggaaa
241 agtgaatggt gtgcatcaca ttaaggtatc actggaagaa aaaaatgcaa ctattattta
301 tgaccctaaa ctacagactc caaagaccct acaggaagct attgatgaca tgggctttga
361 tgctgttatc cataatcctg accctctccc tgttttaact gacaccttgt ttctgactgt
421 tacggcgtca ctgactttgc catgggacca tatccaaagc acattgctga agaccaaggg
481 tgtgacagac attaaaattt accctcagaa aagaactgta gcagtgacaa taatcccttc
541 tatagtgaat gccaatcaga taaaagagct ggttccagaa ctcagtttag atactgggac
601 actggagaaa aagtcaggag cttgtgaaga tcatagtatg gctcaagctg gtgaagtcgt
661 gctgaagatg aaagtggaag ggatgacctg ccattcatgt actagcacta ttgaaggaaa
721 aattgggaaa ctgcaaggtg ttcagcgaat taaagtctcc ctggacaatc aagaagctac
781 tattgtttat caacctcatc ttatctcagt agaggaaatg aaaaagcaga ttgaagctat
841 gggctttcca gcatttgtca aaaagcagcc caagtacctc aaattgggag ctattgatgt
901 agaacgtcta aagaacacac cagttaaatc ctcagaaggg tcacagcaaa ggagtccatc
961 atataccaat gattcaacag ccactttcat cattgatggc atgcattgta aatcatgtgt
1021 gtcaaatatt gaaagtactt tatctgcact ccaatatgta agcagcatag tagtttcttt
1081 agagaatagg tctgccattg tgaagtataa tgcaagctca gtcactccag aatccctgag
1141 aaaagcaata gtggctgtat caccggggct atatagagtt agtatcacaa gtgaagttga
1201 gagtacctca aactctccct ccagctcatc tcttcagaag attcctttga atgtagttag
1261 ccagcctctg acacaagaaa ctgtgataaa cattgatggc atgacttgta attcctgtgt
1321 gcagtctatt gagggtgtca tatcaaaaaa gccaggtgta aaatccatac gagtctccct
1381 tgcaaatagc aatgggactg ttgagtatga tcctctacta acctctccag aaacgttgag
1441 aggagcaata gaagacatgg gatttgatgc taccttgtca gacacgaatg agccgttggt
1501 agtaatagct cagccttcat cggaaatgcc gcttctgact tcaactaatg aattttatac
1561 taaagggatg acaccagttc aagacaagga ggaaggaaag aattcatcta agtgttacat
1621 acaggtcact ggcatgactt gcgcttcctg tgtagcaaac attgaacgga atttaaggcg
1681 ggaagaagga atatattcta tacttgtggc cctgatggct ggcaaggcag aagtaaggta
1741 taatcctgct gttatacaac ccccaatgat agcagagttc atccgagaac ttggatttgg
1801 agccactgtg atagaaaatg ctgatgaagg agatggtgtt ttggaacttg ttgtgagggg
1861 aatgacgtgt gcctcctgcg tacataaaat agagtctagt ctcacaaaac acagagggat
1921 cctatactgc tccgtggccc tggcaaccaa caaagcacat attaaatatg acccagaaat
1981 tattggtcct agagatatta tccatacaat tgaaagctta ggttttgaag cttctttggt
2041 caagaaggat cggtcagcaa gtcacttaga tcataaacga gaaataagac aatggagacg
2101 gtcttttctt gtgagtctgt ttttctgtat tcctgtaatg gggctgatga catatatgat
2161 ggttatggac caccactttg caactcttca ccataatcaa aacatgagta aagaagaaat
2221 gatcaacctt cattcttcta tgttcctgga gcgccagatt cttccaggat tgtctgttat
2281 gaatttgctg tcctttttat tgtgtgtacc tgtacagttt ttcggaggct ggtacttcta
2341 cattcaggct tataaagcac tgaagcataa gacagcaaat atggacgtac tgattgtgct
2401 ggcaaccacc attgcatttg cctactcttt gattattctt ctagttgcaa tgtatgagag
2461 agccaaagtg aaccctatta ctttctttga cacaccccct atgctgtttg tgtttattgc
2521 actaggccga tggctggaac atatagcaaa gggcaaaaca tcagaggctc ttgcaaagtt
2581 aatttcacta caagctacag aagcaactat tgtaactctt gattctgata atatcctcct
2641 cagtgaagaa caagtggatg tggaacttgt acaacgtgga gatatcatta aagtagttcc
2701 aggaggcaaa tttccagtgg atggtcgtgt tattgaagga cattctatgg tagatgagtc
2761 cctcatcaca ggggaggcaa tgcctgtggc taagaaacct ggcagcacag tgattgctgg
2821 ttccattaac cagaacgggt cactgcttat ctgcgcaaca catgttggag cagacacaac
2881 cctttctcaa attgtcaaac ttgtggaaga ggcacaaaca tcaaaggctc ctatccagca
2941 gtttgcagac aaactcagtg gctattttgt tccttttatt gtttttgttt ccattgccac
3001 cctcttggta tggattgtaa ttggatttct gaattttgaa attgtggaaa cctactttcc
3061 tggctacaat agaagtatct cccgaacaga aacgataata cgatttgctt tccaagcctc
3121 tatcacagtt ctgtgtattg catgtccctg ttcactggga ctggccactc caactgctgt
3181 gatggtgggt acaggagtag gtgctcaaaa tggcatacta ataaaaggtg gagagccatt
3241 ggagatggct cataaggtaa aggtagtggt atttgataag actggaacca ttactcacgg
3301 aaccccagtg gtgaatcaag taaaggttct aactgaaagt aacagaatat cacaccataa
3361 aatcttggcc attgtgggaa ctgctgaaag taacagtgaa caccctctag gaacagccat
3421 aaccaaatat tgcaaacagg agctggacac tgaaaccttg ggtacctgca tagatttcca
3481 ggttgtgcca ggctgtggta ttagctgtaa agtcaccaat attgaaggct tgctacataa
3541 gaataactgg aatatagagg acaataatat taaaaatgca tccctggttc aaattgatgc
3601 cagtaatgaa cagtcatcaa cttcgtcttc catgattatt gatgcccaga tctcaaatgc
3661 tcttaatgct cagcagcata aagtcctcat tggtaaccgg gagtggatga ttagaaatgg
3721 tcttgtcatt aataacgatg taaatgattt catgactgaa catgagagaa aaggtcggac
3781 tgctgtatta gtagcagttg atgatgagct gtgtggcttg atagccattg cagacacagt
3841 gaagcctgaa gcagaactgg ctatccatat tctgaaatct atgggcttag aagtagttct
3901 gatgactgga gacaacagta aaacagctag atctattgct tctcaggttg gcattactaa
3961 ggtgtttgct gaagttctac cttctcacaa ggttgctaaa gtgaagcaac ttcaagagga
4021 ggggaaacgg gtagcaatgg tgggagatgg aatcaatgac tccccagctc tggcaatggc
4081 taatgtggga attgctattg gcacaggcac agatgtagcc attgaagcag ctgatgtggt
4141 tttgataagg aatgatcttc tggatgtagt ggcaagtatt gacttatcaa gaaagacagt
4201 caagaggatt cggataaatt ttgtctttgc tctaatttat aatctggttg gaattcccat
4261 agctgctgga gtttttatgc ccattggttt ggttttgcag ccctggatgg gatctgcagc
4321 aatggctgct tcatctgttt ctgtagtact ttcttctctc ttccttaaac tttacaggaa
4381 accaacttac gagagttatg aactgcctgc ccggagccag ataggacaga agagtccttc
4441 agaaatcagc gttcatgttg gaatagatga tacctcaagg aattctccta aactgggttt
4501 gctggaccgg attgttaatt atagcagagc ctctataaac tcactactgt ctgataaacg
4561 ctccctaaac agtgttgtta ccagtgaacc tgacaagcac tcactcctgg tgggagactt
4621 cagggaagat gatgacactg cattataaaa ggccatggag agtgctgcca gtttaacttg
4681 tcatgcactg acacagcatt catgatgtta ccttcacttt tcaaaatatt gtagaaggat
4741 ttttctcatg ctcttatatt agggattcta tttgagttgc gtttatctgt tggcaaaaat
4801 atctttttca aggcatcagc tctgaaccta gctttattta aactgaattt ccagtatatt
4861 tttgtttttt cactaacaac agataaggta gagcagtgag gtttacaaca agccctacaa
4921 ttagagattg ctgaactgct gctaaagtga tttttttttt atttgaccaa aaaaaaaaag
4981 gcccaagaag aagaaaatga aaaatttgaa gatttgagag catgaagata ttcatgcttt
5041 tgaactcaaa atattgaaga tactctcaag cctgtatccc tgcccactgg ggagcaatga
5101 ctttcaaagc actgtgtata aaacatctag ttttagaagg gaaacagttg aaactgttta
5161 aaaatagatg tgccttattt attgcaggct ttctttcccc cattctccct gcatccttgt
5221 ccttgcaggt gcttttttag atgctccaat atgtcttctt ttgttatttt ctttcgagct
5281 aaccagttta gggtggtttt tcattgatta aaaataactg acaactgttc taatattttg
5341 ctccttttta aattttgtag ctcaaaagac cttaaaggtc tgtagggttc cctgcctccc
5401 atctttccac tgttgtaaaa agtatatcaa attattcctt caagtttcct agctctgtgc
5461 tcagtttcag ttcactcctg ccaagttgga ctctaagtta ttcttcatgt agtctgctga
5521 tctcagtctg gaaacttaac attatgagcc ttttctgctc aaaaaatttt caaagattaa
5581 aactattata catatacagg tcatataaaa ttacctggat tcactaaatt tgtttgttgt
5641 tgttgttgtt gttgttgttg ttgttgagac agagtcttgt tttgcagccc aggctggagt
5701 gcagtggcac catcttggct cactgcaacc tctgcctacc ggattcaagg aattctccct
5761 gcctcagcct cctgagtagc taggattaca ggtgcctgcc accacacccg gctaattttc
5821 atatttttca gtagagacgg ggtttcgcca tgttggctag cctggtctta aactcctaac
5881 ctcaggtgat ccacccgcct tggcctccca aagtgctggg attacaggtg tgagcctcca
5941 tgcccagcct aaatttgtat tttttgaatt gagtataaca ctttgctagt atatataatt
6001 taatagattt tatttatctt tttagtgttt cagataacct ctcaaaaaga ctttaaaata
6061 atgctattac acaaaagctg catttaccaa aaaatacaag taaaatcata atacagaaac
6121 taaaatttcc ctaggttatg acgcttttta gctaaatata tactcttctc tagtttaaaa
6181 catttgaact tgcctagtta gtgtggttgg caaatttagg agcttgttcc cattgccaaa
6241 tggatttaga aattcccttg tgagtgcctg gtagctaata cactggtcag agatctggta
6301 cttgtaagac tatttaaatt tctttgttag ttgcaagatg gatttcatat gcagaatatg
6361 taaatgaaga ggactcataa gtaaattcct aacattttgt tcccattacc agaagcaaag
6421 ctgctgctaa cccaacatct ggcacatagg atttgtactc ggtaaatgtt agttcttttc
6481 tccccttgag gtcagtaata aatacaaaaa aaaaatcatt tttctagagc agagtcttaa
6541 aatcaggtgg gggtagggga tggacttctt cctttcctac cccttttctc ttttatcctt
6601 tcatatatac acatgcaaag tttacaacct tattccatgc tgtctttcag atttagaaaa
6661 gatctaattt ctgtctcagc tgtcttaaag agagatccaa gcttttgatg aaggtgctat
6721 taatctagaa aggcaaaccc atttcactga aatatcaatg ggtttgcata tctaggccct
6781 ttttttagac caatgcctat gccatcctcc atgctttcag tttgagtttt attatttatt
6841 attttaattc cagtggccca tcttataata caacttgttt cttctagaag acagagctga
6901 tagggtaaat gttgaaaaaa gaagcatgcc tccttctccc tcccacccac ctcaagcagt
6961 tgaacacagc cagttattct tccattatta tgtgtacctt ggagtcatcc tcttggtctt
7021 gtattcatat tgtgggacag tgggaatagc agcttgtagt attgaaataa tcaaagagat
7081 aatttcagct cttacaacaa gaacagaaaa catgctaatt agaaaaagtc ctgctttaag
7141 taatatgtag ccacatttga atcctctacc acaagtcttt ttggcaatct tgaactttca
7201 ttagcttcaa agagaagctg tctttacagg agaaagaggt gattatggag ggaatcaaaa
7261 ttactgcttt cagctagtag ctagctttta gtcaggagtt agtaatgaga aattttataa
7321 atgtgtattt ctgtgtattc acatacatat atatatacac acatatatat gtacatacac
7381 atacatacat attaccatac tgaagggaaa tggatttata tttgaatttg atatttgaat
7441 atttgaagtt ctctatttat atttcattta tcactcttct gtattcactc agcaaccatg
7501 cccttagtct gaagataaca aggatacttt aatatccagt gccggttcag actcacctat
7561 gtggcacctt aaacttaaat atccaaagag cccttttgaa tttcaaagat taaaacacag
7621 ctagagtagt agtattgtag tctcaagatg tatggtgtgt catttgtgaa aatagaaacg
7681 ttatttttcc tagtttagta tcaacatttt agaatgtcaa atttgatgcc ttgtgaacaa
7741 gtaattttat attgtgcttt aattttttaa aaagtattct ttattcatat gtatagaatg
7801 cttaaaatag cactgtagac aagatgtttc caaaacttta agtgcgcata tcttttctgt
7861 atacaggctt aaaatcaaaa atgtatgtta agagaatttt ttctattact tatggatcat
7921 gctttaaaat gatttttctt gatatttatt ttactccatt ttgttttttt ctctgggtga
7981 ggcatctggt tactggttat tttaaaaaga ataaagacat tcctggaatc actccttttg
8041 ggtttttgtt tgttttgttt cttttctaca tttttaagta ttattttaca aaatagaaaa
8101 aatatagatt catgccaaat tattacctat ttttacacta actttctgca gtccctccat
8161 ctggtatgag taaccagata gagcacaagc atgagttctt gttcttcagt taaaagagct
8221 tctttcacag tgttgataac aaatgccttt tgtagccaaa accaggcgtc tcaaccttac
8281 gtttttagtt aaagaaatgt ttagctaaac gctgttgaac attgattgtt tggtaccgaa
8341 aacagcagtg gacgatgttg tgcaatatcc atctactgta gttaagatat tcagtagttt
8401 gtttttcata agcatgtaat tgatcatatt tctgccaagg atgtgccttc aactttataa
8461 ttatagtgtt gtaaaata
//