LOCUS HUMSQUAL 1649 bp mRNA linear HUM 26-JUL-1993
DEFINITION Human hepatic squalene synthetase mRNA, complete cds.
ACCESSION L06105
VERSION L06105.1
KEYWORDS hepatic protein; squalene; squalene synthetase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1649)
AUTHORS McKenzie,T.L., Jiang,G., Straubhaar,J.R., Conrad,D.G. and
Shechter,I.
TITLE Molecular cloning, expression, and characterization of the cDNA for
the rat hepatic squalene synthase
JOURNAL J. Biol. Chem. 267 (30), 21368-21374 (1992)
PUBMED 1400448
REFERENCE 2 (bases 1 to 1649)
AUTHORS Jiang,G., McKenzie,T.L., Conrad,D.G. and Shechter,I.
TITLE Transcriptional regulation by lovastatin and 25-hydroxycholesterol
in HepG2 cells and molecular cloning and expression of the cDNA for
the human hepatic squalene synthase
JOURNAL J. Biol. Chem. 268 (17), 12818-12824 (1993)
PUBMED 7685352
COMMENT Original source text: Homo sapiens Liver cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..1649
/db_xref="H-InvDB:HIT000191697"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_line="HepG2"
/tissue_type="Liver"
CDS 45..1298
/experiment="experimental evidence, no additional details
recorded"
/codon_start=1
/product="squalene synthetase"
/protein_id="AAA36645.1"
/translation="MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQDSLSSSLKTCY
KYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHS
FLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDK
HVTSEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIR
DYLEDQQGGREFWPQEVWSRYVKKLGDFAKPENIDLAVQCLNELITNALHHIPDVITY
LSRLRNQSVFNFCAIPQVMAIATLAACYNNQQVFKGAVKIRKGQAVTLMMDATNMPAV
KAIIYQYMEEIYHRIPDSDPSSSKTRQIISTIRTQNLPNCQLISRSHYSPIYLSFVML
LAALSWQYLTTLSQVTEDYVQTGEH"
polyA_site 1649
BASE COUNT 431 a 386 c 413 g 419 t
ORIGIN
1 agaggtgaga gagtcgcgcc cgggagtccg ccgcctgcgc caggatggag ttcgtgaaat
61 gccttggcca ccccgaagag ttctacaacc tggtgcgctt ccggatcggg ggcaagcgga
121 aggtgatgcc caagatggac caggactcgc tcagcagcag cctgaaaact tgctacaagt
181 atctcaatca gaccagtcgc agtttcgcag ctgttatcca ggcgctggat ggggaaatgc
241 gcaacgcagt gtgcatattt tatctggttc tccgagctct ggacacactg gaagatgaca
301 tgaccatcag tgtggaaaag aaggtcccgc tgttacacaa ctttcactct ttcctttacc
361 aaccagactg gcggttcatg gagagcaagg agaaggatcg ccaggtgctg gaggacttcc
421 caacgatctc ccttgagttt agaaatctgg ctgagaaata ccaaacagtg attgccgaca
481 tttgccggag aatgggcatt gggatggcag agtttttgga taagcatgtg acctctgaac
541 aggagtggga caagtactgc cactatgttg ctgggctggt cggaattggc ctttcccgtc
601 ttttctcagc ctcagagttt gaagacccct tagttggtga agatacagaa cgtgccaact
661 ctatgggcct gtttctgcag aaaacaaaca tcatccgtga ctatctggaa gaccagcaag
721 gaggaagaga gttctggcct caagaggttt ggagcaggta tgttaagaag ttaggggatt
781 ttgctaagcc ggagaatatt gacttggccg tgcagtgcct gaatgaactt ataaccaatg
841 cactgcacca catcccagat gtcatcacct acctttcgag actcagaaac cagagtgtgt
901 ttaacttctg tgctattcca caggtgatgg ccattgccac tttggctgcc tgttataata
961 accagcaggt gttcaaaggg gcagtgaaga ttcggaaagg gcaagcagtg acccttatga
1021 tggatgccac caatatgcca gctgtcaaag ccatcatata tcagtatatg gaagagattt
1081 atcatagaat ccccgactca gacccatctt ctagcaaaac aaggcagatc atctccacca
1141 tccggacgca gaatcttccc aactgtcagc tgatttcccg aagccactac tcccccatct
1201 acctgtcgtt tgtcatgctt ttggctgccc tgagctggca gtacctgacc actctctccc
1261 aggtaacaga agactatgtt cagactggag aacactgatc ccaaatttgt ccatagctga
1321 agtccaccat aaagtggatt tacttttttt ctttaaggat ggatgttgtg ttctctttat
1381 ttttttccta ctactttaat ccctaaaaga acgctgtgtg gctgggacct ttaggaaagt
1441 gaaatgcagg tgagaagaac ctaaacataa aaggaaaggg tgcctcatcc cagcaacctg
1501 tccttgtggg tgatgatcac tgtgctgctt gcggctcatg gcagagcatt cagtgccacg
1561 gtttaggtga agtcgctgca tatgtgactg tcatgagatc ctacttagta tgatcctggc
1621 tagaatgata attaaaagta tttaatttg
//