LOCUS HUMMRPX 5011 bp mRNA linear HUM 10-FEB-1997
DEFINITION Human multidrug resistance-associated protein (MRP) mRNA, complete
cds.
ACCESSION L05628
VERSION L05628.1
KEYWORDS multidrug resistance-associated protein; transporter.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5011)
AUTHORS Cole,S.P., Bhardwaj,G., Gerlach,J.H., Mackie,J.E., Grant,C.E.,
Almquist,K.C., Stewart,A.J., Kurz,E.U., Duncan,A.M. and Deeley,R.G.
TITLE Overexpression of a transporter gene in a multidrug-resistant human
lung cancer cell line
JOURNAL Science 258 (5088), 1650-1654 (1992)
PUBMED 1360704
REFERENCE 2 (bases 197 to 377)
AUTHORS Cole,S.P. and Deeley,R.G.
TITLE Multidrug resistance-associated protein: sequence correction
JOURNAL Science 260 (5110), 879 (1993)
PUBMED 8098549
REFERENCE 3 (bases 1 to 5011)
AUTHORS Stride,B.D., Valdimarsson,G., Gerlach,J.H., Wilson,G.M., Cole,S.P.
and Deeley,R.G.
TITLE Structure and expression of the messenger RNA encoding the murine
multidrug resistance protein, an ATP-binding cassette transporter
JOURNAL Mol. Pharmacol. 49 (6), 962-971 (1996)
PUBMED 8649356
REFERENCE 4 (bases 1 to 5011)
AUTHORS Gerlach,J.H.
TITLE Direct Submission
JOURNAL Submitted (30-JAN-1997) Cancer Research Labs, Queen's University,
Kingston, ON K7L 3N6, Canada
COMMENT On Feb 10, 1997 this sequence version replaced gi:292332.
FEATURES Location/Qualifiers
source 1..5011
/db_xref="H-InvDB:HIT000191684"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..5011
/gene="MRP"
CDS 197..4792
/gene="MRP"
/note="putative"
/codon_start=1
/product="multidrug resistance-associated protein"
/protein_id="AAB46616.1"
/translation="MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCF
YLWACFPFYFLYLSRHDRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFL
APVFLVSPTLLGITTLLATFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTA
LKEDAQVDLFRDITFYVYFSLLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSR
ITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVV
YSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAI
HDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSG
MRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQ
VILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEI
LNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFA
VYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEE
LEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGC
GKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSV
IQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAV
DAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELL
ARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQL
SSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGL
FISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAV
FGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIP
EVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESV
SRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLE
CVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVE
RLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGG
EKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPV
LFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQ
LVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDY
TRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV"
BASE COUNT 1063 a 1499 c 1394 g 1055 t
ORIGIN
1 ccaggcggcg ttgcggcccc ggccccggct ccctgcgccg ccgccgccgc cgccgccgcc
61 gccgccgccg ccgccgccag cgctagcgcc agcagccggg cccgatcacc cgccgcccgg
121 tgcccgccgc cgcccgcgcc agcaaccggg cccgatcacc cgccgcccgg tgcccgccgc
181 cgcccgcgcc accggcatgg cgctccgggg cttctgcagc gccgatggct ccgacccgct
241 ctgggactgg aatgtcacgt ggaataccag caaccccgac ttcaccaagt gctttcagaa
301 cacggtcctc gtgtgggtgc cttgttttta cctctgggcc tgtttcccct tctacttcct
361 ctatctctcc cgacatgacc gaggctacat tcagatgaca cctctcaaca aaaccaaaac
421 tgccttggga tttttgctgt ggatcgtctg ctgggcagac ctcttctact ctttctggga
481 aagaagtcgg ggcatattcc tggccccagt gtttctggtc agcccaactc tcttgggcat
541 caccacgctg cttgctacct ttttaattca gctggagagg aggaagggag ttcagtcttc
601 agggatcatg ctcactttct ggctggtagc cctagtgtgt gccctagcca tcctgagatc
661 caaaattatg acagccttaa aagaggatgc ccaggtggac ctgtttcgtg acatcacttt
721 ctacgtctac ttttccctct tactcattca gctcgtcttg tcctgtttct cagatcgctc
781 acccctgttc tcggaaacca tccacgaccc taatccctgc ccagagtcca gcgcttcctt
841 cctgtcgagg atcaccttct ggtggatcac agggttgatt gtccggggct accgccagcc
901 cctggagggc agtgacctct ggtccttaaa caaggaggac acgtcggaac aagtcgtgcc
961 tgttttggta aagaactgga agaaggaatg cgccaagact aggaagcagc cggtgaaggt
1021 tgtgtactcc tccaaggatc ctgcccagcc gaaagagagt tccaaggtgg atgcgaatga
1081 ggaggtggag gctttgatcg tcaagtcccc acagaaggag tggaacccct ctctgtttaa
1141 ggtgttatac aagacctttg ggccctactt cctcatgagc ttcttcttca aggccatcca
1201 cgacctgatg atgttttccg ggccgcagat cttaaagttg ctcatcaagt tcgtgaatga
1261 cacgaaggcc ccagactggc agggctactt ctacaccgtg ctgctgtttg tcactgcctg
1321 cctgcagacc ctcgtgctgc accagtactt ccacatctgc ttcgtcagtg gcatgaggat
1381 caagaccgct gtcattgggg ctgtctatcg gaaggccctg gtgatcacca attcagccag
1441 aaaatcctcc acggtcgggg agattgtcaa cctcatgtct gtggacgctc agaggttcat
1501 ggacttggcc acgtacatta acatgatctg gtcagccccc ctgcaagtca tccttgctct
1561 ctacctcctg tggctgaatc tgggcccttc cgtcctggct ggagtggcgg tgatggtcct
1621 catggtgccc gtcaatgctg tgatggcgat gaagaccaag acgtatcagg tggcccacat
1681 gaagagcaaa gacaatcgga tcaagctgat gaacgaaatt ctcaatggga tcaaagtgct
1741 aaagctttat gcctgggagc tggcattcaa ggacaaggtg ctggccatca ggcaggagga
1801 gctgaaggtg ctgaagaagt ctgcctacct gtcagccgtg ggcaccttca cctgggtctg
1861 cacgcccttt ctggtggcct tgtgcacatt tgccgtctac gtgaccattg acgagaacaa
1921 catcctggat gcccagacag ccttcgtgtc tttggccttg ttcaacatcc tccggtttcc
1981 cctgaacatt ctccccatgg tcatcagcag catcgtgcag gcgagtgtct ccctcaaacg
2041 cctgaggatc tttctctccc atgaggagct ggaacctgac agcatcgagc gacggcctgt
2101 caaagacggc gggggcacga acagcatcac cgtgaggaat gccacattca cctgggccag
2161 gagcgaccct cccacactga atggcatcac cttctccatc cccgaaggtg ctttggtggc
2221 cgtggtgggc caggtgggct gcggaaagtc gtccctgctc tcagccctct tggctgagat
2281 ggacaaagtg gaggggcacg tggctatcaa gggctccgtg gcctatgtgc cacagcaggc
2341 ctggattcag aatgattctc tccgagaaaa catccttttt ggatgtcagc tggaggaacc
2401 atattacagg tccgtgatac aggcctgtgc cctcctccca gacctggaaa tcctgcccag
2461 tggggatcgg acagagattg gcgagaaggg cgtgaacctg tctgggggcc agaagcagcg
2521 cgtgagcctg gcccgggccg tgtactccaa cgctgacatt tacctcttcg atgatcccct
2581 ctcagcagtg gatgcccatg tgggaaaaca catctttgaa aatgtgattg gccccaaggg
2641 gatgctgaag aacaagacgc ggatcttggt cacgcacagc atgagctact tgccgcaggt
2701 ggacgtcatc atcgtcatga gtggcggcaa gatctctgag atgggctcct accaggagct
2761 gctggctcga gacggcgcct tcgctgagtt cctgcgtacc tatgccagca cagagcagga
2821 gcaggatgca gaggagaacg gggtcacggg cgtcagcggt ccagggaagg aagcaaagca
2881 aatggagaat ggcatgctgg tgacggacag tgcagggaag caactgcaga gacagctcag
2941 cagctcctcc tcctatagtg gggacatcag caggcaccac aacagcaccg cagaactgca
3001 gaaagctgag gccaagaagg aggagacctg gaagctgatg gaggctgaca aggcgcagac
3061 agggcaggtc aagctttccg tgtactggga ctacatgaag gccatcggac tcttcatctc
3121 cttcctcagc atcttccttt tcatgtgtaa ccatgtgtcc gcgctggctt ccaactattg
3181 gctcagcctc tggactgatg accccatcgt caacgggact caggagcaca cgaaagtccg
3241 gctgagcgtc tatggagccc tgggcatttc acaagggatc gccgtgtttg gctactccat
3301 ggccgtgtcc atcgggggga tcttggcttc ccgctgtctg cacgtggacc tgctgcacag
3361 catcctgcgg tcacccatga gcttctttga gcggaccccc agtgggaacc tggtgaaccg
3421 cttctccaag gagctggaca cagtggactc catgatcccg gaggtcatca agatgttcat
3481 gggctccctg ttcaacgtca ttggtgcctg catcgttatc ctgctggcca cgcccatcgc
3541 cgccatcatc atcccgcccc ttggcctcat ctacttcttc gtccagaggt tctacgtggc
3601 ttcctcccgg cagctgaagc gcctcgagtc ggtcagccgc tccccggtct attcccattt
3661 caacgagacc ttgctggggg tcagcgtcat tcgagccttc gaggagcagg agcgcttcat
3721 ccaccagagt gacctgaagg tggacgagaa ccagaaggcc tattacccca gcatcgtggc
3781 caacaggtgg ctggccgtgc ggctggagtg tgtgggcaac tgcatcgttc tgtttgctgc
3841 cctgtttgcg gtgatctcca ggcacagcct cagtgctggc ttggtgggcc tctcagtgtc
3901 ttactcattg caggtcacca cgtacttgaa ctggctggtt cggatgtcat ctgaaatgga
3961 aaccaacatc gtggccgtgg agaggctcaa ggagtattca gagactgaga aggaggcgcc
4021 ctggcaaatc caggagacag ctccgcccag cagctggccc caggtgggcc gagtggaatt
4081 ccggaactac tgcctgcgct accgagagga cctggacttc gttctcaggc acatcaatgt
4141 cacgatcaat gggggagaaa aggtcggcat cgtggggcgg acgggagctg ggaagtcgtc
4201 cctgaccctg ggcttatttc ggatcaacga gtctgccgaa ggagagatca tcatcgatgg
4261 catcaacatc gccaagatcg gcctgcacga cctccgcttc aagatcacca tcatccccca
4321 ggaccctgtt ttgttttcgg gttccctccg aatgaacctg gacccattca gccagtactc
4381 ggatgaagaa gtctggacgt ccctggagct ggcccacctg aaggacttcg tgtcagccct
4441 tcctgacaag ctagaccatg aatgtgcaga aggcggggag aacctcagtg tcgggcagcg
4501 ccagcttgtg tgcctagccc gggccctgct gaggaagacg aagatccttg tgttggatga
4561 ggccacggca gccgtggacc tggaaacgga cgacctcatc cagtccacca tccggacaca
4621 gttcgaggac tgcaccgtcc tcaccatcgc ccaccggctc aacaccatca tggactacac
4681 aagggtgatc gtcttggaca aaggagaaat ccaggagtac ggcgccccat cggacctcct
4741 gcagcagaga ggtcttttct acagcatggc caaagacgcc ggcttggtgt gagccccaga
4801 gctggcatat ctggtcagaa ctgcagggcc tatatgccag cgcccaggga ggagtcagta
4861 cccctggtaa accaagcctc ccacactgaa accaaaacat aaaaaccaaa cccagacaac
4921 caaaacatat tcaaagcagc agccaccgcc atccggtccc ctgcctggaa ctggctgtga
4981 agacccagga gagacagaga tgcgaaccac c
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