LOCUS AH005286 4923 bp DNA linear HUM 01-AUG-2016
DEFINITION Homo sapiens surfactant protein D (SP-D) gene, complete cds.
ACCESSION AH005286 L05483 L05484 L05485
VERSION AH005286.2
KEYWORDS collagen; lectin; surfactant protein D.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4923)
AUTHORS Rust,K., Grosso,L., Zhang,V., Chang,D., Persson,A., Longmore,W.,
Cai,G.Z. and Crouch,E.
TITLE Human surfactant protein D: SP-D contains a C-type lectin
carbohydrate recognition domain
JOURNAL Arch. Biochem. Biophys. 290 (1), 116-126 (1991)
PUBMED 1898081
REFERENCE 2 (bases 1 to 694)
AUTHORS Lu,J., Willis,A.C. and Reid,K.B.
TITLE Purification, characterization and cDNA cloning of human lung
surfactant protein D
JOURNAL Biochem. J. 284 (PT 3), 795-802 (1992)
PUBMED 1339284
REFERENCE 3 (bases 1 to 4923)
AUTHORS Crouch,E., Rust,K., Veile,R., Donis-Keller,H. and Grosso,L.
TITLE Genomic organization of human surfactant protein D (SP-D). SP-D is
encoded on chromosome 10q22.2-23.1
JOURNAL J. Biol. Chem. 268 (4), 2976-2983 (1993)
PUBMED 8428971
COMMENT On or before Aug 1, 2016 this sequence version replaced L05483.1,
L05484.1, L05485.1, AH005286.1.
FEATURES Location/Qualifiers
source 1..4923
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/map="10q22.2-23.1"
/sex="male"
/tissue_type="placenta"
/tissue_lib="Stratagene; lambda FIX II"
gene 1..4910
/gene="SP-D"
intron <1..246
/gene="SP-D"
/experiment="experimental evidence, no additional details
recorded"
/citation=[3]
exon 247..448
/gene="SP-D"
/experiment="experimental evidence, no additional details
recorded"
/citation=[3]
/number=1
CDS join(250..448,1630..1746,2007..2123,2439..2555,2998..3114,
3725..3808,4446..4822)
/gene="SP-D"
/codon_start=1
/product="surfactant protein D"
/protein_id="AAB59450.1"
/translation="MLLFLLSALVLLTQPLGYLEAEMKTYSHRTMPSACTLVMCSSVE
SGLPGRDGRDGREGPRGEKGDPGLPGAAGQAGMPGQAGPVGPKGDNGSVGEPGPKGDT
GPSGPPGPPGVPGPAGREGALGKQGNIGPQGKPGPKGEAGPKGEVGAPGMQGSAGARG
LAGPKGERGVPGERGVPGNTGAAGSAGAMGPQGSPGARGPPGLKGDKGIPGDKGAKGE
SGLPDVASLRQQVEALQGQVQHLQAAFSQYKKVELFPNGQSVGEKIFKTAGFVKPFTE
AQLLCTQAGGQLASPRSAAENAALQQLVVAKNEAAFLSMTDSKTEGKFTYPTGESLVY
SNWAPGEPNDDGGSEDCVEIFTNGKWNDRACGEKRLVVCEF"
misc_difference 282
/gene="SP-D"
/note="base 282 is an 'a' in cDNA sequence reported by Lu
et al.,1991"
/replace="a"
misc_difference 341
/gene="SP-D"
/note="base 341 is a 'c' in cDNA sequence reported by Lu
et al.,1992"
/replace="c"
intron order(449..694,795..1629)
/gene="SP-D"
/number=1
gap 695..794
/estimated_length=unknown
exon 1630..1746
/gene="SP-D"
/experiment="experimental evidence, no additional details
recorded"
/number=2
/function="collagen encoding exon"
intron 1747..2006
/gene="SP-D"
/experiment="experimental evidence, no additional details
recorded"
/number=2
exon 2007..2123
/gene="SP-D"
/experiment="experimental evidence, no additional details
recorded"
/number=3
/function="collagen encoding exon"
intron 2124..2438
/gene="SP-D"
/experiment="experimental evidence, no additional details
recorded"
/number=3
exon 2439..2555
/gene="SP-D"
/experiment="experimental evidence, no additional details
recorded"
/number=4
/function="collagen encoding exon"
intron 2556..2997
/gene="SP-D"
/experiment="experimental evidence, no additional details
recorded"
/number=4
exon 2998..3114
/gene="SP-D"
/experiment="experimental evidence, no additional details
recorded"
/number=5
/function="collagen encoding exon"
intron 3115..3724
/gene="SP-D"
/experiment="experimental evidence, no additional details
recorded"
/number=5
exon 3725..3808
/gene="SP-D"
/experiment="experimental evidence, no additional details
recorded"
/number=6
/function="encodes linking segment between collagen and
lectin domains"
intron order(3809..4056,4157..4445)
/gene="SP-D"
/number=6
gap 4057..4156
/estimated_length=unknown
exon 4446..4904
/gene="SP-D"
/experiment="experimental evidence, no additional details
recorded"
/citation=[1]
/citation=[3]
/number=7
/function="lectin or carbohydrate recognition domain
(CRD)"
regulatory 4905..4910
/regulatory_class="polyA_signal_sequence"
/gene="SP-D"
BASE COUNT 1090 a 1174 c 1376 g 1083 t
ORIGIN
1 cacctgcaat gggatgctgc tgtaacctat gtctagagtt ccagctggta actcatgctc
61 tccatccaag acctttggcc ctccttgcct aacgctttga ttcctggcgg ctcttaaggc
121 ccattagcag aggacagaag ggagggaaag gggtcttctt gtcacctcta gaagcttgag
181 ccaagtccct aaaccatgtc catgaagtca taagcatgtc ttttcctttt tctgttcacc
241 tctcaggcca tgctgctctt cctcctctct gcactggtcc tgctcacaca gcccctgggc
301 tacctggaag cagaaatgaa gacctactcc cacagaacaa tgcccagtgc ttgcaccctg
361 gtcatgtgta gctcagtgga gagtggcctg cctggtcgcg atggacggga tgggagagag
421 ggccctcggg gcgagaaggg ggacccaggt agggtggggc cctgggctta tcctgctggg
481 gaggaatggt cattggaact gtaactagcc cagcaactct gggtactttg ttatggaagt
541 ctggagacgt gtttcttcct cccaagaagg cgagttccac actgctccac cagctggcaa
601 acgtggctgt gtgctgagcc ccatgtgcct cctccagcac caactgccta gctcctccac
661 taggatccga tcttctatca gagcagcaac gtgtnnnnnn nnnnnnnnnn nnnnnnnnnn
721 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
781 nnnnnnnnnn nnnngaattc agatgtttcc aggtggtggt gctgctggga tacgccagca
841 cagattcttc cacccatcca gcaaatttac ccacaaccac atgctcaccc cccatggagg
901 cctggctctc tgccacggga gcatggcttc caagctgaaa tgtcacctcc tgtcgtctgc
961 aaatctccct cgattctcct tgactcttaa aatgcccact ttctctttga agaagaaagc
1021 tcgtgagtgt gtgagtgctg ggtggggacg atcagaatga gatgagggac acttatgcat
1081 gtcttccgtt gttgcccttg aatcacagtg tattatgacc cctgctgagc aggacctgag
1141 gctaagctca gatttgcatc ttgcctagtg ctaggtataa agtagatgct gcatagatgg
1201 ctcttagtga acaaataaat gagcaaatcg accaataact gaatgaacaa gttagcacca
1261 cctgtctggt gccatttctg gttggcttcc ctaatatata tatatggaat gcaagaagtc
1321 catgatcaca ggtaagagct gacaaattgc ctgccatcaa tacagtggcc ttggggtagg
1381 gcaaggagca ccgcatagaa ggtcaggcag gtcttggctt taatcgctct gaaggcttct
1441 tcctcatcta taaaaatggg gatgtttgat acccatttcc tggatcacca ctgggcctgg
1501 gtgtgtgacg ggtggaagtc tcatgctctg cagaatccta aaggggaatg ctaggggcct
1561 gatccagcag gaggctggcc ctttctgggt ctagggccag gtctttgtcc atttcttctg
1621 ctgctacagg tttgccagga gctgcagggc aagcagggat gcctggacaa gctggcccag
1681 ttgggccaaa aggggacaat ggctctgttg gagaacctgg accaaaggga gacactgggc
1741 caagtggtgg aggccaactg ggtgtggact tcaggtgttt ccaggtggtg cagctgcaag
1801 gatatgccag tgggcacgca cagagcccca tcccaggaag aaggttgtct gaaggtggca
1861 ctgggtcatt tcaggacaga tgggacctgc tgttgggagg acaacaatgc tgcctccctt
1921 gcctctgtta ttaccctcca cctttactac acactcctcc tgccaagagg attcattgtt
1981 actgaccggc tggtgctttt gctcaggacc tccaggacct cccggtgtgc ctggtccagc
2041 tggaagagaa ggtgccctgg ggaagcaggg gaacatagga cctcagggca agccaggccc
2101 aaaaggagaa gctgggccta aaggtaggtg gctggtctgt ggccaggtct gagaagggaa
2161 aggaggaagg acaagggtcc atgatatgac tgaggcgtgc tctagagtgc caggagagcc
2221 agcccttgat gctgcaaagg cttgccatgc accctcccaa tccccacaac tgcaatattt
2281 tgggtgtggg tggaggagag gagcggcaga aagcaaggag agtctcccca cttctctctc
2341 tgaccctaaa gttgcgggca aaaagctcca ttgctaacaa aaccacacct gctgaacgcg
2401 ctcttagctg tgtttgttcc tgtgtgttcc ttcttcagga gaagtaggtg ccccaggcat
2461 gcagggctcg gcaggggcaa gaggcctcgc aggccctaag ggagagcgag gtgtccctgg
2521 tgagcgtgga gtccctggaa acacaggggc agcaggtgag cagtggaaag agctgggctg
2581 ggctgggtcc agttctcctg tgcctgcttg gagctgtcaa tgcctacacc ccctccaccc
2641 accacaaagg cagaggtggt atcgctggga acatggagag aatctgtatc aagaagggtg
2701 catgaggggc cttccttggg gactgttcct atctaggaga gtgaagcgcc aagcaatgga
2761 gaaggtctgt atacaggaag ttagttgttg ggtggcgggc agttttcaca gcgggttgat
2821 tgctgggtga cagggacagt cagtgtacag ggagctgcat ggctggggta ctggggaccc
2881 atctgtctat ttctgggcaa ataaaggata gttagtccat gtatgggaag gtaaaaatgc
2941 taaaaacaaa aaaaataaaa atgagtacat agctcaccca gtcttctttt accccagggt
3001 ctgctggagc catgggtccc cagggaagtc caggtgccag gggacccccg ggattgaagg
3061 gggacaaagg cattcctgga gacaaaggag caaagggaga aagtgggctt ccaggtaagg
3121 tagcagctcc tggcccaggg aagccccgct gggatgggtg ggcagagagg aagccctcct
3181 catcccagag gaggggctct gggatgtgtg ccccattaat ggcagctggt gggtggaact
3241 caggaaaggc ggacaggctg gaaggcagga gcatggggct ctggtcttag ccacttagta
3301 ctcatgggaa agcaacctgg gcagcttctc catctgacta tcgggaaaac tacaactcgc
3361 cttcccaatt cataggacag ttttgggcat taaaaaccca gtggatagga aacacatgag
3421 tgtgtattcc tgcccagcaa cccccccacc cacccaatgg agatgccatt atattccaag
3481 actttaaagt cacaatgtca tctggttcag tgtcagtgaa gtacaggcag caatttgttc
3541 atagcagaac cataagacat ccttacacag cagaggccag ctgtgtcagt agatgtgggc
3601 ttgctgtggg tcagccccac aattgtgccc gaaatcagag acacccttcc tttggggccc
3661 gagactctga gctcttacct tcgctctctg ggaagtcttt acttggcctt tttctcccct
3721 ccagatgttg cttctctgag gcagcaggtt gaggccttac agggacaagt acagcacctc
3781 caggctgctt tctctcagta taagaaaggt gagttcctgg atctgaacct ggacccagca
3841 ctggcattgg gccccacact agatcttgac cttggtttgg cctttggctg gggctagacc
3901 tttggctgga cctgaggcag agctgccctg ggtctaggat gggaatgagc tgggacctgt
3961 gtagggctgg acctgggact gtgcaggggt agggctcagg ctgggatggg ctaagaggcg
4021 acacgtctcg gtgaactcaa gtgaatcaag ggaagannnn nnnnnnnnnn nnnnnnnnnn
4081 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
4141 nnnnnnnnnn nnnnnngaat tcctaactgc acgtttgctg cttgtgtgac tttgagcctc
4201 tagcttctct aaactccagt actctccatc tgtaagtggg gaatcatggt gtcacctcac
4261 agggtaggtc atggtggacg ggggctgttc tggaacaatc tctcttgcat tctctctggc
4321 atcctgatgc ggtgcctgtt tgggaggtct gaaaggctca ggttggagca cagaggtctc
4381 acagcccctg agctttggcc aggtgatgcc acaaccccaa cctgactttc ttcttctcct
4441 actagttgag ctcttcccaa atggccaaag tgtgggggag aagattttca agacagcagg
4501 ctttgtaaaa ccatttacgg aggcacagct gctgtgcaca caggctggtg gacagttggc
4561 ctctccacgc tctgccgctg agaatgccgc cttgcaacag ctggtcgtag ctaagaacga
4621 ggctgctttc ctgagcatga ctgattccaa gacagagggc aagttcacct accccacagg
4681 agagtccctg gtctattcca actgggcccc aggggagccc aacgatgatg gcgggtcaga
4741 ggactgtgtg gagatcttca ccaatggcaa gtggaatgac agggcttgtg gagaaaagcg
4801 tcttgtggtc tgcgagttct gagccaactg gggtgggtgg ggcagtgctt ggcccaggag
4861 tttggcaaga agtcaaggct tagaccctca tgctgccaat atctaataaa aatggagacc
4921 atc
//