LOCUS HUMSPRR1A 2541 bp DNA linear HUM 20-JUL-1998
DEFINITION Homo sapiens small proline-rich protein 1 (SPRR1A) gene, complete
cds.
ACCESSION L05187
VERSION L05187.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2541)
AUTHORS Gibbs,S., Fijneman,R., Wiegant,J., van Kessel,A.G., van De Putte,P.
and Backendorf,C.
TITLE Molecular characterization and evolution of the SPRR family of
keratinocyte differentiation markers encoding small proline-rich
proteins
JOURNAL Genomics 16 (3), 630-637 (1993)
PUBMED 8325635
REFERENCE 2 (bases 1 to 2541)
AUTHORS Sark,M.W.J., Fischer,D.F., de Meijer,E., van de Putte,P. and
Backendorf,C.
TITLE AP-1 and Ets transcription factors regulate the expression of the
human SPRR1A keratinocyte terminal differentiation marker
JOURNAL J. Biol. Chem. (1998) In press
REFERENCE 3 (bases 1 to 2541)
AUTHORS Backendorf,C.
TITLE Direct Submission
JOURNAL Submitted (08-AUG-1993) Molecular Genetics, LIC, Leiden University,
PO Box 9502, Leiden 2300 RA, The Netherlands
REFERENCE 4 (bases 1 to 2541)
AUTHORS Backendorf,C.
TITLE Direct Submission
JOURNAL Submitted (17-JUL-1998) Molecular Genetics, LIC, Leiden University,
PO Box 9502, Leiden 2300 RA, The Netherlands
REMARK Sequence update by submitter
COMMENT On Jul 17, 1998 this sequence version replaced gi:385224.
FEATURES Location/Qualifiers
source 1..2541
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/map="1q21-22"
/cell_line="primary foreskin keratinocyte"
/cell_type="keratinocyte"
/tissue_type="skin"
/tissue_lib="EMBL3"
gene 737..>2260
/gene="SPRR1A"
misc_feature 737..743
/gene="SPRR1A"
/note="AP-1 binding site"
misc_feature 790..793
/gene="SPRR1A"
/note="Ets binding site"
regulatory 816..820
/regulatory_class="TATA_box"
/gene="SPRR1A"
exon 845..889
/gene="SPRR1A"
/number=1
intron 890..1971
/gene="SPRR1A"
/number=1
misc_feature 1970..1971
/gene="SPRR1A"
/note="splice acceptor site"
exon 1972..>2260
/gene="SPRR1A"
/number=2
mRNA 1991..2260
/gene="SPRR1A"
/product="small proline-rich protein 1"
CDS 1991..2260
/gene="SPRR1A"
/note="N-terminal domain amino acids with internal
duplication, conserved in cornified envelope precursors;
C-terminal domain amino acids conserved in cornified
envelope precursors; six octapeptide repeats; exon 2"
/codon_start=1
/product="small proline-rich protein 1"
/protein_id="AAC26838.1"
/translation="MNSQQQKQPCTPPPQPQQQQVKQPCQPPPQEPCIPKTKEPCQPK
VPEPCHPKVPEPCQPKIPEPCQPKVPEPCPSTVTPAPAQQKTKQK"
BASE COUNT 741 a 571 c 625 g 604 t
ORIGIN
1 ctgcagggag gcaggtagaa aaggcttttg ggttttcagg tggggggcag tctagcctga
61 tcagaaagga ggaaaaggcc agggcagatg tctgggtgga gtgaagggaa aaagtgatcc
121 cagaagaagg attagcccct gaaagtccct gaagtaggag aagggtaaag gtgtggttgg
181 tgaaggaaag caggttttcc cagattagca accagtcagg gggaggaagg tgagagtggg
241 agagtcataa gtaaattatt ctgaatgtgt gtagtttaat ggaattggga aaaagatggg
301 ggaaatggat ggaaggtctt ggactctgag acaaggggtc tataatcagt ccatttcatt
361 atttctagct tccaccttca ccaaggcaga caaggagggc ccacctcagc tcctctgctc
421 cccctccctt tcccacctat tcatgtgtgc aagagtgccc tgtcccacag aacacgggga
481 acaaccatct caatgacaag gacagcaggt ggcaaggctc aacaggactc agatgtcccc
541 ccagggttaa ctcatgaaac cctccatgaa gcctgctgct cacccctccc tcaaggcaag
601 ccctgcacct gggtctgagg atgagggtgg cagtgaaaat taggccagtg acatcatttt
661 cagccagcta gtgccaaaaa atatcaggtg gtgttcatca aataagccga gccaaccggt
721 gatgaggatg gtagtgtgag tcatgtgtga caggtgagga atgaaaacag agtgcccgag
781 agcttctatt tccttgaggc agggctcatt catcttataa aagccagctg gccattgcct
841 tcacaccaaa cccaagggac cacacagccc attctgctcc gtataccagg taagtctctg
901 attgcaacaa actggcaatt ctagtgtact ttttcattat tagaaattag ctaaaggcaa
961 atatgtgtaa gcaggttaat ccagggtttc aatgggagat agagaatagt ggaatatctt
1021 tattttaagt taaattacag tctggatttg aaaggacctt agagatggtt agggctccca
1081 cctcagtaga tagtcattga actgggagtc ctggagaaga ttgttcaaat gcccatggga
1141 agttcatagc agaactagaa ctcaggccag agcactctca gtaacactgc aatttccccc
1201 tgacaagata tttatagaaa ttttaattta ttagatggat ctctactgag catttattcc
1261 atttaaggca gtatgctagg cactttggac aaatcaatgc cctaacgtac ttacttaaca
1321 aacataaaac ctagcaggaa ggtaatacat atatataaat aaatgaaatg caaagtagat
1381 agtaattggc atgacggaga tgggcagaga agggctgtgc acttttggga gacttgctca
1441 aggagacctc tagggtgtca agtgatgtga gctatgatgg aggggtattt ggacaagcag
1501 agatgggaag aaaagcattt ggaagggact gtgtaagcac agaccagaag caaaaccata
1561 gaggcttaga tgaatataaa gccatcctat aagtcacagg ctttctacat ggtactagga
1621 gaggaaagtg gtctgatgcc attttccaaa agacctaata tgcggacctc atgtccctca
1681 gaagccagct ttagtagggc atttttccag aacagatata aggtgccttg ggtaggaagg
1741 gagccaagaa gagaactcca ataaaatgga gcagaagaaa ttgcctttta gctcctcctc
1801 ttcaaagggc ctgaaaatta tccaagctta tttcattttt aaatgtaatg ggggagctaa
1861 gggagatgaa aggctttctc ttctaaaggg tcctgaaata aaatctgttt ggcattgaat
1921 ttgtatccat ctttctttaa ttgaatcact gtgtcagctt tctgtctcta gaaaaaaaca
1981 catttgaagc atgaattctc agcagcagaa gcagccttgc accccacccc ctcagcctca
2041 gcagcagcag gtgaaacaac cttgccagcc tccaccccag gaaccatgca tccccaaaac
2101 caaggagccc tgccaaccca aggtgcctga gccctgccac cccaaagtgc ctgagccctg
2161 ccagcccaag attccagagc cctgccagcc caaggtgcct gagccctgcc cttcaacggt
2221 cactccagca ccagcccagc agaagaccaa gcagaagtaa tgtggtccac agccatgccc
2281 ttgaggagct ggccactgga tactgaacac cctactccat tctgcttatg aatcccattt
2341 gcctattgac cctgcagtta gcatgctgtc accctgaatc ataatcgctc ctttgcacct
2401 ctaaaaagat gtcccttacc ctcattctgg aggctcctga gcctctgcgt aaggctgaac
2461 gtctcactga ctgagctagt cttcttgttg ctcgggtgca tttgaggatg gatttgggga
2521 aggtcaagtg accatcccta g
//