LOCUS HUMERCC6A 4714 bp mRNA linear HUM 08-NOV-1994
DEFINITION Human excision repair protein ERCC6 mRNA, complete cds.
ACCESSION L04791
VERSION L04791.1
KEYWORDS active gene repair; helicase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4714)
AUTHORS Troelstra,C., van Gool,A., de Wit,J., Vermeulen,W., Bootsma,D. and
Hoeijmakers,J.H.
TITLE ERCC6, a member of a subfamily of putative helicases, is involved
in Cockayne's syndrome and preferential repair of active genes
JOURNAL Cell 71 (6), 939-953 (1992)
PUBMED 1339317
COMMENT Original source text: Homo sapiens testis, placenta mRNA.
FEATURES Location/Qualifiers
source 1..4714
/db_xref="H-InvDB:HIT000191659"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="10q11-21"
/tissue_type="testis, placenta"
gene 1..4714
/gene="ERCC6"
CDS 80..4561
/gene="ERCC6"
/standard_name="excision repair cross complementing rodent
repair deficiency, complementation group 6"
/note="putative casein kinase II phosphorylation site bp
1526..1549 and 3281..3301; putative helicase domains I-VI
bp 1658..2929; putative nucleotide binding fold bp
3479..3493; homology to helicase subfamily bp 1658..3100"
/codon_start=1
/product="excision repair protein"
/protein_id="AAA52397.1"
/db_xref="GDB:G00-119-882"
/translation="MPNEGIPHSSQTQEQDCLQSQPVSNNEEMAIKQESGGDGEVEEY
LSFRSVGDGLSTSAVGCASAAPRRGPALLHIDRHQIQAVEPSAQALELQGLGVDVYDQ
DVLEQGVLQQVDNAIHEASRASQLVDVEKEYRSVLDDLTSCTTSLRQINKIIEQLSPQ
AATSRDINRKLDSVKRQKYNKEQQLKKITAKQKHLQAILGGAEVKIELDHASLEEDAE
PGPSSLGSMLMPVQETAWEELIRTGQMTPFGTQIPQKQEKKPRKIMLNEASGFEKYLA
DQAKLSFERKKQGCNKRAARKAPAPVTPPAPVQNKNKPNKKARVLSKKEERLKKHIKK
LQKRALQFQGKVGLPKARRPWESDMRPEAEGDSEGEESEYFPTEEEEEEEDDEVEGAE
ADLSGDGTDYELKPLPKGGKRQKKVPVQEIDDDFFPSSGEEAEAASVGEGGGGGRKVG
RYRDDGDEDYYKQRLRRWNKLRLQDKEKRLKLEDDSEESDAEFDEGFKVPGFLFKKLF
KYQQTGVRWLWELHCQQAGGILGDEMGLGKTIQIIAFLAGLSYSKIRTRGSNYRFEGL
GPTVIVCPTTVMHQWVKEFHTWWPPFRVAILHETGSYTHKKEKLIRDVAHCHGILITS
YSYIRLMQDDISRYDWHYVILDEGHKIRNPNAAVTLACKQFRTPHRIILSGSPMQNNL
RELWSLFDFIFPGKLGTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACVLRDTINP
YLLRRMKSDVKMSLSLPDKNEQVLFCRLTDEQHKVYQNFVDSKEVYRILNGEMQIFSG
LIALRKICNHPDLFSGGPKNLKGLPDDELEEDQFGYWKRSGKMIVVESLLKIWHKQGQ
RVLLFSQSRQMLDILEVFLRAQKYTYLKMDGTTTIASRQPLITRYNEDTSIFVFLLTT
RVGGLGVNLTGANRVVIYDPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKI
YHRQIFKQFLTNRVLKDPKQRRFFKSNDLYELFTLTSPDASQSTETSAIFAGTGSDVQ
TPKCHLKRRIQPAFGADHDVPKRKKFPASNISVNDATSSEEKSEAKGAEVNAVTSNRS
DPLKDDPHMSSNVTSNDRLGEETNAVSGPEELSVISGNGECSNSSGTGKTSMPSGDES
IDEKLGLSYKRERPSQAQTEAFWENKQMENNFYKHKSKTKHHSVAEEETLEKHLRPKQ
KPKNSKHCRDAKFEGTRIPHLVKKRRYQKQDSENKSEAKEQSNDDYVLEKLFKKSVGV
HSVMKHDAIMDGASPDYVLVEAEANRVAQDALKALRLSRQRCLGAVSGVPTWTGHRGI
SGAPAGKKSRFGKKRNSNFSVQHPSSTSPTEKCQDGIMKKEGKDNVPEHFSGRAEDAD
SSSGPLASSSLLAKMRARNHLILPERLESESGHLQEASALLPTTEHDDLLVEMRNFIA
FQAHTDGQASTREILQEFESKLSASQSCVFRELLRNLCTFHRTSGGEGIWKLKPEYC"
regulatory 1475..1522
/regulatory_class="other"
/gene="ERCC6"
/standard_name="bipartite nuclear location signal"
/note="G00-119-882; putative"
regulatory 3191..3244
/regulatory_class="other"
/gene="ERCC6"
/standard_name="bipartite nuclear location signal"
/note="G00-119-882; putative"
BASE COUNT 1433 a 993 c 1220 g 1068 t
ORIGIN
1 tgggttccaa ggcggctggc ggcggtagcg tctctgtttc cttgtgggcg ctcgcgcggc
61 cctgggtagt ctgtagagaa tgccaaatga gggaatcccc cactcaagtc aaactcagga
121 gcaagactgt ttacagagtc aacctgtcag taataatgaa gaaatggcaa tcaagcaaga
181 aagtggtggt gatggggagg tggaggagta cctgtccttt cgttctgtgg gtgacgggct
241 gtccacctct gctgtggggt gcgcatcagc agctccgagg agagggccag ccctgctgca
301 catcgaccga catcagatcc aggcagtaga gcctagcgcc caggcccttg agctgcaggg
361 tttgggtgtg gacgtctatg accaggacgt gctggaacag ggagtgcttc agcaggtgga
421 caatgccatc catgaggcca gccgtgcctc ccagctcgtt gacgtggaga aggagtatcg
481 gtcggtcctg gatgacctca cgtcatgtac gacatcccta aggcaaatca ataaaattat
541 tgaacagctt agccctcaag ctgccaccag cagagacatc aacaggaaac tagattctgt
601 aaaacgacag aagtataata aggaacaaca gctaaaaaag atcactgcaa aacaaaagca
661 tctccaggcc atccttggag gagcagaggt gaaaattgaa ctagatcacg ccagtctgga
721 ggaggatgca gagccggggc catccagtct tggcagcatg ctcatgcctg tccaggagac
781 tgcctgggaa gagctcatcc gcactggcca gatgacacct tttggtaccc agatccctca
841 gaaacaggag aaaaagccca gaaaaatcat gcttaatgaa gcatcaggct tcgaaaagta
901 tttggcagat caagcaaaac tgtcttttga aaggaagaag caaggttgta ataaaagagc
961 agctagaaaa gctccagccc cagtcacgcc tccagcccca gtgcaaaata aaaacaaacc
1021 aaacaagaaa gccagagttc tgtccaaaaa agaggagcgt ttgaaaaagc acatcaagaa
1081 actccagaag agggctttgc agttccaggg gaaagtggga ttgccaaagg caaggagacc
1141 ttgggagtca gacatgaggc cagaggcaga gggagactct gagggtgaag agtctgagta
1201 tttccccaca gaggaggagg aagaggagga agatgacgag gtggaggggg cagaggcgga
1261 cctgtctgga gatggtactg actatgagct gaagcctctg cccaagggcg ggaaacggca
1321 gaagaaagtg ccagtgcagg agattgatga tgactttttc ccaagttctg gggaagaagc
1381 tgaagctgct tctgtaggag aaggaggagg aggaggtcgg aaagtgggaa gataccgaga
1441 tgatggagat gaagattatt ataagcagcg gttaaggaga tggaataaac tgagactgca
1501 ggacaaagag aaacgtctga agctggagga cgattctgag gaaagtgatg ctgaatttga
1561 cgaaggtttt aaagtgccag gttttctgtt caaaaagctt tttaagtacc agcagacagg
1621 tgttaggtgg ctgtgggaat tgcactgcca gcaggcagga ggaattctgg gagatgaaat
1681 gggattgggc aagaccatcc agataattgc cttcttggca ggtctgagct acagcaagat
1741 caggactcgt ggttcaaatt acaggtttga ggggttgggt ccaactgtaa ttgtctgtcc
1801 aacaacagtg atgcatcagt gggtgaagga atttcacacg tggtggcctc cgttcagagt
1861 ggcaattcta catgaaaccg gttcctatac ccacaaaaag gagaaactaa ttcgagatgt
1921 tgctcattgt catggaattt tgatcacatc ttactcctac attcgattga tgcaggatga
1981 cattagcagg tatgactggc actatgtgat cttggacgaa ggacacaaaa ttcgaaatcc
2041 aaatgctgct gtcacccttg cttgcaaaca gtttcgcacc cctcatcgga tcattctgtc
2101 tggctcaccg atgcaaaata acctccgaga gctgtggtcg ctctttgact tcatcttccc
2161 gggaaagtta ggcacgttgc ctgtgtttat ggagcagttc tccgtcccca tcaccatggg
2221 gggatattca aatgcttccc cagtacaggt caaaactgct tacaagtgtg catgtgtctt
2281 acgagatacc ataaatccat acctactgcg gagaatgaag tcagatgtca agatgagcct
2341 ttctttgcca gataaaaatg aacaggtctt attttgccgt cttacagatg agcagcataa
2401 agtctaccaa aatttcgttg attccaaaga agtttacagg attctcaatg gagagatgca
2461 gattttctcc ggacttatag ccctaagaaa aatttgcaac caccctgatc tcttttctgg
2521 aggtcccaag aatctcaaag gtcttcctga tgatgaacta gaagaagatc agtttgggta
2581 ctggaaacgt tctgggaaaa tgattgttgt tgagtctttg ttgaaaatat ggcacaagca
2641 gggtcagcga gtattgctgt tttctcagtc aaggcagatg ctggacatac ttgaagtatt
2701 ccttagagcc caaaagtata cctatctcaa gatggatggt accactacaa tagcttcaag
2761 acagccactg attacgagat acaatgagga cacatccata tttgtgtttc ttctgaccac
2821 gcgggtgggc ggcttaggtg tcaacctgac gggggcaaac agagttgtca tctatgaccc
2881 agactggaac ccaagcacgg acacgcaggc ccgggagcga gcatggagaa taggccagaa
2941 gaagcaagtg actgtgtaca ggctcctgac tgcgggcacc attgaagaaa agatctacca
3001 ccgacaaatc ttcaagcagt ttttgacaaa tagagtgcta aaagacccaa aacaaaggcg
3061 gtttttcaaa tccaatgatc tctatgagct atttactctg actagtcctg atgcatccca
3121 gagcactgaa acaagtgcaa tttttgcagg aactggatca gatgttcaga cacccaaatg
3181 ccatctaaaa agaaggattc aaccagcctt tggagcagac catgatgttc caaaacgcaa
3241 gaagttccct gcttctaaca tatctgtaaa tgatgccaca tcatctgaag agaaatctga
3301 ggctaaagga gctgaagtaa atgcagtaac ttctaatcga agtgatcctt tgaaagatga
3361 ccctcacatg agtagtaatg taactagcaa tgataggctt ggagaagaga caaatgcagt
3421 atctggacca gaagagttgt cagtgattag tggaaatggg gaatgttcaa attcttcagg
3481 aacaggcaaa acttctatgc catctggtga tgaaagcatt gatgaaaagt taggtctttc
3541 ttacaaaaga gaaagaccca gccaggctca aacagaagct ttttgggaga ataaacaaat
3601 ggaaaataat ttttataagc acaagtcaaa aacaaaacat catagtgtgg cagaagaaga
3661 gaccctggag aaacatctga gaccaaagca aaagcctaag aactctaagc attgcagaga
3721 cgccaagttt gaaggaactc gaattccaca cctggtgaag aaaaggcgtt accagaagca
3781 agacagtgaa aacaagagtg aggccaagga acagagcaat gacgattatg ttttggaaaa
3841 gcttttcaaa aaatcagttg gcgtgcacag tgtcatgaag cacgatgcca tcatggatgg
3901 agccagccca gattatgtac tggtggaggc agaagccaac cgagtggccc aggatgccct
3961 gaaagcactg aggctctctc gtcagcggtg tctgggagca gtgtctggtg ttcccacctg
4021 gactggccac agggggattt ctggtgcacc agcaggaaaa aagagtagat ttggtaagaa
4081 aaggaattct aacttctctg tgcagcatcc ttcatcaaca tctccaacag agaagtgcca
4141 ggatggcatc atgaaaaagg agggaaaaga taatgtccct gagcatttta gtggaagagc
4201 agaagatgca gactcttcat ccgggcccct cgcttcctcc tcactcttgg ctaaaatgag
4261 agctagaaac cacctgattc tgccagagcg tttagaaagt gaaagcgggc acctgcagga
4321 agcttctgcc ctgctgccca ccacagaaca cgatgacctt ctggtggaga tgagaaactt
4381 catcgctttc caggcccaca ctgatggcca ggccagcacc agggagatac tgcaggagtt
4441 tgaatccaag ttatctgcat cacagtcttg tgtcttccga gaactattga gaaatctgtg
4501 cactttccat agaacttctg gtggtgaagg aatttggaaa ctcaagccag aatactgcta
4561 aacaacattg cttcctaaac tttcaagtcc ctttttctaa cgggcatttc tgattattaa
4621 tttattatta ataatcatgt ttgtcaatgg aagttggctg cacttgatgt ttgtttgcat
4681 gatgtctacc tcagaattaa aactttaagg aagg
//