LOCUS HUMKV21CH 3777 bp mRNA linear HUM 27-APR-1993
DEFINITION Homo sapiens potassium channel Kv2.1 mRNA, complete cds.
ACCESSION L02840
VERSION L02840.1
KEYWORDS potassium channel.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3777)
AUTHORS Ikeda,S.R., Soler,F., Zuhlke,R.D., Joho,R.H. and Lewis,D.L.
TITLE Heterologous expression of the human potassium channel Kv2.1 in
clonal mammalian cells by direct cytoplasmic microinjection of cRNA
JOURNAL Eur. J. Physiol. (1992) In press
COMMENT Original source text: Homo sapiens male adult cerebral cortex cDNA
to mRNA.
FEATURES Location/Qualifiers
source 1..3777
/db_xref="H-InvDB:HIT000191497"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/sex="male"
/tissue_type="cerebral cortex"
/dev_stage="adult"
mRNA 1..3680
5'UTR 1..198
CDS 199..2763
/function="delayed rectifier"
/standard_name="human Kv2.1 (DRK1)"
/experiment="experimental evidence, no additional details
recorded"
/codon_start=1
/product="voltage-gated potassium channel"
/protein_id="AAA36156.1"
/translation="MTKHGSRSTSSLPPEPMEIVRSKACSRRVRLNVGGLAHEVLWRT
LDRLPRTRLGKLRDCNTHDSLLEVCDDYSLDDNEYFFDRHPGAFTSILNFYRTGRLHM
MEEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQMNEELKREAETLREREGEEFD
NTCCAEKRKKLWDLLEKPNSSVAAKILAIISIMFIVLSTIALSLNTLPELQSLDEFGQ
STDNPQLAHVEAVCIAWFTMEYLLRFLSSPKKWKFFKGPLNAIDLLAILPYYVTIFLT
ESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFL
AMGIMIFSSLVFFAEKDEDDTKFKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGL
CCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNMKDAF
ARSIEMMDIVVEKNGENMGKKDKVQDNHLSPNKWKWTKRTLSETSSSKSFETKEQGSP
EKARSSSSPQHLNVQQLEDMYNKMAKTQSQPILNTKESAAQSKPKEELEMESIPSPVA
PLPTRTEGVIDMRSMSSIDSFISCATDFPEATRFSHSPLTSLPSKTGGSTAPEVGWRG
ALGASGGRFVEANPSPDASQHSSFFIESPKSSMKTNNPLKLRALKVNFMEGDPSPLLP
VLGMYHDPLRNRGSAAAAVAGLECATLLDKAVLSPESSIYTTASAKTPPRSPEKHTAI
AFNFEAGVHQYIDADTDDEGQLLYSVDSSPPKSLPGSTSPKFSTGTRSEKNHFESSPL
PTSPKFLRQNCIYSTEALTGKGPSGQEKCKLENHISPDVRVLPGGGAHGSTRDQSI"
3'UTR 2761..3777
polyA_site 3777
BASE COUNT 956 a 1063 c 972 g 786 t
ORIGIN
1 cctgcccagg agcgccgccc tggggcagtc gggatggagg tggagaacag gccgtgacgc
61 gcgcgggggc ccccctgcac ccccagcagc ccacgacgct ccctgccccc ctcccgcagc
121 agcgggcctt gccgtcgagt gacagcggcc tggggggcag ggggggcggg ggcggccgga
181 tcagcgatgc cggcgggcat gacgaagcat ggctcccgct ccaccagctc gctgccgccc
241 gagcccatgg agatcgtgcg cagcaaggcg tgctctcggc gggtccgcct caacgtcggg
301 gggctggcgc acgaggtact ctggcgtacc ctggaccgcc tgccccgcac gcggctgggc
361 aagctccgcg actgcaacac gcacgactcg ctgctcgagg tgtgcgatga ctacagcctc
421 gacgacaacg agtacttctt tgaccgccac ccgggcgcct tcacctccat cctcaacttc
481 taccgcactg ggcgactgca catgatggag gagatgtgcg cgctcagctt cagccaagag
541 ctcgactact ggggcatcga cgagatctac ctggagtcct gctgccaggc ccgctaccac
601 cagaagaaag agcagatgaa cgaggagctc aagcgtgagg ccgagactct acgggagcgg
661 gaaggcgagg agttcgataa cacgtgctgc gcagagaaga ggaaaaaact ctgggaccta
721 ctggagaagc ccaattcctc tgtggctgcc aagatccttg ccataatttc catcatgttc
781 atcgtcctct ccaccattgc cctgtccctc aacacgctgc ctgagctaca gagcctcgat
841 gagttcggcc agtccacaga caacccccag ctggcccacg tggaggccgt gtgcatcgca
901 tggttcacca tggagtacct gctgaggttc ctctcctcgc ccaagaagtg gaagttcttc
961 aagggcccac tcaatgccat tgacttgttg gccattctgc catactatgt caccattttc
1021 ctcaccgaat ccaacaagag cgtgctgcaa ttccagaatg tccgccgcgt ggtccagatc
1081 ttccgcatca tgcgaattct ccgcatcctt aagcttgcac gccactccac tggcctccag
1141 tctctgggct tcactttgcg gaggagctac aatgagttgg gcttgctcat cctcttcctt
1201 gccatgggca ttatgatctt ctccagcctt gtcttctttg ctgagaagga tgaggacgac
1261 accaagttca aaagcatccc agcctctttc tggtgggcca ccatcaccat gactactgtt
1321 gggtatggag acatctaccc caagactctc ctggggaaaa ttgttggggg actctgctgc
1381 attgcaggag tcctggtgat tgctcttccc atccccatca tcgtcaataa cttctctgag
1441 ttctataagg agcagaagag acaggagaaa gcaatcaaac ggcgagaggc tctggagaga
1501 gccaagagga atggcagcat cgtatccatg aacatgaagg atgcttttgc ccggagcatt
1561 gagatgatgg acattgtggt tgagaaaaat ggggagaata tgggtaagaa agacaaagta
1621 caagataacc acttgtctcc taacaaatgg aaatggacaa agaggacact gtctgaaacc
1681 agctcaagta agtcctttga aaccaaggaa cagggatccc ctgaaaaagc cagatcgtct
1741 tctagtcctc agcacctgaa cgttcagcag ttggaagaca tgtacaataa gatggccaag
1801 acccaatccc aacccatcct caataccaag gagtcagcag cacagagcaa accaaaggaa
1861 gaacttgaaa tggagagtat ccccagcccc gtagcccctc tgcccactcg cacagaaggg
1921 gtcattgaca tgcgaagtat gtcaagcatt gatagtttca ttagctgtgc cacagacttc
1981 cctgaggcca ccagattctc ccacagccct ttgacatcac tccccagcaa gactgggggc
2041 agcacagccc cagaagtggg ctggcgggga gctctgggtg ccagtggtgg taggtttgtg
2101 gaggccaacc ccagccctga tgccagccag cactctagtt tcttcatcga gagccccaag
2161 agttccatga aaactaacaa ccctttgaag ctccgagcac ttaaagtcaa cttcatggag
2221 ggtgacccca gtccactcct ccccgttcta gggatgtacc atgaccctct caggaaccgg
2281 gggagtgctg cggctgctgt cgctggactg gagtgtgcca cgcttttgga caaggctgtg
2341 ctgagcccag agtcctccat ctacaccaca gcaagtgcta agacaccccc ccggtctcct
2401 gagaaacaca cagcaatagc gttcaacttt gaggcgggtg tccaccagta cattgacgca
2461 gacacagatg atgagggaca gctgctctac agtgtggact ccagcccccc caaaagcctc
2521 cctgggagca ccagtccgaa gttcagcacg gggacaagat cggagaaaaa ccactttgaa
2581 agctcccctt tacccacctc ccctaagttc ttaaggcaga actgtattta ctccacagaa
2641 gcattgactg gaaaaggccc cagtggtcag gaaaagtgca aacttgagaa ccacatctcc
2701 cctgacgtcc gtgtgttgcc agggggagga gcccatggaa gcacacgaga tcagagcatc
2761 tgaactgccc tgccttggag gagagacttt tgggtgaggt ccaaagagga gagctgttca
2821 gcttacctgc cacagagctt ttctgcatga actctggaac agaaaggccc tgtaaagccc
2881 tcagagagaa gagagactcc agagaaggct ccctaagacc ttgagagcca tgacaggtcc
2941 atcagcatga agttggccaa gccatagggc acagcacctc cttgtaacaa ctctatagcc
3001 ctctttggga gatgacatga gtggaactca cagccaccac taccaccact ttagacagga
3061 ccgaggccac atactcccca ttctctcgtg gctttccatc tcagcctcgg agggcaacat
3121 tgacagtcct cctggcttca gctagagaag gatgctggaa caagcggctg gtgttgaaag
3181 agtgggttga ccaatttggt attgaatgtt gcccagccac ccctaggaac acctgtccat
3241 cacctcctgg atggattcca ctgttagaca gctacaggga atgattggtc atgggaagtc
3301 tctgcgccat aagccacgat cccagcgcaa aacccttact caaatgtctt cattgacttc
3361 ggtatttcat agtacccgag attttatttt gagataccat cagggtgagt tgcaccactt
3421 gtactcaatt ctaattgccc cctggcaatc tgggaagggt tcagaaggtg ggcacccagc
3481 caacagcatg aactcagagc attgttttag ggttggagga ggaacacgct ttctttacat
3541 cactagtgta gactcaaaag atatgcaagt gtcaaatatg caaaagaaat agtttattca
3601 aagagactgt gtgttactga agaacagcat aaaaatatga tttttttact tgcaaaaatg
3661 aaaggaaaaa aataccacgc attgaaatgc ccagttcaga ctgaataatt cctgctgcag
3721 caaggaaagt acctactata atagaaattc tgttttgttt tctgtggttt tcaagtt
//