LOCUS HUMDRA 2881 bp mRNA linear HUM 31-DEC-1994
DEFINITION Homo sapiens colon mucosa-associated (DRA) mRNA, complete cds.
ACCESSION L02785
VERSION L02785.1
KEYWORDS colon mucosa-associated protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2881)
AUTHORS Schweinfest,C.W., Henderson,K.W., Suster,S., Kondoh,N. and
Papas,T.S.
TITLE Identification of a colon mucosa gene that is down-regulated in
colon adenomas and adenocarcinomas
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 90 (9), 4166-4170 (1993)
PUBMED 7683425
COMMENT Original source text: Homo sapiens colon cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..2881
/db_xref="H-InvDB:HIT000191494"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_type="epithelial cell"
/tissue_type="colon"
gene 1..2881
/gene="DRA"
CDS 185..2479
/gene="DRA"
/note="Nuclear localization signal at AA 569-573, 576-580,
579-583; acidic transcr. activ. domain 620-640,; homeobox
motif 653-676"
/codon_start=1
/protein_id="AAA58443.1"
/translation="MIEPFGNQYIVARPVYSTNAFEENHKKTGRHHKTFLDHLKVCCS
CSPQKAKRIVLSLFPIASWLPAYRLKEWLLSDIVSGISTGIVAVLQGLAFALLVDIPP
VYGLYASFFPAIIYLFFGTSRHISVGPFPILSMMVGLAVSGAVSKAVPDRNATTLGLP
NNSNNSSLLDDERVRVAAAASVTVLSGIIQLAFGILRIGFVVIYLSESLISGFTTAAA
VHVLVSQLKFIFQLTVPSHTDPVSIFKVLYSVFSQIEKTNIADLVTALIVLLVVSIVK
EINQRFKDKLPVPIPIEFIMTVIAAGVSYGCDFKNRFKVAVVGDMNPGFQPPITPDVE
TFQNTVGDCFGIAMVAFAVAFSVASVYSLKYDYPLDGNQELIALGLGNIVCGVFRGFA
GSTALSRSAVQESTGGKTQIAGLIGAIIVLIVVLAIGFLLAPLQKSVLAALALGNLKG
MLMQFAEIGRLWRKDKYDCLIWIMTFIFTIVLGLGLGLAASVAFQLLTIVFRTQFPKC
STLANIGRTNIYKNKKDYYDMYEPEGVKIFRCPSPIYFANIGFFRRKLIDAVGFSPLR
ILRKRNKALRKIRKLQKQGLLQVTPKGFICTVDTIKDSDEELDNNQIEVLDQPINTTD
LPFHIDWNDDLPLNIEVPKISLHSLILDFSAVSFLDVSSVRGLKSILQEFIRIKVDVY
IVGTDDDFIEKLNRYEFFDGEVKSSIFFLTIHDAVLHILMKKDYSTSKFNPSQEKDGK
IDFTINTNGGLRNRVYEVPVETKF"
BASE COUNT 839 a 578 c 596 g 868 t
ORIGIN
1 atccactcag gtctacaggc tcttagaact agaacttaga actttatctt gaaaatgtac
61 cactgttgca gaagctcctc acagagtatg tgtcaggcat ttttaacctg ctaaaggcaa
121 gaagaagtgt tcaccacata gttgcaaagg tcttcaactt gccacagcca acagaaaaat
181 caaaatgatt gaaccctttg ggaatcagta tattgtggcc aggccagtgt attctacaaa
241 tgcttttgag gaaaatcata aaaagacagg aagacatcat aagacatttc tggatcatct
301 caaagtgtgt tgtagctgtt ccccacaaaa ggccaagaga attgtcctct ctttgttccc
361 catagcatct tggttgccag cataccggct taaagaatgg ttgctcagtg atattgtttc
421 tggtatcagc acagggattg tggccgtact acaaggttta gcatttgctc tgctggtcga
481 cattccccca gtctatgggt tgtatgcatc ctttttccca gccataatct accttttctt
541 cggcacttcc agacacatat ccgtgggtcc gtttccgatt ctgagtatga tggtgggact
601 agcagtttca ggagcagttt caaaagcagt cccagatcgc aatgcaacta ctttgggatt
661 gcctaacaac tcgaataatt cttcactact ggatgacgag agggtgaggg tggcggcggc
721 ggcatcagtc acagtgcttt ctggaatcat ccagttggct tttgggattc tgcggattgg
781 atttgtagtg atatacctgt ctgagtccct catcagtggc ttcactactg ctgctgctgt
841 tcatgttttg gtttcccaac tcaaattcat ttttcagttg acagtcccgt cacacactga
901 tccagtttca attttcaaag tactatactc tgtattctca caaatagaga agactaatat
961 tgcagacctg gtgacagctc tgattgtcct tttggttgta tccattgtta aagaaataaa
1021 tcagcgcttc aaagacaaac ttccagtgcc cattccaatc gaattcatta tgaccgtgat
1081 tgcagcaggt gtatcctacg gctgtgactt taaaaacagg tttaaagtgg ctgtggttgg
1141 ggacatgaat cctggatttc agccccctat tacacctgac gtggagactt tccaaaacac
1201 cgtaggagat tgcttcggca tcgcaatggt tgcatttgca gtggcctttt cagttgccag
1261 cgtctattcc ctcaaatacg attatccact tgatggcaat caggagttaa tagccttggg
1321 actgggtaac atagtctgtg gagtattcag aggatttgct gggagtactg ccctctccag
1381 atcagcagtt caggagagca caggaggcaa aacacagatt gctgggctta ttggtgccat
1441 catcgtgctg attgtcgttc tagccattgg atttctcctg gcgcctctac aaaagtccgt
1501 cctggcagct ttagcattgg gaaacttaaa gggaatgctg atgcagtttg ctgaaatagg
1561 cagattgtgg cgaaaggaca aatatgattg tttaatttgg atcatgacct tcatcttcac
1621 cattgtcctg ggactcgggt taggcctggc agctagtgtg gcatttcaac tgctaaccat
1681 cgtgttcagg acccaatttc caaaatgcag cacgctggct aatattggaa gaaccaacat
1741 ctataagaat aaaaaagatt attatgatat gtatgagcca gaaggagtga aaattttcag
1801 atgtccatct cctatctact ttgcaaacat tggtttcttt aggcggaaac ttatcgatgc
1861 tgttggcttt agtccacttc gaattctacg caagcgcaac aaagctttga ggaaaatccg
1921 aaaactgcag aagcaaggct tgctacaagt gacaccaaaa ggatttatat gtactgttga
1981 caccataaaa gattctgacg aagagctgga caacaatcag atagaagtac tggaccagcc
2041 aatcaatacc acagacctgc ctttccacat tgactggaat gatgatcttc ctctcaacat
2101 tgaggtcccc aaaatcagcc tccacagcct cattctcgac ttttcagcag tgtcctttct
2161 tgatgtttct tcagtgaggg gccttaaatc gattttgcaa gaatttatca ggatcaaggt
2221 agatgtgtat atcgttggaa ctgatgatga cttcattgag aagcttaacc ggtatgaatt
2281 ttttgatggt gaagtgaaaa gctcaatatt tttcttaaca atccatgatg ctgttttgca
2341 tattttgatg aagaaagatt acagtacttc aaagtttaat cccagtcagg aaaaagatgg
2401 aaaaattgat tttaccataa atacaaatgg aggattacgt aatcgggtat atgaggtgcc
2461 agttgaaaca aaattctaat caacatataa ttcagaagga tcttcatctg actatgacat
2521 aaaaacaact ttatacccag aaagttattg ataagttcat acattgtacg aagagtattt
2581 ttgacagaat atgtttcaaa ctttggaaca agatggttct agcatggcat atttttcaca
2641 tatctagtat gaaattatat aagtattcta aattttatat cttgtagctt tatcaaaggg
2701 tgaaaattat tttgttcata catatttttg tagcactgac agatttccat cctagtcact
2761 accttcatgc ataggtttag cagtatagtg gcgccactgt tttgaatctc ataatttata
2821 caggtcatat taatatattt ccattaaaaa atcagttgta cagtgaaaaa aaaaaagaaa
2881 a
//