LOCUS RATPIT1B 2407 bp mRNA linear ROD 27-APR-1993
DEFINITION Rattus norvegicus PIT-1-beta (PIT-1) mRNA, complete cds.
ACCESSION L01507
VERSION L01507.1
KEYWORDS DNA-dependent dimerization; POU-homeodomain protein; nuclear
protein; pituitary specific; splice variant; transcriptional
activator.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 2407)
AUTHORS Konzak,K.E. and Moore,D.D.
TITLE Functional isoforms of Pit-1 generated by alternative messenger RNA
splicing
JOURNAL Mol. Endocrinol. 6 (2), 241-247 (1992)
PUBMED 1569967
COMMENT Original source text: Rattus norvegicus (strain Sprague-Dawley)
pituitary cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..2407
/organism="Rattus norvegicus"
/mol_type="mRNA"
/strain="Sprague-Dawley"
/db_xref="taxon:10116"
/cell_line="GC3"
/tissue_type="pituitary"
gene 83..1036
/gene="PIT-1"
CDS 83..1036
/gene="PIT-1"
/codon_start=1
/product="PIT-1-beta"
/protein_id="AAA41852.1"
/translation="MSCQPFTSADTFIPLNSDASAALPLRMHHSAAEGLPASNHATNV
MSTVPSILSLIQTPKCLHTYFSMTTMGNTATGLHYSVPSCHYGNQPSTYGVMAGTLTP
CLYKFPDHTLSHGFPPLHQPLLAEDPTASEFKQELRRKSKLVEEPIDMDSPEIRELEQ
FANEFKVRRIKLGYTQTNVGEALAAVHGSEFSQTTICRFENLQLSFKNACKLKAILSK
WLEEAEQVGALYNEKVGANERKRKRRTTISIAAKDALERHFGEHSKPSSQEIMRMAEE
LNLEKEVVRVWFCNRRQREKRVKTSLNQSLFSISKEHLECR"
CDS 161..1036
/gene="PIT-1"
/note="alternate start"
/codon_start=1
/product="PIT-1-beta"
/protein_id="AAA41853.1"
/translation="MHHSAAEGLPASNHATNVMSTVPSILSLIQTPKCLHTYFSMTTM
GNTATGLHYSVPSCHYGNQPSTYGVMAGTLTPCLYKFPDHTLSHGFPPLHQPLLAEDP
TASEFKQELRRKSKLVEEPIDMDSPEIRELEQFANEFKVRRIKLGYTQTNVGEALAAV
HGSEFSQTTICRFENLQLSFKNACKLKAILSKWLEEAEQVGALYNEKVGANERKRKRR
TTISIAAKDALERHFGEHSKPSSQEIMRMAEELNLEKEVVRVWFCNRRQREKRVKTSL
NQSLFSISKEHLECR"
misc_feature 224..301
/gene="PIT-1"
/note="beta-specific splice sequence; encodes amino acids
specific to Pit-1-beta isoform"
BASE COUNT 724 a 497 c 498 g 688 t
ORIGIN
1 cgtgaatcgg ccctttgata cagtaatata ataaaagcgg actggcaagc ggtgcgtctt
61 agttctctac tctcttgtgg gaatgagttg ccaacctttc acctcggctg atacctttat
121 acctctgaat tctgacgctt ctgctgccct gcctctgaga atgcaccaca gtgccgctga
181 gggtctccca gcctccaacc acgccaccaa cgtgatgtcc acagtcccgt ctattttgtc
241 tttgatccaa actcctaaat gtttgcacac atatttctcg atgacaacga tgggaaatac
301 agcgacagga cttcattatt ctgtgccttc ctgtcattat ggaaaccagc catccaccta
361 cggagtgatg gcaggcactt taaccccttg tctttacaag tttccagacc acaccctgag
421 tcatgggttt cctcccctgc accaacctct gctggcggag gacccaacag cctctgaatt
481 taagcaggaa ctcaggcgga aaagtaaatt ggtggaagag ccaatagaca tggactcccc
541 ggaaatccga gaactggagc agtttgccaa cgaatttaaa gtgagaagaa ttaagttagg
601 atacacccag acaaacgtgg gcgaagctct ggccgctgtc cacggctccg aattcagtca
661 aacaaccatc tgccgatttg aaaacttgca gctcagtttc aaaaatgctt gcaaactgaa
721 agcaatttta tccaagtggc tggaggaagc tgagcaggtc ggagctttgt acaatgaaaa
781 agtgggagca aacgaaagga agaggaaacg gaggacaact atcagtatcg ccgctaagga
841 tgctttggag agacactttg gagagcacag caaaccttct tcgcaggaga tcatgcggat
901 ggctgaagaa ttgaatctcg agaaagaagt agtaagagtg tggttttgca accgaaggca
961 gagagaaaaa cgggtgaaaa cgagtctcaa tcaaagtctg ttctctattt caaaggagca
1021 tcttgagtgc agataagact tgcctgtggt agccatgtgt ggtagccttt ccattccttt
1081 ctgatttcaa gaaaaatcag aagttactta gcttcataaa ctagattaaa tcagcaaccc
1141 ctgcagtttt tgtttcactt tcttctttct ttccctttta gatccaatga tttaaaacaa
1201 gacgttttat ttagttgttc tcagaattca tagcattgcc tttactccta aatcatcacc
1261 aagaatgctc acaatacctc ttccaattct gcctttatac ctaatacaca gagaggtggg
1321 gataactggg agagaggcca tcatatatgt gaatattttg agtttaaaat taccttttgt
1381 aagtcaattt attgttcttt aaattttaat cagtaaggac aaatatttac cgactattaa
1441 ccagggatgg ctcaaggttg ataatctatt gacttggcca gagagatgtc tcagtggtta
1501 agagcatctg ttgctcttcc agaggatgtg ggttccatca cctatacagc tcacaactgt
1561 ctgtcacact atttccagag gaaatccaag gagtctcctg ggttccattg acactcggcc
1621 tgaaaatgag cacagacata catgtagaca aaatactcat acatatacag taaaaataat
1681 aaatctataa acaaaaagaa aatatattgg tttatactca gtatgcccct agcactatgt
1741 tttgttttgt tttgttttgg agtaaggttt gacaatccag aggtgactag agacaactaa
1801 gaattttatt aattgccttc agaaataatc ttcagtcaga atctattgat atctttgaca
1861 ttaacactta ggacacgttt tttgaacaat ttgtaggagc atttaggcat gacatctggg
1921 cgtattcttt tatacacatt agctttctga ggctctgcta cagaaaacat gtgagctgca
1981 agctaaactt gctgacccaa ataatccttc agttttggct ttgttttgtt ttgtttggta
2041 gtgagttcaa tcctgagcac aagtgaaatt taaaaatgaa aaatatggtt tagggatccc
2101 taacctatat cataaatctg tgtggaagct gcactagggc gaggctacgt ggcttacttg
2161 ctgttatgtt tccagtgact gaaaaagcac tggctcctag taggtatgta tagaccatgc
2221 taaaaggaat gggcccaatg gtgaacaacc gctacaaata tgaagggtac caggcaacct
2281 gaaaaatcta acttgttttt gaagtctcat tgtagaaact cactgaggtt ccttaacaaa
2341 gtgtcaattt tggtctcact ggtcacattt tgatttatta ataaaaattg gaaatatgaa
2401 aaaaaaa
//