LOCUS HUMI69KAA 1785 bp mRNA linear HUM 16-AUG-1993
DEFINITION Human 69 kD autoantigen mRNA sequence.
ACCESSION L01100
VERSION L01100.1
KEYWORDS 69 kD autoantigen; autoantigen.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1785)
AUTHORS Pietropaolo,M., Castano,L., Babu,S., Buelow,R., Kuo,Y.L.,
Martin,S., Martin,A., Powers,A.C., Prochazka,M., Naggert,J. et al.
TITLE Islet cell autoantigen 69 kD (ICA69). Molecular cloning and
characterization of a novel diabetes-associated autoantigen
JOURNAL J. Clin. Invest. 92 (1), 359-371 (1993)
PUBMED 8326004
COMMENT Original source text: Homo sapiens (library: lambda gt11 cDNA
library from A. Permutt) adult islet of Langerhans cDNA to mRNA.
/map= chromosome 6 6cM.
FEATURES Location/Qualifiers
source 1..1785
/db_xref="H-InvDB:HIT000191445"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 179..1630
/standard_name="ICA69"
/codon_start=1
/product="69 kD autoantigen"
/protein_id="AAA02564.1"
/translation="MSGHKCSYPWDLQDRYAQDKSVVNKMQQRYWETKQAFIKATGKK
EDEHVVASDADLDAKLELFHSIQRTCLDLSKAIVLYQKRICFLSQEENELGKFLRSQG
FQDKTRAGKMMQATGKALCFSSQQRLALRNPLCRFHQEVETFRHRAISDTWLTVNRME
QCRTEYRGALLWMKDVSQELDPDLYKQMEKFRKVQTQVRLAKKNFDKLKMDVCQKVDL
LGASRCNLLSHMLATYQTTLLHFWEKTSHTMAAIHESFKGYQPYEFTTLKSLQDPMKK
LVEKEEKKKINQQESTDAAVQEPSQLISLEEENQRKESSSFKTEDGKSILSALDKGST
HTACSGPIDELLDMKSEEGACLGPVAGTPEPEGADKDDLLLLSEIFNASSLEEGEFSK
EWAAVFGDGQVKEPVPTMALGEPDPKAQTGSGFLPSQLLDQNMKDLQASLQEPAKAAS
DLTAWFSLFADLDPLSNPDAVGKTDKEHELLNA"
BASE COUNT 561 a 398 c 428 g 398 t
ORIGIN
1 cgggcggggg ataccccagg agatgggggt cgaggagaga ccccggggag tagagagaga
61 gaaactcact ccccgagtcc ccgaccctcc ccaagcaagg ttataatata acttatcctc
121 tcatgctttt ttcctgcccc ttctccccaa atcatcaaca atagaagaag aagaaaacat
181 gtcaggacac aaatgcagtt atccctggga cttacaggat cgatatgctc aagataagtc
241 agttgtaaat aagatgcaac agagatattg ggagacgaag caggccttta ttaaagccac
301 agggaagaag gaagatgaac atgttgttgc ctctgacgcg gacctggatg ccaagctaga
361 gctgtttcat tcaattcaga gaacctgtct ggacttatcg aaagcaattg tactctatca
421 aaagaggata tgtttcttgt ctcaagaaga aaacgaactg ggaaaatttc ttcgatccca
481 aggtttccaa gataaaacca gagcaggaaa gatgatgcaa gcgacaggaa aggccctctg
541 cttttcttcc cagcaaaggt tggccttacg aaatcctttg tgtcgatttc accaagaagt
601 ggagactttt cggcatcggg ccatctcaga tacttggctg acggtgaacc gcatggaaca
661 gtgcaggacg gaatatagag gagcactatt atggatgaag gacgtgtctc aggagcttga
721 tccagacctc tacaagcaaa tggagaagtt caggaaggtg caaacacaag tgcgccttgc
781 aaaaaaaaac tttgacaaat tgaagatgga tgtgtgtcaa aaagtggatc ttcttggagc
841 gagcagatgc aatctcttgt ctcacatgct agcaacatac cagaccactc tgcttcattt
901 ttgggagaaa acttctcaca ctatggcagc catccatgag agtttcaaag gttatcaacc
961 atatgaattt actactttaa agagcttaca agaccctatg aaaaaattag ttgagaaaga
1021 agagaagaag aaaatcaacc agcaggaaag tacagatgca gccgtgcagg agccgagcca
1081 attaatttca ttagaggaag aaaaccagcg caaggaatcc tctagtttta agactgaaga
1141 tggaaaaagt attttatctg ccttagacaa aggctctaca catactgcat gctcaggacc
1201 catagatgaa ctattagaca tgaaatctga ggaaggtgct tgcctgggac cagtggcagg
1261 gaccccggaa cctgaaggtg ctgacaaaga tgacctgctg ctgttgagtg agatcttcaa
1321 tgcttcctcc ttggaagagg gcgagttcag caaagagtgg gccgctgtgt ttggagacgg
1381 ccaagtgaag gagccagtgc ccactatggc cctgggagag ccagacccca aggcccagac
1441 aggctcaggt ttccttcctt cgcagctttt agaccaaaat atgaaagact tacaggcctc
1501 gctacaagaa cctgctaagg ctgcctcaga cctgactgcc tggttcagcc tcttcgctga
1561 cctcgaccca ctctcaaatc ctgatgctgt tgggaaaacc gataaagaac acgaattgct
1621 caatgcatga atctgtaccc ttcggagggc actcacatgc cgcccccagc agctcccctg
1681 ggggctagca gaagtataaa gtgatcagta tgctgtttta ataattatgt gccattttaa
1741 taaaatgaaa gggtcaacgg ccctgttaaa aaaaaaaaaa aaaaa
//