LOCUS KC806059 1163 bp mRNA linear HUM 28-FEB-2014
DEFINITION Homo sapiens p14ARF/p16INK4a fusion protein (p14ARF/p16INK4a
fusion) mRNA, complete cds.
ACCESSION KC806059
VERSION KC806059.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1163)
AUTHORS Williams,R.T., Barnhill,L.M., Kuo,H.H., Lin,W.D., Batova,A.,
Yu,A.L. and Diccianni,M.B.
TITLE Chimeras of p14ARF and p16: Functional Hybrids with the Ability to
Arrest Growth
JOURNAL PLoS ONE 9 (2), E88219 (2014)
PUBMED 24505435
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 1163)
AUTHORS Williams,R.T., Barnhill,L.M., Diccianni,M.B. and Yu,A.L.
TITLE A unique frameshift mutation produces two chimeric INK4a proteins
with altered tumor suppressor function
JOURNAL Unpublished
REFERENCE 3 (bases 1 to 1163)
AUTHORS Williams,R.T., Barnhill,L.M., Diccianni,M.B. and Yu,A.L.
TITLE Direct Submission
JOURNAL Submitted (20-MAR-2013) Pediatrics Hematology/Oncology, University
of California, San Diego, 200 W. Arbor Dr., San Diego, CA
92103-8447, USA
FEATURES Location/Qualifiers
source 1..1163
/db_xref="H-InvDB:HIT000722605"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_line="M2"
/cell_type="melanoma"
gene 1..1163
/gene="p14ARF/p16INK4a fusion"
exon 1..353
/gene="p14ARF/p16INK4a fusion"
/note="p14ARF"
/number=1-beta
CDS 161..673
/gene="p14ARF/p16INK4a fusion"
/codon_start=1
/product="p14ARF/p16INK4a fusion protein"
/protein_id="AGN04211.1"
/translation="MVRRFLVTLRIRRACGPPRVRVFVVHIPRLTGEWAAPGAPAAVA
LVLMLLRSQRLGQQPLPRRPGHDDGQRPSGGAAAAPRRGAQLRRPRHSHPIVHDAARE
GFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARYLRAAAGGTRGSNHARID
AAEGPSDIPD"
exon 354..659
/gene="p14ARF/p16INK4a fusion"
/note="p16INK4a"
/number=2
exon 660..1150
/gene="p14ARF/p16INK4a fusion"
/note="p14ARF"
/number=3
BASE COUNT 246 a 330 c 354 g 233 t
ORIGIN
1 cgctcaggga aggcgggtgc gcgcctgcgg ggcggagatg ggcagggggc ggtgcgtggg
61 tcccagtctg cagttaaggg ggcaggagtg gcgctgctca cctctggtgc caaagggcgg
121 cgcagcggct gccgagctcg gccctggagg cggcgagaac atggtgcgca ggttcttggt
181 gaccctccgg attcggcgcg cgtgcggccc gccgcgagtg agggttttcg tggttcacat
241 cccgcggctc acgggggagt gggcagcgcc aggggcgccc gccgctgtgg ccctcgtgct
301 gatgctactg aggagccagc gtctagggca gcagccgctt cctagaagac caggtcatga
361 tgatgggcag cgcccgagtg gcggagctgc tgctgctcca cggcgcggag cccaactgcg
421 ccgaccccgc cactctcacc cgatcgtgca cgacgctgcc cgggagggct tcctggacac
481 gctggtggtg ctgcaccggg ccggggcgcg gctggacgtg cgcgatgcct ggggccgtct
541 gcccgtggac ctggctgagg agctgggcca tcgcgatgtc gcacggtacc tgcgcgcggc
601 tgcggggggc accagaggca gtaaccatgc ccgcatagat gccgcggaag gtccctcaga
661 catccccgat tgaaagaacc agagaggctc tgagaaacct cgggaaactt agatcatcag
721 tcaccgaagg tcctacaggg ccacaactgc ccccgccaca acccaccccg ctttcgtagt
781 tttcatttag aaaatagagc ttttaaaaat gtcctgcctt ttaacgtaga tatatgcctt
841 cccccactac cgtaaatgtc catttatatc attttttata tattcttata aaaatgtaaa
901 aaagaaaaac accgcttctg ccttttcact gtgttggagt tttctggagt gagcactcac
961 gccctaagcg cacattcatg tgggcatttc ttgcgagcct cgcagcctcc ggaagctgtc
1021 gacttcatga caagcatttt gtgaactagg gaagctcagg ggggttactg gcttctcttg
1081 agtcacactg ctagcaaatg gcagaaccaa agctcaaata aaaataaaat aattttcatt
1141 cattcactca aaaaaaaaaa aaa
//