LOCUS       KC143287                 424 bp    mRNA    linear   HUM 06-FEB-2013
DEFINITION  Homo sapiens neprilysin-411 (MME) mRNA, partial cds, alternatively
            spliced.
ACCESSION   KC143287
VERSION     KC143287.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 424)
  AUTHORS   Canudas,J., Sarasa,L., Insua,D., Pesini,P. and Sarasa,M.
  TITLE     Neprilysin is poorly expressed in the frontal cortex of aged dogs
            suffering cognitive dysfunction
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 424)
  AUTHORS   Canudas,J., Sarasa,L., Insua,D., Pesini,P. and Sarasa,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-NOV-2012) R&D Laboratory, Araclon Biotech Ltd, C/
            Franz Schubert, 2, Zaragoza, Aragon 50012, Spain
FEATURES             Location/Qualifiers
     source          1..424
                     /db_xref="H-InvDB:HIT000722482"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /tissue_type="brain; hippocampus"
     gene            <1..424
                     /gene="MME"
     CDS             <1..367
                     /gene="MME"
                     /EC_number="3.4.24.11"
                     /note="NEP-411; alternatively spliced; missing exon 14;
                     beta-amyloid degrading enzyme"
                     /codon_start=2
                     /product="neprilysin-411"
                     /protein_id="AGE12493.1"
                     /translation="EDRNDPMLLYNKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTV
                     NISITNEEDVVVYAPEYLTKLKPILTKYSARPFMVQPQKQQLGDVVQTMSMGIWKMLW
                     GGFMWKQHLLERVNMWSRI"
     exon            <1..88
                     /gene="MME"
                     /number=12
     exon            89..225
                     /gene="MME"
                     /number=13
     exon            226..354
                     /gene="MME"
                     /number=15
     exon            355..424
                     /gene="MME"
                     /number=16
BASE COUNT          136 a           72 c           94 g          121 t
ORIGIN      
        1 tgaagatcga aatgatccaa tgcttctgta taacaagatg acattggccc agatccaaaa
       61 taacttttca ctagagatca atgggaagcc attcagctgg ttgaatttca caaatgaaat
      121 catgtcaact gtgaatatta gtattacaaa tgaggaagat gtngttgttt atgctccaga
      181 atatttaacc aaacttaagc ccattcttac caaatattct gccaggccct ttatggtaca
      241 acctcagaaa cagcaacttg gagacgttgt gcaaactatg tcaatgggaa tatggaaaat
      301 gctgtgggga ggctttatgt ggaagcagca tttgctggag agagtaaaca tgtggtcgag
      361 gatttgattg cacagatccg agaagttttt attcagactt tagatgacct cacttggatg
      421 gatg
//