LOCUS HUMALDHA1 1560 bp mRNA linear HUM 31-OCT-1994
DEFINITION Human aldehyde dehydrogenase 1 mRNA.
ACCESSION K03000
VERSION K03000.1
KEYWORDS aldehyde dehydrogenase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1560)
AUTHORS Hsu,L.C., Tani,K., Fujiyoshi,T., Kurachi,K. and Yoshida,A.
TITLE Cloning of cDNAs for human aldehyde dehydrogenases 1 and 2
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 82 (11), 3771-3775 (1985)
PUBMED 2987944
COMMENT Original source text: Human liver, cDNA to mRNA, clone
lambda-ALDH1-1.
Reprint kindly provided by A.Yoshida 10-SEP-1985. 50% of Orientals
have only the ALDH1 isozyme, which in some cases produces an
enzymatically inactive ALDH1 enzyme, and are missing the ALDH2
isozyme (commonly designated 'atypical'). A very high incidence of
acute alcohol intoxication in Orientals, as compared to Caucasians,
can be directly attributed to genetic differences in the ALDH
isozymes. A poly-A signal is located at positions 1542-1547.
FEATURES Location/Qualifiers
source 1..1560
/db_xref="H-InvDB:HIT000191401"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="9q21.1"
gene 1..1560
/gene="ALDH1"
mRNA <1..1560
/gene="ALDH1"
/product="ALDH-1 mRNA"
CDS <1..1023
/gene="ALDH1"
/note="aldehyde dehydrogenase 1 (EC 1.2.1.3)"
/codon_start=1
/protein_id="AAA51695.1"
/db_xref="GDB:G00-119-667"
/translation="ICGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHV
ASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNL
KRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVR
RSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKG
YFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDI
DKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVK
ISQKNS"
BASE COUNT 480 a 289 c 349 g 442 t
ORIGIN 253 bp upstream of Sau3A site; chromosome 9q21.1.
1 atatgtggcc aaatcattcc ttggaatttc ccgttggtta tgctcatttg gaagataggg
61 cctgcactga gctgtggaaa cacagtggtt gtcaaaccag cagagcaaac tcctctcact
121 gctctccacg tggcatcttt aataaaagag gcagggtttc ctcctggagt agtgaatatt
181 gttcctggtt atgggcctac agcaggggca gccatttctt ctcacatgga tatagacaaa
241 gtagccttca caggatcaac agaggttggc aagttgatca aagaagctgc cgggaaaagc
301 aatctgaaga gggtgaccct ggagcttgga ggaaagagcc cttgcattgt gttagctgat
361 gccgacttgg acaatgctgt tgaatttgca caccatgggg tattctacca ccagggccag
421 tgttgtatag ccgcatccag gatttttgtg gaagaatcaa tttatgatga gtttgttcga
481 aggagtgttg agcgggctaa gaagtatatc cttggaaatc ctctgacccc aggagtcact
541 caaggccctc agattgacaa ggaacaatat gataaaatac ttgacctcat tgagagtggg
601 aagaaagaag gggccaaact ggaatgtgga ggaggcccgt gggggaataa aggctacttt
661 gtccagccca cagtgttctc taatgttaca gatgagatgc gcattgccaa agaggagatt
721 tttggaccag tgcagcaaat catgaagttt aaatctttag atgacgtgat caaaagagca
781 aacaatactt tctatggctt atcagcagga gtgtttacca aagacattga taaagccata
841 acaatctcct ctgctctgca ggcaggaaca gtgtgggtga attgctatgg cgtggtaagt
901 gcccagtgcc cctttggtgg attcaagatg tctggaaatg gaagagaact gggagagtac
961 ggtttccatg aatatacaga ggtcaaaaca gtcacagtga aaatctctca gaagaactca
1021 taaagaaaat acaagagtgg agagaagctc ttcaatagct aagcatctcc ttacagtcac
1081 taatatagta gattttaaag acaaaatttt tcttttcttg atttttttta aacataagct
1141 aaatcatatt agtattaata ctacccatag aaaacttgac atgtagcttc ttctgaaaga
1201 attatttgcc ttctgaaatg tgacccccaa gtcctatcct aaataaaaaa agacaaattc
1261 ggatgtatga tctctctagc tttgtcatag ttatgtgatt ttcctttgta gctacttttg
1321 caggataata attttataga aaaggaacag ttgcatttag cttctttccc ttagtgactc
1381 ttgaagtact taacatacac gttaactgca gagtaaattg ctctgttccc agtagttata
1441 aagtccttgg actgttttga aaagtttcct aggatgtcat gtctgcttgt caaaagaaat
1501 aatccctgta atatttagct gtaaactgaa tataaagctt aataaaaaca accttgcata
//