LOCUS AH002732 3195 bp DNA linear HUM 01-AUG-2016 DEFINITION Homo sapiens isolate Chronic lymphocytic leukemia (CLL) patient immunoglobulin delta-chain (IGHD) gene, complete cds, alternatively spliced. ACCESSION AH002732 K02875 K02876 K02877 K02878 K02879 K02880 K02881 K02882 VERSION AH002732.2 KEYWORDS C-region; germline; immunoglobulin heavy chain; immunoglobulin-delta. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3195) AUTHORS White,M.B., Shen,A.L., Word,C.J., Tucker,P.W. and Blattner,F.R. TITLE Human immunoglobulin D: genomic sequence of the delta heavy chain JOURNAL Science 228 (4700), 733-737 (1985) PUBMED 3922054 COMMENT On or before Aug 1, 2016 this sequence version replaced K02875.1, K02876.1, K02877.1, K02878.1, K02879.1, K02880.1, K02881.1, K02882.1, AH002732.1. FEATURES Location/Qualifiers source 1..3195 /organism="Homo sapiens" /mol_type="genomic DNA" /isolate="Chronic lymphocytic leukemia (CLL) patient" /db_xref="taxon:9606" /map="14q32.33" /cell_type="lymphocyte" /germline gene 1..3147 /gene="IGHD" intron <1..100 /gene="IGHD" /note="J-C intron; G00-120-084" CDS join(101..403,696..797,1096..1167,1496..1819,2096..2419, 2820..2977,3139..3147) /gene="IGHD" /note="membrane bound form" /codon_start=3 /product="immunoglobulin delta-chain" /protein_id="AAA52771.1" /db_xref="GDB:G00-120-084" /translation="PTKAPDVFPIISGCRHPKDNSPVVLACLITGYHPTSVTVTWYMG TQSQPQRTFPEIQRRDSYYMTSSQLSTPLQQWRQGEYKCVVQHTASKSKKEIFRWPES PKAQASSVPTAQPQAEGSLAKATTAPATTRNTGRGGEEKKKEKEKEEQEERETKTPEC PSHTQPLGVYLLTPAVQDLWLRDKATFTCFVVGSDLKDAHLTWEVAGKVPTGGVEEGL LERHSNGSQSQHSRLTLPRSLWNAGTSVTCTLNHPSLPPQRLMALREPAAQAPVKLSL NLLASSDPPEAASWLLCEVSGFSPPNILLMWLEDQREVNTSGFAPARPPPQPRSTTFW AWSVLRVPAPPSPQPATYTCVVSHEDSRTLLNASRSLEVSYLAMTPLIPQSKDENSDD YTTFDDVGSLWTTLSTFVALFILTLLYSGIVTFIKVK" CDS join(101..403,696..797,1096..1167,1496..1819,2096..2419, 2620..2648) /gene="IGHD" /note="secreted form" /codon_start=3 /product="immunoglobulin delta-chain" /protein_id="AAA52770.1" /db_xref="GDB:G00-120-084" /translation="PTKAPDVFPIISGCRHPKDNSPVVLACLITGYHPTSVTVTWYMG TQSQPQRTFPEIQRRDSYYMTSSQLSTPLQQWRQGEYKCVVQHTASKSKKEIFRWPES PKAQASSVPTAQPQAEGSLAKATTAPATTRNTGRGGEEKKKEKEKEEQEERETKTPEC PSHTQPLGVYLLTPAVQDLWLRDKATFTCFVVGSDLKDAHLTWEVAGKVPTGGVEEGL LERHSNGSQSQHSRLTLPRSLWNAGTSVTCTLNHPSLPPQRLMALREPAAQAPVKLSL NLLASSDPPEAASWLLCEVSGFSPPNILLMWLEDQREVNTSGFAPARPPPQPRSTTFW AWSVLRVPAPPSPQPATYTCVVSHEDSRTLLNASRSLEVSYVTDHGPMK" exon 101..403 /gene="IGHD" /note="C-delta-1 domain; G00-120-084; putative" /number=1 intron 404..>495 /gene="IGHD" /note="G00-120-084" /number=1 gap 496..595 /estimated_length=unknown intron <596..746 /gene="IGHD" /note="G00-120-084" /number=1 exon 696..797 /gene="IGHD" /note="hinge-1 domain; G00-120-084" /number=2 intron 798..>895 /gene="IGHD" /note="G00-120-084" /number=2 gap 896..995 /estimated_length=unknown intron <996..1095 /gene="IGHD" /note="G00-120-084" /number=2 exon 1096..1167 /gene="IGHD" /note="hinge-2 domain; G00-120-084; putative" /number=3 intron 1168..>1295 /gene="IGHD" /note="G00-120-084" /number=3 gap 1296..1395 /estimated_length=unknown intron <1396..1495 /gene="IGHD" /note="G00-120-084" /number=3 exon 1496..1819 /gene="IGHD" /note="C-delta-2 domain; G00-120-084" /number=4 intron 1820..>1895 /gene="IGHD" /note="G00-120-084" /number=4 intron 1820..>1895 /gene="IGHD" /note="IgD-s intron D" gap 1896..1995 /estimated_length=unknown intron <1996..2095 /gene="IGHD" /note="G00-120-084" /number=4 exon 2096..2419 /gene="IGHD" /note="C-delta-3 domain; G00-120-084; putative" /number=5 intron 2420..>2495 /gene="IGHD" /note="G00-120-084" /number=5 gap 2496..2595 /estimated_length=unknown intron <2596..>2695 /gene="IGHD" /note="G00-120-084" /number=5 intron <2596..2619 /gene="IGHD" /note="G00-120-084" /number=5 exon 2620..>2648 /gene="IGHD" /note="secreted terminus domain; G00-120-084" /number=6 gap 2696..2795 /estimated_length=unknown intron <2796..2819 /gene="IGHD" /note="G00-120-084" /number=5 exon 2820..2977 /gene="IGHD" /note="first domain of membrane terminus; G00-120-084; putative" /number=6 intron 2978..>2995 /gene="IGHD" /note="G00-120-084" /number=6 gap 2996..3095 /estimated_length=unknown intron <3096..3138 /gene="IGHD" /note="IgD-Mb" /number=6 exon 3139..>3147 /gene="IGHD" /note="membrane-bound form (second domain of membrane terminus); G00-120-084; putative" /number=7 BASE COUNT 536 a 858 c 645 g 456 t ORIGIN 182 bp upstream of SphI site; chromosome 14q32.3. 1 tttccctgcc tcccgtcacc ctgccgccag ggcctctgcc ctgccctgcc ccttgtcctc 61 aggtttccag cctcagactc ccactgtgtc tgtcttccag cacccaccaa ggctccggat 121 gtgttcccca tcatatcagg gtgcagacac ccaaaggata acagccctgt ggtcctggca 181 tgcttgataa ctgggtacca cccaacgtcc gtgactgtca cctggtacat ggggacacag 241 agccagcccc agagaacctt ccctgagata caaagacggg acagctacta catgacaagc 301 agccagctct ccacccccct ccagcagtgg cgccaaggcg agtacaaatg cgtggtccag 361 cacaccgcca gcaagagtaa gaaggagatc ttccgctggc caggtaggtc gcaccggaga 421 tcacccagaa gggcccccca ggacccccag caccttccac tcagggcctg accacaaaga 481 cagaagcaag ggctgnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 541 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnntaggc 601 tgcctgtgcc ccccacctgc ctgtccacaa cccagcctct ggtacatcca tgccctctgc 661 cctaagcctc acctgcactt ttccttggat ttcagagtct ccaaaggcac aggcctcctc 721 cgtgcccact gcacaacccc aagcagaggg cagcctcgcc aaggcaacca cagccccagc 781 caccacccgt aacacaggtg agaagcccct tccctgcaca ctccaccccc acccacctgc 841 tcattcctca gccgcctcct ccaggcagcc cttcataact ccttgtctga gtctcnnnnn 901 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 961 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnngtcat tagctggatt tagccattcc 1021 acaatgtaca catatttcaa acattgtgtt gtatatgata aacatgtata atttttgtca 1081 attaaaaatt tttaggaaga ggaggagaag agaagaagaa ggagaaggag aaagaggaac 1141 aagaagagag agagacaaag acaccaggtt ttttctgacc cctgggctat caaaacacct 1201 attgcccaat aactagttgg ccgttggtgc cctaaactat tgaagcgatt gctgttatgt 1261 ggatgggccc cggacactta gaaactcgtg accccnnnnn nnnnnnnnnn nnnnnnnnnn 1321 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1381 nnnnnnnnnn nnnnngaagc tggggagagg agagcacagt ggttaagtca gtccctgcag 1441 cccaactgct cccgaaggtc cggccacagc tgctctcgtt tgctctcccc tgcagagtgt 1501 ccgagccaca cccagcctct tggcgtctac ctgctaaccc ctgcagtgca ggacctgtgg 1561 ctccgggaca aagccacctt cacctgcttc gtggtgggca gtgacctgaa ggatgctcac 1621 ctgacctggg aggtggctgg gaaggtcccc acagggggcg tggaggaagg gctgctggag 1681 cggcacagca acggctccca gagccagcac agccgtctga ccctgcccag gtccttgtgg 1741 aacgcgggga cctccgtcac ctgcacactg aaccatccca gcctcccacc ccagaggttg 1801 atggcgctga gagaacccgg tgagcctggc tcccaggtgg ggagacgagg gtgcccacag 1861 cctgctgacc cctacgcccg ccccagggcc atgacnnnnn nnnnnnnnnn nnnnnnnnnn 1921 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1981 nnnnnnnnnn nnnnnccaca ggaaaggaga agggaggcac cacaccctgg ccggccccac 2041 ttctctccca gtgcccccgt ggccagagcc tgacagcccc cccacctccc cgcagctgcg 2101 caggcacccg tcaagctttc tctgaacctg ctggcctcgt ctgaccctcc cgaggcggcc 2161 tcgtggctcc tgtgtgaggt gtctggcttc tcgcccccca acatcctcct gatgtggctg 2221 gaggaccagc gtgaggtgaa cacttctggg tttgcccccg cacgcccccc tccacagccc 2281 aggagcacca cgttctgggc ctggagtgtg ctgcgtgtcc cagccccgcc cagccctcag 2341 ccagccacct acacgtgtgt ggtcagccac gaggactccc ggactctgct caacgccagc 2401 cggagcctag aagtcagctg tgagtcaccc ccaggccagg gttgggacgg ggactctgag 2461 gggggccata aggagctgga atccatacta ggcagnnnnn nnnnnnnnnn nnnnnnnnnn 2521 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2581 nnnnnnnnnn nnnnngacac gccgattttt tgttattaga tgtaacagac catggcccca 2641 tgaaatgatc ccggaccaga tccgtccgca cccgccactc agcagctctg gccgannnnn 2701 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 2761 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnncgctc ggcccccgtt cctccccaga 2821 cctggccatg acccccctga tccctcagag caaggatgag aacagcgatg actacacgac 2881 ctttgatgat gtgggcagcc tgtggaccac cctgtccacg tttgtggccc tcttcatcct 2941 caccctcctc tacagcggca ttgtcacttt catcaaggtc aggggagcgg ccaggnnnnn 3001 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3061 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnntcagg cttctagccc ctgtctgacc 3121 ccaggggctg tctttcaggt gaagtagccc cagaagagca ggacgccctg tacctgcaga 3181 gaagggaagc agcct //