LOCUS       AH002732                3195 bp    DNA     linear   HUM 01-AUG-2016
DEFINITION  Homo sapiens isolate Chronic lymphocytic leukemia (CLL) patient
            immunoglobulin delta-chain (IGHD) gene, complete cds, alternatively
            spliced.
ACCESSION   AH002732 K02875 K02876 K02877 K02878 K02879 K02880 K02881 K02882
VERSION     AH002732.2
KEYWORDS    C-region; germline; immunoglobulin heavy chain;
            immunoglobulin-delta.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3195)
  AUTHORS   White,M.B., Shen,A.L., Word,C.J., Tucker,P.W. and Blattner,F.R.
  TITLE     Human immunoglobulin D: genomic sequence of the delta heavy chain
  JOURNAL   Science 228 (4700), 733-737 (1985)
   PUBMED   3922054
COMMENT     On or before Aug 1, 2016 this sequence version replaced K02875.1,
            K02876.1, K02877.1, K02878.1, K02879.1, K02880.1, K02881.1,
            K02882.1, AH002732.1.
FEATURES             Location/Qualifiers
     source          1..3195
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /isolate="Chronic lymphocytic leukemia (CLL) patient"
                     /db_xref="taxon:9606"
                     /map="14q32.33"
                     /cell_type="lymphocyte"
                     /germline
     gene            1..3147
                     /gene="IGHD"
     intron          <1..100
                     /gene="IGHD"
                     /note="J-C intron; G00-120-084"
     CDS             join(101..403,696..797,1096..1167,1496..1819,2096..2419,
                     2820..2977,3139..3147)
                     /gene="IGHD"
                     /note="membrane bound form"
                     /codon_start=3
                     /product="immunoglobulin delta-chain"
                     /protein_id="AAA52771.1"
                     /db_xref="GDB:G00-120-084"
                     /translation="PTKAPDVFPIISGCRHPKDNSPVVLACLITGYHPTSVTVTWYMG
                     TQSQPQRTFPEIQRRDSYYMTSSQLSTPLQQWRQGEYKCVVQHTASKSKKEIFRWPES
                     PKAQASSVPTAQPQAEGSLAKATTAPATTRNTGRGGEEKKKEKEKEEQEERETKTPEC
                     PSHTQPLGVYLLTPAVQDLWLRDKATFTCFVVGSDLKDAHLTWEVAGKVPTGGVEEGL
                     LERHSNGSQSQHSRLTLPRSLWNAGTSVTCTLNHPSLPPQRLMALREPAAQAPVKLSL
                     NLLASSDPPEAASWLLCEVSGFSPPNILLMWLEDQREVNTSGFAPARPPPQPRSTTFW
                     AWSVLRVPAPPSPQPATYTCVVSHEDSRTLLNASRSLEVSYLAMTPLIPQSKDENSDD
                     YTTFDDVGSLWTTLSTFVALFILTLLYSGIVTFIKVK"
     CDS             join(101..403,696..797,1096..1167,1496..1819,2096..2419,
                     2620..2648)
                     /gene="IGHD"
                     /note="secreted form"
                     /codon_start=3
                     /product="immunoglobulin delta-chain"
                     /protein_id="AAA52770.1"
                     /db_xref="GDB:G00-120-084"
                     /translation="PTKAPDVFPIISGCRHPKDNSPVVLACLITGYHPTSVTVTWYMG
                     TQSQPQRTFPEIQRRDSYYMTSSQLSTPLQQWRQGEYKCVVQHTASKSKKEIFRWPES
                     PKAQASSVPTAQPQAEGSLAKATTAPATTRNTGRGGEEKKKEKEKEEQEERETKTPEC
                     PSHTQPLGVYLLTPAVQDLWLRDKATFTCFVVGSDLKDAHLTWEVAGKVPTGGVEEGL
                     LERHSNGSQSQHSRLTLPRSLWNAGTSVTCTLNHPSLPPQRLMALREPAAQAPVKLSL
                     NLLASSDPPEAASWLLCEVSGFSPPNILLMWLEDQREVNTSGFAPARPPPQPRSTTFW
                     AWSVLRVPAPPSPQPATYTCVVSHEDSRTLLNASRSLEVSYVTDHGPMK"
     exon            101..403
                     /gene="IGHD"
                     /note="C-delta-1 domain; G00-120-084; putative"
                     /number=1
     intron          404..>495
                     /gene="IGHD"
                     /note="G00-120-084"
                     /number=1
     gap             496..595
                     /estimated_length=unknown
     intron          <596..746
                     /gene="IGHD"
                     /note="G00-120-084"
                     /number=1
     exon            696..797
                     /gene="IGHD"
                     /note="hinge-1 domain; G00-120-084"
                     /number=2
     intron          798..>895
                     /gene="IGHD"
                     /note="G00-120-084"
                     /number=2
     gap             896..995
                     /estimated_length=unknown
     intron          <996..1095
                     /gene="IGHD"
                     /note="G00-120-084"
                     /number=2
     exon            1096..1167
                     /gene="IGHD"
                     /note="hinge-2 domain; G00-120-084; putative"
                     /number=3
     intron          1168..>1295
                     /gene="IGHD"
                     /note="G00-120-084"
                     /number=3
     gap             1296..1395
                     /estimated_length=unknown
     intron          <1396..1495
                     /gene="IGHD"
                     /note="G00-120-084"
                     /number=3
     exon            1496..1819
                     /gene="IGHD"
                     /note="C-delta-2 domain; G00-120-084"
                     /number=4
     intron          1820..>1895
                     /gene="IGHD"
                     /note="G00-120-084"
                     /number=4
     intron          1820..>1895
                     /gene="IGHD"
                     /note="IgD-s intron D"
     gap             1896..1995
                     /estimated_length=unknown
     intron          <1996..2095
                     /gene="IGHD"
                     /note="G00-120-084"
                     /number=4
     exon            2096..2419
                     /gene="IGHD"
                     /note="C-delta-3 domain; G00-120-084; putative"
                     /number=5
     intron          2420..>2495
                     /gene="IGHD"
                     /note="G00-120-084"
                     /number=5
     gap             2496..2595
                     /estimated_length=unknown
     intron          <2596..>2695
                     /gene="IGHD"
                     /note="G00-120-084"
                     /number=5
     intron          <2596..2619
                     /gene="IGHD"
                     /note="G00-120-084"
                     /number=5
     exon            2620..>2648
                     /gene="IGHD"
                     /note="secreted terminus domain; G00-120-084"
                     /number=6
     gap             2696..2795
                     /estimated_length=unknown
     intron          <2796..2819
                     /gene="IGHD"
                     /note="G00-120-084"
                     /number=5
     exon            2820..2977
                     /gene="IGHD"
                     /note="first domain of membrane terminus; G00-120-084;
                     putative"
                     /number=6
     intron          2978..>2995
                     /gene="IGHD"
                     /note="G00-120-084"
                     /number=6
     gap             2996..3095
                     /estimated_length=unknown
     intron          <3096..3138
                     /gene="IGHD"
                     /note="IgD-Mb"
                     /number=6
     exon            3139..>3147
                     /gene="IGHD"
                     /note="membrane-bound form (second domain of membrane
                     terminus); G00-120-084; putative"
                     /number=7
BASE COUNT          536 a          858 c          645 g          456 t
ORIGIN      182 bp upstream of SphI site; chromosome 14q32.3.
        1 tttccctgcc tcccgtcacc ctgccgccag ggcctctgcc ctgccctgcc ccttgtcctc
       61 aggtttccag cctcagactc ccactgtgtc tgtcttccag cacccaccaa ggctccggat
      121 gtgttcccca tcatatcagg gtgcagacac ccaaaggata acagccctgt ggtcctggca
      181 tgcttgataa ctgggtacca cccaacgtcc gtgactgtca cctggtacat ggggacacag
      241 agccagcccc agagaacctt ccctgagata caaagacggg acagctacta catgacaagc
      301 agccagctct ccacccccct ccagcagtgg cgccaaggcg agtacaaatg cgtggtccag
      361 cacaccgcca gcaagagtaa gaaggagatc ttccgctggc caggtaggtc gcaccggaga
      421 tcacccagaa gggcccccca ggacccccag caccttccac tcagggcctg accacaaaga
      481 cagaagcaag ggctgnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      541 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnntaggc
      601 tgcctgtgcc ccccacctgc ctgtccacaa cccagcctct ggtacatcca tgccctctgc
      661 cctaagcctc acctgcactt ttccttggat ttcagagtct ccaaaggcac aggcctcctc
      721 cgtgcccact gcacaacccc aagcagaggg cagcctcgcc aaggcaacca cagccccagc
      781 caccacccgt aacacaggtg agaagcccct tccctgcaca ctccaccccc acccacctgc
      841 tcattcctca gccgcctcct ccaggcagcc cttcataact ccttgtctga gtctcnnnnn
      901 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      961 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnngtcat tagctggatt tagccattcc
     1021 acaatgtaca catatttcaa acattgtgtt gtatatgata aacatgtata atttttgtca
     1081 attaaaaatt tttaggaaga ggaggagaag agaagaagaa ggagaaggag aaagaggaac
     1141 aagaagagag agagacaaag acaccaggtt ttttctgacc cctgggctat caaaacacct
     1201 attgcccaat aactagttgg ccgttggtgc cctaaactat tgaagcgatt gctgttatgt
     1261 ggatgggccc cggacactta gaaactcgtg accccnnnnn nnnnnnnnnn nnnnnnnnnn
     1321 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1381 nnnnnnnnnn nnnnngaagc tggggagagg agagcacagt ggttaagtca gtccctgcag
     1441 cccaactgct cccgaaggtc cggccacagc tgctctcgtt tgctctcccc tgcagagtgt
     1501 ccgagccaca cccagcctct tggcgtctac ctgctaaccc ctgcagtgca ggacctgtgg
     1561 ctccgggaca aagccacctt cacctgcttc gtggtgggca gtgacctgaa ggatgctcac
     1621 ctgacctggg aggtggctgg gaaggtcccc acagggggcg tggaggaagg gctgctggag
     1681 cggcacagca acggctccca gagccagcac agccgtctga ccctgcccag gtccttgtgg
     1741 aacgcgggga cctccgtcac ctgcacactg aaccatccca gcctcccacc ccagaggttg
     1801 atggcgctga gagaacccgg tgagcctggc tcccaggtgg ggagacgagg gtgcccacag
     1861 cctgctgacc cctacgcccg ccccagggcc atgacnnnnn nnnnnnnnnn nnnnnnnnnn
     1921 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1981 nnnnnnnnnn nnnnnccaca ggaaaggaga agggaggcac cacaccctgg ccggccccac
     2041 ttctctccca gtgcccccgt ggccagagcc tgacagcccc cccacctccc cgcagctgcg
     2101 caggcacccg tcaagctttc tctgaacctg ctggcctcgt ctgaccctcc cgaggcggcc
     2161 tcgtggctcc tgtgtgaggt gtctggcttc tcgcccccca acatcctcct gatgtggctg
     2221 gaggaccagc gtgaggtgaa cacttctggg tttgcccccg cacgcccccc tccacagccc
     2281 aggagcacca cgttctgggc ctggagtgtg ctgcgtgtcc cagccccgcc cagccctcag
     2341 ccagccacct acacgtgtgt ggtcagccac gaggactccc ggactctgct caacgccagc
     2401 cggagcctag aagtcagctg tgagtcaccc ccaggccagg gttgggacgg ggactctgag
     2461 gggggccata aggagctgga atccatacta ggcagnnnnn nnnnnnnnnn nnnnnnnnnn
     2521 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2581 nnnnnnnnnn nnnnngacac gccgattttt tgttattaga tgtaacagac catggcccca
     2641 tgaaatgatc ccggaccaga tccgtccgca cccgccactc agcagctctg gccgannnnn
     2701 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2761 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnncgctc ggcccccgtt cctccccaga
     2821 cctggccatg acccccctga tccctcagag caaggatgag aacagcgatg actacacgac
     2881 ctttgatgat gtgggcagcc tgtggaccac cctgtccacg tttgtggccc tcttcatcct
     2941 caccctcctc tacagcggca ttgtcacttt catcaaggtc aggggagcgg ccaggnnnnn
     3001 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3061 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnntcagg cttctagccc ctgtctgacc
     3121 ccaggggctg tctttcaggt gaagtagccc cagaagagca ggacgccctg tacctgcaga
     3181 gaagggaagc agcct
//