LOCUS       HUMFX                   1126 bp    mRNA    linear   HUM 08-NOV-1994
DEFINITION  Human factor X mRNA.
ACCESSION   K01886
VERSION     K01886.1
KEYWORDS    Stuart factor; factor X; serine protease.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1126)
  AUTHORS   Leytus,S.P., Chung,D.W., Kisiel,W., Kurachi,K. and Davie,E.W.
  TITLE     Characterization of a cDNA coding for human factor X
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 81 (12), 3699-3702 (1984)
   PUBMED   6587384
COMMENT     Original source text: Human liver, cDNA to mRNA, clone
            lambda-X-1137.
            In processing, factor X (Stuart factor) is converted to Xa by
            cleavage of a glycopeptide from the amino-terminal end of the heavy
            chain. It then acts as a serine protease in converting prothrombin
            to thrombin.
FEATURES             Location/Qualifiers
     source          1..1126
                     /db_xref="H-InvDB:HIT000191371"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /map="13q34"
     gene            1..1126
                     /gene="F10"
     mRNA            <1..1126
                     /gene="F10"
                     /product="factor X mRNA"
     CDS             <1..1116
                     /gene="F10"
                     /note="factor X precursor peptide"
                     /codon_start=1
                     /protein_id="AAA52486.1"
                     /db_xref="GDB:G00-119-890"
                     /translation="GFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLA
                     DNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFD
                     LLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTA
                     AHCLYQAKRFEGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFR
                     MNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLS
                     SSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGI
                     YTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK"
     mat_peptide     <1..195
                     /gene="F10"
                     /product="factor X light chain"
     mat_peptide     205..1113
                     /gene="F10"
                     /product="factor X heavy chain"
     mat_peptide     361..1113
                     /gene="F10"
                     /product="factor Xa heavy chain"
BASE COUNT          269 a          341 c          342 g          174 t
ORIGIN      5 bp upstream of TaqI site.
        1 ggattcgaag gcaaaaactg tgaattattc acacggaagc tctgcagcct ggacaacggg
       61 gactgtgacc agttctgcca cgaggaacag aactctgtgg tgtgctcctg cgcccgcggg
      121 tacaccctgg ctgacaacgg caaggcctgc attcccacag ggccctaccc ctgtgggaaa
      181 cagaccctgg aacgcaggaa gaggtcagtg gcccaggcca ccagcagcag cggggaggcc
      241 cctgacagca tcacatggaa gccatatgat gcagccgacc tggaccccac cgagaacccc
      301 ttcgacctgc ttgacttcaa ccagacgcag cctgagaggg gcgacaacaa cctcaccagg
      361 atcgtgggag gccaggaatg caaggacggg gagtgtccct ggcaggccct gctcatcaat
      421 gaggaaaacg agggtttctg tggtggaacc attctgagcg agttctacat cctaacggca
      481 gcccactgtc tctaccaagc caagagattc gaaggggacc ggaacacgga gcaggaggag
      541 ggcggtgagg cggtgcacga ggtggaggtg gtcatcaagc acaaccggtt cacaaaggag
      601 acctatgact tcgacatcgc cgtgctccgg ctcaagaccc ccatcacctt ccgcatgaac
      661 gtggcgcctg cctgcctccc cgagcgtgac tgggccgagt ccacgctgat gacgcagaag
      721 acggggattg tgagcggctt cgggcgcacc cacgagaagg gccggcagtc caccaggctc
      781 aagatgctgg aggtgcccta cgtggaccgc aacagctgca agctgtccag cagcttcatc
      841 atcacccaga acatgttctg tgccggctac gacaccaagc aggaggatgc ctgccagggg
      901 gacagcgggg gcccgcacgt cacccgcttc aaggacacct acttcgtgac aggcatcgtc
      961 agctggggag agggctgtgc ccgtaagggg aagtacggga tctacaccaa ggtcaccgcc
     1021 ttcctcaagt ggatcgacag gtccatgaaa accaggggct tgcccaaggc caagagccat
     1081 gccccggagg tcataacgtc ctctccatta aagtgagatc ccactc
//