LOCUS       HUMA1ACM                1520 bp    mRNA    linear   HUM 30-OCT-1994
DEFINITION  Human alpha-1-antichymotrypsin (AACT) mRNA, complete cds.
ACCESSION   K01500
VERSION     K01500.1
KEYWORDS    alpha-1-antichymotrypsin.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1520)
  AUTHORS   Chandra,T., Stackhouse,R., Kidd,V.J., Robson,K.J. and Woo,S.L.
  TITLE     Sequence homology between human alpha 1-antichymotrypsin, alpha
            1-antitrypsin, and antithrombin III
  JOURNAL   Biochemistry 22 (22), 5055-5061 (1983)
   PUBMED   6606438
COMMENT     Original source text: Human liver, cDNA to mRNA, library of Chandra
            et al, clone phACT235.
            [1] reports that the deduced amino acid sequence is 42% homologous
            with alpha-1-antitrypsin (mostly in the N-terminal half). It is
            only 33% homologous with human antithrombin III. The signal peptide
            contains two potential start codons [1]; the first is used in the
            Features table.
FEATURES             Location/Qualifiers
     source          1..1520
                     /db_xref="H-InvDB:HIT000191366"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /map="14q32.1"
                     /tissue_type="liver"
                     /tissue_lib="Chandra et al."
     gene            1..1520
                     /gene="AACT"
     mRNA            <1..1520
                     /gene="AACT"
                     /product="alpha-1-antichymotrypsin mRNA"
     CDS             12..1313
                     /gene="AACT"
                     /codon_start=1
                     /product="alpha-1-antichymotrypsin"
                     /protein_id="AAA51543.1"
                     /db_xref="GDB:G00-118-955"
                     /translation="MERMLPLLALGLLAAGFCPAVLCHPNSPLDEENLTQENQDRGTH
                     VDLGLASANVDFAFSLYKQLVLKALDKNVIFSPLSISTALAFLSLGAHNTTLTEILKA
                     SSSPHGDLLRQKFTQSFQHLRAPSISSSDELQLSMGNAMFVKEQLSLLDRFTEDAKRL
                     YGSEAFATDFQDSAAAKKLINDYVKNGTRGKITDLIKDPDSQTMMVLVNYIFFKAKWE
                     MPFDPQDTHQSRFYLSKKKWVMVPMMSLHHLTIPYFRDEELSCTVVELKYTGNASALF
                     ILPDQDKMEEVEAMLLPETLKRWRDSLEFREIGELYLPKFSISRDYNLNDILLQLGIE
                     EAFTSKADLSGITGARNLAVSQVVHKVVSDVFEEGTEASAATAVKITLLSALVETRTI
                     VRFNRPFLMIIVPTDTQNIFFMSKVTNPSKPRACIKQWGSQ"
     sig_peptide     12..86
                     /gene="AACT"
     mat_peptide     87..1310
                     /gene="AACT"
                     /product="alpha-1-antichymotrypsin"
                     /note="G00-118-955"
BASE COUNT          372 a          418 c          392 g          338 t
ORIGIN      146 bp 5' to AvaII site.
        1 cagagttgag aatggagaga atgttacctc tcctggctct ggggctcttg gcggctgggt
       61 tctgccctgc tgtcctctgc caccctaaca gcccacttga cgaggagaat ctgacccagg
      121 agaaccaaga ccgagggaca cacgtggacc tcggattagc ctccgccaac gtggacttcg
      181 ctttcagcct gtacaagcag ttagtcctga aggcccttga taagaatgtc atcttctccc
      241 cactgagcat ctccaccgcc ttggccttcc tgtctctggg ggcccataat accaccctga
      301 cagagattct caaggcctcg agttcacctc acggagactt actgaggcag aaattcactc
      361 agagcttcca gcacctccgc gcaccctcaa tcagttccag cgatgagctg cagctgagta
      421 tgggaaatgc catgtttgtc aaagagcaac tcagtctgct ggacaggttc acggaggatg
      481 ccaagaggct gtatggctcc gaggcctttg ccactgactt tcaggactca gctgcagcta
      541 agaagctcat caacgactac gtgaagaatg gaactagggg gaaaatcaca gatctgatca
      601 aggaccccga ctcgcagaca atgatggtcc tggtgaatta catcttcttt aaagccaaat
      661 gggagatgcc ctttgacccc caagatactc atcagtcaag gttctacttg agcaagaaaa
      721 agtgggtaat ggtgcccatg atgagtttgc atcacctgac tataccttac ttccgggacg
      781 aggagctgtc ctgcaccgtg gtggagctga agtacacagg caatgccagc gcactcttca
      841 tcctccctga tcaagacaag atggaggaag tggaagccat gctgctccca gagaccctga
      901 agcggtggag agactctctg gagttcagag agataggtga gctctacctg ccaaagtttt
      961 ccatctcgag ggactataac ctgaacgaca tacttctcca gctgggcatt gaggaagcct
     1021 tcaccagcaa ggctgacctg tcagggatca caggggccag gaacctagca gtctcccagg
     1081 tggtccataa ggtcgtgtct gatgtatttg aggagggcac agaagcatct gctgccacag
     1141 cagtcaaaat caccctcctt tctgcattag tggagacaag gaccattgtg cgtttcaaca
     1201 ggcccttcct gatgatcatt gtccctacag acacccagaa catcttcttc atgagcaaag
     1261 tcaccaatcc cagcaagcct agagcttgca tcaagcagtg gggctctcag taaggaactt
     1321 ggaatgcaag ctggatgcct gggtctctgg gcacagctgg cccctgtgca ccgtagtggc
     1381 catggcatgt gtggccctgt ctgcttatcc ttggaaggtg acagcgattc cctgtgaagc
     1441 tctcacacgc acaggggccc atggactctt cagtctggag ggtcctggcc tcctgacagc
     1501 aataaataat ttcgttggcc
//