LOCUS HUMA1ACM 1520 bp mRNA linear HUM 30-OCT-1994 DEFINITION Human alpha-1-antichymotrypsin (AACT) mRNA, complete cds. ACCESSION K01500 VERSION K01500.1 KEYWORDS alpha-1-antichymotrypsin. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1520) AUTHORS Chandra,T., Stackhouse,R., Kidd,V.J., Robson,K.J. and Woo,S.L. TITLE Sequence homology between human alpha 1-antichymotrypsin, alpha 1-antitrypsin, and antithrombin III JOURNAL Biochemistry 22 (22), 5055-5061 (1983) PUBMED 6606438 COMMENT Original source text: Human liver, cDNA to mRNA, library of Chandra et al, clone phACT235. [1] reports that the deduced amino acid sequence is 42% homologous with alpha-1-antitrypsin (mostly in the N-terminal half). It is only 33% homologous with human antithrombin III. The signal peptide contains two potential start codons [1]; the first is used in the Features table. FEATURES Location/Qualifiers source 1..1520 /db_xref="H-InvDB:HIT000191366" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /map="14q32.1" /tissue_type="liver" /tissue_lib="Chandra et al." gene 1..1520 /gene="AACT" mRNA <1..1520 /gene="AACT" /product="alpha-1-antichymotrypsin mRNA" CDS 12..1313 /gene="AACT" /codon_start=1 /product="alpha-1-antichymotrypsin" /protein_id="AAA51543.1" /db_xref="GDB:G00-118-955" /translation="MERMLPLLALGLLAAGFCPAVLCHPNSPLDEENLTQENQDRGTH VDLGLASANVDFAFSLYKQLVLKALDKNVIFSPLSISTALAFLSLGAHNTTLTEILKA SSSPHGDLLRQKFTQSFQHLRAPSISSSDELQLSMGNAMFVKEQLSLLDRFTEDAKRL YGSEAFATDFQDSAAAKKLINDYVKNGTRGKITDLIKDPDSQTMMVLVNYIFFKAKWE MPFDPQDTHQSRFYLSKKKWVMVPMMSLHHLTIPYFRDEELSCTVVELKYTGNASALF ILPDQDKMEEVEAMLLPETLKRWRDSLEFREIGELYLPKFSISRDYNLNDILLQLGIE EAFTSKADLSGITGARNLAVSQVVHKVVSDVFEEGTEASAATAVKITLLSALVETRTI VRFNRPFLMIIVPTDTQNIFFMSKVTNPSKPRACIKQWGSQ" sig_peptide 12..86 /gene="AACT" mat_peptide 87..1310 /gene="AACT" /product="alpha-1-antichymotrypsin" /note="G00-118-955" BASE COUNT 372 a 418 c 392 g 338 t ORIGIN 146 bp 5' to AvaII site. 1 cagagttgag aatggagaga atgttacctc tcctggctct ggggctcttg gcggctgggt 61 tctgccctgc tgtcctctgc caccctaaca gcccacttga cgaggagaat ctgacccagg 121 agaaccaaga ccgagggaca cacgtggacc tcggattagc ctccgccaac gtggacttcg 181 ctttcagcct gtacaagcag ttagtcctga aggcccttga taagaatgtc atcttctccc 241 cactgagcat ctccaccgcc ttggccttcc tgtctctggg ggcccataat accaccctga 301 cagagattct caaggcctcg agttcacctc acggagactt actgaggcag aaattcactc 361 agagcttcca gcacctccgc gcaccctcaa tcagttccag cgatgagctg cagctgagta 421 tgggaaatgc catgtttgtc aaagagcaac tcagtctgct ggacaggttc acggaggatg 481 ccaagaggct gtatggctcc gaggcctttg ccactgactt tcaggactca gctgcagcta 541 agaagctcat caacgactac gtgaagaatg gaactagggg gaaaatcaca gatctgatca 601 aggaccccga ctcgcagaca atgatggtcc tggtgaatta catcttcttt aaagccaaat 661 gggagatgcc ctttgacccc caagatactc atcagtcaag gttctacttg agcaagaaaa 721 agtgggtaat ggtgcccatg atgagtttgc atcacctgac tataccttac ttccgggacg 781 aggagctgtc ctgcaccgtg gtggagctga agtacacagg caatgccagc gcactcttca 841 tcctccctga tcaagacaag atggaggaag tggaagccat gctgctccca gagaccctga 901 agcggtggag agactctctg gagttcagag agataggtga gctctacctg ccaaagtttt 961 ccatctcgag ggactataac ctgaacgaca tacttctcca gctgggcatt gaggaagcct 1021 tcaccagcaa ggctgacctg tcagggatca caggggccag gaacctagca gtctcccagg 1081 tggtccataa ggtcgtgtct gatgtatttg aggagggcac agaagcatct gctgccacag 1141 cagtcaaaat caccctcctt tctgcattag tggagacaag gaccattgtg cgtttcaaca 1201 ggcccttcct gatgatcatt gtccctacag acacccagaa catcttcttc atgagcaaag 1261 tcaccaatcc cagcaagcct agagcttgca tcaagcagtg gggctctcag taaggaactt 1321 ggaatgcaag ctggatgcct gggtctctgg gcacagctgg cccctgtgca ccgtagtggc 1381 catggcatgt gtggccctgt ctgcttatcc ttggaaggtg acagcgattc cctgtgaagc 1441 tctcacacgc acaggggccc atggactctt cagtctggag ggtcctggcc tcctgacagc 1501 aataaataat ttcgttggcc //