LOCUS JF327843 1998 bp mRNA linear HUM 29-MAR-2011
DEFINITION Homo sapiens histone-lysine N-methyltransferase (EZH2) mRNA,
complete cds, alternatively spliced.
ACCESSION JF327843
VERSION JF327843.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1998)
AUTHORS Ma,K., Tian,C. and Zheng,J.
TITLE EZH2 and DNA remodeling
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 1998)
AUTHORS Ma,K., Tian,C. and Zheng,J.
TITLE Direct Submission
JOURNAL Submitted (11-FEB-2011) GCBA, University of Nebraska Medical
Center, Omaha, NE 68105, USA
FEATURES Location/Qualifiers
source 1..1998
/db_xref="H-InvDB:HIT000653769"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_type="neural progenitor cells"
/PCR_primers="fwd_name: ezh2 F with BamH1, fwd_seq:
cgggatccgccgccaccatggtgggccagactgggaag, fwd_name: ezh2 F
in Mid for seq, fwd_seq: gtggagttggtgaatgcc, rev_name:
ezh2 R with Mlu1, rev_seq: cgacgcgttcaagggatttccatttctc,
rev_name: ezh2 R in Mid for Seq, rev_seq:
ggagccgtcctttttcag"
gene 1..1998
/gene="EZH2"
/note="enhancer of zeste homolog 2"
CDS 1..1998
/gene="EZH2"
/note="alternatively spliced; member of the Polycomb-group
(PcG) family; involved in maintaining the transcriptional
repressive state of genes over successive cell
generations; associates with the embryonic ectoderm
development protein, the VAV1 oncoprotein, and the
X-linked nuclear protein; may play a role in the
hematopoietic and central nervous systems"
/codon_start=1
/product="histone-lysine N-methyltransferase"
/protein_id="AEA07595.1"
/translation="MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSS
NRQKILERTEILNQEWKQRRIQPVHILTSVSSLRGTREVEDETVLHNIPYMGDEVLDQ
DGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQYNDDDDDDDGDDPEEREEK
QKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALP
PECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHATPNTYKRKNTETAL
DNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPNNSSRPSTPTINVL
ESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPPENVE
WSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPAPAEDVDTPP
RKKKRKHRLWAAHCRKIQLKKGQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCG
AADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIIS
QDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGD
HRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIEREMEIP"
BASE COUNT 651 a 391 c 498 g 458 t
ORIGIN
1 atgggccaga ctgggaagaa atctgagaag ggaccagttt gttggcggaa gcgtgtaaaa
61 tcagagtaca tgcgactgag acagctcaag aggttcagac gagctgatga agtaaagagt
121 atgtttagtt ccaatcgtca gaaaattttg gaaagaacgg aaatcttaaa ccaagaatgg
181 aaacagcgaa ggatacagcc tgtgcacatc ctgacttctg tgagctcatt gcgcgggact
241 agggaggtgg aagatgaaac tgttttacat aacattcctt atatgggaga tgaagtttta
301 gatcaggatg gtactttcat tgaagaacta ataaaaaatt atgatgggaa agtacacggg
361 gatagagaat gtgggtttat aaatgatgaa atttttgtgg agttggtgaa tgcccttggt
421 caatataatg atgatgacga tgatgatgat ggagacgatc ctgaagaaag agaagaaaag
481 cagaaagatc tggaggatca ccgagatgat aaagaaagcc gcccacctcg gaaatttcct
541 tctgataaaa tttttgaagc catttcctca atgtttccag ataagggcac agcagaagaa
601 ctaaaggaaa aatataaaga actcaccgaa cagcagctcc caggcgcact tcctcctgaa
661 tgtaccccca acatagatgg accaaatgct aaatctgttc agagagagca aagcttacac
721 tcctttcata cgcttttctg taggcgatgt tttaaatatg actgcttcct acatcctttt
781 catgcaacac ccaacactta taagcggaag aacacagaaa cagctctaga caacaaacct
841 tgtggaccac agtgttacca gcatttggag ggagcaaagg agtttgctgc tgctctcacc
901 gctgagcgga taaagacccc accaaaacgt ccaggaggcc gcagaagagg acggcttccc
961 aataacagta gcaggcccag cacccccacc attaatgtgc tggaatcaaa ggatacagac
1021 agtgataggg aagcagggac tgaaacgggg ggagagaaca atgataaaga agaagaagag
1081 aagaaagatg aaacttcgag ctcctctgaa gcaaattctc ggtgtcaaac accaataaag
1141 atgaagccaa atattgaacc tcctgagaat gtggagtgga gtggtgctga agcctcaatg
1201 tttagagtcc tcattggcac ttactatgac aatttctgtg ccattgctag gttaattggg
1261 accaaaacat gtagacaggt gtatgagttt agagtcaaag aatctagcat catagctcca
1321 gctcccgctg aggatgtgga tactcctcca aggaaaaaga agaggaaaca ccggttgtgg
1381 gctgcacact gcagaaagat acagctgaaa aagggtcaaa accgctttcc gggatgccgc
1441 tgcaaagcac agtgcaacac caagcagtgc ccgtgctacc tggctgtccg agagtgtgac
1501 cctgacctct gtcttacttg tggagccgct gaccattggg acagtaaaaa tgtgtcctgc
1561 aagaactgca gtattcagcg gggctccaaa aagcatctat tgctggcacc atctgacgtg
1621 gcaggctggg ggatttttat caaagatcct gtgcagaaaa atgaattcat ctcagaatac
1681 tgtggagaga ttatttctca agatgaagct gacagaagag ggaaagtgta tgataaatac
1741 atgtgcagct ttctgttcaa cttgaacaat gattttgtgg tggatgcaac ccgcaagggt
1801 aacaaaattc gttttgcaaa tcattcggta aatccaaact gctatgcaaa agttatgatg
1861 gttaacggtg atcacaggat aggtattttt gccaagagag ccatccagac tggcgaagag
1921 ctgttttttg attacagata cagccaggct gatgccctga agtatgtcgg catcgaaaga
1981 gaaatggaaa tcccttga
//