LOCUS JF289274 4062 bp mRNA linear HUM 29-DEC-2011
DEFINITION Homo sapiens Ufd2a-III/UBE4B-III splice isoform (Ube4B) mRNA,
complete cds, alternatively spliced.
ACCESSION JF289274
VERSION JF289274.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4062)
AUTHORS Mammen,A.L., Mahoney,J.A., St Germain,A., Badders,N., Taylor,J.P.,
Rosen,A. and Spinette,S.
TITLE A Novel Conserved Isoform of the Ubiquitin Ligase UFD2a/UBE4B Is
Expressed Exclusively in Mature Striated Muscle Cells
JOURNAL PLoS ONE 6 (12), E28861 (2011)
PUBMED 22174917
REMARK Publication Status: Online-Only
REFERENCE 2 (bases 1 to 4062)
AUTHORS Mammen,A.L., Mahoney,J.A., St. Germain,A., Rosen,A. and Spinette,S.
TITLE Direct Submission
JOURNAL Submitted (01-FEB-2011) Biology, Rhode Island College, 600 Mt
Pleasant Ave, Providence, RI 02908, USA
FEATURES Location/Qualifiers
source 1..4062
/db_xref="H-InvDB:HIT000715329"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="striated muscle"
gene 1..4062
/gene="Ube4B"
CDS 1..4062
/gene="Ube4B"
/note="Ufd2a/Ube4B; ubiquitin ligase E3 and E4 activity;
alternative splice form specific for striated muscle
cells; alternatively spliced"
/codon_start=1
/product="UFD2A-III/UBE4B-III splice isoform"
/protein_id="AEK06331.1"
/translation="MEELSADEIRRRRLARLAGGQTSQPTTPLTSPQRENPPGPPIAA
SAPGPSQSLGLNVHNMTPATSPIGASGVAHRSQSSEGVSSLSSSPSNSLETQSQSLSR
SQSMDIDGVSCEKSMSQVDVDSGIENMEVDENDRREKRSLSDKEPSSGPEVSEEQALQ
LVCKIFRVSWKDRDRDVIFLSSLSAQFKQNPKEVFSDFKDLIGQILMEVLMMSTQTRD
ENPFASLTATSQPIAAAARSPDRNLLLNTGSNPGTSPMFCSVASFGASSLSSLYESSP
APTPSFWSSVPVMGPSLASPSRAASQLAVPSTPLSPHSAASGTAAGSQPSSPRYRPYT
VTHPWASSGVSILSSSPSPPALASSPQAVPASSSRQRPSSTGPPLPPASPSATSRRPS
SLRISPSMYDNPFSFLFLALSGDSSDEEDEEEDDDDGDGDDEGGGGGDDFSCVQFGSS
LGASGGASNWDSYSDHFTIETCKETDMLNYLIECFDRVGIEEKKAPKMCSQPAVSQLL
SNIRSQCISHTALVLQGSLTQPRSLQQPSFLVPYMLCRNLPYGFIQELVRTTHQDEEV
FKQIFIPILQGLALAAKECSLDSDYFKYPLMALGELCETKFGKTHPVCNLVASLRLWL
PKSLSPGCGRELQRLSYLGAFFSFSVFAEDDVKVVEKYFSGPAITLENTRVVSQSLQH
YLELGRQELFKILHSILLNGETREAALSYMAAVVNANMKKAQMQTDDRLVSTDGFMLN
FLWVLQQLSTKIKLETVDPTYIFHPRCRITLPNDETRVNATMEDVNDWLTELYGDQPP
FSEPKFPTECFFLTLHAHHLSILPSCRRYIRRLRAIRELNRTVEDLKNNESQWKDSPL
ATRHREMLKRCKTQLKKLVRCKACADAGLLDESFLRRCLNFYGLLIQLLLRILDPAYP
DITLPLNSDVPKVFAALPEFYVEDVAEFLFFIVQYSPQALYEPCTQDIVMFLVVMLCN
QNYIRNPYLVAKLVEVMFMTNPAVQPRTQKFFEMIENHPLSTKLLVPSLMKFYTDVEH
TGATSEFYDKFTIRYHISTIFKSLWQNIAHHGTFMEEFNSGKQFVRYINMLINDTTFL
LDESLESLKRIHEVQEEMKNKEQWDQLPRDQQQARQSQLAQDERVSRSYLALATETVD
MFHILTKQVQKPFLRPELGPRLAAMLNFNLQQLCGPKCRDLKVENPEKYGFEPKKLLD
QLTDIYLQLDCARFAKAIADDQRSYSKELFEEVISKMRKAGIKSTIAIEKFKLLAEKV
EEIVAKNARAEIDYSDAPDEFRDPLMDTLMTDPVRLPSGTIMDRSIILRHLLNSPTDP
FNRQTLTESMLEPVPELKEQIQAWMREKQNSDH"
exon 811..1197
/gene="Ube4B"
/note="alternatively spliced"
exon 1198..1350
/gene="Ube4B"
/note="alternatively spliced"
misc_feature 3832..4032
/gene="Ube4B"
/note="U-box domain"
BASE COUNT 1034 a 1072 c 962 g 994 t
ORIGIN
1 atggaggagc tgagcgctga tgagattcga cggaggcgcc ttgcacgact tgctggtgga
61 cagacctctc agccaaccac cccactcacc tctccccaga gggagaaccc tccggggcct
121 cccatagcgg catcagcccc aggaccctct cagagtcttg gtctcaatgt ccacaacatg
181 accccagcta cctccccaat aggtgcatca ggagtagccc atcgaagcca gagcagtgaa
241 ggagtcagtt ctctcagcag ctcgccctct aatagccttg aaacgcaatc tcagtctctc
301 tcacgttccc agagcatgga tatcgatggt gtctcatgtg agaaaagcat gtcccaggtg
361 gatgtggatt caggaattga aaacatggag gttgatgaaa atgatcgaag agaaaagcgg
421 agcctcagtg ataaggagcc ttcctcgggc cctgaagtgt ctgaagagca ggccttacag
481 ctggtctgta agatcttccg tgtctcttgg aaggaccggg acagagatgt catctttctt
541 tcttctcttt ctgcacagtt taagcagaac ccaaaagaag tattctccga ttttaaggac
601 ttgattggcc agattttaat ggaagtgcta atgatgtcca ctcagaccag agatgaaaac
661 ccatttgcca gtctgacagc cacatcacag ccaattgctg cagcagcacg gtcaccagac
721 agaaatctct tgctaaacac tggctccaat ccaggaacaa gccccatgtt ctgcagcgtg
781 gcttcctttg gtgccagctc tttgtctagt ctctatgaaa gtagtccggc tcccactccc
841 agtttctgga gctctgttcc cgtgatgggc ccgtctcttg cctcaccttc ccgtgcagcc
901 agccagttgg ctgtgccttc cactcccctc agtcctcaca gtgcagcctc tggaactgct
961 gcgggaagcc agccttcatc cccgcggtat cgcccctaca ctgtcactca cccatgggcg
1021 tcctcaggcg tctccattct gtcgagctcc ccaagtcccc ctgccctcgc cagtagcccc
1081 caagcagtgc ccgccagcag ttccagacag aggcccagca gcacgggtcc acccctacca
1141 cccgcctcac ccagtgccac gagcagacgc ccctcctccc tgaggatctc tcctagtatg
1201 tacgacaatc ctttctcctt cctcttcctc gcactttctg gggacagtag tgatgaagaa
1261 gatgaagaag aagatgatga tgatggtgat ggtgatgatg aaggtggtgg tggtggtgat
1321 gatttttctt gtgtccagtt tgggtccagt ttgggagcct ctggtggagc aagtaattgg
1381 gattcctaca gtgaccattt caccattgaa acctgcaaag agacagatat gctgaactac
1441 ctcatcgagt gtttcgaccg agttggaata gaggaaaaaa aagcaccaaa gatgtgcagc
1501 cagccagcag tcagccagct tctgagcaac atccgctcac agtgcatatc ccatactgct
1561 ttagtactac aaggctccct aacacagccc aggtccttgc agcagccgtc cttcctagtg
1621 ccgtatatgc tgtgtaggaa tctcccatat ggcttcattc aggaactggt gagaaccact
1681 caccaggatg aagaagtgtt caagcagata tttatcccca ttttacaagg cctggctctt
1741 gctgccaaag agtgctccct cgacagtgac tactttaaat accccctcat ggcactaggt
1801 gagctctgtg aaaccaagtt tgggaagaca caccctgtgt gcaatttggt tgcttctttg
1861 cggttgtggt tgccgaaatc cttaagtcct ggctgtgggc gggagctgca gagactctct
1921 tacttagggg ctttctttag cttctcagtc tttgcagaag atgatgttaa agtggttgaa
1981 aaatacttct cagggcctgc cattaccctg gaaaacactc gtgtggttag ccaatcattg
2041 cagcattact tagagctcgg aaggcaagag ctttttaaga ttctgcatag tattttgtta
2101 aatggcgaaa cccgtgaggc tgctctcagt tacatggcgg ctgtcgtcaa tgccaatatg
2161 aagaaagcac agatgcagac agatgataga ttggtgtcta cagatggatt tatgctgaat
2221 ttcctttggg tactgcagca gctaagtaca aaaatcaagt tagaaacagt tgatcccacg
2281 tatatttttc acccaagatg tcggattact cttcccaatg atgagacgcg tgtgaatgca
2341 acgatggaag atgtgaatga ctggctgact gaactctatg gcgatcagcc tccattttct
2401 gagccgaaat tccctacgga gtgcttcttt ctcaccctgc atgctcacca cctctctatt
2461 ctgcctagtt gccgtcgcta tatccgcaga ctccgggcta tccgggagct caatagaact
2521 gtagaagatt tgaaaaataa tgaaagccaa tggaaagatt ccccactggc aactagacac
2581 cgcgaaatgc tgaagcgctg taaaactcag cttaagaaac tggtacggtg caaggcctgt
2641 gctgatgctg gcctacttga cgagagcttc ctgagaagat gtctgaattt ttatggcctt
2701 ctcattcagc tgctgctccg catcctggac cccgcatatc ccgatataac actgccttta
2761 aattcagatg tccccaaggt atttgcagcg ttgcctgagt tttatgtaga agatgttgca
2821 gaatttttat tttttattgt acaatactct ccccaggcgc tttatgagcc ctgtactcag
2881 gatattgtga tgttccttgt tgtgatgttg tgcaaccaga actacatccg aaacccatat
2941 ttggtggcca aactggtaga agtcatgttt atgaccaacc ctgctgttca gccacgaacc
3001 cagaagtttt ttgaaatgat tgagaaccat cctctctcca ccaagttgtt ggtaccttcc
3061 ctgatgaagt tctatacaga tgttgagcat accggagcca ccagcgagtt ttatgacaag
3121 ttcacaattc gctatcacat tagcaccatt tttaaaagcc tttggcaaaa catagctcac
3181 catggcacct ttatggagga gttcaactcc gggaagcagt ttgttcgcta tataaacatg
3241 ttgataaacg acacgacgtt tttgctcgat gaaagtctgg agtctctgaa gcgaatccat
3301 gaagtgcagg aagagatgaa gaacaaagaa cagtgggacc agttgccccg ggatcagcag
3361 caggctcgtc agtctcagct tgctcaggat gagcgtgtgt cccgctctta cctcgccctg
3421 gccaccgaaa ccgtggacat gttccacatc ctcacgaagc aggtccagaa gcccttcctc
3481 agaccggagc ttggaccccg attggctgca atgctgaact ttaatcttca gcaactttgt
3541 ggccccaagt gccgtgacct gaaagttgaa aaccctgaga aatacggctt tgaaccaaag
3601 aagctgttgg accaactgac ggatatttac ttacagctgg actgtgctcg gttcgcgaaa
3661 gccattgctg acgaccagag atcctacagt aaggaattgt ttgaagaagt tatttcaaag
3721 atgcggaagg cagggatcaa atccacaata gcaatagaaa aatttaagct gctcgccgag
3781 aaagtggagg agatagtggc caagaacgca cgcgcagaaa tcgactacag cgacgctcct
3841 gatgagttca gagaccctct gatggacacc ctcatgacag accccgtgcg gctgccctct
3901 ggcaccatca tggaccgctc catcatcctg cggcacctgc tcaactcccc cacggacccc
3961 ttcaaccggc agacgctgac agagagcatg ctggaaccag tgccagaact gaaagagcag
4021 attcaggcgt ggatgagaga gaaacagaac agcgatcact aa
//