LOCUS HUMENDO 2620 bp mRNA linear HUM 27-APR-1993
DEFINITION Human endoglin mRNA, 3' end.
ACCESSION J05481
VERSION J05481.1
KEYWORDS endoglin.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2620)
AUTHORS Gougos,A. and Letarte,M.
TITLE Primary structure of endoglin, an RGD-containing glycoprotein of
human endothelial cells
JOURNAL J. Biol. Chem. 265 (15), 8361-8364 (1990)
PUBMED 1692830
COMMENT Original source text: Human umbilical cord vein endothelial cell,
cDNA to mRNA, clone 18A/11A.
Draft entry and computer-readable sequence for [1] kindly submitted
by M.Letarte, 05-APR-1990.
FEATURES Location/Qualifiers
source 1..2620
/db_xref="H-InvDB:HIT000191336"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS <1..1938
/note="endoglin precursor"
/codon_start=1
/protein_id="AAA35800.1"
/translation="GASCSLSPTSLAETVHCDLQPVGPERGEVTYTTSQVSKGCVAQA
PNAILEVHVLFLEFPTGPSQLELTLQASKQNGTWPREVLLVLSVNSSVFLHLQALGIP
LHLAYNSSLVTFQEPPGVNTTELPSFPKTQILEWAAERGPITSAAELNDPQSILLRLG
QAQGSLSFCMLEASQDMGRTLEWRPRTPALVRGCHLEGVAGHKEAHILRVLPGHSAGP
RTVTVKVELSCAPGDLDAVLILQGPPYVSWLIDANHNMQIWTTGEYSFKIFPEKNIRG
FKLPDTPQGLLGEARMLNASIVASFVELPLASIVSLHASSCGGRLQTSPAPIQTTPPK
DTCSPELLMSLIQTKCADDAMTLVLKKELVAHLKCTITGLTFWDPSCEAEDRGDKFVL
RSAYSSCGMQVSASMISNEAVVNILSSSSPQRKKVHCLNMDSLSFQLGLYLSPHFLQA
SNTIEPGQQSFVQVRVSPSVSEFLLQLDSCHLDLGPEGGTVELIQGRAAKGNCVSLLS
PSPEGDPRFSFLLHFYTVPIPKTGTLSCTVALRPKTGSQDQEVHRTVFMRLNIISPDL
SGCTSKGLVLPAVLGITFGAFLIGALLTAALWYIYSHTRSPSKREPVVAVAAPASSES
SSTNHSIGSTQSTPCSTSSMA"
sig_peptide <1..36
/note="endoglin signal peptide"
mat_peptide 37..1935
/product="endoglin"
misc_feature 880..888
/note="RGD-tripeptide"
BASE COUNT 545 a 890 c 717 g 468 t
ORIGIN
1 ggggccagct gcagcctcag ccccacaagt cttgcagaaa cagtccattg tgaccttcag
61 cctgtgggcc ccgagagggg cgaggtgaca tataccacta gccaggtctc gaagggctgc
121 gtggctcagg cccccaatgc catccttgaa gtccatgtcc tcttcctgga gttcccaacg
181 ggcccgtcac agctggagct gactctccag gcatccaagc aaaatggcac ctggccccga
241 gaggtgcttc tggtcctcag tgtaaacagc agtgtcttcc tgcatctcca ggccctggga
301 atcccactgc acttggccta caattccagc ctggtcacct tccaagagcc cccgggggtc
361 aacaccacag agctgccatc cttccccaag acccagatcc ttgagtgggc agctgagagg
421 ggccccatca cctctgctgc tgagctgaat gacccccaga gcatcctcct ccgactgggc
481 caagcccagg ggtcactgtc cttctgcatg ctggaagcca gccaggacat gggccgcacg
541 ctcgagtggc ggccgcgtac tccagccttg gtccggggct gccacttgga aggcgtggcc
601 ggccacaagg aggcgcacat cctgagggtc ctgccgggcc actcggccgg gccccggacg
661 gtgacggtga aggtggaact gagctgcgca cccggggatc tcgatgccgt cctcatcctg
721 cagggtcccc cctacgtgtc ctggctcatc gacgccaacc acaacatgca gatctggacc
781 actggagaat actccttcaa gatctttcca gagaaaaaca ttcgtggctt caagctccca
841 gacacacctc aaggcctcct gggggaggcc cggatgctca atgccagcat tgtggcatcc
901 ttcgtggagc taccgctggc cagcattgtc tcacttcatg cctccagctg cggtggtagg
961 ctgcagacct cacccgcacc gatccagacc actcctccca aggacacttg tagcccggag
1021 ctgctcatgt ccttgatcca gacaaagtgt gccgacgacg ccatgaccct ggtactaaag
1081 aaagagcttg ttgcgcattt gaagtgcacc atcacgggcc tgaccttctg ggaccccagc
1141 tgtgaggcag aggacagggg tgacaagttt gtcttgcgca gtgcttactc cagctgtggc
1201 atgcaggtgt cagcaagtat gatcagcaat gaggcggtgg tcaatatcct gtcgagctca
1261 tcaccacagc ggaaaaaggt gcactgcctc aacatggaca gcctctcttt ccagctgggc
1321 ctctacctca gcccacactt cctccaggcc tccaacacca tcgagccggg gcagcagagc
1381 tttgtgcagg tcagagtgtc cccatccgtc tccgagttcc tgctccagtt agacagctgc
1441 cacctggact tggggcctga gggaggcacc gtggaactca tccagggccg ggcggccaag
1501 ggcaactgtg tgagcctgct gtccccaagc cccgagggtg acccgcgctt cagcttcctc
1561 ctccacttct acacagtacc catacccaaa accggcaccc tcagctgcac ggtagccctg
1621 cgtcccaaga ccgggtctca agaccaggaa gtccatagga ctgtcttcat gcgcttgaac
1681 atcatcagcc ctgacctgtc tggttgcaca agcaaaggcc tcgtcctgcc cgccgtgctg
1741 ggcatcacct ttggtgcctt cctcatcggg gccctgctca ctgctgcact ctggtacatc
1801 tactcgcaca cgcgttcccc cagcaagcgg gagcccgtgg tggcggtggc tgccccggcc
1861 tcctcggaga gcagcagcac caaccacagc atcgggagca cccagagcac cccctgctcc
1921 accagcagca tggcatagcc ccggcccccc gcgctcgccc agcaggagag actgagcagc
1981 cgccagctgg gagcactggt gtgaactcac cctgggagcc agtcctccac tcgacccaga
2041 atggagcctg ctctccgcgc ctacccttcc cgcctccctc tcagaggcct gctgccagtg
2101 cagccactgg cttggaacac cttggggtcc ctccacccca cagaaccttc aacccagtgg
2161 gtctgggata tggctgccca ggagacagac cacttgccac gctgttgtaa aaacccaagt
2221 ccctgtcatt tgaacctgga tccagcactg gtgaactgag ctgggcagga agggagaact
2281 tgaaacagat tcaggccagc ccagccaggc caacagcacc tccccgctgg gaagagaaga
2341 gggcccagcc cagagccacc tggatctatc cctgcggcct ccacacctga acttgcctaa
2401 ctaactggca ggggagacag gagcctagcg gagcccagcc tgggagccca gagggtggca
2461 agaacagtgg gcgttgggag cctagctcct gccacatgga gccccctctg ccggtcgggc
2521 agccagcaga gggggagtag ccaagctgct tgtcctgggc ctgcccctgt gtattcacca
2581 ccaataaatc agaccatgaa accagtgaaa aaaaaaaaaa
//