LOCUS HUMASFB 2228 bp mRNA linear HUM 31-OCT-1994
DEFINITION Human arylsulfatase B (ASB) mRNA, complete cds.
ACCESSION J05225
VERSION J05225.1
KEYWORDS arylsulfatase B.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2228)
AUTHORS Peters,C., Schmidt,B., Rommerskirch,W., Rupp,K., Zuhlsdorf,M.,
Vingron,M., Meyer,H.E., Pohlmann,R. and von Figura,K.
TITLE Phylogenetic conservation of arylsulfatases. cDNA cloning and
expression of human arylsulfatase B
JOURNAL J. Biol. Chem. 265 (6), 3374-3381 (1990)
PUBMED 2303452
COMMENT Original source text: Human testis DNA (bases 1-44), clone AB9.2,
and cDNA to mRNA (bases 45-2228), clone ASB2.
Draft entry and computer-readable sequence for [1] kindly submitted
by C.Peters, 20-DEC-1989.
FEATURES Location/Qualifiers
source 1..2228
/db_xref="H-InvDB:HIT000191321"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="5p11-q13"
gene 1..2228
/gene="ARSB"
CDS 7..1608
/gene="ARSB"
/note="arylsulfatase B precursor (EC 3.1.6.1)"
/codon_start=1
/protein_id="AAA51784.1"
/db_xref="GDB:G00-119-008"
/translation="MGPRGAASLPRGPGPRRLLLPVVLPLLLLLLLAPPGSGAGASRP
PHLVFLLADDLGWNDVGFHGSRIRTPHLDALAAGGVLLDNYYTQPLCTPSRSQLLTGR
YQIRTGLQHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRR
GFDTYFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKR
AIALITNHPPEKPLFLYLALQSVHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEA
VGNVTAALKSSGLWNNTVFIFSTDNGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVAS
PLLKQKGVKNRELIHISDWLPTLVKLARGHTNGTKPLDGFDVWKTISEGSPSPRIELL
HNIDPNFVDSSPCPRNSMAPAKDDSSLPEYSAFNTSVHAAIRHGNWKLLTGYPGCGYW
FPPPSQYNVSEIPSSDPPTKTLWLFDIDRDPEERHDLSREYPHIVTKLLSRLQFYHKH
SVPVYFPAQDPRCDPKATGVWGPWM"
sig_peptide 7..129
/gene="ARSB"
/note="arylsulfatase B signal peptide"
mat_peptide 130..1605
/gene="ARSB"
/product="arylsulfatase B"
regulatory 2206..2211
/regulatory_class="polyA_signal_sequence"
/gene="ARSB"
/note="putative"
BASE COUNT 532 a 620 c 543 g 533 t
ORIGIN
1 acaaggatgg gtccgcgcgg cgcggcgagc ttgccccgag gccccggacc tcggcggctg
61 ctcctccccg tcgtcctccc gctgctgctg ctgctgttgt tggcgccgcc gggctcgggc
121 gccggggcca gccggccgcc ccacctggtc ttcttgctgg cagacgacct aggctggaac
181 gacgtcggct tccacggctc ccgcatccgc acgccgcacc tggacgcgct ggcggccggc
241 ggggtgctcc tggacaacta ctacacgcag ccgctgtgca cgccgtcgcg gagccagctg
301 ctcactggcc gctaccagat ccgtacaggt ttacagcacc aaataatctg gccctgtcag
361 cccagctgtg ttcctctgga tgaaaaactc ctgccccagc tcctaaaaga agcaggttat
421 actacccata tggtcggaaa atggcacctg ggaatgtacc ggaaagaatg ccttccaacc
481 cgccgaggat ttgataccta ctttggatat ctcctgggta gtgaagatta ttattcccat
541 gaacgctgta cattaattga cgctctgaat gtcacacgat gtgctcttga ttttcgagat
601 ggcgaagaag ttgcaacagg atataaaaat atgtattcaa caaacatatt caccaaaagg
661 gctatagccc tcataactaa ccatccacca gagaagcctc tgtttctcta ccttgctctc
721 cagtctgtgc atgagcccct tcaggtccct gaggaatact tgaagccata tgactttatc
781 caagacaaga acaggcatca ctatgcagga atggtgtccc ttatggatga agcagtagga
841 aatgtcactg cagctttaaa aagcagtggg ctctggaaca acacggtgtt catcttttct
901 acagataacg gagggcagac tttggcaggg ggtaataact ggccccttcg aggaagaaaa
961 tggagcctgt gggaaggagg cgtccgaggg gtgggctttg tggcaagccc cttgctgaag
1021 cagaagggcg tgaagaaccg ggagctcatc cacatctctg actggctgcc aacactcgtg
1081 aagctggcca ggggacacac caatggcaca aagcctctgg atggcttcga cgtgtggaaa
1141 accatcagtg aaggaagccc atcccccaga attgagctgc tgcataatat tgacccaaac
1201 ttcgtggact cttcaccgtg tcccaggaac agcatggctc cagcaaagga tgactcttct
1261 cttccagaat attcagcctt taacacatct gtccatgctg caattagaca tggaaattgg
1321 aaactcctca cgggctaccc aggctgtggt tactggttcc ctccaccgtc tcaatacaat
1381 gtttctgaga taccctcatc agacccacca accaagaccc tctggctctt tgatattgat
1441 cgggaccctg aagaaagaca tgacctgtcc agagaatatc ctcacatcgt cacaaagctc
1501 ctgtcccgcc tacagttcta ccataaacac tcagtccccg tgtacttccc tgcacaggac
1561 ccccgctgtg atcccaaggc cactggggtg tggggccctt ggatgtagga tttcagggag
1621 gctagaaaac ctttcaattg gaagttggac ctcaggcctt ttctcacgac tcttgtctca
1681 tttgttatcc caacctgggt tcacttggcc cttctcttgc tcttaaacca caccgaggtg
1741 tctaatttca acccctaatg catttaagaa gctgataaaa tctgcaacac tcctgctgtt
1801 ggctggagca tgtgtctaga ggtgggggtg gctgggttta tccccctttc ctaagccttg
1861 ggacagctgg gaacttaact tgaaatagga agttctcact gaatcctgga ggctggaaca
1921 gctggctctt ttagactcac aagtcagacg ttcgattccc ctctgccaat agccagtttt
1981 attggagtga atcacatttc ttacgcaaat gaagggagca gacagtgatt aatggttctg
2041 ttggccaagg cttctccctg tcggtgaagg atcatgttca ggcactccaa gtgaaccacc
2101 cctcttggtt caccccttac tcacttatct catcacagag cataaggccc attttgttgt
2161 tcaggtcaac agcaaaatgg cctgcaccat gactgtggct tttaaaataa agaaatgtgt
2221 ttttatcg
//