LOCUS HUMRYR 15346 bp mRNA linear HUM 09-JAN-1995
DEFINITION Human ryanodine receptor mRNA, complete cds.
ACCESSION J05200
VERSION J05200.1
KEYWORDS ryanodine receptor; skeletal muscle sarcoplasmic reticulum Ca+2
release channel.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 15346)
AUTHORS Zorzato,F., Fujii,J., Otsu,K., Phillips,M., Green,N.M., Lai,F.A.,
Meissner,G. and MacLennan,D.H.
TITLE Molecular cloning of cDNA encoding human and rabbit forms of the
Ca2+ release channel (ryanodine receptor) of skeletal muscle
sarcoplasmic reticulum
JOURNAL J. Biol. Chem. 265 (4), 2244-2256 (1990)
PUBMED 2298749
COMMENT Original source text: Human (adult) muscle, cDNA to mRNA, and DNA.
Draft entry and printed sequence for [1] kindly submitted by
D.H.MacLennan, 30-NOV-1989.
FEATURES Location/Qualifiers
source 1..15346
/db_xref="H-InvDB:HIT000191318"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="19q13.1"
gene 1..15346
/gene="RYR1"
mRNA <1..15345
/gene="RYR1"
/product="RYR mRNA"
CDS 106..15204
/gene="RYR1"
/note="ryanodine receptor"
/codon_start=1
/protein_id="AAA60294.1"
/db_xref="GDB:G00-120-359"
/translation="MGDAEGEDEVQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNR
LCFLEPTSNAQNVPPDLAICCFVLEQSLSVRALQEMLANTVEAGVESSQGGGHRTLLY
GHAILLRHAHSRMYLSCLTTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGE
KVRVGDDIILVSVSSERYLHLSTASGELQVDASFMQTLWNMNPICSRCEEGFVTGGHV
LRLFHGHMDECLTISPADSDDQRRLVYYEGGAVCTHARSLWRLEPLRISWSGSHLRWG
QPLRVRHVTTGQYLALTEDQGLVVVDASKAHTKATSFCFRISKEKLDVAPKRDVEGMG
PPEIKYGESLCFVQHVASGLWLTYAAPDPKALRLGVLKKKAMLHQEGHMDDALSLTRC
QQEESQAARMIHSTNGLYNQFIKSLDSFSGKPRGSGPPAGTALPIEGVILSLQDLIIY
FEPPSEDLQHEEKQSKLRSLRNRQSLFQEEGMLSMVLNCIDRLNVYTTAAHFAEFAGE
EAAESWKEIVNLLYELLASLIRGNRSNCALFSTNLDWLVSKLDRLEASSGILEVLYCV
LIESPEVLNIIQENHIKSIISLLDKHGRNHKVLDVLCSLCVCNGVAVRSNQDLITENL
LPGRELLLQTNLINYVTSIRPNIFVGRAEGTTQYSKWYFEVMVDEVTPFLTAQATHLR
VGWALTEGYTPYPGAGEGWGGNGVGDDLYSYGFDGLHLWTGHVARPVTSPGQHLLAPE
DVISCCLDLSVPSISFRINGCPVQGVFESFNLDGLFFPVVSFSAGVKVRFLLGGRHGE
FKFLPPPGYAPCHEAVLPRERLHLEPIKEYRREGPRGPHLVGPSRCLSHTDFVPCPVD
TVQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGPVRDDNKRLHPCLVDFHSLPE
PERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLKKTKLPKTYMMSNGYKPAPLDLS
HVRLTPAQTTLVDRLAENGHNVWARDRVGQGWSYSAVQDIPARRNPRLVPYRLLDEAT
KRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQVENQSRCDRVRIFRAEKSYTVQSGRWY
FEFEAVTTGEMRVGWARPELRPDVELGADELAYVFNGHRGQRWHLGSEPFGRPWQPGD
VVGCMIDLTENTIIFTLNGEVLMSDSGSETAFREIEIGDGFLPVCSLGPGQVGHLNLG
QDVSSLRFFAICGLQEGFEPFAINMQRPVTTWFSKGLPQFEPVPLEHPHYEVSRVDGT
VDTPPCLRLTHRTWGSQNSLVEMLFLRLSLPVQFHQHFRCTAGATPLAPPGLQPPAED
EARAAEPDPDYENLRRSAGGWSEAENGKEGTAKEGAPGGTPQAGRGAPARAENEKDAT
TEKNKKRGFLFKAKKVAMMTQPPATPTLPRLPHDVVPADNRDDPEIILNTTTYYYSVR
VFAGQEPSCVWAGWVTPDYHQHDMSFDLSKVRVVTVTMGDEQGNVHSSLKCSNCYMVW
GGDFVSPGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPAVFV
LPTHQNVIQFELGKQKNIMPLSAAMFQSERKNPAPQCPPRLEMQMLMPVSWSRMPNHF
LQVETRRAGERLGWAVQCQEPLTMMALHIPEENRCMDILELSERLDLQRFHSHTLRLY
RAVCALGNNRVAHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIHLESACRSRR
SMLSEYIVPLTPETRAITLFPPGRSTENGHPRHGLPGVGVTTSLRPPHHFSPPCFVAA
LPAAGAAEAPARLSPAIPLEALRDKALRMLGEAVRDGGQHARDPVGASVEFQFVPVLK
LVSTLLVMGIFGDEDVKQILKMIEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQ
EKEDEEKEEEEAAEGEKEEGLEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLA
AFAERYVDKLQANQRSRYGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTD
EEDCPLPEEIRQDLLDFHQDLLAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKK
KEEKPEEERSAEESKPRSLQELVSHMVVRWAQEDFVQSPELVRAMFSLLHRQYDGLGE
LLRALPRAYTISPSSVEDTMSLLECLGQIRSLLIVQMGPQEENLMIQSIGNIMNNKVF
YQHPNLMRALGMHETVMEVMVNVLGGGESKEIRFPKMVTSCCRFLCYFCRISRQNQRS
MFDHLSYLLENSGIGLGMQGSTPLDVAAASVIDNNELALALQEQDLEKVVSYLAGCGL
QSCPMLVAKGYPDIGWKPCGGERYLDFLRFAVFVNGESVEENANVVVRLLIRKPECFG
PALRGEGGSGLLAAIEEAIRISEDPARDGPGIRRDRRREHFGEEPPEENRVHLGHAIM
SFYAALIDLLGRCAPEMHLIQAGKGEALRIRAILRSLVPLEDLVGIISLPLQIPTLGK
DGALVQPKMSASFVPDHKASMVLFLDRVYGIENQDFLLHVLDVGFLPDMRAAASLDTA
TFSTTEMALAVNRYLCLAVLPLITKCAPLFAGTEHRAIMVDSMLHTVYRLSRGRSLTK
AQRDVIEDCLMSLCRYIRPSMLQHLLRRLVFDVPILNEFAKMPLKLLTNHYERCWKYY
CLPTGWANFGVTSEEELHLTRKLFWGIFDSLAHKKYDPELYRMAMPCLCAIAGALPPD
YVDASYSSKAEKKATVDAEGNFDPRPVETLNVIIPEKLDSFINKFAEYTHEKWAFDKI
QNNWSYGENIDEELKTHPMLRPYKTFSEKDKEIYRWPIKESLKAMIAWEWTIEKAREG
EEEKTEKKKTAKISQSAQTYDPREGYNPQPPDLSAVTLSRELQAMAEQLAENYHNTWG
RKKKQELEAKGGGTHPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAVTRGLKDME
LDSSSIEKRFAFGFLQQLLRWMDISQEFIAHLEAVVSSGRVEKSPHEQEIKFFAKILL
PLINQYFTNHCLYFLSTPAKVLGSGGHASNKEKEMITSLFCKLAALVRHRVSLFGTDA
PAVVNCLHILARSLDARTVMKSGPEIVKAGLRSFFESASEDIEKMVENLRLGKVSQAR
TQVKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDDVILDDVQVSCYRTLCSIYSLGT
TKNTYVEKLRPALGECLARLAAAMPVAFLEPQLNEYNACSVYTTKSPRERAILGLPNS
VEEMCPDIPVLERLMADIGGLAESGARYTEMPHVIEITLPMLCSYLPRWWERGPEAPP
SALPAGAPPPCTAVTSDHLNSLLGNILRIIVNNLGIDEASWMKRLAVFAQPIVSRARP
ELLQSHFIPTIGRLRKRAGKVVSEEEQLALEAKAEAQEGELLVRDEFSVLCRDLYALY
PLLIRYVDNNRAQWLTEPNPSAEELFRMVGEIFIYWSKSHNFKREEQNFVVQNEINNM
SFLTADNKSKMAKSGGSDQERTKKKRRGDRYSVQTSLIVATLKKMLPIGLNMCAPTDQ
DLITLAKTRYALKDTDEEVREFLHNNLHLQGKVEGSPSLRWQMALYRGVPGREEDADD
PEKIVRRVQEVSAVLYYLDQTEHPYKSKKAVWHKLLSKQRRRAVVACFRMTPLYNLPT
HRACNMFLESYKAAWILTEDHSFEDRMIDDLSKAGEQEEEEEEVEEKKPDPLHQLVLH
FSRTALTEKSKLDEDYLYMAYADIMAKSCHLEEGGENGEAEEEVEVSFEEKQMEKQRL
LYQQARLHTRGAAEMVLQMISACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYLK
DKKEVGFFQSIQALMQTCSVLDLNAFERQNKAEGLGMVNEDGTVINRQNGEKVMADDE
FTQDLFRFLQLLCEGHNNDFQNYLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYY
SGKDVIEEQGKRNFSKAMSVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHV
FAHMMMKLAQDSSQIELLKELLDLQKDMVVMLLSLLEGNVVNGMIARQMVDMLVESSS
NVEMILKFFDMFLKLKDIVGSEAFQDYVTDPRGLISKKDFQKAMDSQKQFSGPEIQFL
LSCSEADENEMINCEEFANRFQEPARDIGFNVAVLLTNLSEHVPHDPRLHNFLELAES
ILEYFRPYLGRIEIMGASRRIERIYFEISETNRAQWEMPQVKESKRQFIFDVVNEGGE
AEKMELFVSFCEDTIFEMQIAAQISEPEGEPETDEDEGAGAAEAGAEGAEEGAAGLEG
TAATAAAGATARVVAAAGRALRGLSYRSLRRRVRRLRRLTAREAATAVAALLWAAVTR
AGAAGAGAAAGALGLLWGSLFGGGLVEGAKKVTVTELLAGMPDPTSDEVHGEQPAGPG
GDADGEGASEGAGDAAEGAGDEEEAVHEAGPGGADGAVAVTDGGPFRPEGAGGLGDMG
DTTPAEPPTPEGSPILKRKLGVDGVEEELPPEPEPEPEPELEPEKADAENGEKEEVPE
PTPEPPKKQAPPSPPPKKEEAGGEFWGELEVQRVKFLNYLSRNFYTLRFLALFLAFAI
NFILLFYKVSDSPPGEDDMEGSAAGDVSGAGSGGSSGWGLGAGEEAEGDEDENMVYYF
LEESTGYMEPALRCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELARKLEFDGLYIT
EQPEDDDVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIYGRERIAELLGMDLAT
LEITAHNERKPNPPPGLLTWLMSIDVKYQIWKFGVIFTDNSFLYLGWYMVMSLLGHYN
NFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFRKFY
NKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFF
FFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHT
LEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLS
"
BASE COUNT 3253 a 4577 c 4709 g 2807 t
ORIGIN 648 bp upstream of SalI site; chromosome 19 proximal long arm.
1 gtctccgagg tctccgaccc cgcccgcgcc cagccctccc gcccagcccg cagccccctc
61 cctctgttcc ccgacctcag accctgggct tccgacctcg acatcatggg tgacgcagaa
121 ggcgaagacg aggtccagtt cctgcggacg gacgatgagg tggtcctgca gtgcagcgct
181 accgtgctca aggagcagct caagctctgc ctggccgccg agggcttcgg caaccgcctg
241 tgcttcctgg agcccactag caacgcgcag aatgtgcccc ccgatctggc catctgttgc
301 ttcgtcctgg agcagtccct gtctgtgcga gccctgcagg agatgctggc taacacggtg
361 gaggctggcg tggagtcatc ccagggcggg ggacacagga cgctcctgta tggccatgcc
421 atcctgctcc ggcatgcaca cagccgcatg tatctgagct gcctcaccac ctcccgctcc
481 atgactgaca agctggcctt cgatgtggga ctgcaggagg acgcaacagg agaggcttgc
541 tggtggacca tgcacccagc ctccaagcag aggtctgaag gagaaaaggt ccgcgttggg
601 gatgacatca tccttgtcag tgtctcctcc gagcgctacc tgcacctgtc gaccgccagt
661 ggggagctcc aggttgacgc ttccttcatg cagacactgt ggaacatgaa ccccatctgc
721 tcccgctgcg aagagggctt cgtgacggga ggtcacgtcc tccgcctctt tcatggacat
781 atggatgagt gtctgaccat ttcccctgct gacagtgatg accagcgcag acttgtctac
841 tatgaggggg gagctgtgtg cactcatgcc cgctccctct ggaggctgga gccactgaga
901 atcagctgga gtgggagcca cctgcgctgg ggccagccac tccgagtccg gcatgtcact
961 accgggcagt acctagcgct caccgaggac cagggcctgg tggtggttga cgccagcaag
1021 gctcacacca aggctacctc cttctgcttc cgcatctcca aggagaagct ggatgtggcc
1081 cccaagcggg atgtggaggg catgggcccc cctgagatca agtacgggga gtcactgtgc
1141 ttcgtgcagc atgtggcctc aggactgtgg ctcacctatg ccgctccaga ccccaaggcc
1201 ctgcggctcg gcgtgctcaa gaagaaggcc atgctgcacc aggagggcca catggacgac
1261 gcactgtcgc tgacccgctg ccagcaggag gagtcccagg ccgcccgcat gatccacagc
1321 accaatggcc tatacaacca gttcatcaag agcctggaca gcttcagcgg gaagccacgg
1381 ggctcggggc cacccgctgg cacggcgctg cccatcgagg gcgttatcct gagcctgcag
1441 gacctcatca tctacttcga gcctccctcc gaggacttgc agcacgagga gaagcagagc
1501 aagctgcgaa gcctgcgcaa ccgccagagc ctcttccagg aggaggggat gctctccatg
1561 gtcctgaatt gcatagaccg cctaaatgtc tacaccactg ctgcccactt tgctgagttt
1621 gcaggggagg aggcagccga gtcctggaaa gagattgtga atcttctcta tgaactccta
1681 gcttctctaa tccgtggcaa tcgtagcaac tgtgccctct tctccacaaa cttggactgg
1741 ctggtcagca agctggatcg gctggaggcc tcatctggca tcctggaggt cctgtactgt
1801 gtcctcattg agagtccaga ggttctgaac atcatccagg agaatcacat caagtccatc
1861 atctccctcc tggacaagca tgggaggaac cacaaggtcc tggacgtgct atgctccctg
1921 tgtgtgtgta atggtgtggc tgtacgctcc aaccaagatc ttattactga gaacttgctg
1981 cctggccgtg agcttctgct gcagacaaac ctcatcaact atgtcaccag catccgcccc
2041 aacatctttg tgggccgagc ggaaggcacc acgcagtaca gcaaatggta ctttgaggtg
2101 atggtggacg aggtgactcc atttctgaca gctcaggcca cccacttgcg ggtgggctgg
2161 gccctcaccg agggctacac cccctaccct ggggccggcg agggctgggg cggcaacggg
2221 gtcggcgatg acctctattc ctacggcttt gatggactgc atctctggac aggacacgtg
2281 gcacgcccag tgacttcccc agggcagcac ctcctggccc ctgaagacgt gatcagctgc
2341 tgcctggacc tcagcgtgcc gtccatctcc ttccgcatca acggctgccc tgtgcagggt
2401 gtctttgagt ccttcaacct ggacgggctc ttcttccctg ttgtcagctt ctcggctggt
2461 gtcaaggtgc ggttcctcct gggtggccgc catggtgaat tcaagttcct gcccccacct
2521 ggctatgctc catgccatga ggctgtgctc cctcgagagc gactccatct tgaacccatc
2581 aaggagtatc gacgggaggg gccccggggg cctcacctgg tgggccccag tcgctgcctc
2641 tcacacaccg acttcgtgcc ctgccctgtg gacactgtcc agattgtcct gccgccccat
2701 ctggagcgca ttcgggagaa gctggcggag aacatccacg agctctgggc gctaacccgc
2761 atcgagcagg gctggaccta cggcccggtt cgggatgaca acaagaggct gcacccgtgt
2821 cttgtggact tccacagcct tccagagcct gagaggaact acaacctgca gatgtctggg
2881 gagacgctca agactctgct ggctctgggc tgccacgtgg gcatggcgga tgagaaggcg
2941 gaggacaacc tgaagaagac aaaactcccc aagacgtata tgatgagcaa tgggtacaag
3001 ccggctccgc tggacctgag ccacgtgcgg ctgacgccgg cgcagacaac actggtggac
3061 cgtctggcag aaaatgggca caacgtgtgg gcccgagacc gcgtgggcca gggctggagc
3121 tacagcgcag tgcaggacat cccagcgcgc cgaaaccctc ggctggtgcc ctaccgcctg
3181 ctggatgaag ccaccaagcg cagcaaccgg gacagcctct gccaggccgt gcgcaccctc
3241 ctgggctacg gctacaacat cgagcctcct gaccaggagc ccagtcaggt ggagaaccag
3301 tctcgttgtg accgggtgcg catcttccgg gcagagaaat cctatacagt gcagagcggc
3361 cgctggtact tcgagtttga agcagtcacc acaggcgaga tgcgcgtggg ctgggcgagg
3421 cccgagctga ggcctgatgt agagctggga gctgacgagc tggcctatgt cttcaatggg
3481 caccgcggcc agcgctggca cttgggcagt gaaccatttg ggcgcccctg gcagccgggc
3541 gatgtcgttg gctgtatgat cgacctcaca gagaacacca ttatcttcac cctcaatggc
3601 gaggtcctca tgtctgactc aggctccgaa acagccttcc gggagattga gattggggac
3661 ggcttcctgc ccgtctgcag cttgggacct ggccaggtgg gtcatctgaa cctgggccag
3721 gacgtgagct ctctgaggtt ctttgccatc tgtggcctcc aggaaggctt cgagccattt
3781 gccatcaaca tgcagcgccc agtcaccacc tggttcagca aaggcctgcc ccagtttgag
3841 ccagtgcccc ttgaacaccc tcactatgag gtatcccgag tggacggcac tgtggacacg
3901 cccccctgcc tgcgcctgac ccaccgcacc tggggctccc agaacagcct ggtggagatg
3961 cttttcctgc ggctgagcct cccagtccag ttccaccagc acttccgctg cactgcaggg
4021 gccaccccgc tggcacctcc tggcctgcag ccccccgccg aggacgaggc ccgggcggcg
4081 gaacccgacc ctgactacga aaacctgcgc cgctcagctg ggggctggag cgaggcagag
4141 aacggcaaag aagggactgc gaaggagggc gcccccgggg gcaccccgca ggcggggaga
4201 ggcgcaccgg ccagggcgga gaatgagaag gatgccacca ccgagaagaa caagaagaga
4261 ggcttcttat tcaaggccaa gaaggtcgcc atgatgaccc agccaccggc cacccccacg
4321 ctgccccgac tccctcacga cgtggtgcct gcagacaacc gcgatgaccc cgagatcatc
4381 ctcaacacca ccacgtacta ttactccgtg agggtctttg ctggacagga gcccagctgc
4441 gtgtgggcgg gctgggtcac ccctgactac catcagcacg acatgagctt cgacctcagc
4501 aaggtccggg tcgtgacggt gaccatgggg gatgaacaag gcaacgtcca cagcagcctc
4561 aagtgtagca actgctacat ggtgtggggc ggagactttg tgagtcccgg gcagcagggc
4621 cggatcagcc acacggacct tgtcattggg tgcctggtgg acttggccac tggcttaatg
4681 acctttacag ccaatggcaa agagagcaac acctttttcc aggtggaacc caacactaag
4741 ctatttcctg ccgtcttcgt cctgcccacc caccagaacg tcatccagtt tgagctgggg
4801 aagcagaaga acatcatgcc gttgtcagcc gccatgttcc aaagcgagcg caagaacccg
4861 gccccgcagt gcccaccgcg gctggagatg cagatgctga tgccagtgtc ctggagccgc
4921 atgcccaacc acttcctgca ggtggagacg aggcgtgccg gcgagcggct gggctgggcc
4981 gtgcagtgcc aggagccgct gaccatgatg gcgctgcaca tccccgagga gaaccggtgc
5041 atggacatcc tggagctgtc ggagcgcctg gacctgcagc gcttccactc gcacaccctg
5101 cgcctctacc gcgctgtgtg cgccctgggc aacaatcgcg tggcgcacgc tctgtgcagc
5161 cacgtagacc aagctcagct gctgcacgcc ctggaggacg cgcacctgcc aggcccactg
5221 cgcgcaggct actatgacct cctcatcagc atccacctcg aaagtgcctg ccgcagccgc
5281 cgctccatgc tctctgaata catcgtgccc ctcacgcctg agacccgcgc catcacgctc
5341 ttccctcctg gaaggagcac agaaaatggt cacccccggc atggcctgcc gggagttgga
5401 gtcaccactt cgctgaggcc cccgcatcat ttctcgcccc cctgtttcgt ggccgctctg
5461 ccagctgctg gggcagcaga ggccccggcc cgcctcagcc ctgccatccc gctggaggcc
5521 ctgcgggaca aggcactgag gatgctgggg gaggcggtgc gcgacggtgg gcagcacgct
5581 cgcgaccccg tcggggcctc cgtggagttc cagtttgtgc ctgtgctcaa gctcgtgtcc
5641 accctgctgg tgatgggcat ctttggcgat gaggatgtga aacagatctt gaagatgatt
5701 gagcctgagg tcttcactga ggaagaagag gaggaggacg aggaggaaga gggtgaagag
5761 gaagatgagg aggagaagga ggaggatgag gaggaaacag cacaggaaaa ggaagatgag
5821 gaaaaagagg aagaggaggc agcagaaggg gagaaagaag aaggcttgga ggaagggctg
5881 ctccagatga agttgccaga gtctgtgaag ttacagatgt gccacctgct ggagtatttc
5941 tgtgaccaag agctgcagca ccgtgtggag tccctggcag cctttgcgga gcgctatgtg
6001 gacaagctcc aggccaacca gcggagccgc tatggcctcc tcataaaagc cttcagcatg
6061 accgcagcag agactgcaag acgtacccgc gagttccgct ccccacccca ggaacagatc
6121 aatatgctat tgcaattcaa agatggtaca gatgaggaag actgtcctct ccctgaagag
6181 attcgacagg atttgcttga ctttcatcaa gacctgctgg cacactgtgg aattcagcta
6241 gatggagagg aggaggaacc agaggaagag accaccctgg gcagccgcct catgagcctg
6301 ttggagaaag tgcggctggt gaagaagaag gaagagaaac ctgaggagga gcggtcagca
6361 gaggagagca aaccccggtc cctgcaggag ctggtgtccc acatggtggt gcgctgggcc
6421 caagaggact tcgtgcagag ccccgagctg gtgcgggcca tgttcagcct cctgcaccgg
6481 cagtacgacg ggctgggtga gctgctgcgt gccctgccgc gggcgtacac catctcaccg
6541 tcctccgtgg aagacaccat gagcctgctc gagtgcctcg gccagatccg ctcgctgctc
6601 atcgtgcaga tgggccccca ggaggagaac ctcatgatcc agagcatcgg gaacatcatg
6661 aacaacaaag tcttctacca acacccgaac ctgatgaggg cgctgggcat gcacgagacg
6721 gtcatggagg tcatggtcaa cgtcctcggg ggcggcgagt ccaaggagat ccgcttcccc
6781 aagatggtga caagctgctg ccgcttcctc tgctatttct gccgaatcag ccggcagaac
6841 cagcgctcca tgtttgacca cctgagctac ctgctggaga acagtggcat cggcctgggc
6901 atgcagggct ccacgcccct ggacgtggct gctgcctccg tcattgacaa caatgagctg
6961 gccttggcat tgcaggagca ggacctggaa aaggttgtgt cctacctggc aggctgtggc
7021 ctccagagct gccccatgct tgtggccaaa gggtacccag acattggctg gaagccctgt
7081 ggtggagagc gctacctgga cttcctgcgc tttgctgtct tcgtcaacgg cgagagcgtg
7141 gaggagaacg ccaatgtggt ggtgcggctg ctcatccgga agcctgagtg cttcggaccc
7201 gccctgcggg gtgagggtgg ctcagggctg ctggctgcca tcgaagaggc catccgcatc
7261 tccgaggacc ctgcgaggga tggcccaggc atccgcaggg accggcggcg cgagcacttt
7321 ggtgaggaac cgcctgaaga aaaccgggtg cacctgggac acgccatcat gtccttctat
7381 gccgccttga tcgacctgct cggacgctgt gcaccagaga tgcatctaat ccaagccggc
7441 aagggtgagg ccctgcggat ccgcgccatc ctccgctccc ttgtgccctt ggaggacctt
7501 gtgggcatca tcagcctccc actgcagatt cccaccctgg gcaaagatgg ggctctggtg
7561 cagccaaaga tgtcagcatc cttcgtgccg gaccacaagg cgtccatggt gctcttcctg
7621 gaccgtgtgt atggcatcga gaaccaggac ttcttgctgc acgtgctgga cgtggggttc
7681 ctgcccgaca tgagggcagc cgcctcgctg gacacggcca ctttcagcac caccgagatg
7741 gcgctggccg tgaaccgcta cctgtgcctg gccgtgctgc cgctcatcac caagtgtgcg
7801 ccgctctttg cgggcacaga acaccgcgcc atcatggtgg actctatgct gcataccgtg
7861 taccgcctgt ctcggggtcg ttcgctcacc aaggcgcagc gtgacgtcat cgaggactgc
7921 ctcatgtcgc tctgcaggta catccgcccg tcgatgctgc agcacctgtt gcgccgcctg
7981 gtgttcgacg tgcccatcct caacgagttc gccaagatgc cactcaagct cctcaccaac
8041 cactatgagc gctgttggaa gtactactgc ctacccacgg gctgggccaa cttcggggtc
8101 acctcagagg aggagctgca cctcacacgg aaactcttct ggggcatctt tgactctctg
8161 gcccataaga aatacgaccc ggagctgtac cgcatggcca tgccttgtct gtgcgccatt
8221 gccggggctc tgccccccga ctatgtggat gcctcatact catctaaggc agagaaaaag
8281 gccacagtgg atgctgaagg caactttgat ccccggcctg tggagaccct caatgtgatc
8341 atcccggaga agctggactc cttcattaac aagtttgcgg agtacacaca cgagaagtgg
8401 gccttcgaca agatccagaa caactggtcc tatggagaga acatagacga ggagctgaag
8461 acccacccca tgctgaggcc ctacaagacc ttttcagaga aggacaaaga gatttaccgc
8521 tggcccatca aggagtccct gaaggccatg attgcctggg aatggacgat agagaaggcc
8581 agggagggtg aggaggagaa gacggaaaag aaaaaaacgg cgaagatatc acaaagtgcc
8641 cagacctatg atcctcgaga aggctacaac cctcagcccc ccgaccttag tgctgttacc
8701 ctgtcccggg agctgcaggc catggcagaa caactggcag aaaattacca caacacgtgg
8761 ggacggaaga agaagcagga gctggaagcc aaaggcggtg ggacccaccc cctgctggtc
8821 ccctacgaca cgctcacggc caaggagaag gcacgagatc gagagaaggc ccaggagcta
8881 ctgaaattcc tgcagatgaa tggctacgcg gttacaagag gccttaagga catggaactg
8941 gactcgtctt ccattgaaaa gcggtttgcc tttggcttcc tgcagcagct gctgcgctgg
9001 atggacattt ctcaggagtt cattgcccac ctggaggctg tggtcagcag tgggcgagtg
9061 gaaaagtccc cacatgaaca ggagattaaa ttctttgcca agatcctgct ccctttgatc
9121 aaccagtact tcaccaacca ctgcctctat ttcttgtcca ctccggctaa agtgctgggc
9181 agcggtggcc acgcctctaa caaggagaag gaaatgatca ccagcctctt ctgcaaactt
9241 gctgctctcg tccgccaccg agtctctctc tttgggacag acgccccagc tgtggtcaac
9301 tgtcttcaca tcctggcccg ctccctggat gccaggacag tgatgaagtc aggccctgag
9361 atcgtgaagg ctggcctccg ctccttcttc gagagtgcct cggaggacat cgagaagatg
9421 gtggagaacc tgcggctggg caaggtgtcg caggcgcgca cccaggtgaa aggcgtgggc
9481 cagaacctca cctacaccac tgtggcactg ctgccggtcc tcaccaccct cttccagcac
9541 atcgcccagc accagttcgg agatgacgtc atcctggacg acgtccaggt ctcttgctac
9601 cgaacgctgt gcagtatcta ctccctggga accaccaaga acacttatgt ggaaaagctt
9661 cggccagccc tcggggagtg cctggcccgt ctggcagcag ccatgccggt ggcgttcctg
9721 gagccgcagc tgaacgagta caacgcctgc tccgtgtaca ccaccaagtc tccgcgggag
9781 cgggccatcc tggggctccc caacagtgtg gaggagatgt gtcccgacat cccggtgctg
9841 gagcggctca tggcagacat tggggggctg gccgagtcag gtgcccgcta cacagagatg
9901 ccgcatgtca tcgagatcac gctgcccatg ctatgcagct acctgccccg atggtgggag
9961 cgcgggcccg aggcaccccc ttccgccctg cccgccggcg cccccccacc ctgcacagct
10021 gtcacctctg accacctcaa ctccctgctg gggaatatcc tgagaatcat cgtcaacaac
10081 ctgggcattg acgaggcctc ctggatgaag cggctggctg tgttcgcaca gcccattgtg
10141 agccgtgcac ggccggagct cctgcagtcc cacttcatcc caactatcgg gcggctgcgc
10201 aagagggcag ggaaggtggt gtccgaggag gagcagctgg ccctggaggc caaggcggag
10261 gcccaggagg gcgagctgct ggtgcgggac gagttctctg tgctctgccg ggacctctac
10321 gccctgtatc cgctgctcat ccgctacgtg gacaacaaca gggcgcagtg gctgacggag
10381 ccgaatccca gcgcggagga gctgttcagg atggtgggcg agatcttcat ctactggtcc
10441 aagtcccaca acttcaagcg cgaggagcag aactttgtgg tccagaatga gatcaacaac
10501 atgtccttcc tgactgctga caacaaaagc aaaatggcta agtccggtgg ctcggaccag
10561 gaacgcacca agaagaagcg ccggggggac cggtactctg tgcagacgtc actgatcgtg
10621 gccacactga agaagatgct gcccatcggc ctgaatatgt gtgcgcccac cgaccaagac
10681 ctcatcacgc tggccaagac ccgttacgcc ctgaaagaca cagatgagga ggtccgggaa
10741 tttctgcaca acaaccttca ccttcaggga aaggtcgaag gctccccgtc tctgcgctgg
10801 cagatggctc tgtaccgggg cgtcccgggt cgcgaggagg acgccgatga ccccgagaaa
10861 atcgtgcgca gagtccagga agtgtcagcc gtgctctact acctggacca gaccgagcac
10921 ccttacaagt ctaagaaggc cgtgtggcac aagcttttgt ccaaacagcg ccggcgggca
10981 gtcgtggcct gtttccgtat gacgcccctg tacaacctgc ccacgcaccg ggcatgtaac
11041 atgttcctgg agagctacaa ggctgcatgg atcctgactg aagaccacag ttttgaggac
11101 cgcatgatag atgacctttc aaaagctggg gagcaggagg aggaggagga agaggtggaa
11161 gagaagaagc cagaccccct gcaccagttg gtcctgcact tcagccgcac tgccctgacg
11221 gaaaagagca aactggatga ggattacctg tacatggcct atgctgatat catggcaaag
11281 agctgccacc tggaggaggg aggggagaac ggtgaagctg aagaggaggt tgaggtctcc
11341 tttgaggaga aacagatgga gaagcagagg ctcttgtacc agcaagcacg gctgcacacc
11401 cggggggcgg ccgagatggt gctgcagatg atcagtgcct gcaaaggaga gacaggtgcc
11461 atggtgtcct ccaccctgaa gctgggcatc tccatcctca atggaggcaa tgctgaggtc
11521 cagcagaaaa tgctggatta tcttaaggac aagaaggaag ttggcttctt ccagagtatc
11581 caggcactga tgcaaacatg cagcgtcctg gatctcaatg cctttgagag acagaacaag
11641 gccgaggggc tgggcatggt gaatgaggat ggcactgtca tcaatcgcca gaacggagag
11701 aaggtcatgg cggatgatga attcacacaa gacctgttcc gattcctaca attgctctgt
11761 gaggggcaca ataatgattt ccagaactac ctacggacac agacagggaa cacgaccact
11821 attaacatca tcatttgcac tgtggactac ctcctgcggc tgcaggaatc catcagcgac
11881 ttctactggt actactcggg caaggatgtc attgaagagc agggcaagag gaacttctcc
11941 aaagccatgt cggtggctaa gcaggtgttc aacagcctca ctgagtacat ccagggtccc
12001 tgcaccggga accagcagag cctggcgcac agtcgcctat gggacgcagt ggtgggattc
12061 ctgcacgtgt tcgcccacat gatgatgaag ctcgctcagg actcaagcca gatcgagctg
12121 ctgaaggagc tgctggatct gcagaaggac atggtggtga tgttgctgtc gctactagaa
12181 gggaacgtgg tgaacggcat gatcgcccgg cagatggtgg acatgctcgt ggaatcctca
12241 tccaatgtgg agatgatcct caagttcttc gacatgttcc tgaaactcaa ggacattgtg
12301 ggctctgaag ccttccagga ctacgtaacg gatccccgtg gcctcatctc caagaaggac
12361 ttccagaagg ccatggacag ccagaagcag ttcagcggtc cagaaatcca gttcctgctt
12421 tcgtgctccg aagcggatga gaacgaaatg atcaactgcg aagagttcgc caaccgcttc
12481 caggagccag cacgcgacat cggcttcaac gtggcggtgc tgctgaccaa cctgtcggag
12541 catgtgccgc atgaccctcg cctgcacaac ttcctggagc tggccgagag catccttgag
12601 tacttccgcc cctacctggg ccgcatcgag atcatgggcg cgtcacgccg catcgagcgc
12661 atctacttcg agatctcaga gaccaaccgc gcccagtggg agatgcccca ggtgaaggag
12721 tccaagcgcc agttcatctt cgacgtggtg aacgagggcg gcgaggctga gaagatggag
12781 ctcttcgtga gtttctgcga ggacaccatc ttcgagatgc agatcgccgc gcagatctcg
12841 gagcccgagg gcgagccgga gaccgacgag gacgagggcg cgggcgcggc ggaggcgggc
12901 gcggaaggcg cggaggaggg cgcggcgggg ctcgagggca cggcggccac ggcggcggcg
12961 ggggcgacgg cgcgggttgt ggcggccgca ggccgggccc tgcgaggcct cagctaccgc
13021 agcctgcggc ggcgcgtgcg gcggctgcgg cggcttacgg cccgcgaggc ggccaccgca
13081 gtggcggcgc tgctctgggc agcagtgacg cgcgctgggg ccgctggcgc gggggcggcg
13141 gcgggcgcgc tgggcctgct ctggggctcg ctgttcggcg gcggcctggt ggagggcgcc
13201 aagaaggtga cggtgaccga gctcctggca ggcatgcccg accccaccag cgacgaggtg
13261 cacggcgagc agccggccgg gccgggcgga gacgcagacg gcgagggtgc cagcgagggc
13321 gctggagacg ccgcggaggg cgctggagac gaggaggagg cggtgcacga ggccgggccg
13381 ggcggtgccg acggggcggt ggccgtgacc gatgggggcc ccttccggcc cgaaggggct
13441 ggcggtctcg gggacatggg ggacacgacg cctgcggaac cgcccacacc cgagggctct
13501 cccatcctca agaggaaatt gggggtggat ggagtggagg aggagctccc gccagagcca
13561 gagcccgagc cggaaccaga gctggagccg gagaaagccg atgccgagaa tggggagaag
13621 gaagaagttc ccgagcccac accagagccc cccaagaagc aagcacctcc ctcaccccct
13681 ccaaagaagg aggaagctgg aggcgaattc tggggagaac tggaggtgca gagggtgaag
13741 ttcctgaact acctgtcccg gaacttttac accctgcggt tccttgccct cttcttggca
13801 tttgccatca acttcatctt gctgttttat aaggtctcag actctccacc aggggaggac
13861 gacatggaag gctcagctgc tggggatgtg tcaggtgcag gctctggtgg cagctctggc
13921 tggggcttgg gggccggaga ggaggcagag ggcgatgagg atgagaacat ggtgtactac
13981 ttcctggagg aaagcacagg ctacatggaa cccgccctgc ggtgtctgag cctcctgcat
14041 acactggtgg cctttctctg catcattggc tataattgtc tcaaggtgcc cctggtaatc
14101 tttaagcggg agaaggagct ggcccggaag ctggagtttg atggcctgta catcacggag
14161 cagcctgagg acgatgacgt gaaggggcag tgggaccgac tggtgctcaa cacgccgtct
14221 ttccctagca actactggga caagtttgtc aagcgcaagg tcctggacaa acatggggac
14281 atctacgggc gggagcggat tgctgagcta ctgggcatgg acctggccac actagagatc
14341 acagcccaca atgagcgcaa gcccaacccg ccgccagggc tgctgacctg gctcatgtcc
14401 atcgatgtca agtaccagat ctggaagttc ggggtcatct tcacagacaa ctccttcctg
14461 tacctgggct ggtatatggt gatgtccctc ttgggacact acaacaactt cttctttgct
14521 gcccatctcc tggacatcgc catgggggtc aagacgctgc gcaccatcct gtcctctgtc
14581 acccacaatg ggaaacagct ggtgatgacc gtgggccttc tggcggtggt cgtctacctg
14641 tacaccgtgg tggccttcaa cttcttccgc aagttctaca acaagagcga ggatgaggat
14701 gaacctgaca tgaagtgtga tgacatgatg acgtgttacc tgtttcacat gtacgtgggt
14761 gtccgggctg gcggaggcat tggggacgag atcgaggacc ccgcgggtga cgaatacgag
14821 ctctacaggg tggtcttcga catcaccttc ttcttcttcg tcatcgtcat cctgttggcc
14881 atcatccagg gtctgatcat cgacgctttt ggtgagctcc gagaccaaca agagcaagtg
14941 aaggaggata tggagaccaa gtgcttcatc tgtggaatcg gcagtgacta ctttgatacg
15001 acaccgcatg gcttcgagac tcacacgctg gaggagcaca acctggccaa ttacatgttt
15061 ttcctgatgt atttgataaa caaggatgag acagaacaca cgggtcagga gtcttatgtc
15121 tggaagatgt accaagagag atgttgggat ttcttcccag ctggtgattg tttccgtaag
15181 cagtatgagg accagcttag ctgacacacc cccagctggc cctccacccc cacctcaagt
15241 gccttattct cacagcaagc cccttagtcc ccaagcccct ccccctaagg cagctggggg
15301 agaggtgacc tagtactgga aaataaatct gtcgtacgcc ccccag
//