LOCUS HUMCARN 2935 bp mRNA linear HUM 12-AUG-2004
DEFINITION Homo sapiens carboxypeptidase N precursor (CPN2) mRNA, complete
cds.
ACCESSION J05158
VERSION J05158.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2935)
AUTHORS Tan,F., Weerasinghe,D.K., Skidgel,R.A., Tamei,H., Kaul,R.K.,
Roninson,I.B., Schilling,J.W. and Erdos,E.G.
TITLE The deduced protein sequence of the human carboxypeptidase N high
molecular weight subunit reveals the presence of leucine-rich
tandem repeats
JOURNAL J. Biol. Chem. 265 (1), 13-19 (1990)
PUBMED 2378615
REFERENCE 2 (bases 1 to 2935)
AUTHORS Skidgel,R.A.
TITLE Direct Submission
JOURNAL Submitted (17-NOV-1989) Pharmacology, Univeristy of Illinois at
Chicago, 835 S. Wolcott, M/C 868, Chicago, IL 60612, USA
REFERENCE 3 (bases 1 to 2935)
AUTHORS Skidgel,R.A.
TITLE Direct Submission
JOURNAL Submitted (12-AUG-2004) Pharmacology, Univeristy of Illinois at
Chicago, 835 S. Wolcott, M/C 868, Chicago, IL 60612, USA
REMARK Sequence update by submitter
COMMENT On Aug 12, 2004 this sequence version replaced J05158.1.
FEATURES Location/Qualifiers
source 1..2935
/db_xref="H-InvDB:HIT000191314"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="CT-56; W-9; CBN-1"
/cell_line="HepGT2"
/cell_type="heptoblastoma"
/tissue_type="liver"
gene 1..2935
/gene="CPN2"
/gene_synonym="ACBP"
CDS 5..1642
/gene="CPN2"
/gene_synonym="ACBP"
/EC_number="3.4.17.3"
/note="arginine carboxypeptidase; kininase I"
/codon_start=1
/product="carboxypeptidase N precursor"
/protein_id="AAA51921.2"
/db_xref="GDB:G00-127-893"
/translation="MLPGAWLLWTSLLLLARPAQPCPMGCDCFVQEVFCSDEELATVP
LDIPPYTKNIIFVETSFTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDL
EVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQAL
PRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGS
LQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNM
LRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFR
DLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLAL
HGNPWQCDCHLAYLFNWLQQYTDRLLNIQTYCAGPAYLKGQVVPALNEKQLVCPVTRD
HLGFQVTWPDESKAGGSWDLAVQERAARSQCTYSNPEGTVVLACDQAQCRWLNVQLSP
RQGSLGLQYNASQEWDLRSSCGSLRLTMSIEARAAGP"
sig_peptide 5..67
/gene="CPN2"
/gene_synonym="ACBP"
misc_feature 68..268
/gene="CPN2"
/gene_synonym="ACBP"
/note="Region: N-terminal domain"
misc_feature 269..1204
/gene="CPN2"
/gene_synonym="ACBP"
/note="Region: leucine-rich repeat domain"
misc_feature 1205..1639
/gene="CPN2"
/gene_synonym="ACBP"
/note="Region: C-terminal domain"
regulatory 1914..1919
/regulatory_class="polyA_signal_sequence"
/gene="CPN2"
/gene_synonym="ACBP"
/note="putative"
regulatory 2601..2606
/regulatory_class="polyA_signal_sequence"
/gene="CPN2"
/gene_synonym="ACBP"
/note="putative"
regulatory 2920..2925
/regulatory_class="polyA_signal_sequence"
/gene="CPN2"
/gene_synonym="ACBP"
/note="putative"
BASE COUNT 634 a 932 c 689 g 680 t
ORIGIN
1 gaagatgctc cctggagcct ggctgctctg gacctccctc ctgctcctgg ccaggcctgc
61 ccagccctgt cccatgggtt gtgactgctt cgtccaggag gtgttctgct cagatgagga
121 gcttgccacc gtcccgctgg acatcccgcc atatacgaaa aacatcatct ttgtggagac
181 ctcgttcacc acattggaaa ccagagcttt tggcagtaac cccaacttga ccaaggtggt
241 cttcctcaac actcagctct gccagtttag gccggatgcc tttggggggc tgcccaggct
301 ggaggacctg gaggtcacag gcagtagctt cttgaacctc agcaccaaca tcttctccaa
361 cctgacctcg ctgggcaagc tcaccctcaa cttcaacatg ctggaggctc tgcccgaggg
421 tcttttccag cacctggctg ccctggagtc cctccacctg caggggaacc agctccaggc
481 cctgcccagg aggctcttcc agcctctgac ccatctgaag acactcaacc tggcccagaa
541 cctcctggcc cagctcccgg aggagctgtt ccacccactc accagcctgc agaccctgaa
601 gctgagcaac aacgcgctct ctggtctccc ccagggtgtg tttggcaaac tgggcagcct
661 gcaggagctc ttcctggaca gcaacaacat ctcggagctg ccccctcagg tgttctccca
721 gctcttctgc ctagagaggc tgtggctgca acgcaacgcc atcacgcacc tgccgctctc
781 catctttgcc tccctgggta atctgacctt tctgagcttg cagtggaaca tgcttcgggt
841 cctgcctgcc ggcctctttg cccacacccc atgcctggtt ggcctgtctc tgacccataa
901 ccagctggag actgtcgctg agggcacctt tgcccacctg tccaacctgc gttccctcat
961 gctctcatac aatgccatta cccacctccc agctggcatc ttcagagacc tggaggagtt
1021 ggtcaaactc tacctgggca gcaacaacct tacggcgctg cacccagccc tcttccagaa
1081 cctgtccaag ctggagctgc tcagcctctc caagaaccag ctgaccacac ttccggaggg
1141 catcttcgac accaactaca acctgttcaa cctggccctg cacggtaacc cctggcagtg
1201 cgactgccac ctggcctacc tcttcaactg gctgcagcag tacaccgatc ggctcctgaa
1261 catccagacc tactgcgctg gccctgccta cctcaaaggc caggtggtgc ccgccttgaa
1321 tgagaagcag ctggtgtgtc ccgtcacccg ggaccacttg ggcttccagg tcacgtggcc
1381 ggacgaaagc aaggcagggg gcagctggga tctggctgtg caggaaaggg cagcccggag
1441 ccagtgcacc tacagcaacc ccgagggcac cgtggtgctc gcctgtgacc aggcccagtg
1501 tcgctggctg aacgtccagc tctctcctcg gcagggctcc ctgggactgc agtacaatgc
1561 tagtcaggag tgggacctga ggtcgagctg cggttctctg cggctcacca tgtctatcga
1621 ggctcgggca gcagggccct agtagcagcg catacaggag ctggggaagg gggcctctgg
1681 ggcctgacca ggcgacaggt aggggcggag gggagctgag tctccgaagc cttggctttt
1741 cacatgcaag ggacagggtt acatccccaa ggtgaggggg tggagtctgg tctgctccac
1801 taaccagggt ctcctcctcc tcttccttca tcgcttctcc tggagtgtgc ggcctaataa
1861 ggccatcctt atgccttgca aagcaccctc aaaagctgca ccacagcctg gagaataaaa
1921 tatcctcagc cctgatgcct ccccattatg taacacccaa ccgctctcac ctacaccctg
1981 aggtctattc actgcatccc agtgatacaa agtggaggcc actgccttct gacatctggc
2041 tcaaaagccc agtgtctgtt tccatttatt tccctggaat ttcatttaaa attggtatag
2101 agaaaaaaag gatgtgacag aagcagagat gaccagaaag cacaggggca gggttctgac
2161 tggcgtgtgg gagaccctgt ggccggcacc cacctccaca cgaggactaa gctctgattt
2221 ttttatcttg cccaaattcc tacctaaggg gtctagggag tcgcgcctta caaatcataa
2281 attctcatca gatgggtttt atttgaccct gtatatcatg acttattttt aatctgacta
2341 tggcataaca ttacaagacg aggcaaaaat atttaacccc caaatatatt tccttgccct
2401 accttgaact tgccctgcag agtctcttgt gaggagaatc cacatcctat aaagaagccc
2461 ctttcccctt tgttttcctt cctttctttc cagtccagga gatcatcaac taagagccag
2521 gcaccccttt taagtcgata agaaacagtt tacaacctgc tctctctctc tctgaagtct
2581 gctgagagct tcccctgcac aataaaactt ggcctccacg atcctttatc ttaacctgaa
2641 cattcctttc cattgatccc aggtcttcag ctaagctcaa ccaattgtca accagaaaat
2701 gtttaaattt acctacagcc tggaagcacc cacccccgct gcttcgagtt gtcctgcctt
2761 tctgaactca accaatgtat ttcttaaatg tatttgattg atgcctcatt cctccctaaa
2821 atgtataaaa ccaagctgta cctcgaccac cttgggcaca tgttcccagg ccctcctgag
2881 gtctgtgtca cgggccatgg ccactcatat ttggctcaga ataaatctct tcaaa
//