LOCUS       HUMTCOBI                1537 bp    mRNA    linear   HUM 13-JAN-1995
DEFINITION  human transcobalamin I mRNA, complete cds.
ACCESSION   J05068
VERSION     J05068.1
KEYWORDS    granule protein; transcobalamin.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1537)
  AUTHORS   Johnston,J., Bollekens,J., Allen,R.H. and Berliner,N.
  TITLE     Structure of the cDNA encoding transcobalamin I, a neutrophil
            granule protein
  JOURNAL   J. Biol. Chem. 264 (27), 15754-15757 (1989)
   PUBMED   2777761
COMMENT     Original source text: Human blood neutrophil, cDNA to mRNA.
            Draft entry and computer readable sequence for [J. Biol. Chem.
            (1989) In press] kindly provided
            by J.Johnston on 21-AUG-1989.
FEATURES             Location/Qualifiers
     source          1..1537
                     /db_xref="H-InvDB:HIT000191310"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /map="11q11-q12"
                     /cell_line="neutrophyl"
                     /tissue_type="blood"
     gene            1..1537
                     /gene="TCN1"
     CDS             76..1377
                     /gene="TCN1"
                     /note="transcobalamin I precursor"
                     /codon_start=1
                     /protein_id="AAA61058.1"
                     /db_xref="GDB:G00-118-882"
                     /translation="MRQSHQLPLVGLLLFSFIPSQLCEICEVSEENYIRLKPLLNTMI
                     QSNYNRGTSAVNVVLSLKLVGIQIQTLMQKMIQQIKYNVKSRLSDVSSGELALIILAL
                     GVCRNAEENLIYDYHLTDKLENKFQAEIENMEAHNGTPLTNYYQLSLDVLALCLFNGN
                     YSTAEVVNHFTPENKNYYFGSQFSVDTGAMAVLALTCVKKSLINGQIKADEGSLKNIS
                     IYTKSLVEKILSEKKENGLIGNTFSTGEAMQALFVSSDYYNENDWNCQQTLNTVLTEI
                     SQGAFSNPNAAAQVLPALMGKTFLDINKDSSCVSASGNFNISADEPITVTPPDSQSYI
                     SVNYSVRINETYFTNVTVLNGSVFLSVMEKAQKMNDTIFGFTMEERSWGPYITCIQGL
                     CANNNDRTYWELLSGGEPLSQGAGSYVVRNGENLEVRWSKY"
     sig_peptide     76..144
                     /gene="TCN1"
                     /note="transcobalamin signal peptide"
     mat_peptide     145..1374
                     /gene="TCN1"
                     /product="transcobalamin I"
BASE COUNT          472 a          342 c          309 g          414 t
ORIGIN      
        1 gctctcatta ccttctgccc atcacttaat aaatagccag ccaattcatc aacattctgg
       61 tacactgttg gagagatgag acagtcacac cagctgcccc tagtggggct cttactgttt
      121 tcttttattc caagccaact atgcgagatt tgtgaggtaa gtgaagaaaa ctacatccgc
      181 ctaaaacctc tgttgaatac aatgatccag tcaaactata acaggggaac cagcgctgtc
      241 aatgttgtgt tgtccctcaa acttgttgga atccagatcc aaaccctgat gcaaaagatg
      301 atccaacaaa tcaaatacaa tgtgaaaagc agattgtcag atgtaagctc gggagagctt
      361 gccttgatta tactggcttt gggagtatgt cgtaacgctg aggaaaactt aatatatgat
      421 taccacctga ctgacaagct agaaaataaa ttccaagcag aaattgaaaa tatggaagca
      481 cacaatggca ctcccctgac taactactac cagctcagcc tggacgtttt ggccttgtgt
      541 ctgttcaatg ggaactactc aaccgccgaa gttgtcaacc acttcactcc tgaaaataaa
      601 aactattatt ttggtagcca gttctcagta gatactggtg caatggctgt cctggctctg
      661 acctgtgtga agaagagtct aataaatggg cagatcaaag cagatgaagg cagtttaaag
      721 aacatcagta tttatacaaa gtcactggta gaaaagattc tgtctgagaa aaaagaaaat
      781 ggtctcattg gaaacacatt tagcacagga gaagccatgc aggccctctt tgtatcatca
      841 gactattata atgaaaatga ctggaattgc caacaaactc tgaatacagt gctcacggaa
      901 atttctcaag gagcattcag taatccaaac gctgcagccc aggtcttacc tgccctgatg
      961 ggaaagacct tcttggatat taacaaagac tcttcttgcg tctctgcttc aggtaacttc
     1021 aacatctccg ctgatgagcc tataactgtg acacctcctg actcacaatc atatatctcc
     1081 gtcaattact ctgtgagaat caatgaaaca tatttcacca atgtcactgt gctaaatggt
     1141 tctgtcttcc tcagtgtgat ggagaaagcc cagaaaatga atgatactat atttggtttc
     1201 acaatggagg agcgctcatg ggggccctat atcacctgta ttcagggcct atgtgccaac
     1261 aataatgaca gaacctactg ggaacttctg agtggaggcg aaccactgag ccaaggagct
     1321 ggtagttacg ttgtccgcaa tggagaaaac ttggaggttc gctggagcaa atactaataa
     1381 gcccaaactt tcctcagctg cataaaatcc atttgcagtg gagttccatg tttattgtcc
     1441 ttatgccttc ttcttcattt atcccagtac gagcaggaga gttaataacc tccccttctc
     1501 tctctacatg ttcaataaaa gttgttgaaa gattaac
//