LOCUS HUMALP1GC 2487 bp mRNA linear HUM 31-OCT-1994
DEFINITION Human alkaline phosphatase (ALP-1) mRNA, complete cds.
ACCESSION J04948
VERSION J04948.1
KEYWORDS alkaline phosphatase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2487)
AUTHORS Watanabe,S., Watanabe,T., Li,W.B., Soong,B.W. and Chou,J.Y.
TITLE Expression of the germ cell alkaline phosphatase gene in human
choriocarcinoma cells
JOURNAL J. Biol. Chem. 264 (21), 12611-12619 (1989)
PUBMED 2745460
COMMENT Original source text: Human choriocarcinoma cell line JEG 3, cDNA
to mRNA, clone TPAP15A.
Draft entry and computer-readable sequence for [1] kindly submitted
by J.Y.Chou,03-JUN-1989.
FEATURES Location/Qualifiers
source 1..2487
/db_xref="H-InvDB:HIT000191289"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="2q37"
gene 1..2487
/gene="ALPP"
mRNA 1..2487
/gene="ALPP"
/note="ALP-1"
CDS 53..1651
/gene="ALPP"
/note="alkaline phosphatase precursor (EC 3.1.31.)"
/codon_start=1
/protein_id="AAA51700.1"
/db_xref="GDB:G00-119-672"
/translation="MQGPWVLLLLGLRLQLSLGIIPVEEENPDFWNRQAAEALGAAKK
LQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPETFLAMDRFPYVALSKTY
SVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGK
SVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVI
LGGGRKYMFPMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKHQGARYVWNRTELLQAS
LDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALLLLSRNPRGFFLFVEGGRI
DHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHLFSFGGYPLRGSS
IFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDGET
HAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPRAGTTDAAHPG
PSVVPALLPLLAGTLLLLGTATAP"
sig_peptide 53..142
/gene="ALPP"
/note="alkaline phosphatase signal peptide"
mat_peptide 143..1648
/gene="ALPP"
/product="alkaline phosphatase"
BASE COUNT 487 a 827 c 724 g 449 t
ORIGIN 189 bp upstream of PstI site; chromosome 2q37.
1 catactccat acctgggatt tccgcctcgc cgctctccga ctgcttccag acatgcaggg
61 gccctgggtg ctgctcctgc tgggcctgag gctacagctc tccctgggca tcatcccagt
121 tgaggaggag aacccggact tctggaaccg ccaggcagcc gaggccctgg gtgccgccaa
181 gaagctgcag cctgcacaga cagccgccaa gaacctcatc atcttcctgg gtgacgggat
241 gggggtgtct acggtgacag ctgccaggat cctaaaaggg cagaagaagg acaaactggg
301 gcctgagacc ttcctggcca tggaccgctt cccgtacgtg gctctgtcca agacatacag
361 tgtagacaag catgtgccag acagtggagc cacagccacg gcctacctgt gcggggtcaa
421 gggcaacttc cagaccattg gcttgagtgc agccgcccgc tttaaccagt gcaacacgac
481 acgcggcaac gaggtcatct ccgtgatgaa tcgggccaag aaagcaggaa agtcagtggg
541 agtggtaacc accacacggg tgcagcatgc ctcgccagcc ggcacctacg cccacacggt
601 gaaccgcaac tggtactcgg atgccgacgt gcctgcctcg gcccgccagg aggggtgcca
661 ggacatcgcc acgcagctca tctccaacat ggacattgat gtgatcctag gtggaggccg
721 aaagtacatg tttcccatgg ggaccccaga ccctgagtac ccagatgact acagccaagg
781 tgggaccagg ctggacggga agaatctggt gcaggaatgg ctggcgaagc accagggtgc
841 ccggtacgtg tggaaccgca ctgagctcct gcaggcttcc ctggacccgt ctgtgaccca
901 tctcatgggt ctctttgagc ctggagacat gaaatacgag atccaccgag actccacact
961 ggacccctcc ctgatggaga tgacagaggc tgccctgctc ctgctgagca ggaacccccg
1021 cggcttcttc ctcttcgtgg agggtggtcg catcgaccat ggtcatcatg aaagcagggc
1081 ttaccgggca ctgactgaga cgatcatgtt cgacgacgcc attgagaggg cgggccagct
1141 caccagcgag gaggacacgc tgagcctcgt cactgccgac cactcccacc tcttctcctt
1201 cggaggctac cccctgcgag ggagctccat cttcgggctg gcccctggca aggcccggga
1261 caggaaggcc tacacggtcc tcctatacgg aaacggtcca ggctatgtgc tcaaggacgg
1321 cgcccggccg gatgttacgg agagcgagag cgggagcccc gagtatcggc agcagtcagc
1381 agtgcccctg gacggagaga cccacgcagg cgaggacgtg gcggtgttcg cgcgcggccc
1441 gcaggcgcac ctggttcacg gcgtgcagga gcagaccttc atagcgcacg tcatggcctt
1501 cgccgcctgc ctggagccct acaccgcctg cgacctggcg ccccgcgccg gcaccaccga
1561 cgccgcgcac ccggggccgt ccgtggtccc cgcgttgctt cctctgctgg cagggacctt
1621 gctgctgctg gggacggcca ctgctccctg agtgtcccgt ccctgggggc tcctgcttcc
1681 ccatcccgga gttcccctgc tccccacctc cagtcgtcct gccggacctc cacctggagc
1741 tgtcaccccc ggagtcgcca cacagacgtt cctgccatgg aaccttccct cccggtgcac
1801 cctggggacc gagcccttga caccacgcct ttgctttatc ttgctcttaa attttggccc
1861 caactccagg gactggggat ttgtgcctgg cagctgcctg catttcagga aaagaggagg
1921 ctcagaccat ccagcccccg cccatatcct gaggtggatc aggcaggctc tctccccggg
1981 gacatgaggc acccatacct aggaccccct gcgccttttt tagcttcagt catggcagca
2041 cctgagggac acaaggactt gggtgcatca ggacgccttg gagaagcgtg gcttcctgcc
2101 accctgcaac ccaccctccc agccaaggag gctgctgtgg tggggatccc caggggcttt
2161 gacacagtcc tctgctgtcc tccactgggc taattctaca cccctgtgcc cctcctaggg
2221 gcccatgagt cagagaggct tgccccaagt cacagccact cagatgttcg acgcccccta
2281 aggtccattc cagcacccac ctgagttccg aggagcacct gggaagctct gggtgcagga
2341 tagcagtcca gagtccatgc cccgctaggc catctgggtg ctgggcatgg atttctcagc
2401 aaggaagact cattaccttc cctccctggg cctccattct ctcctgggaa acacaaagca
2461 ataataaaag gaagtgttag acaatgt
//