LOCUS HUMBPIAA 1813 bp mRNA linear HUM 31-OCT-1994
DEFINITION Human bactericidal permeability increasing protein (BPI) mRNA,
complete cds.
ACCESSION J04739
VERSION J04739.1
KEYWORDS bactericidal permeability increasing protein; bactericidal protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1813)
AUTHORS Gray,P.W., Flaggs,G., Leong,S.R., Gumina,R.J., Weiss,J., Ooi,C.E.
and Elsbach,P.
TITLE Cloning of the cDNA of a human neutrophil bactericidal protein.
Structural and functional correlations
JOURNAL J. Biol. Chem. 264 (16), 9505-9509 (1989)
PUBMED 2722846
COMMENT Original source text: Human myeloid leukemia cell line HL-60, cDNA
to mRNA, clone 4.
Draft entry and computer-readable sequence for [1] kindly submitted
by P.Gray, 21-MAR-1989.
FEATURES Location/Qualifiers
source 1..1813
/db_xref="H-InvDB:HIT000191280"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="Unassigned"
gene 1..1813
/gene="BPI"
mRNA <1..1813
/gene="BPI"
/note="bactericidal permeability increasing protein"
CDS 31..1494
/gene="BPI"
/note="bactericidal permeability increasing protein (BPI)
precursor"
/codon_start=1
/protein_id="AAA51841.1"
/db_xref="GDB:G00-131-572"
/translation="MRENMARGPCNAPRWVSLMVLVAIGTAVTAAVNPGVVVRISQKG
LDYASQQGTAALQKELKRIKIPDYSDSFKIKHLGKGHYSFYSMDIREFQLPSSQISMV
PNVGLKFSISNANIKISGKWKAQKRFLKMSGNFDLSIEGMSISADLKLGSNPTSGKPT
ITCSSCSSHINSVHVHISKSKVGWLIQLFHKKIESALRNKMNSQVCEKVTNSVSSKLQ
PYFQTLPVMTKIDSVAGINYGLVAPPATTAETLDVQMKGEFYSENHHNPPPFAPPVME
FPAAHDRMVYLGLSDYFFNTAGLVYQEAGVLKMTLRDDMIPKESKFRLTTKFFGTFLP
EVAKKFPNMKIQIHVSASTPPHLSVQPTGLTFYPAVDVQAFAVLPNSSLASLFLIGMH
TTGSMEVSAESNRLVGELKLDRLLLELKHSNIGPFPVELLQDIMNYIVPILVLPRVNE
KLQKGFPLPTPARVQLYNVVLQPHQNFLLFGADVVYK"
sig_peptide 31..123
/gene="BPI"
/note="bactericidal permeability increasing protein signal
peptide"
mat_peptide 124..1491
/gene="BPI"
/product="bactericidal permeability increasing protein"
BASE COUNT 452 a 500 c 441 g 420 t
ORIGIN
1 caggccttga ggttttggca gctctggagg atgagagaga acatggccag gggcccttgc
61 aacgcgccga gatgggtgtc cctgatggtg ctcgtcgcca taggcaccgc cgtgacagcg
121 gccgtcaacc ctggcgtcgt ggtcaggatc tcccagaagg gcctggacta cgccagccag
181 caggggacgg ccgctctgca gaaggagctg aagaggatca agattcctga ctactcagac
241 agctttaaga tcaagcatct tgggaagggg cattatagct tctacagcat ggacatccgt
301 gaattccagc ttcccagttc ccagataagc atggtgccca atgtgggcct taagttctcc
361 atcagcaacg ccaatatcaa gatcagcggg aaatggaagg cacaaaagag attcttaaaa
421 atgagcggca attttgacct gagcatagaa ggcatgtcca tttcggctga tctgaagctg
481 ggcagtaacc ccacgtcagg caagcccacc atcacctgct ccagctgcag cagccacatc
541 aacagtgtcc acgtgcacat ctcaaagagc aaagtcgggt ggctgatcca actcttccac
601 aaaaaaattg agtctgcgct tcgaaacaag atgaacagcc aggtctgcga gaaagtgacc
661 aattctgtat cctccaagct gcaaccttat ttccagactc tgccagtaat gaccaaaata
721 gattctgtgg ctggaatcaa ctatggtctg gtggcacctc cagcaaccac ggctgagacc
781 ctggatgtac agatgaaggg ggagttttac agtgagaacc accacaatcc acctcccttt
841 gctccaccag tgatggagtt tcccgctgcc catgaccgca tggtatacct gggcctctca
901 gactacttct tcaacacagc cgggcttgta taccaagagg ctggggtctt gaagatgacc
961 cttagagatg acatgattcc aaaggagtcc aaatttcgac tgacaaccaa gttctttgga
1021 accttcctac ctgaggtggc caagaagttt cccaacatga agatacagat ccatgtctca
1081 gcctccaccc cgccacacct gtctgtgcag cccaccggcc ttaccttcta ccctgccgtg
1141 gatgtccagg cctttgccgt cctccccaac tcctccctgg cttccctctt cctgattggc
1201 atgcacacaa ctggttccat ggaggtcagc gccgagtcca acaggcttgt tggagagctc
1261 aagctggata ggctgctcct ggaactgaag cactcaaata ttggcccctt cccggttgaa
1321 ttgctgcagg atatcatgaa ctacattgta cccattcttg tgctgcccag ggttaacgag
1381 aaactacaga aaggcttccc tctcccgacg ccggccagag tccagctcta caacgtagtg
1441 cttcagcctc accagaactt cctgctgttc ggtgcagacg ttgtctataa atgaaggcac
1501 caggggtgcc gggggctgtc agccgcacct gttcctgatg ggctgtgggg caccggctgc
1561 ctttccccag ggaatcctct ccagatctta accaagagcc ccttgcaaac ttcttcgact
1621 cagattcaga aatgatctaa acacgaggaa acattattca ttggaaaagt gcatggtgtg
1681 tattttaggg attatgagct tctttcaagg gctaaggctg cagagatatt tcctccagga
1741 atcgtgtttc aattgtaacc aagaaatttc catttgtgct tcatgaaaaa aaacttctgg
1801 tttttttcat gtg
//