LOCUS HUMGFB 6757 bp mRNA linear HUM 08-NOV-1994
DEFINITION Human basic fibroblast growth factor (bFGF) 22.5 kd, 21 kd and 18
kd protein mRNA, complete cds.
ACCESSION J04513
VERSION J04513.1
KEYWORDS 18 kDa basic fibroblast growth factor; 21 kDa basic fibroblast
growth factor; 22.5 kDa basic fibroblast growth factor; basic
fibroblast growth factor; growth factor; heparin binding protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6757)
AUTHORS Prats,H., Kaghad,M., Prats,A.C., Klagsbrun,M., Lelias,J.M.,
Liauzun,P., Chalon,P., Tauber,J.P., Amalric,F., Smith,J.A. and
Caput,D.
TITLE High molecular mass forms of basic fibroblast growth factor are
initiated by alternative CUG codons
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 86 (6), 1836-1840 (1989)
PUBMED 2538817
COMMENT Original source text: Human hepatoma SK-HEP-1 cell line, cDNA to
mRNA, clone pUC-SK1.
Draft entry and computer-readable sequence for [1] kindly submitted
by D.Caput, 03-MAR-1989.
FEATURES Location/Qualifiers
source 1..6757
/db_xref="H-InvDB:HIT000191268"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="4q25-q27"
mRNA 1..6757
/product="bFGF mRNA"
gene 302..934
/gene="FGF2"
CDS 302..934
/gene="FGF2"
/note="basic fibroblast growth factor (ctg start codon);
putative"
/codon_start=1
/transl_except=(pos:302..304,aa:Met)
/protein_id="AAA52531.1"
/db_xref="GDB:G00-119-910"
/translation="MGDRGRGRALPGGRLGGRGRGRAPERVGGRGRGRGTAAPRAAPA
ARGSRPGPAGTMAAGSITTLPALPEDGGSGAFPPGHFKDPKRLYCKNGGFFLRIHPDG
RVDGVREKSDPHIKLQLQAEERGVVSIKGVCANRYLAMKEDGRLLASKCVTDECFFFE
RLESNNYNTYRSRKYTSWYVALKRTGQYKLGSKTGPGQKAILFLPMSAKS"
CDS 344..934
/gene="FGF2"
/note="21 kd basic fibroblast growth factor (ctg start
codon; put.); putative"
/codon_start=1
/transl_except=(pos:344..346,aa:Met)
/protein_id="AAA52532.1"
/db_xref="GDB:G00-119-910"
/translation="MGGRGRGRAPERVGGRGRGRGTAAPRAAPAARGSRPGPAGTMAA
GSITTLPALPEDGGSGAFPPGHFKDPKRLYCKNGGFFLRIHPDGRVDGVREKSDPHIK
LQLQAEERGVVSIKGVCANRYLAMKEDGRLLASKCVTDECFFFERLESNNYNTYRSRK
YTSWYVALKRTGQYKLGSKTGPGQKAILFLPMSAKS"
CDS 467..934
/gene="FGF2"
/note="18 kd basic fibroblast growth factor"
/codon_start=1
/protein_id="AAA52533.1"
/db_xref="GDB:G00-119-910"
/translation="MAAGSITTLPALPEDGGSGAFPPGHFKDPKRLYCKNGGFFLRIH
PDGRVDGVREKSDPHIKLQLQAEERGVVSIKGVCANRYLAMKEDGRLLASKCVTDECF
FFERLESNNYNTYRSRKYTSWYVALKRTGQYKLGSKTGPGQKAILFLPMSAKS"
BASE COUNT 2038 a 1201 c 1333 g 2185 t
ORIGIN Unreported; chromosome 4q21-qter.
1 cggccccaga aaacccgagc gagtaggggg cggcgcgcag gagggaggag aactgggggc
61 gcgggaggct ggtgggtgtc gggggtggag atgtagaaga tgtgacgccg cggcccggcg
121 ggtgccagat tagcggacgg ctgcccgcgg ttgcaacggg atcccgggcg ctgcagcttg
181 ggaggcggct ctccccaggc ggcgtccgcg gagacaccca tccgtgaacc ccaggtcccg
241 ggccgccggc tcgccgcgca ccaggggccg gcggacagaa gagcggccga gcggctcgag
301 gctgggggac cgcgggcgcg gccgcgcgct gccgggcggg aggctggggg gccggggccg
361 gggccgtgcc ccggagcggg tcggaggccg gggccggggc cgggggacgg cggctccccg
421 cgcggctcca gcggctcggg gatcccggcc gggccccgca gggaccatgg cagccgggag
481 catcaccacg ctgcccgcct tgcccgagga tggcggcagc ggcgccttcc cgcccggcca
541 cttcaaggac cccaagcggc tgtactgcaa aaacgggggc ttcttcctgc gcatccaccc
601 cgacggccga gttgacgggg tccgggagaa gagcgaccct cacatcaagc tacaacttca
661 agcagaagag agaggagttg tgtctatcaa aggagtgtgt gctaaccgtt acctggctat
721 gaaggaagat ggaagattac tggcttctaa atgtgttacg gatgagtgtt tcttttttga
781 acgattggaa tctaataact acaatactta ccggtcaagg aaatacacca gttggtatgt
841 ggcactgaaa cgaactgggc agtataaact tggatccaaa acaggacctg ggcagaaagc
901 tatacttttt cttccaatgt ctgctaagag ctgattttaa tggccacatc taatctcatt
961 tcacatgaaa gaagaagtat attttagaaa tttgttaatg agagtaaaag aaaataaatg
1021 tgtatagctc agtttggata attggtcaaa caatttttta tccagtagta aaatatgtaa
1081 ccattgtccc agtaaagaaa aataacaaaa gttgtaaaat gtatattctc ccttttatat
1141 tgcatctgct gttacccagt gaagcttacc tagagcaatg atctttttca cgcatttgct
1201 ttattcgaaa agaggctttt aaaatgtgca tgtttagaaa caaaatttct tcatggaaat
1261 catatacatt agaaaatcac agtcagatgt ttaatcaatc caaaatgtcc actatttctt
1321 atgtcattcg ttagtctaca tgtttctaaa catataaatg tgaatttaat caattccttt
1381 catagtttta taattctctg gcagttcctt atgatagagt ttataaaaca gtcctgtgta
1441 aactgctgga agttcttcca cagtcaggtc aattttgtca aacccttctc tgtacccata
1501 cagcagcagc ctagcaactc tgctggtgat gggagttgta ttttcagtct tcgccaggtc
1561 attgagatcc atccactcac atcttaagca ttcttcctgg caaaaattta tggtgaatga
1621 atatggcttt aggcggcaga tgatatacat atctgacttc ccaaaagctc caggatttgt
1681 gtgctgttgc cgaatactca ggacggacct gaattctgat tttataccag tctcttcaaa
1741 aacttctcga accgctgtgt ctcctacgta aaaaaagaga tgtacaaatc aataataatt
1801 acacttttag aaactgtatc atcaaagatt ttcagttaaa gtagcattat gtaaaggctc
1861 aaaacattac cctaacaaag taaagttttc aatacaaatt ctttgccttg tggatatcaa
1921 gaaatcccaa aatattttct taccactgta aattcaagaa gcttttgaaa tgctgaatat
1981 ttctttggct gctacttgga ggcttatcta cctgtacatt tttggggtca gctcttttta
2041 acttcttgct gctctttttc ccaaaaggta aaaatataga ttgaaaagtt aaaacatttt
2101 gcatggctgc agttcctttg tttcttgaga taagattcca aagaacttag attcatttct
2161 tcaacaccga aatgctggag gtgtttgatc agttttcaag aaacttggaa tataaataat
2221 tttataattc aacaaaggtt ttcacatttt ataaggttga tttttcaatt aaatgcaaat
2281 ttgtgtggca ggatttttat tgccattaac atatttttgt ggctgctttt tctacacatc
2341 cagatggtcc ctctaactgg gctttctcta attttgtgat gttctgtcat tgtctcccaa
2401 agtatttagg agaagccctt taaaaagctg ccttcctcta ccactttgct ggaaagcttc
2461 acaattgtca cagacaaaga tttttgttcc aatactcgtt ttgcctctat ttttcttgtt
2521 tgtcaaatag taaatgatat ttgcccttgc agtaattcta ctggtgaaaa acatgcaaag
2581 aagaggaagt cacagaaaca tgtctcaatt cccatgtgct gtgactgtag actgtcttac
2641 catagactgt cttacccatc ccctggatat gctcttgttt tttccctcta atagctatgg
2701 aaagatgcat agaaagagta taatgtttta aaacataagg cattcatctg ccatttttca
2761 attacatgct gacttccctt acaattgaga tttgcccata ggttaaacat ggttagaaac
2821 aactgaaagc ataaaagaaa aatctaggcc gggtgcagtg gctcatgcct atattccctg
2881 cactttggga ggccaaagca ggaggatcgc ttgagcccag gagttcaaga ccaacctggt
2941 gaaaccccgt ctctacaaaa aaacacaaaa aatagccagg catggtggcg tgtacatgtg
3001 gtctcagata cttgggaggc tgaggtggga gggttgatca cttgaggctg agaggtcaag
3061 gttgcagtga gccataatcg tgccactgca gtccagccta ggcaacagag tgagactttg
3121 tctcaaaaaa agagaaattt tccttaataa gaaaagtaat ttttactctg atgtgcaata
3181 catttgttat taaatttatt atttaagatg gtagcactag tcttaaattg tataaaatat
3241 cccctaacat gtttaaatgt ccatttttat tcattatgct ttgaaaaata attatgggga
3301 aatacatgtt tgttattaaa tttattatta aagatagtag cactagtctt aaatttgata
3361 taacatctcc taacttgttt aaatgtccat ttttattctt tatgcttgaa aataaattat
3421 ggggatccta tttagctctt agtaccacta atcaaaagtt cggcatgtag ctcatgatct
3481 atgctgtttc tatgtcgtgg aagcaccgga tgggggtagt gagcaaatct gccctgctca
3541 gcagtcacca tagcagctga ctgaaaatca gcactgcctg agtagttttg atcagtttaa
3601 cttgaatcac taactgactg aaaattgaat gggcaaataa gtgcttttgt ctccagagta
3661 tgcgggagac ccttccacct caagatggat atttcttccc caaggatttc aagatgaatt
3721 gaaattttta atcaagatag tgtgctttat tctgttgtat tttttattat tttaatatac
3781 tgtaagccaa actgaaataa catttgctgt tttataggtt tgaagaacat aggaaaaact
3841 aagaggtttt gtttttattt ttgctgatga agagatatgt ttaaatatgt tgtattgttt
3901 tgtttagtta caggacaata atgaaatgga gtttatattt gttatttcta ttttgttata
3961 tttaataata gaattagatt gaaataaaat ataatgggaa ataatctgca gaatgtgggt
4021 ttcctggtgt ttcctctgac tctagtgcac tgatgatctc tgataaggct cagctgcttt
4081 atagttctct ggctaatgca gcagatactc ttcctgccag tggtaatacg attttttaag
4141 aaggcagttt gtcaatttta atcttgtgga tacctttata ctcttagggt attattttat
4201 acaaaagcct tgaggattgc attctatttt ctatatgacc ctcttgatat ttaaaaaaca
4261 ctatggataa caattcttca tttacctagt attatgaaag aatgaaggag ttcaaacaaa
4321 tgtgtttccc agttaactag ggtttactgt ttgagccaat ataaatgttt aactgtttgt
4381 gatggcagta ttcctaaagt acattgcatg ttttcctaaa tacagagttt aaataatttc
4441 agtaattctt agatgattca gcttcatcat taagaatatc ttttgtttta tgttgagtta
4501 gaaatgcctt catatagaca tagtctttca gacctctact gtcagttttc atttctagct
4561 gctttcaggg ttttatgaat tttcaggcaa agctttaatt tatactaagc ttaggaagta
4621 tggctaatgc caacggcagt ttttttcttc ttaattccac atgactgagg catatatgat
4681 ctctgggtag gtgagttgtt gtgacaacca caagcacttt tttttttttt aaagaaaaaa
4741 aggtagtgaa tttttaatca tctggacttt aagaaggatt ctggagtata cttaggcctg
4801 aaattatata tatttggctt ggaaatgtgt ttttcttcaa ttacatctac aagtaagtac
4861 agctgaaatt cagaggaccc ataagagttc acatgaaaaa aatcaattca tttgaaaagg
4921 caagatgcag gagagaggaa gccttgcaaa cctgcagact gctttttgcc caatatagat
4981 tgggtaaggc tgcaaaacat aagcttaatt agctcacatg ctctgctctc acgtggcacc
5041 agtggatagt gtgagagaat taggctgtag aacaaatggc cttctctttc agcattcaca
5101 ccactacaaa atcatctttt atatcaacag aagaataagc ataaactaag caaaaggtca
5161 ataagtacct gaaaccaaga ttggctagag atatatctta atgcaatcca ttttctgatg
5221 gattgttacg agttggctat ataatgtatg tatggtattt tgatttgtgt aaaagtttta
5281 aaaatcaagc tttaagtaca tggacatttt taaataaaat atttaaagac aatttagaaa
5341 attgccttaa tatcattgtt ggctaaatag aataggggac atgcatatta aggaaaaggt
5401 catggagaaa taatattggt atcaaacaaa tacattgatt tgtcatgata cacattgaat
5461 ttgatccaat agtttaagga ataggtagga aaatttggtt tctatttttc gatttcctgt
5521 aaatcagtga cataaataat tcttagctta ttttatattt ccttgtctta aatactgagc
5581 tcagtaagtt gtgttagggg attatttctc agttgagact ttcttatatg acattttact
5641 atgttttgac ttcctgacta ttaaaaataa atagtagaaa caattttcat aaagtgaaga
5701 attatataat cactgcttta taactgactt tattatattt atttcaaagt tcatttaaag
5761 gctactattc atcctctgtg atggaatggt caggaatttg ttttctcata gtttaattcc
5821 aacaacaata ttagtcgtat ccaaaataac ctttaatgct aaactttact gatgtatatc
5881 caaagcttct ccttttcaga cagattaatc cagaagcagt cataaacaga agaataggtg
5941 gtatgttcct aatgatatta tttctactaa tggaataaac tgtaatatta gaaattatgc
6001 tgctaattat atcagctctg aggtaatttc tgaaatgttc agactcagtc ggaacaaatt
6061 ggaaaattta aatttttatt cttagctata aagcaagaaa gtaaacacat taatttcctc
6121 aacattttta agccaattaa aaatataaaa gatacacacc aatatcttct tcaggctctg
6181 acaggcctcc tggaaacttc cacatatttt tcaactgcag tataaagtca gaaaataaag
6241 ttaacataac tttcactaac acacacatat gtagatttca caaaatccac ctataattgg
6301 tcaaagtggt tgagaatata ttttttagta attgcatgca aaatttttct agcttccatc
6361 ctttctccct cgtttcttct ttttttgggg gagctggtaa ctgatgaaat cttttcccac
6421 cttttctctt caggaaatat aagtggtttt gtttggttaa cgtgatacat tctgtatgaa
6481 tgaaacattg gagggaaaca tctactgaat ttctgtaatt taaaatattt tgctgctagt
6541 taactatgaa cagatagaag aatcttacag atgctgctat aaataagtag aaaatataaa
6601 tttcatcact aaaatatgct attttaaaat ctatttccta tattgtattt ctaatcagat
6661 gtattactct tattatttct attgtatgtg ttaatgattt tatgtaaaaa tgtaattgct
6721 tttcatgagt agtatgaata aaattgatta gtttgtg
//