LOCUS HUMAMYI 1462 bp mRNA linear HUM 07-NOV-1994
DEFINITION Human islet amyloid protein mRNA, complete cds.
ACCESSION J04422
VERSION J04422.1
KEYWORDS Alu repeat; IAPP gene; islet amyloid protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1462)
AUTHORS Sanke,T., Bell,G.I., Sample,C., Rubenstein,A.H. and Steiner,D.F.
TITLE An islet amyloid peptide is derived from an 89-amino acid precursor
by proteolytic processing
JOURNAL J. Biol. Chem. 263 (33), 17243-17246 (1988)
PUBMED 3053705
COMMENT Original source text: Human insulinoma, cDNA to mRNA, clone
lambda-hIAP-1.
Draft entry and computer-readable sequence for [1] kindly provided
by G.I.Bell, 24-OCT-1988.
FEATURES Location/Qualifiers
source 1..1462
/db_xref="H-InvDB:HIT000191258"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="12p12.3-p12.1"
/tissue_type="insulinoma"
gene 1..1462
/gene="IAPP"
mRNA <1..1462
/gene="IAPP"
/note="amyloid mRNA; G00-120-074"
CDS 137..406
/gene="IAPP"
/note="precursor"
/codon_start=1
/product="islet amyloid polypeptide"
/protein_id="AAA52281.1"
/db_xref="GDB:G00-120-074"
/translation="MGILKLQVFLIVLSVALNHLKATPIESHQVEKRKCNTATCATQR
LANFLVHSSNNFGAILSSTNVGSNTYGKRNAVEVLKREPLNYLPL"
sig_peptide 137..202
/gene="IAPP"
/note="G00-120-074; putative"
mat_peptide 236..346
/gene="IAPP"
/product="islet amyloid polypeptide"
/note="G00-120-074"
repeat_region 780..1061
/gene="IAPP"
/rpt_family="Alu"
BASE COUNT 438 a 262 c 318 g 444 t
ORIGIN 332 bp upstream of BamHI site.
1 gattactagt tagcaaatga gggggtaaat attccagtgg atacaagctt ggactctttt
61 cttgaagctt tctttctatc agaagcattt gctgatattg ctgacattga aacattaaaa
121 gaaaatttga gaagcaatgg gcatcctgaa gctgcaagta tttctcattg tgctctctgt
181 tgcattgaac catctgaaag ctacacccat tgaaagtcat caggtggaaa agcggaaatg
241 caacactgcc acatgtgcaa cgcagcgcct ggcaaatttt ttagttcatt ccagcaacaa
301 ctttggtgcc attctctcat ctaccaacgt gggatccaat acatatggca agaggaatgc
361 agtagaggtt ttaaagagag agccactgaa ttacttgccc ctttagagga caatgtaact
421 ctatagttat tgttttatgt tctagtgatt tcctgtataa tttaacagtg cccttttcat
481 ctccagtgtg aatatatggt ctgtgtgtct gatgtttgtt gctaggacat ataccttctc
541 aaaagattgt tttatatgta gtactaacta aggtcccata ataaaaagat agtatctttt
601 aaaatgaaat gtttttgcta tagatttgta ttttaaaaca taagaacgtc attttgggac
661 ctatatctca gtggcacagg tttaagaacg aaggagaaaa aggtagtttg aaccttggta
721 aattgtaaac agctaataat gaagttattc ttgacatgag aaaatcagta attggaccag
781 gcgcggtggc tcttgcctgt agtcccggca ctttgggagg ccgaggcagg cagatcacaa
841 ggtcaggagt tcgagaccag cctgaccaac gtggtgaaac cctgtctcta ctggaaatac
901 ggaaattagc cgggggtggt gacatgtgcc tgtaatccca gctactcagg aggctaaggc
961 aggagaatcg cttgaaccca ggaggcggag gttgcagtga gccgagattg caccactgca
1021 ctccagcctg ggtggcagag tgagactcgt ctcaaaaaaa agaaagaaaa ttagtaattg
1081 taagtacccc tgataagcaa attagtaatt gtcaataccc ctgttaagca attccttttt
1141 gcagtatatt tctgaaatga cagaatgctg ttttaaaaac aaagaaataa aatcctgctc
1201 ctgactcggt caaaatattt tttaaagtct attgtttgtt gtgcttgctg gtactaagag
1261 gctatttaaa agtataaaac tgctttgtat ccatgagggt ttcattgtgt gttagcagca
1321 gtgagcttct attaaatgta tatgtcattt attttgttta agtggctttc agcaaacctc
1381 agtcatattc ttatgcaggg tattgcgaaa caacttgtgt tctattaatc gtgtcttcaa
1441 ttaaaagacc acagacttct gg
//