LOCUS HUMMAC1A 4740 bp mRNA linear HUM 07-JAN-1995
DEFINITION Human Mac-1 gene encoding complement receptor type 3, CD11b,
complete cds.
ACCESSION J03925
VERSION J03925.1
KEYWORDS complement receptor; glycoprotein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4740)
AUTHORS Corbi,A.L., Kishimoto,T.K., Miller,L.J. and Springer,T.A.
TITLE The human leukocyte adhesion glycoprotein Mac-1 (complement
receptor type 3, CD11b) alpha subunit. Cloning, primary structure,
and relation to the integrins, von Willebrand factor and factor B
JOURNAL J. Biol. Chem. 263 (25), 12403-12411 (1988)
PUBMED 2457584
COMMENT Original source text: Human myeloid, cDNA to mRNA, clone lambda
M14/M23.
Submitted in computer readable form by T.A. Springer 23-MAY-1988.
FEATURES Location/Qualifiers
source 1..4740
/db_xref="H-InvDB:HIT000191220"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="16p11.2"
gene 1..4740
/gene="ITGAM"
CDS 73..3534
/gene="ITGAM"
/note="glycoprotein Mac-1"
/codon_start=1
/protein_id="AAA59544.1"
/db_xref="GDB:G00-120-599"
/translation="MALRVLLLTALTLCHGFNLDTENAMTFQENARGFGQSVVQLQGS
RVVVGAPQEIVAANQRGSLYQCDYSTGSCEPIRLQVPVEAVNMSLGLSLAATTSPPQL
LACGPTVHQTCSENTYVKGLCFLFGSNLRQQPQKFPEALRGCPQEDSDIAFLIDGSGS
IIPHDFRRMKEFVSTVMEQLKKSKTLFSLMQYSEEFRIHFTFKEFQNNPNPRSLVKPI
TQLLGRTHTATGIRKVVRELFNITNGARKNAFKILVVITDGEKFGDPLGYEDVIPEAD
REGVIRYVIGVGDAFRSEKSRQELNTIASKPPRDHVFQVNNFEALKTIQNQLREKIFA
IEGTQTGSSSSFEHEMSQEGFSAAITSNGPLLSTVGSYDWAGGVFLYTSKEKSTFINM
TRVDSDMNDAYLGYAAAIILRNRVQSLVLGAPRYQHIGLVAMFRQNTGMWESNANVKG
TQIGAYFGASLCSVDVDSNGSTDLVLIGAPHYYEQTRGGQVSVCPLPRGQRARWQCDA
VLYGEQGQPWGRFGAALTVLGDVNGDKLTDVAIGAPGEEDNRGAVYLFHGTSGSGISP
SHSQRIAGSKLSPRLQYFGQSLSGGQDLTMDGLVDLTVGAQGHVLLLRSQPVLRVKAI
MEFNPREVARNVFECNDQVVKGKEAGEVRVCLHVQKSTRDRLREGQIQSVVTYDLALD
SGRPHSRAVFNETKNSTRRQTQVLGLTQTCETLKLQLPNCIEDPVSPIVLRLNFSLVG
TPLSAFGNLRPVLAEDAQRLFTALFPFEKNCGNDNICQDDLSITFSFMSLDCLVVGGP
REFNVTVTVRNDGEDSYRTQVTFFFPLDLSYRKVSTLQNQRSQRSWRLACESASSTEV
SGALKSTSCSINHPIFPENSEVTFNITFDVDSKASLGNKLLLKANVTSENNMPRTNKT
EFQLELPVKYAVYMVVTSHGVSTKYLNFTASENTSRVMQHQYQVSNLGQRSLPISLVF
LVPVRLNQTVIWDRPQVTFSENLSSTCHTKERLPSHSDFLAELRKAPVVNCSIAVCQR
IQCDIPFFGIQEEFNATLKGNLSFDWYIKTSHNHLLIVSTAEILFNDSVFTLLPGQGA
FVRSQTETKVEPFEVPNPLPLIVGSSVGGLLLLALITAALYKLGFFKRQYKDMMSEGG
PPGAEPQ"
BASE COUNT 1095 a 1271 c 1289 g 1085 t
ORIGIN 1 bp upstream of EcoRI site.
1 gaattccgtg gttcctcagt ggtgcctgca acccctggtt cacctccttc caggttctgg
61 ctccttccag ccatggctct cagagtcctt ctgttaacag ccttgacctt atgtcatggg
121 ttcaacttgg acactgaaaa cgcaatgacc ttccaagaga acgcaagggg cttcgggcag
181 agcgtggtcc agcttcaggg atccagggtg gtggttggag ccccccagga gatagtggct
241 gccaaccaaa ggggcagcct ctaccagtgc gactacagca caggctcatg cgagcccatc
301 cgcctgcagg tccccgtgga ggccgtgaac atgtccctgg gcctgtccct ggcagccacc
361 accagccccc ctcagctgct ggcctgtggt cccaccgtgc accagacttg cagtgagaac
421 acgtatgtga aagggctctg cttcctgttt ggatccaacc tacggcagca gccccagaag
481 ttcccagagg ccctccgagg gtgtcctcaa gaggatagtg acattgcctt cttgattgat
541 ggctctggta gcatcatccc acatgacttt cggcggatga aggagtttgt ctcaactgtg
601 atggagcaat taaaaaagtc caaaaccttg ttctctttga tgcagtactc tgaagaattc
661 cggattcact ttaccttcaa agagttccag aacaacccta acccaagatc actggtgaag
721 ccaataacgc agctgcttgg gcggacacac acggccacgg gcatccgcaa agtggtacga
781 gagctgttta acatcaccaa cggagcccga aagaatgcct ttaagatcct agttgtcatc
841 acggatggag aaaagtttgg cgatcccttg ggatatgagg atgtcatccc tgaggcagac
901 agagagggag tcattcgcta cgtcattggg gtgggagatg ccttccgcag tgagaaatcc
961 cgccaagagc ttaataccat cgcatccaag ccgcctcgtg atcacgtgtt ccaggtgaat
1021 aactttgagg ctctgaagac cattcagaac cagcttcggg agaagatctt tgcgatcgag
1081 ggtactcaga caggaagtag cagctccttt gagcatgaga tgtctcagga aggcttcagc
1141 gctgccatca cctctaatgg ccccttgctg agcactgtgg ggagctatga ctgggctggt
1201 ggagtctttc tatatacatc aaaggagaaa agcaccttca tcaacatgac cagagtggat
1261 tcagacatga atgatgctta cttgggttat gctgccgcca tcatcttacg gaaccgggtg
1321 caaagcctgg ttctgggggc acctcgatat cagcacatcg gcctggtagc gatgttcagg
1381 cagaacactg gcatgtggga gtccaacgct aatgtcaagg gcacccagat cggcgcctac
1441 ttcggggcct ccctctgctc cgtggacgtg gacagcaacg gcagcaccga cctggtcctc
1501 atcggggccc cccattacta cgagcagacc cgagggggcc aggtgtccgt gtgccccttg
1561 cccagggggc agagggctcg gtggcagtgt gatgctgttc tctacgggga gcagggccaa
1621 ccctggggcc gctttggggc agccctaaca gtgctggggg acgtaaatgg ggacaagctg
1681 acggacgtgg ccattggggc cccaggagag gaggacaacc ggggtgctgt ttacctgttt
1741 cacggaacct caggatctgg catcagcccc tcccatagcc agcggatagc aggctccaag
1801 ctctctccca ggctccagta ttttggtcag tcactgagtg ggggccagga cctcacaatg
1861 gatggactgg tagacctgac tgtaggagcc caggggcacg tgctgctgct caggtcccag
1921 ccagtactga gagtcaaggc aatcatggag ttcaatccca gggaagtggc aaggaatgta
1981 tttgagtgta atgatcaggt ggtgaaaggc aaggaagccg gagaggtcag agtctgcctc
2041 catgtccaga agagcacacg ggatcggcta agagaaggac agatccagag tgttgtgact
2101 tatgacctgg ctctggactc cggccgccca cattcccgcg ccgtcttcaa tgagacaaag
2161 aacagcacac gcagacagac acaggtcttg gggctgaccc agacttgtga gaccctgaaa
2221 ctacagttgc cgaattgcat cgaggaccca gtgagcccca ttgtgctgcg cctgaacttc
2281 tctctggtgg gaacgccatt gtctgctttc gggaacctcc ggccagtgct ggcggaggat
2341 gctcagagac tcttcacagc cttgtttccc tttgagaaga attgtggcaa tgacaacatc
2401 tgccaggatg acctcagcat caccttcagt ttcatgagcc tggactgcct cgtggtgggt
2461 gggccccggg agttcaacgt gacagtgact gtgagaaatg atggtgagga ctcctacagg
2521 acacaggtca ccttcttctt cccgcttgac ctgtcctacc ggaaggtgtc cacactccag
2581 aaccagcgct cacagcgatc ctggcgcctg gcctgtgagt ctgcctcctc caccgaagtg
2641 tctggggcct tgaagagcac cagctgcagc ataaaccacc ccatcttccc ggaaaactca
2701 gaggtcacct ttaatatcac gtttgatgta gactctaagg cttcccttgg aaacaaactg
2761 ctcctcaagg ccaatgtgac cagtgagaac aacatgccca gaaccaacaa aaccgaattc
2821 caactggagc tgccggtgaa atatgctgtc tacatggtgg tcaccagcca tggggtctcc
2881 actaaatatc tcaacttcac ggcctcagag aataccagtc gggtcatgca gcatcaatat
2941 caggtcagca acctggggca gaggagcctc cccatcagcc tggtgttctt ggtgcccgtc
3001 cggctgaacc agactgtcat atgggaccgc ccccaggtca ccttctccga gaacctctcg
3061 agtacgtgcc acaccaagga gcgcttgccc tctcactccg actttctggc tgagcttcgg
3121 aaggcccccg tggtgaactg ctccatcgct gtctgccaga gaatccagtg tgacatcccg
3181 ttctttggca tccaggaaga attcaatgct accctcaaag gcaacctctc gtttgactgg
3241 tacatcaaga cctcgcataa ccacctcctg atcgtgagca cagctgagat cttgtttaac
3301 gattccgtgt tcaccctgct gccgggacag ggggcgtttg tgaggtccca gacggagacc
3361 aaagtggagc cgttcgaggt ccccaacccc ctgccgctca tcgtgggcag ctctgtcggg
3421 ggactgctgc tcctggccct catcaccgcc gcgctgtaca agctcggctt cttcaagcgg
3481 caatacaagg acatgatgag tgaagggggt cccccggggg ccgaacccca gtagcggctc
3541 cttcccgaca gagctgcctc tcggtggcca gcaggactct gcccagacca cacgtagccc
3601 ccaggctgct ggacacgtcg gacagcgaag tatccccgac aggacgggct tgggcttcca
3661 tttgtgtgtg tgcaagtgtg tatgtgcgtg tgtgcgagtg tgtgcaagtg tctgtgtgca
3721 agtgtgtgca cgtgtgcgtg tgcgtgcatg tgcactcgca cgcccatgtg tgagtgtgtg
3781 caagtatgtg agtgtgtcca gtgtgtgtgc gtgtgtccat gtgtgtgcag tgtgtgcatg
3841 tgtgcgagtg tgtgcatgtg tgtgctcagg ggctgtggct cacgtgtgtg actcagagtg
3901 tctctggcgt gtgggtaggt gacggcagcg tagcctctcc ggcagaaggg aactgcctgg
3961 gctcccttgt gcgtgggtaa gccgctgctg ggttttcctc cgggagaggg gacggtcaat
4021 cctgtgggtg aagagagagg gaaacacagc agcatctctc cactgaaaga agtgggactt
4081 cccgtcgcct gcgagcctgc ggcctgctgg agcctgcgca gcttggatgg atactccatg
4141 agaaaagccg tgggtggaac caggagcctc ctccacacca gcgctgatgc ccaataaaga
4201 tgcccactga ggaatcatga agcttccttt ctggattcat ttattatttc aatgtgactt
4261 taattttttg gatggataag cctgtctatg gtacaaaaat cacaaggcat tcaagtgtac
4321 agtgaaaagt ctccctttcc agatattcaa gtcacctcct taaaggtagt caagattgtg
4381 ttttgaggtt tccttcagac agattccagg cgatgtgcaa gtgtatgcac gtgtgcacac
4441 accacacaca tacacacaca caagcttttt tacacaaatg gtagcatact ttatattggt
4501 ctgtatcttg ctttttttca ccaatatttc tcagacatcg gttcatatta agacataaat
4561 tactttttca ttcttttata ccgctgcata gtattccatt gtgtgagtgt accataatgt
4621 atttaaccag tcttcttttg atatactatt ttcatctctt gttattgcat ctgctgagtt
4681 aataaatcaa atatatgtca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//