LOCUS       HUMIRBPM                4124 bp    mRNA    linear   HUM 06-JAN-1995
DEFINITION  Human interstitial retinol binding protein (IRBP) mRNA, complete
            cds.
ACCESSION   J03912 M45751 M45753
VERSION     J03912.1
KEYWORDS    retinol binding protein.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4124)
  AUTHORS   Liou,G.I., Fong,S.-L., Gosden,J., van Tuinen,P., Ledbetter,D.H.,
            Christie,S., Rout,D., Bhattacharya,S., Cook,R.G., Li,Y., Wang,C.
            and Bridges,C.D.B.
  TITLE     Human interstitial retinol-binding protein (IRBP): cloning, partial
            sequence, and chromosomal localization
  JOURNAL   Somat. Cell Mol. Genet. 13 (4), 315-323 (1987)
   PUBMED   3455009
REFERENCE   2  (bases 1 to 4124)
  AUTHORS   Fong,S.L. and Bridges,C.D.
  TITLE     Internal quadruplication in the structure of human interstitial
            retinol-binding protein deduced from its cloned cDNA
  JOURNAL   J. Biol. Chem. 263 (30), 15330-15334 (1988)
   PUBMED   3170584
REFERENCE   3  (bases 1 to 4124)
  AUTHORS   Fong,S.L., Fong,W.B., Morris,T.A., Kedzie,K.M. and Bridges,C.D.
  TITLE     Characterization and comparative structural features of the gene
            for human interstitial retinol-binding protein
  JOURNAL   J. Biol. Chem. 265 (7), 3648-3653 (1990)
   PUBMED   2303470
COMMENT     Original source text: Human, cDNA to mRNA, (library of J.Nathans),
            clones H.20IRBP, H.12IRBP, H.8IRBP, H.4IRBP and H.18IRBP.
            [2]  revises [1].
            [3]  revises [2].
            Draft entry and computer-readable sequence for [2] kindly provided
            by C.D.B.Bridges, 13-MAY-1988.
FEATURES             Location/Qualifiers
     source          1..4124
                     /db_xref="H-InvDB:HIT000191218"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /map="10q11.2"
     gene            1..4124
                     /gene="RBP3"
     CDS             1..3741
                     /gene="RBP3"
                     /note="precursor"
                     /codon_start=1
                     /product="retinol-binding protein"
                     /protein_id="AAA59188.1"
                     /db_xref="GDB:G00-120-341"
                     /translation="MREWVLLMSVLLCGLAGPTHLFQPSLVLDMAKVLLDNYCFPENL
                     LGMQEAIQQAIKSHEILSISDPQTLASVLTAGVQSSLNDPRLVISYEPSTPEPPPQVP
                     ALTSLSEEELLAWLQRGLRHEVLEGNVGYLRVDSVPGQEVLSMMGEFLVAHVWGNLMG
                     TSALVLDLRHCTGGQVSGIPYIISYLHPGNTILHVDTIYNRPSNTTTEIWTLPQVLGE
                     RYGADKDVVVLTSSQTRGVAEDIAHILKQMRRAIVVGERTGGGALDLRKLRIGESDFF
                     FTVPVSRSLGPLGGGSQTWEGSGVLPCVGTPAEQALEKALAILTLRSALPGVVHCLQE
                     VLKDYYTLVDRVPTLLQHLASMDFSTVVSEEDLVTKLNAGLQAASEDPRLLVRAIGPT
                     ETPSWPAPDAAAEDSPGVAPELPEDEAIRQALVDSVFQVSVLPGNVGYLRFDSFADAS
                     VLGVLAPYVLRQVWEPLQDTEHLIMDLRHNPGGPSSAVPLLLSYFQGPEAGPVHLFTT
                     YDRRTNITQEHFSHMELPGPRYSTQRGVYLLTSHRTATAAEEFAFLMQSLGWATLVGE
                     ITAGNLLHTRTVPLLDTPEGSLALTVPVLTFIDNHGEAWLGGGVVPDAIVLAEEALDK
                     AQEVLEFHQSLGALVEGTGHLLEAHYARPEVVGQTSALLRAKLAQGAYRTAVDLESLA
                     SQLTADLQEVSGDHRLLVFHSPGELVVEEAPPPPPAVPSPEELTYLIEALFKTEVLPG
                     QLGYLRFDAMAELETVKAVGPQLVRLVWQQLVDTAALVIDLRYNPGSYSTAIPLLCSY
                     FFEAEPRQHLYSVFDRATSKVTEVWTLPQVAGQRYGSHKDLYILMSHTSGSAAEAFAH
                     TMQDLQRATVIGEPTAGGALSVGIYQVGSSPLYASMPTQMAMSATTGKAWDLAGVEPD
                     ITVPMSEALSIAQDIVALRAKVPTVLQTAGKLVADNYASAELGAKMATKLSGLQSRYS
                     RVTSEVALAEILGADLQMLSGDPHLKAAHIPENAKDRIPGIVPMQIPSPEVFEELIKF
                     SFHTNVLEDNIGYLRFDMFGDGELLTQVSRLLVEHIWKKIMHTDAMIIDMRFNIGGPT
                     SSIPILCSYFFDEGPPVLLDKIYSRPDDSVSELWTHAQVVGERYGSKKSMVILTSSVT
                     AGTAEEFTYIMKRLGRALVIGEVTSGGCQPPQTYHVDDTNLYLTIPTARSVGASDGSS
                     WEGVGVTPHVVVPAEEALARAKEMLQHNQLRVKRSPGLQDHL"
     sig_peptide     1..48
                     /gene="RBP3"
                     /note="retinol binding protein signal peptide"
     mat_peptide     49..3738
                     /gene="RBP3"
                     /product="retinol-binding protein"
     old_sequence    1390
                     /gene="RBP3"
                     /citation=[2]
     old_sequence    2470..2472
                     /gene="RBP3"
                     /citation=[2]
     old_sequence    2651..2652
                     /gene="RBP3"
                     /citation=[2]
     old_sequence    2964..2965
                     /gene="RBP3"
                     /citation=[2]
     old_sequence    2993..2994
                     /gene="RBP3"
                     /citation=[2]
     old_sequence    3005..3006
                     /gene="RBP3"
                     /citation=[2]
     old_sequence    3016..3023
                     /gene="RBP3"
                     /citation=[2]
     old_sequence    3067..3068
                     /gene="RBP3"
                     /citation=[2]
     old_sequence    3431
                     /gene="RBP3"
                     /citation=[2]
     old_sequence    3717..3719
                     /gene="RBP3"
                     /citation=[2]
     old_sequence    3736..3737
                     /gene="RBP3"
                     /citation=[2]
     old_sequence    4011..4023
                     /gene="RBP3"
                     /citation=[2]
     old_sequence    4049
                     /gene="RBP3"
                     /citation=[2]
     old_sequence    4124
                     /gene="RBP3"
                     /citation=[2]
BASE COUNT          814 a         1287 c         1218 g          805 t
ORIGIN      Chromosome 10p11.2-q11.2.
        1 atgagagaat gggttctgct catgtccgtg ctgctctgtg gcctggctgg ccccacacac
       61 ctgttccagc caagcctggt gctggacatg gccaaggtcc tcttggataa ctactgcttc
      121 ccggagaacc tgctgggcat gcaggaagcc atccagcagg ccatcaagag ccatgagatt
      181 ctgagcatct cagacccgca gacgctggcc agtgtgctga cagccggggt gcagagctcc
      241 ctgaacgatc ctcgcctggt catctcctat gagcccagca cccccgagcc tcccccacaa
      301 gtcccagcac tcaccagcct ctcagaagag gaactgcttg cctggctgca aaggggcctc
      361 cgccatgagg ttctggaggg taatgtgggc tacctgcggg tggacagcgt cccgggccag
      421 gaggtgctga gcatgatggg ggagttcctg gtggcccacg tgtgggggaa tctcatgggc
      481 acctccgcct tagtgctgga tctccggcac tgcacaggag gccaggtctc tggcattccc
      541 tacatcatct cctacctgca cccagggaac accatcctgc acgtggacac tatctacaac
      601 cgcccctcca acaccaccac ggagatctgg accttgcccc aggtcctggg agaaaggtac
      661 ggtgccgaca aggatgtggt ggtcctcacc agcagccaga ccaggggcgt ggccgaggac
      721 atcgcgcaca tccttaagca gatgcgcagg gccatcgtgg tgggcgagcg gactggggga
      781 ggggccctgg acctccggaa gctgaggata ggcgagtctg acttcttctt cacggtgccc
      841 gtgtccaggt ccctggggcc ccttggtgga ggcagccaga cgtgggaggg cagcggggtg
      901 ctgccctgtg tggggactcc ggccgagcag gccctggaga aagccctggc catcctcact
      961 ctgcgcagcg cccttccagg ggtagtccac tgcctccagg aggtcctgaa ggactactac
     1021 acgctggtgg accgtgtgcc caccctgctg cagcacttgg ccagcatgga cttctccacg
     1081 gtggtctccg aggaagatct ggtcaccaag ctcaatgccg gcctgcaggc tgcgtctgag
     1141 gatcccaggc tcctggtgcg agccatcggg cccacagaaa ctccttcttg gcccgcgccc
     1201 gacgctgcag ccgaagactc accaggggtg gccccagagt tgcctgagga cgaggctatc
     1261 cggcaagcac tggtggactc tgtgttccag gtgtcggtgc tgccaggcaa tgtgggctac
     1321 ctgcgcttcg atagttttgc tgacgcctcc gtcctgggtg tgttggcccc atatgtcctg
     1381 cgccaggtgt gggagccgct acaggacacg gagcacctca tcatggacct gcgccacaac
     1441 cctggagggc catcctctgc tgtgcccctg ctcctgtcct acttccaggg ccctgaggcc
     1501 ggccccgtgc acctcttcac cacctatgat cgccgcacca acatcacgca ggagcacttc
     1561 agccacatgg agctcccggg cccacgctac agcacccaac gtggggtgta tctgctcacc
     1621 agccaccgca ccgccacggc cgcggaggag ttcgccttcc ttatgcagtc gctgggctgg
     1681 gccacactgg taggtgagat caccgcgggc aacctgctgc acacccgcac ggtgccgctg
     1741 ctggacacac ccgaaggcag cctcgcgctc accgtgccgg tcctcacctt catcgacaat
     1801 cacggcgagg cctggctggg tggtggagtg gtgcccgatg ccatcgtgct ggccgaggag
     1861 gccctggaca aagcccagga agtgctggag ttccaccaaa gcctgggggc cttggtggag
     1921 ggcacagggc acctgctgga ggcccactat gctcggccag aggtcgtggg gcagaccagt
     1981 gccctcctgc gggccaagct ggcccagggc gcctaccgca cagctgtgga cttggagtct
     2041 ctggcctctc agctcacagc agacctccag gaggtgtctg gggaccaccg cttgctagtg
     2101 ttccacagcc ctggcgagct ggtggtagag gaagcacccc caccaccccc tgctgtcccc
     2161 tctccagagg agctcaccta ccttattgag gccctgttca agacagaggt gctgcccggc
     2221 cagctgggct acctgcgttt tgacgccatg gctgaactgg agacagtgaa ggccgtgggg
     2281 ccacagctgg tgcggctggt atggcaacag ctggtggaca cggctgcgct ggtgatcgac
     2341 ctgcgctaca accctggcag ctactccacg gccatcccgc tgctctgctc ctacttcttt
     2401 gaggcagagc cccgccagca cctgtattct gtctttgaca gggccacctc aaaagtcacg
     2461 gaggtgtgga ccttgcccca ggtcgccggc cagcgctacg gctcacacaa ggacctctac
     2521 atcctgatga gccacaccag tggctctgcg gccgaggcct ttgcacacac catgcaggac
     2581 ctgcagcggg ccacggtcat tggggagccc acggccggag gcgcactctc tgtgggcatc
     2641 taccaggtgg gcagcagccc cttatatgca tccatgccca cccagatggc catgagtgcc
     2701 accacaggca aggcctggga cctggctggt gtggagcccg acatcactgt gcccatgagc
     2761 gaagcccttt ccatagccca ggacatagtg gctctgcgtg ccaaggtgcc cacggtgctg
     2821 cagacggccg ggaagctggt ggctgataac tatgcctctg ccgagctggg ggccaagatg
     2881 gccaccaaac tgagcggtct gcagagccgc tactccaggg tgacctcaga agtggcccta
     2941 gccgagatcc tgggggctga cctgcagatg ctctccggag acccacacct gaaggcagcc
     3001 catatccctg agaatgccaa ggaccgcatt cctggaattg tgcccatgca gatcccttcc
     3061 cctgaagtat ttgaagagct gatcaagttt tccttccaca ctaacgtgct tgaggacaac
     3121 attggctact tgaggtttga catgtttggg gacggtgagc tgctcaccca ggtctccagg
     3181 ctgctggtgg agcacatctg gaagaagatc atgcacacgg atgccatgat catcgacatg
     3241 aggttcaaca tcggtggccc cacatcctcc attcccatct tgtgctccta cttctttgat
     3301 gaaggccctc cagttctgct ggacaagatc tacagccggc ctgatgactc tgtcagtgaa
     3361 ctctggacac acgcccaggt tgtaggtgaa cgctatggct ccaagaagag catggtcatt
     3421 ctgaccagca gtgtgacggc cggcaccgcg gaggagttca cctatatcat gaagaggctg
     3481 ggccgggccc tggtcattgg ggaggtgacc agtgggggct gccagccacc acagacctac
     3541 cacgtggatg acaccaacct ctacctcact atccccacgg cccgttctgt gggggcctcg
     3601 gatggcagct cctgggaagg ggtgggggtg acaccccatg tggttgtccc tgcagaagag
     3661 gctctcgcca gggccaagga gatgctccag cacaaccagc tgagggtgaa gcggagccca
     3721 ggcctgcagg accacctgta gggaagggcc ccataggcag agccccaggg cagacagaac
     3781 ctctgggaca cacaccaagg gcactcctgc aggtggcccg gcctgaggtt cccaggagca
     3841 gcaaaggggc ctgctgagct ctggttaggt tacagctgga ggtgtgtata tatacacaca
     3901 cacacatgta tatacacata tatatgtgta tgtatatata tgtatatata tatggctttc
     3961 caataaccac ctaaatttta acaaaggttc cttctaagtg gtagaacttg gggtggtatt
     4021 tttaccttcc ttcttcatac tttgctcttt ttcttaaata ctcattaatg tgcatatatc
     4081 attattttca gatgcagcta tcattattcc aaaatacaaa ataa
//