LOCUS       HUMADXR                 1830 bp    mRNA    linear   HUM 16-OCT-2002
DEFINITION  Homo sapiens adrenodoxin reductase precursor species (FDXR) mRNA,
            alternatively spliced, complete cds.
ACCESSION   J03826
VERSION     J03826.1
KEYWORDS    adrenodoxin reductase; alternative splicing;
            ferridoxin(adrenodoxin)-NADPH+ oxidoreductase; flavoprotein.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1830)
  AUTHORS   Solish,S.B., Picado-Leonard,J., Morel,Y., Kuhn,R.W., Mohandas,T.K.,
            Hanukoglu,I. and Miller,W.L.
  TITLE     Human adrenodoxin reductase: two mRNAs encoded by a single gene on
            chromosome 17cen----q25 are expressed in steroidogenic tissues
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 85 (19), 7104-7108 (1988)
   PUBMED   2845396
COMMENT     Draft entry and sequence for [1] kindly submitted by W.L.Miller,
            03-JAN-1989.  Adrenodoxin reductase encodes two species of mRNA
            that apparently arise by alternative processing of the primary
            transcript and is not tissue specific.
FEATURES             Location/Qualifiers
     source          1..1830
                     /db_xref="H-InvDB:HIT000191210"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /map="17cen-q25"
                     /clone="lambda haAR-1; lambda htAR-1."
                     /tissue_type="adrenal; testis"
     gene            1..1830
                     /gene="FDXR"
     exon            <1..629
                     /gene="FDXR"
                     /note="adrenodoxin reductase precursor species 1;
                     G00-119-659"
     CDS             21..1514
                     /gene="FDXR"
                     /note="adrenodoxin reductase precursor species 2"
                     /codon_start=1
                     /protein_id="AAB59498.1"
                     /db_xref="GDB:G00-119-659"
                     /translation="MASRCWRWWGWSAWPRTRLPPAGSTPSFCHHFSTQEKTPQICVV
                     GSGPAGFYTAQHLLKHPQAHVDIYEKQPVPFGLVRFGVAPDHPEVKNVINTFTQTAHS
                     GRCAFWGNVEVGRDVTVPELQEAYHAVVLSYGAEDHRALEIPGEELPGVCSARAFVGW
                     YNGLPENQELEPDLSCDTAVILGQGNVALDVARILLTPPEHLEALLLCQRTDITKAAL
                     GVLRQSRVKTVWLVGRRGPLQVAFTIKELREMIQLPGARPILDPVDFLGLQDKIKEVP
                     RPRKRLTELLLRTATEKPGPAEAARQASASRAWGLRFFRSPQQVLPSPDGRRAAGVRL
                     AVTRLEGVDEATRAVPTGDMEDLPCGLVLSSIGYKSRPVDPSVPFDSKLGVIPNVEGR
                     VMDVPGLYCSGWVKRGPTGVIATTMTDSFLTGQMLLQDLKAGLLPSGPRPGYAAIQAL
                     LSSRGVRPVSFSDWEKLDAEEVARGQGTGKPREKLVDPQEMLRLLGH"
     mat_peptide     117..1511
                     /gene="FDXR"
                     /product="adrenodoxin reductase species 2"
     CDS             join(21..629,648..1514)
                     /gene="FDXR"
                     /note="adrenodoxin reductase precursor species 1"
                     /codon_start=1
                     /protein_id="AAB59497.1"
                     /db_xref="GDB:G00-119-659"
                     /translation="MASRCWRWWGWSAWPRTRLPPAGSTPSFCHHFSTQEKTPQICVV
                     GSGPAGFYTAQHLLKHPQAHVDIYEKQPVPFGLVRFGVAPDHPEVKNVINTFTQTAHS
                     GRCAFWGNVEVGRDVTVPELQEAYHAVVLSYGAEDHRALEIPGEELPGVCSARAFVGW
                     YNGLPENQELEPDLSCDTAVILGQGNVALDVARILLTPPEHLERTDITKAALGVLRQS
                     RVKTVWLVGRRGPLQVAFTIKELREMIQLPGARPILDPVDFLGLQDKIKEVPRPRKRL
                     TELLLRTATEKPGPAEAARQASASRAWGLRFFRSPQQVLPSPDGRRAAGVRLAVTRLE
                     GVDEATRAVPTGDMEDLPCGLVLSSIGYKSRPVDPSVPFDSKLGVIPNVEGRVMDVPG
                     LYCSGWVKRGPTGVIATTMTDSFLTGQMLLQDLKAGLLPSGPRPGYAAIQALLSSRGV
                     RPVSFSDWEKLDAEEVARGQGTGKPREKLVDPQEMLRLLGH"
     sig_peptide     21..116
                     /gene="FDXR"
                     /note="adrenodoxin reductase signal peptide species 1"
     sig_peptide     21..116
                     /gene="FDXR"
                     /note="adrenodoxin reductase signal peptide species 2"
     mat_peptide     join(117..629,648..1511)
                     /gene="FDXR"
                     /product="adrenodoxin reductase species 1"
     mat_peptide     117..629
                     /gene="FDXR"
                     /product="adrenodoxin reductase species 1"
     mat_peptide     648..1511
                     /gene="FDXR"
                     /product="adrenodoxin reductase species 1"
     variation       388
                     /gene="FDXR"
                     /note="a in lambda htAR-1; g in lambda haAR-1"
                     /replace="g"
     exon            648..>1514
                     /gene="FDXR"
                     /note="adrenodoxin reductase precursor species 1"
     variation       1001
                     /gene="FDXR"
                     /note="g in lambda htAR-1; a in lambda haAR-1"
                     /replace="a"
     variation       1828
                     /gene="FDXR"
                     /note="c in lambda htAR-1; a in lambda haAR-1"
                     /replace="a"
BASE COUNT          323 a          556 c          612 g          339 t
ORIGIN      
        1 gggggttgct gctcccagcc atggcttcgc gctgctggcg ctggtggggc tggtcggcgt
       61 ggcctcggac ccggctgcct cccgccggga gcaccccgag cttctgccac catttctcca
      121 cacaggagaa gaccccccag atctgtgtgg tgggcagtgg cccagctggc ttctacacgg
      181 cccaacacct gctaaagcac ccccaggccc acgtggacat ctacgagaaa cagcctgtgc
      241 cctttggcct ggtgcgcttt ggtgtggcgc ctgatcaccc cgaggtgaag aatgtcatca
      301 acacatttac ccagacggcc cattctggcc gctgtgcctt ctggggcaac gtggaggtgg
      361 gcagggacgt gacggtgccg gagctgcagg aggcctacca cgctgtggtg ctgagctacg
      421 gggcagagga ccatcgggcc ctggaaattc ctggtgagga gctgccaggt gtgtgctccg
      481 cccgggcctt cgtgggctgg tacaacgggc ttcctgagaa ccaggagctg gagccagacc
      541 tgagctgtga cacagccgtg attctggggc aggggaacgt ggctctggac gtggcccgca
      601 tcctactgac cccacctgag cacctggagg ccctcctttt gtgccagaga acggacatca
      661 cgaaggcagc cctgggtgta ctgaggcaga gtcgagtgaa gacagtgtgg ctagtgggcc
      721 ggcgtggacc cctgcaagtg gccttcacca ttaaggagct tcgggagatg attcagttac
      781 cgggagcccg gcccattttg gatcctgtgg atttcttggg tctccaggac aagatcaagg
      841 aggtcccccg cccgaggaag cggctgacgg aactgctgct tcgaacggcc acagagaagc
      901 cagggccggc ggaagctgcc cgccaggcat cggcctcccg tgcctggggc ctccgctttt
      961 tccgaagccc ccagcaggtg ctgccctcac cagatgggcg gcgggcagca ggtgtccgcc
     1021 tagcagtcac tagactggag ggtgtcgatg aggccacccg tgcagtgccc acgggagaca
     1081 tggaagacct cccttgtggg ctggtgctca gcagcattgg gtataagagc cgccctgtcg
     1141 acccaagcgt gccctttgac tccaagcttg gggtcatccc caatgtggag ggccgggtta
     1201 tggatgtgcc aggcctctac tgcagcggct gggtgaagag aggacctaca ggtgtcatag
     1261 ccacaaccat gactgacagc ttcctcaccg gccagatgct gctgcaggac ctgaaggctg
     1321 ggttgctccc ctctggcccc aggcctggct acgcagccat ccaggccctg ctcagcagcc
     1381 gaggggtccg gccagtctct ttctcagact gggagaagct ggatgccgag gaggtggccc
     1441 ggggccaggg cacggggaag cccagggaga agctggtgga tcctcaggag atgctgcgcc
     1501 tcctgggcca ctgagcccag ccccagcccc ggcccccagc agggaaggga tgagtgttgg
     1561 gaggggaagg gctgggtccg tctgagtggg actttgcacc tctgctgatc ccggccggcc
     1621 ctggcttgga ggcttggctg ctcttccagc gtctctcctc cctcctgggg aaggtcgccc
     1681 ttgcgcgcaa ggttttagct ttcagcaact gaggtaacct tagggacagg tggaggtgtg
     1741 ggccgatcta accccttacc catctctcta ctgctggact gtggagggtc accaggttgg
     1801 gaacatgctg gaaataaaac agctgcaccc
//