LOCUS HUMADXR 1830 bp mRNA linear HUM 16-OCT-2002 DEFINITION Homo sapiens adrenodoxin reductase precursor species (FDXR) mRNA, alternatively spliced, complete cds. ACCESSION J03826 VERSION J03826.1 KEYWORDS adrenodoxin reductase; alternative splicing; ferridoxin(adrenodoxin)-NADPH+ oxidoreductase; flavoprotein. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1830) AUTHORS Solish,S.B., Picado-Leonard,J., Morel,Y., Kuhn,R.W., Mohandas,T.K., Hanukoglu,I. and Miller,W.L. TITLE Human adrenodoxin reductase: two mRNAs encoded by a single gene on chromosome 17cen----q25 are expressed in steroidogenic tissues JOURNAL Proc. Natl. Acad. Sci. U.S.A. 85 (19), 7104-7108 (1988) PUBMED 2845396 COMMENT Draft entry and sequence for [1] kindly submitted by W.L.Miller, 03-JAN-1989. Adrenodoxin reductase encodes two species of mRNA that apparently arise by alternative processing of the primary transcript and is not tissue specific. FEATURES Location/Qualifiers source 1..1830 /db_xref="H-InvDB:HIT000191210" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /map="17cen-q25" /clone="lambda haAR-1; lambda htAR-1." /tissue_type="adrenal; testis" gene 1..1830 /gene="FDXR" exon <1..629 /gene="FDXR" /note="adrenodoxin reductase precursor species 1; G00-119-659" CDS 21..1514 /gene="FDXR" /note="adrenodoxin reductase precursor species 2" /codon_start=1 /protein_id="AAB59498.1" /db_xref="GDB:G00-119-659" /translation="MASRCWRWWGWSAWPRTRLPPAGSTPSFCHHFSTQEKTPQICVV GSGPAGFYTAQHLLKHPQAHVDIYEKQPVPFGLVRFGVAPDHPEVKNVINTFTQTAHS GRCAFWGNVEVGRDVTVPELQEAYHAVVLSYGAEDHRALEIPGEELPGVCSARAFVGW YNGLPENQELEPDLSCDTAVILGQGNVALDVARILLTPPEHLEALLLCQRTDITKAAL GVLRQSRVKTVWLVGRRGPLQVAFTIKELREMIQLPGARPILDPVDFLGLQDKIKEVP RPRKRLTELLLRTATEKPGPAEAARQASASRAWGLRFFRSPQQVLPSPDGRRAAGVRL AVTRLEGVDEATRAVPTGDMEDLPCGLVLSSIGYKSRPVDPSVPFDSKLGVIPNVEGR VMDVPGLYCSGWVKRGPTGVIATTMTDSFLTGQMLLQDLKAGLLPSGPRPGYAAIQAL LSSRGVRPVSFSDWEKLDAEEVARGQGTGKPREKLVDPQEMLRLLGH" mat_peptide 117..1511 /gene="FDXR" /product="adrenodoxin reductase species 2" CDS join(21..629,648..1514) /gene="FDXR" /note="adrenodoxin reductase precursor species 1" /codon_start=1 /protein_id="AAB59497.1" /db_xref="GDB:G00-119-659" /translation="MASRCWRWWGWSAWPRTRLPPAGSTPSFCHHFSTQEKTPQICVV GSGPAGFYTAQHLLKHPQAHVDIYEKQPVPFGLVRFGVAPDHPEVKNVINTFTQTAHS GRCAFWGNVEVGRDVTVPELQEAYHAVVLSYGAEDHRALEIPGEELPGVCSARAFVGW YNGLPENQELEPDLSCDTAVILGQGNVALDVARILLTPPEHLERTDITKAALGVLRQS RVKTVWLVGRRGPLQVAFTIKELREMIQLPGARPILDPVDFLGLQDKIKEVPRPRKRL TELLLRTATEKPGPAEAARQASASRAWGLRFFRSPQQVLPSPDGRRAAGVRLAVTRLE GVDEATRAVPTGDMEDLPCGLVLSSIGYKSRPVDPSVPFDSKLGVIPNVEGRVMDVPG LYCSGWVKRGPTGVIATTMTDSFLTGQMLLQDLKAGLLPSGPRPGYAAIQALLSSRGV RPVSFSDWEKLDAEEVARGQGTGKPREKLVDPQEMLRLLGH" sig_peptide 21..116 /gene="FDXR" /note="adrenodoxin reductase signal peptide species 1" sig_peptide 21..116 /gene="FDXR" /note="adrenodoxin reductase signal peptide species 2" mat_peptide join(117..629,648..1511) /gene="FDXR" /product="adrenodoxin reductase species 1" mat_peptide 117..629 /gene="FDXR" /product="adrenodoxin reductase species 1" mat_peptide 648..1511 /gene="FDXR" /product="adrenodoxin reductase species 1" variation 388 /gene="FDXR" /note="a in lambda htAR-1; g in lambda haAR-1" /replace="g" exon 648..>1514 /gene="FDXR" /note="adrenodoxin reductase precursor species 1" variation 1001 /gene="FDXR" /note="g in lambda htAR-1; a in lambda haAR-1" /replace="a" variation 1828 /gene="FDXR" /note="c in lambda htAR-1; a in lambda haAR-1" /replace="a" BASE COUNT 323 a 556 c 612 g 339 t ORIGIN 1 gggggttgct gctcccagcc atggcttcgc gctgctggcg ctggtggggc tggtcggcgt 61 ggcctcggac ccggctgcct cccgccggga gcaccccgag cttctgccac catttctcca 121 cacaggagaa gaccccccag atctgtgtgg tgggcagtgg cccagctggc ttctacacgg 181 cccaacacct gctaaagcac ccccaggccc acgtggacat ctacgagaaa cagcctgtgc 241 cctttggcct ggtgcgcttt ggtgtggcgc ctgatcaccc cgaggtgaag aatgtcatca 301 acacatttac ccagacggcc cattctggcc gctgtgcctt ctggggcaac gtggaggtgg 361 gcagggacgt gacggtgccg gagctgcagg aggcctacca cgctgtggtg ctgagctacg 421 gggcagagga ccatcgggcc ctggaaattc ctggtgagga gctgccaggt gtgtgctccg 481 cccgggcctt cgtgggctgg tacaacgggc ttcctgagaa ccaggagctg gagccagacc 541 tgagctgtga cacagccgtg attctggggc aggggaacgt ggctctggac gtggcccgca 601 tcctactgac cccacctgag cacctggagg ccctcctttt gtgccagaga acggacatca 661 cgaaggcagc cctgggtgta ctgaggcaga gtcgagtgaa gacagtgtgg ctagtgggcc 721 ggcgtggacc cctgcaagtg gccttcacca ttaaggagct tcgggagatg attcagttac 781 cgggagcccg gcccattttg gatcctgtgg atttcttggg tctccaggac aagatcaagg 841 aggtcccccg cccgaggaag cggctgacgg aactgctgct tcgaacggcc acagagaagc 901 cagggccggc ggaagctgcc cgccaggcat cggcctcccg tgcctggggc ctccgctttt 961 tccgaagccc ccagcaggtg ctgccctcac cagatgggcg gcgggcagca ggtgtccgcc 1021 tagcagtcac tagactggag ggtgtcgatg aggccacccg tgcagtgccc acgggagaca 1081 tggaagacct cccttgtggg ctggtgctca gcagcattgg gtataagagc cgccctgtcg 1141 acccaagcgt gccctttgac tccaagcttg gggtcatccc caatgtggag ggccgggtta 1201 tggatgtgcc aggcctctac tgcagcggct gggtgaagag aggacctaca ggtgtcatag 1261 ccacaaccat gactgacagc ttcctcaccg gccagatgct gctgcaggac ctgaaggctg 1321 ggttgctccc ctctggcccc aggcctggct acgcagccat ccaggccctg ctcagcagcc 1381 gaggggtccg gccagtctct ttctcagact gggagaagct ggatgccgag gaggtggccc 1441 ggggccaggg cacggggaag cccagggaga agctggtgga tcctcaggag atgctgcgcc 1501 tcctgggcca ctgagcccag ccccagcccc ggcccccagc agggaaggga tgagtgttgg 1561 gaggggaagg gctgggtccg tctgagtggg actttgcacc tctgctgatc ccggccggcc 1621 ctggcttgga ggcttggctg ctcttccagc gtctctcctc cctcctgggg aaggtcgccc 1681 ttgcgcgcaa ggttttagct ttcagcaact gaggtaacct tagggacagg tggaggtgtg 1741 ggccgatcta accccttacc catctctcta ctgctggact gtggagggtc accaggttgg 1801 gaacatgctg gaaataaaac agctgcaccc //