LOCUS       HUMRODSA                1279 bp    mRNA    linear   HUM 09-JAN-1995
DEFINITION  Human uroporphyrinogen III synthase mRNA, complete cds.
ACCESSION   J03824
VERSION     J03824.1
KEYWORDS    uroporphyrinogen III synthase.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1279)
  AUTHORS   Tsai,S.F., Bishop,D.F. and Desnick,R.J.
  TITLE     Human uroporphyrinogen III synthase: molecular cloning, nucleotide
            sequence, and expression of a full-length cDNA
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 85 (19), 7049-7053 (1988)
   PUBMED   3174619
COMMENT     Original source text: Human (adult) liver, cDNA to mRNA, clone
            pUROS-2.
            Draft entry and computer-readable sequence for [1] kindly provided
            by D.F.Bishop, 10-AUG-1988.
FEATURES             Location/Qualifiers
     source          1..1279
                     /db_xref="H-InvDB:HIT000191209"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /map="10q25.2-q26.3"
     gene            1..1279
                     /gene="UROS"
     CDS             197..994
                     /gene="UROS"
                     /note="uroporphyrinogen III synthase (EC 4.2.1.75)"
                     /codon_start=1
                     /protein_id="AAA60273.1"
                     /db_xref="GDB:G00-128-112"
                     /translation="MKVLLLKDAKEDDCGQDPYIRELGLYGLEATLIPVLSFEFLSLP
                     SFSEKLSHPEDYGGLIFTSPRAVEAAELCLEQNNKTEVWERSLKEKWNAKSVYVVGNA
                     TASLVSKIGLDTEGETCGNAEKLAEYICSRESSALPLLFPCGNLKREILPKALKDKGI
                     AMESITVYQTVAHPGIQGNLNSYYSQQGVPASITFFSPSGLTYSLKHIQELSGDNIDQ
                     IKFAAIGPTTARALAAQGLPVSCTAESPTPQALATGIRKALQPHGCC"
BASE COUNT          292 a          352 c          354 g          281 t
ORIGIN      85 bp upstream of PstI site.
        1 tcctggggcc cagcgcgggt ggctgccgcg gcccctcggg ctgcgtgggg agggggcttc
       61 cgcccctgtt gtcattgctc ctgcagcctt ttcgctggga ctgcgcgaca ccgccccccg
      121 accgggtgcc cgctgtgtgc caggccgggt gctgggcacg gtcccgcgag tgccctataa
      181 ggactgccag gcaataatga aggttctttt actgaaggat gcgaaggaag atgactgtgg
      241 ccaggatccg tatatcaggg aattaggatt atatggactt gaagccactt tgatccctgt
      301 tttatcgttt gagtttttgt ctcttcccag tttctctgag aagctttctc atcctgaaga
      361 ttacggggga ctcattttta ccagccccag agcagtggaa gcagcagagt tatgtttgga
      421 gcaaaacaat aaaactgaag tctgggaaag gtctctgaaa gaaaaatgga atgccaagtc
      481 agtgtatgtg gttggaaatg ctactgcttc tctagtgagt aaaattggcc tggatacaga
      541 aggagaaacc tgtggaaatg cagaaaagct tgcagaatat atttgttcca gggagtcctc
      601 agcactgcct cttctatttc cctgtggaaa cctcaaaaga gaaatcctgc caaaagcgct
      661 caaggacaaa gggattgcca tggaaagcat aactgtgtat cagacagttg cacacccagg
      721 aatccaaggg aacctgaaca gctactattc ccagcagggg gttccagcca gcatcacatt
      781 ttttagtccc tctggcctca catacagtct caagcacatt caggagttat ctggtgacaa
      841 tatcgatcaa attaagtttg cagccatcgg ccccactacg gctcgcgcgc tggccgccca
      901 gggccttcct gtaagctgca ctgcagagag ccccacgcca caagccctgg ccactggcat
      961 caggaaggct ctccagcccc atggctgctg ctgagtcagc cacctagcgc tggccccatg
     1021 cagcctccct gggctgggct ggctctggat ggagccaggc atcggcaagg gctctcggga
     1081 gctgctgccg tcagactcct gcctcaagcc tgagtggaag cacctgagga ccggggatcg
     1141 ggacctgacc tggggctggc ctcaggccca cgtgcacgtg actgccctct gtggaagcca
     1201 gcttaaaccc tagccctgtg agagcttcct gtgcccagca ggaaggaagt caaataaacc
     1261 acactgacta cctgtgctt
//