LOCUS HUMTAUA 1108 bp mRNA linear HUM 13-JAN-1995 DEFINITION Human microtubule-associated protein tau mRNA, complete cds. ACCESSION J03778 VERSION J03778.1 KEYWORDS epitope. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1108) AUTHORS Goedert,M., Wischik,C.M., Crowther,R.A., Walker,J.E. and Klug,A. TITLE Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau JOURNAL Proc. Natl. Acad. Sci. U.S.A. 85 (11), 4051-4055 (1988) PUBMED 3131773 COMMENT Original source text: Human fetal brain, cDNA to mRNA, clones PHF5 and PHF7. Draft entry and computer-readable sequence [1] kindly submitted by R.Crowther, 08-JUL-1988. The microtubule-associated protein tau constitutes at least a part of the paired helical filament (PHF) core in Alzheimer disease. FEATURES Location/Qualifiers source 1..1108 /db_xref="H-InvDB:HIT000191198" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /map="17q21" gene 1..1108 /gene="MTBT1" CDS 38..1096 /gene="MTBT1" /note="microtubule-associated protein tau" /codon_start=1 /protein_id="AAA60615.1" /db_xref="GDB:G00-119-434" /translation="MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLK AEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPP GQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTP PTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQ IVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPG GGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSP QLATLADEVSASLAKQGL" BASE COUNT 293 a 344 c 314 g 157 t ORIGIN Chromosome 17q21. 1 ccgcctctgt cgactatcag gtgaactttg aaccaggatg gctgagcccc gccaggagtt 61 cgaagtgatg gaagatcacg ctgggacgta cgggttgggg gacaggaaag atcagggggg 121 ctacaccatg caccaagacc aagagggtga cacggacgct ggcctgaaag ctgaagaagc 181 aggcattgga gacaccccca gcctggaaga cgaagctgct ggtcacgtga cccaagctcg 241 catggtcagt aaaagcaaag acgggactgg aagcgatgac aaaaaagcca agggggctga 301 tggtaaaacg aagatcgcca caccgcgggg agcagcccct ccaggccaga agggccaggc 361 caacgccacc aggattccag caaaaacccc gcccgctcca aagacaccac ccagctctgg 421 tgaacctcca aaatcagggg atcgcagcgg ctacagcagc cccggctccc caggcactcc 481 cggcagccgc tcccgcaccc cgtcccttcc aaccccaccc acccgggagc ccaagaaggt 541 ggcagtggtc cgtactccac ccaagtcgcc gtcttccgcc aagagccgcc tgcagacagc 601 ccccgtgccc atgccagacc tgaagaatgt caagtccaag atcggctcca ctgagaacct 661 gaagcaccag ccgggaggcg ggaaggtgca aatagtctac aaaccagttg acctgagcaa 721 ggtgacctcc aagtgtggct cattaggcaa catccatcat aaaccaggag gtggccaggt 781 ggaagtaaaa tctgagaagc ttgacttcaa ggacagagtc cagtcgaaga ttgggtccct 841 ggacaatatc acccacgtcc ctggcggagg aaataaaaag attgaaaccc acaagctgac 901 cttccgcgag aacgccaaag ccaagacaga ccacggggcg gagatcgtgt acaagtcgcc 961 agtggtgtct ggggacacgt ctccacggca tctcagcaat gtctcctcca ccggcagcat 1021 cgacatggta gactcgcccc agctcgccac gctagctgac gaggtgtctg cctccctggc 1081 caagcagggt ttgtgatcag gcccctgg //