LOCUS HUMUMPS 2244 bp mRNA linear HUM 14-JAN-1995
DEFINITION Human UMP synthase mRNA, complete cds.
ACCESSION J03626
VERSION J03626.1
KEYWORDS UMP synthase; orotate phosphoribosyltransferase;
orotidine-5'-monophosphate decarboxylase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2244)
AUTHORS Suttle,D.P., Bugg,B.Y., Winkler,J.K. and Kanalas,J.J.
TITLE Molecular cloning and nucleotide sequence for the complete coding
region of human UMP synthase
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 85 (6), 1754-1758 (1988)
PUBMED 3279416
COMMENT Original source text: Human peripheral blood acute lymphoblastic
leukemia cell (HPB-ALL), cDNA to mRNA, clones HUSc[33,39,1-5].
Draft entry and computer-readable sequence for [1] kindly provided
by D.P.Suttle, 19-FEB-1988.
FEATURES Location/Qualifiers
source 1..2244
/db_xref="H-InvDB:HIT000191190"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="3q13"
gene 1..2244
/gene="UMPS"
mRNA <1..>2244
/gene="UMPS"
/note="UMP mRNA (alt.)"
mRNA <1..1759
/gene="UMPS"
/note="UMP mRNA (alt.)"
CDS 105..1547
/gene="UMPS"
/note="UMP synthase"
/codon_start=1
/protein_id="AAA61255.1"
/db_xref="GDB:G00-120-482"
/translation="MAVARAALGPLVTGLYDVQAFKFGDFVLKSGLSSPIYIDLRGIV
SRPRLLSQVADILFQTAQNAGISFDTVCGVPYTALPLATVICSTNQIPMLIRRKETKD
YGTKRLVEGTINPGETCLIIEDVVTSGSSVLETVEVLQKEGLKVTDAIVLLDREQGGK
DKLQAHGIRLHSVCTLSKMLEILEQQKKVDAETVGRVKRFIQENVFVAANHNGSPLSI
KEAPKELSFGARAELPRIHPVASKLLRLMQKKETNLCLSADVSLARELLQLADALGPS
ICMLKTHVDILNDFTLDVMKELITLAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIA
SWADLVNAHVVPGSGVVKGLQEVGLPLHRGCLLIAEMSSTGSLATGDYTRAAVRMAEE
HSEFVVGFISGSRVSMKPEFLHLTPGVQLEAGGDNLGQQYNSPQEVIGKRGSDIIIVG
RGIISAADRLEAAEMYRKAAWEAYLSRLGV"
BASE COUNT 562 a 473 c 592 g 617 t
ORIGIN 5 bp upstream of PstI site; chromosome 3cen-q21.
1 ctgcagacga ggcagggaga ggcgggactt cgcgggcgag acgtcatcgg ggcgccggac
61 gccggggcgc ctgggagttt gaagcaaaca ggcagcgcgc gacaatggcg gtcgctcgtg
121 cagctttggg gccattggtg acgggtctgt acgacgtgca ggctttcaag tttggggact
181 tcgtgctgaa gagcgggctt tcctccccca tctacatcga tctgcggggc atcgtgtctc
241 gaccgcgtct tctgagtcag gttgcagata ttttattcca aactgcccaa aatgcaggca
301 tcagttttga caccgtgtgt ggagtgcctt atacagcttt gccattggct acagttatct
361 gttcaaccaa tcaaattcca atgcttatta gaaggaaaga aacaaaggat tatggaacta
421 agcgtcttgt agaaggaact attaatccag gagaaacctg tttaatcatt gaagatgttg
481 tcaccagtgg atctagtgtt ttggaaactg ttgaggttct tcagaaggag ggcttgaagg
541 tcactgatgc catagtgctg ttggacagag agcagggagg caaggacaag ttgcaggcgc
601 acgggatccg cctccactca gtgtgtacat tgtccaaaat gctggagatt ctcgagcagc
661 agaaaaaagt tgatgctgag acagttggga gagtgaagag gtttattcag gagaatgtct
721 ttgtggcagc gaatcataat ggttctcccc tttctataaa ggaagcaccc aaagaactca
781 gcttcggtgc acgtgcagag ctgcccagga tccacccagt tgcatcgaag cttctcaggc
841 ttatgcaaaa gaaggagacc aatctgtgtc tatctgctga tgtttcactg gccagagagc
901 tgttgcagct agcagatgct ttaggaccta gtatctgcat gctgaagact catgtagata
961 ttttgaatga ttttactctg gatgtgatga aggagttgat aactctggca aaatgccatg
1021 agttcttgat atttgaagac cggaagtttg cagatatagg aaacacagtg aaaaagcagt
1081 atgaaggagg tatctttaaa atagcttcct gggcagatct agtaaatgct cacgtggtgc
1141 caggctcagg agttgtgaaa ggcctgcaag aagtgggcct gcctttgcat cgggggtgcc
1201 tccttattgc ggaaatgagc tccaccggct ccctggccac tggggactac actagagcag
1261 cggttagaat ggctgaggag cactctgaat ttgttgttgg ttttatttct ggctcccgag
1321 taagcatgaa accagaattt cttcacttga ctccaggagt tcagttggaa gcaggaggag
1381 ataatcttgg ccaacagtac aatagcccac aagaagttat tggcaaacga ggttccgata
1441 tcatcattgt aggtcgtggc ataatctcag cagctgatcg tctggaagca gcagagatgt
1501 acagaaaagc tgcttgggaa gcgtatttga gtagacttgg tgtttgagtg cttcagatac
1561 atttttcaga tacaatgtga agacattgaa gatatgtggt cctcctgaaa gtcactggct
1621 ggaaataatc caattattcc tgcttggatt cttccacagg gcctgtgtaa gaatgggttc
1681 tggagttctc atggtcttta ggaaatattg agtaatttgt aatcaccgca ttgatactat
1741 aataagttca ttcttaagct tgcttttttt gagactggtg tttgttagac agccacagtc
1801 ctgtctgggt tagggtcttc cacatttgag gatccttcct atctctccat gggactagac
1861 tgctttgtta ttctatttat tttttaattt ttttcgagac aggatctcac tctgttgccc
1921 aggatggagt gcagtggtga gatcacggct cattgcagcc tcgacctccc aggtgatcct
1981 cccacctcag cttccagatt agctggtgct ataggcatgc accaccacgt ccatctaaat
2041 ttctttatta tttgtagaga tgaggtcttg ccatgttacc caggctggtc tcaactcctg
2101 ggctcaagcg atcctcctgc ctcagtctct caaagtgctg ggattacagg tgtgagccac
2161 tgtgcccagc ctaattgcag taagacaaaa attctagggc accaagaggc taaagtcagc
2221 acagcttttc ttgtgtcctg tatt
//