LOCUS HUMDLDH 2064 bp mRNA linear HUM 27-APR-1993
DEFINITION Human dihydrolipoamide dehydrogenase mRNA, complete cds.
ACCESSION J03620
VERSION J03620.1
KEYWORDS dihydrolipoamide dehydrogenase; dihydrolipoamide:NAD+ oxireductase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2064)
AUTHORS Pons,G., Raefsky-Estrin,C., Carothers,D.J., Pepin,R.A., Javed,A.A.,
Jesse,B.W., Ganapathi,M.K., Samols,D. and Patel,M.S.
TITLE Cloning and cDNA sequence of the dihydrolipoamide dehydrogenase
component human alpha-ketoacid dehydrogenase complexes
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 85 (5), 1422-1426 (1988)
PUBMED 3278312
COMMENT Original source text: Human liver, cDNA to mRNA, clone
lambda-E-3-1.
FEATURES Location/Qualifiers
source 1..2064
/db_xref="H-InvDB:HIT000191189"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
mRNA <1..2064
/product="DLDH mRNA"
CDS 51..1580
/note="dihydrolipoamide dehydrogenase precursor"
/codon_start=1
/protein_id="AAA35764.1"
/translation="MQSWSRVYCSLAKRGHFNRISHGLQGLSAVPLRTYADQPIDADV
TVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAH
GKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYRKITGKN
QVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVV
IGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNT
KVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPR
GRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSV
IYTHPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRV
LGAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKSIN
F"
sig_peptide 51..155
/note="dihydrolipoamide dehydrogenase precursor (EC"
mat_peptide 156..1577
/product="dihydrolipoamide dehydrogenase precursor (EC"
BASE COUNT 638 a 334 c 474 g 618 t
ORIGIN 62 bp upstream of HinfI site.
1 gctcccagcg gaggtgaaag tattggcgga aaggaaaata cagcggaaaa atgcagagct
61 ggagtcgtgt gtactgctcc ttggccaaga gaggccattt caatcgaata tctcatggcc
121 tacagggact ttctgcagtg cctctgagaa cttacgcaga tcagccgatt gatgctgatg
181 taacagttat aggttctggt cctggaggat atgttgctgc tattaaagct gcccagttag
241 gcttcaagac agtctgcatt gagaaaaatg aaacacttgg tggaacatgc ttgaatgttg
301 gttgtattcc ttctaaggct ttattgaaca actctcatta ttaccatatg gcccatggaa
361 aagattttgc atctagagga attgaaatgt ccgaagttcg cttgaattta gacaagatga
421 tggagcagaa gagtactgca gtaaaagctt taacaggtgg aattgcccac ttattcaaac
481 agaataaggt tgttcatgtc aatggatata gaaagataac tggcaaaaat caagtcactg
541 ctacgaaagc tgatggcggc actcaggtta ttgatacaaa gaacattctt atagccacgg
601 gttcagaagt tactcctttt cctggaatca cgatagatga agatacaata gtgtcatcta
661 caggtgcttt atctttaaaa aaagttccag aaaagatggt tgttattggt gcaggagtaa
721 taggtgtaga attgggttca gtttggcaaa gacttggtgc agatgtgaca gcagttgaat
781 ttttaggtca tgtaggtgga gttggaattg atatggagat atctaaaaac tttcaacgca
841 tccttcaaaa acaggggttt aaatttaaat tgaatacaaa ggttactggt gctaccaaga
901 agtcagatgg aaaaattgat gtttctattg aagctgcttc tggtggtaaa gctgaagtta
961 tcacttgtga tgtactcttg gtttgcattg gccgacgacc ctttactaag aatttgggac
1021 tagaagagct gggaattgaa ctagatccca gaggtagaat tccagtcaat accagatttc
1081 aaactaaaat tccaaatatc tatgccattg gtgatgtagt tgctggtcca atgctggctc
1141 acaaagcaga ggatgaaggc attatctgtg ttgaaggaat ggctggtggt gctgtgcaca
1201 ttgactacaa ttgtgtgcca tcagtgattt acacacaccc tgaagttgct tgggttggca
1261 aatcagaaga gcagttgaaa gaagagggta ttgagtacaa agttgggaaa ttcccatttg
1321 ctgctaacag cagagctaag acaaatgctg acacagatgg catggtgaag atccttgggc
1381 agaaatcgac agacagagta ctgggagcac atattcttgg accaggtgct ggagaaatgg
1441 taaatgaagc tgctcttgct ttggaatatg gagcatcctg tgaagatata gctagagtct
1501 gtcatgcaca tccgacctta tcagaagctt ttagagaagc aaatcttgct gcgtcatttg
1561 gcaaatcaat caacttttga attagaagat tatatatttt tttttctgaa atttcctggg
1621 agcttttgta gaagtcacat tcctgaacag gatattctca cagctccaag aatttctagg
1681 actgaattat gaaacttttg gaaggtattt aataggtttg gacaaaatgg aatactctta
1741 tatctatatt ttacataaat ttagtatttt tgtttcagtg cactaatatg taagacaaaa
1801 agctacttat tgtagcatcc tggaatatct ccgtcaactc atattttcat gctgttcatg
1861 aaagattcaa tgcccctgaa tttaaatagc ttttttctct gatacagaaa agttgaattt
1921 tacatggctg gagctagaat ttgatatgtg aacagttgtg tttgaagcac agtgatcaag
1981 ttatttttaa tttggttttc acattggaaa caagtcagtc attcagatat gattcaaatg
2041 tctataaacc gaactgatgt aagt
//