LOCUS HUMTYR 1880 bp mRNA linear HUM 14-JAN-1995
DEFINITION Human tyrosinase mRNA, 3' end.
ACCESSION J03581
VERSION J03581.1
KEYWORDS tyrosinase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1880)
AUTHORS Kwon,B.S., Haq,A.K., Pomerantz,S.H. and Halaban,R.
TITLE Isolation and sequence of a cDNA clone for human tyrosinase that
maps at the mouse c-albino locus
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 84 (21), 7473-7477 (1987)
PUBMED 2823263
REMARK Erratum:[Proc Natl Acad Sci U S A 1988 Sep;85(17):6352]
REFERENCE 2 (bases 1144 to 1190)
AUTHORS Kwon,B.S., Haq,A.K., Pomerantz,S.H. and Halaban,R.
TITLE Correction: Isolation and sequence of a cDNA clone for human
tyrosinase that maps at the mouse c-albino locus
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 85, 6352-6352 (1988)
COMMENT Original source text: Human melanocyte, cDNA to mRNA, cone Pmel34.
[2] revises [1].
Draft entry and printed copy of sequence for [1] kindly provided by
B.S.Kwon, 29-SEP-1987.
FEATURES Location/Qualifiers
source 1..1880
/db_xref="H-InvDB:HIT000191181"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="11q14-q21"
gene 1..1880
/gene="TYR"
mRNA <1..1880
/gene="TYR"
/product="tyrosinase mRNA"
CDS <1..1683
/gene="TYR"
/note="tyrosinase precursor (EC 1.14.18.1)"
/codon_start=1
/protein_id="AAA61241.1"
/db_xref="GDB:G00-120-476"
/translation="LLLAVLYCLLWSFQTSAGHFPRACVSSKNLMEKECCPPWSGTGV
CGQLSGRGSCQNILLSNAPLGPQFPFTGVDDRESWPSVFYNRTCQCSGNFMGFNCGNC
KFGFWGPNCTERRLLVRRNIFDLSAPEKDKFFAYLTLAKHTISSDYVIPIGTYGQMKN
GSTPMFNDINIYDLFVWMHYYVSMDALLGGYEIWRDIDFAHEAPAFLPWHRLFLLRWE
QEIQKLTGDENFTIPYWDWRDAEKCDICTDEYMGGQHPTNPNLLSPASFFSSWQIVCS
RLEEYNSHQSLCNGTPEGPLRRNPGNHDKSTTPRLPSSADVEFCLSLTQYESGSMDKA
ANFSFRNTLEGFASPLTGIADASQSSMHNALHIYMNGHVPGTGSANDPIFLLHHAFVD
SIFEQWLQRHRPLQEVYPEANAPIGHNRESYMVPFIPLYRNGDFFISSKDLGYDYSYL
QDSDPDSFQDYIKSYLEQASRIWSWLLGAAMVGAVLTALLAGPVSLLCRHKRKQLPEE
KQPLLMEKEGLPQLVSEPFIKGLGNRVGPKSPDLTLTQSNVQVPENICWYFL"
sig_peptide <1..36
/gene="TYR"
/note="tyrosinase signal peptide"
mat_peptide 37..1680
/gene="TYR"
/product="tyrosinase"
BASE COUNT 497 a 448 c 421 g 514 t
ORIGIN 53 bp upstream of BalI site; chromosome 11.
1 ctgctcctgg ctgttttgta ctgcctgctg tggagtttcc agacctccgc tggccatttc
61 cctagagcct gtgtctcctc taagaacctg atggagaagg aatgctgtcc accgtggagc
121 gggacaggag tctgtggcca gctttcaggc agaggttcct gtcagaatat ccttctgtcc
181 aatgcaccac ttgggcctca atttcccttc acaggggtgg atgaccggga gtcgtggcct
241 tccgtctttt ataataggac ctgccagtgc tctggcaact tcatgggatt caactgtgga
301 aactgcaagt ttggcttttg gggaccaaac tgcacagaga gacgactctt ggtgagaaga
361 aacatcttcg atttgagtgc cccagagaag gacaaatttt ttgcctacct cactttagca
421 aagcatacca tcagctcaga ctatgtcatc cccataggga cctatggcca aatgaaaaat
481 ggatcaacac ccatgtttaa cgacatcaat atttatgacc tctttgtctg gatgcattat
541 tatgtgtcaa tggatgcact gcttggggga tatgaaatct ggagagacat tgattttgcc
601 catgaagcac cagcttttct gccttggcat agactcttct tgttgcggtg ggaacaagaa
661 atccagaagc tgacaggaga tgaaaacttc actattccat attgggactg gcgggatgca
721 gaaaagtgtg acatttgcac agatgagtac atgggaggtc agcaccccac aaatcctaac
781 ttactcagcc cagcatcatt cttctcctct tggcagattg tctgtagccg attggaggag
841 tacaacagcc atcagtcttt atgcaatgga acgcccgagg gacctttacg gcgtaatcct
901 ggaaaccatg acaaatccac aaccccaagg ctcccctctt cagctgatgt agaattttgc
961 ctgagtttga cccaatatga atctggttcc atggataaag ctgccaattt cagctttaga
1021 aatacactgg aaggatttgc tagtccactt actgggatag cggatgcctc tcaaagcagc
1081 atgcacaatg ccttgcacat ctatatgaat ggacatgtcc caggtacagg atctgccaac
1141 gatcctatct tccttcttca ccatgcattt gttgacagta tttttgagca gtggctccaa
1201 aggcaccgtc ctcttcaaga agtttatcca gaagccaatg cacccattgg acataaccgg
1261 gaatcctaca tggttccttt tataccactg tacagaaatg gtgatttctt tatttcatcc
1321 aaagatctgg gctatgacta tagctatcta caagattcag acccagactc ttttcaagac
1381 tacattaagt cctatttgga acaagcgagt cggatctggt catggctcct tggggcggcg
1441 atggtagggg ccgtcctcac tgccctgctg gcagggcctg tgagcttgct gtgtcgtcac
1501 aagagaaagc agcttcctga agaaaagcag ccactcctca tggagaaaga aggattacca
1561 cagcttgtat cagagccatt tataaaaggc ttaggcaata gagtagggcc aaaaagccct
1621 gacctcactc taactcaaag taatgtccag gttccagaga atatctgctg gtattttctg
1681 taaagaccat ttgcaaaatt gtaacctaat acaaagtgta gccttcttcc aactcaggta
1741 gaacacacct gtctttgtct tgctgttttc actcagccct tttaacattt tcccctaagc
1801 ccatatgtct aaggaaagga tgctatttgg taatgaggaa ctgttatttg tatgtgaatt
1861 aaaagtgctc ttaggaattc
//