LOCUS HUMPTHL 1887 bp mRNA linear HUM 08-JAN-1995
DEFINITION Human, parathyroid-like protein (associated with humoral
hypercalcemia of malignancy) mRNA, complete cds.
ACCESSION J03580
VERSION J03580.1
KEYWORDS parathyroid-like peptide.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1887)
AUTHORS Mangin,M., Webb,A.C., Dreyer,B.E., Posillico,J.T., Ikeda,K.,
Weir,E.C., Stewart,A.F., Bander,N.H., Milstone,L., Barton,D.E.,
Francke,U. and Broadus,A.E.
TITLE Identification of a cDNA encoding a parathyroid hormone-like
peptide from a human tumor associated with humoral hypercalcemia of
malignancy
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 85 (2), 597-601 (1988)
PUBMED 2829195
COMMENT Original source text: Human renal carcinoma, cDNA to mRNA, clone
lanbda-HHM8.
Draft entry and computer-readable sequence for [1] kindly provided
by M.Mangin, 21-DEC-1987.
FEATURES Location/Qualifiers
source 1..1887
/db_xref="H-InvDB:HIT000191180"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="12p12.1-p11.2"
gene 1..1887
/gene="PTHLH"
CDS 939..1418
/gene="PTHLH"
/note="parathyroid-like protein precursor"
/codon_start=1
/protein_id="AAA60216.1"
/db_xref="GDB:G00-120-323"
/translation="MQRRLVQQWSVAVFLLSYAVPSCGRSVEGLSRRLKRAVSEHQLL
HDKGKSIQDLRRRFFLHHLIAEIHTAEIHPVRFGSDDEGRYLTQETNKVETYKEQPLK
TPGKKKKGKPGKRKEQEKKKRRTRSAWLDSGVTGSGLEGDHLSDTSTTSLELDSRRH"
sig_peptide 939..1046
/gene="PTHLH"
/note="parathyroid-like protein signal peptide"
mat_peptide 1047..1415
/gene="PTHLH"
/product="parathyroid-like protein"
BASE COUNT 394 a 572 c 499 g 422 t
ORIGIN 24 bp upstream of BglII site; chromosome 12.
1 ccgtttttgt tcttctaagc aaaagatctc cctctctcta gccgatgctc cccactcagt
61 tcatcccggg aatgggccag ggaggaaggt tctcatgcat cgccccgagc tgccaggcga
121 gcttcgggct ccttaaattc acaggccaac agcccgcgtc ctctccgcgc aggctcccgg
181 ttgcccgcgg tccccggccc agctccttgg cctcctcctc gtcggtccgc ccctggtggt
241 cttggcgccc gctcgtccag ctcggcgcgc cggggaccgc cggctgcccg gggcagtccg
301 cacgccctcg gggatctcgg ctcccggatc cgccgcgccg gcaggagccg gccgggcctg
361 gagggagcaa gcggatgcgc ccacgccccc ggcacgggga tggcgcgaca gggcccgggc
421 tccggggtgg ggctcggcag agctcctgac agctccgggg ctcggcagcg cgggaggggg
481 gagctccgcc gctcgccgct cattcccggc tcggggctcc cctccactcg ctcgggcggc
541 gcggggcccg ttcgggccgc ccgtcgccgc ccccgccccc cgcgcgcccg cccgccagcc
601 cgcctgcgcc ctcgctcgcc ccgcgcgcgt tcctagggcg ccacctcttt gcgactagct
661 cacttctccg gcaggtttgc ctcggagcgt gtgaacattc ctccgctcgg ttttcaactc
721 gcctccaacc tgcgccgccc ggccagcatg tctccccgcc cgtgaagcgg gctgccgcct
781 ccctgccgct ccggctgcca ctaacgaccc gccctcgccg ccacctggcc ctcctgatcg
841 acgacacacg cacttgaaac ttgttctcag ggtgtgtgga atcaactttc cggaagcaac
901 cagcccacca gaggaggtcc cgagcgcgag cggagacgat gcagcggaga ctggttcagc
961 agtggagcgt cgcggtgttc ctgctgagct acgcggtgcc ctcctgcggg cgctcggtgg
1021 agggtctcag ccgccgcctc aaaagagctg tgtctgaaca tcagctcctc catgacaagg
1081 ggaagtccat ccaagattta cggcgacgat tcttccttca ccatctgatc gcagaaatcc
1141 acacagctga aatccacccc gtccgatttg ggtctgatga tgagggcaga tacctaactc
1201 aggaaactaa caaggtggag acgtacaaag agcagccgct caagacacct gggaagaaaa
1261 agaaaggcaa gcccgggaaa cgcaaggagc aggaaaagaa aaaacggcga actcgctctg
1321 cctggttaga ctctggagtg actgggagtg ggctagaagg ggaccacctg tctgacacct
1381 ccacaacgtc gctggagctc gattcacgga ggcattgaaa ttttcagcag agaccttcca
1441 aggacatatt gcaggattct gtaatagtga acatatggaa agtattagaa atatttattg
1501 tctgtaaata ctgtaaatgc attggaataa aactgtctcc cccattgctc tatgaaactg
1561 cacattggtc attgtgaata tttttttttt tgccaaggct aatccaatta ttattatcac
1621 atttaccata atttattttg tccattgatg tatttatttt gtaaatgtat cttggtgctg
1681 ctgaatttct atattttttg taacataatg cactttagat atacatatca agtatgttga
1741 taaatgacac aatgaagtgt ctctattttg tggttgattt taatgaatgc ctaaatataa
1801 ttatccaaat tgattttcct ttgtgcatgt aaaaataaca gtattttaaa tttgtaaaga
1861 atgtctaata aaatataatc taattac
//