LOCUS HUMLOX5A 2484 bp mRNA linear HUM 26-APR-1995
DEFINITION Human 5-lipoxygenase mRNA, complete cds.
ACCESSION J03571
VERSION J03571.1
KEYWORDS 5-lipoxygenase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2484)
AUTHORS Matsumoto,T., Funk,C.D., Radmark,O., Hoog,J.O., Jornvall,H. and
Samuelsson,B.
TITLE Molecular cloning and amino acid sequence of human 5-lipoxygenase
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 85 (1), 26-30 (1988)
PUBMED 2829172
REFERENCE 2 (bases 1 to 2484)
AUTHORS Radmark,O.
TITLE Direct Submission
JOURNAL Submitted (16-JUL-1988) Olof Radmark, Chemistry, Karolinska
Institutet, Box 60400, Stockholm, S-17177, Sweden
COMMENT On Sep 1, 1993 this sequence version replaced gi:187194.
Original source text: Human cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..2484
/db_xref="H-InvDB:HIT000191176"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="lung"
CDS 35..2059
/EC_number="1.13.11.34"
/codon_start=1
/product="5-lipoxygenase"
/protein_id="AAA65450.1"
/translation="MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYN
DFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYR
WITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKC
HKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNT
ISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQE
VQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGD
ENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHP
IFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLC
FPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQD
FVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIP
NAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEE
HFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI"
BASE COUNT 579 a 714 c 664 g 527 t
ORIGIN
1 gggcccggcg ctcgctgctc ccgcggcccg cgccatgccc tcctacacgg tcaccgtggc
61 cactggcagc cagtggttcg ccggcactga cgactacatc tacctcagcc tcgtgggctc
121 ggcgggctgc agcgagaagc acctgctgga caagcccttc tacaacgact tcgagcgtgg
181 cgcggtggat tcatacgacg tgactgtgga cgaggaactg ggcgagatcc agctggtcag
241 aatcgagaag cgcaagtact ggctgaatga cgactggtac ctgaagtaca tcacgctgaa
301 gacgccccac ggggactaca tcgagttccc ctgctaccgc tggatcaccg gcgatgtcga
361 ggttgtcctg agggatggac gcgcaaagtt ggcccgagat gaccaaattc acattctcaa
421 gcaacaccga cgtaaagaac tggaaacacg gcaaaaacaa tatcgatgga tggagtggaa
481 ccctggcttc cccttgagca tcgatgccaa atgccacaag gatttacccc gtgatatcca
541 gtttgatagt gaaaaaggag tggactttgt tctgaattac tccaaagcga tggagaacct
601 gttcatcaac cgcttcatgc acatgttcca gtcttcttgg aatgacttcg ccgactttga
661 gaaaatcttt gtcaagatca gcaacactat ttctgagcgg gtcatgaatc actggcagga
721 agacctgatg tttggctacc agttcctgaa tggctgcaac cctgtgttga tccggcgctg
781 cacagagctg cccgagaagc tcccggtgac cacggagatg gtagagtgca gcctggagcg
841 gcagctcagc ttggagcagg aggtccagca agggaacatt ttcatcgtgg actttgagct
901 gctggatggc atcgatgcca acaaaacaga cccctgcaca ctccagttcc tggccgctcc
961 catctgcttg ctgtataaga acctggccaa caagattgtc cccattgcca tccagctcaa
1021 ccaaatcccg ggagatgaga accctatttt cctcccttcg gatgcaaaat acgactggct
1081 tttggccaaa atctgggtgc gttccagtga cttccacgtc caccagacca tcacccacct
1141 tctgcgaaca catctggtgt ctgaggtttt tggcattgca atgtaccgcc agctgcctgc
1201 tgtgcacccc attttcaagc tgctggtggc acacgtgaga ttcaccattg caatcaacac
1261 caaggcccgt gagcagctca tctgcgagtg tggcctcttt gacaaggcca acgccacagg
1321 gggcggtggg cacgtgcaga tggtgcagag ggccatgaag gacctgacct atgcctccct
1381 gtgctttccc gaggccatca aggcccgggg catggagagc aaagaagaca tcccctacta
1441 cttctaccgg gacgacgggc tcctggtgtg ggaagccatc aggacgttca cggccgaggt
1501 ggtagacatc tactacgagg gcgaccaggt ggtggaggag gacccggagc tgcaggactt
1561 cgtgaacgat gtctacgtgt acggcatgcg gggccgcaag tcctcaggct tccccaagtc
1621 ggtcaagagc cgggagcagc tgtcggagta cctgaccgtg gtgatcttca ccgcctccgc
1681 ccagcacgcc gcggtcaact tcggccagta cgactggtgc tcctggatcc ccaatgcgcc
1741 cccaaccatg cgagccccgc caccgactgc caagggcgtg gtgaccattg agcagatcgt
1801 ggacacgctg cccgaccgcg gccgctcctg ctggcatctg ggtgcagtgt gggcgctgag
1861 ccagttccag gaaaacgagc tgttcctggg catgtaccca gaagagcatt ttatcgagaa
1921 gcctgtgaag gaagccatgg cccgattccg caagaacctc gaggccattg tcagcgtgat
1981 tgctgagcgc aacaagaaga agcagctgcc atattactac ttgtccccag accggattcc
2041 gaacagtgtg gccatctgag cacactgcca gtctcactgt gggaaggcca gctgccccag
2101 ccagatggac tccagcctgc ctggcaggtg tctggccagg cctcttggca gtcacatctc
2161 ttcctccgag gccagtacct ttccatttat tctttgatct tcagggaact gcatagattg
2221 atcaaagtgt aaacaccata gggacccatt ctacacagag caggactgca cagcgtcctg
2281 tccacaccca gctcagcatt tccacaccaa gcagcaacag caaatcacga ccactgatag
2341 atgtctattc ttgttggaga catgggatga ttattttctg ttctatttgt gcttagtcca
2401 attccttgca catagtaggt acccaattca attactattg aatgaattaa gaattggttg
2461 ccataaaaat aaatcagttc attt
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