LOCUS HUMMPRCI 9081 bp mRNA linear HUM 07-JAN-1995
DEFINITION Human cation-independent mannose 6-phosphate receptor mRNA,
complete cds.
ACCESSION J03528
VERSION J03528.1
KEYWORDS mannose 6-phosphate receptor.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 9081)
AUTHORS Oshima,A., Nolan,C.M., Kyle,J.W., Grubb,J.H. and Sly,W.S.
TITLE The human cation-independent mannose 6-phosphate receptor. Cloning
and sequence of the full-length cDNA and expression of functional
receptor in COS cells
JOURNAL J. Biol. Chem. 263 (5), 2553-2562 (1988)
PUBMED 2963003
COMMENT Original source text: Human placenta, cDNA to mRNA (library of
J.E.Sadler), clones PP[4,112,188), RB3 and RC5.
Draft entry and computer-readable sequence for [1] kindly provided
by R.Miller, 04-JAN-1988.
FEATURES Location/Qualifiers
source 1..9081
/db_xref="H-InvDB:HIT000191166"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="12"
/tissue_type="placenta"
/tissue_lib="of J.E.Sadler"
gene 1..9081
/gene="M6PR"
mRNA <1..9081
/gene="M6PR"
/product="MPR-CI mRNA"
CDS 148..7623
/gene="M6PR"
/codon_start=1
/product="mannose 6-phosphate receptor"
/protein_id="AAA59866.1"
/db_xref="GDB:G00-120-162"
/translation="MGAAAGRSPHLGPAPARRPQRSLLLLQLLLLVAAPGSTQAQAAP
FPELCSYTWEAVDTKNNVLYKINICGSVDIVQCGPSSAVCMHDLKTRTYHSVGDSVLR
SATRSLLEFNTTVSCDQQGTNHRVQSSIAFLCGKTLGTPEFVTATECVHYFEWRTTAA
CKKDIFKANKEVPCYVFDEELRKHDLNPLIKLSGAYLVDDSDPDTSLFINVCRDIDTL
RDPGSQLRACPPGTAACLVRGHQAFDVGQPRDGLKVVRKDRLVLSYVREEAGKLDFCD
GHSPAVTITFVCPSERREGTIPKLTAKSNCRYEIEWITEYACHRDYLESKTCSLSGEQ
QDVSIDLTPLAQSGGSSYISDGKEYLFYLNVCGETEIQFCNKKQAAVCQVKKSDTSQV
KAAGRYHNQTLRYSDGDLTLIYFGGDECSSGFQRMSVINFECNKTAGNDGKGTPVFTG
EVDCTYFFTWDTEYACVKEKEDLLCGATDGKKRYDLSALVRHAEPEQNWEAVDGSQTE
TKKKHFFINICHRVLQEGKARGCPEDAAVCAVDKNGSKNLGKFISSPMKEKGNIQLSY
SDGDDCGHGKKIKTNITLVCKPGDLESAPVLRTSGEGGCFYEFEWHTAAACVLSKTEG
ENCTVFDSQAGFSFDLSPLTKKNGAYKVETKKYDFYINVCGPVSVSPCQPDSGACQVA
KSDEKTWNLGLSNAKLSYYDGMIQLNYRGGTPYNNERHTPRATLITFLCDRDAGVGFP
EYQEEDNSTYNFRWYTSYACPEEPLECVVTDPSTLEQYDLSSLAKSEGGLGGNWYAMD
NSGEHVTWRKYYINVCRPLNPVPGCNRYASACQMKYEKDQGSFTEVASISNLGMAKTG
PVVEDSGSLLLEYVNGSACTTSDGRQTTYTTRIHLVCSRGRLNSHPIFSLNWECVVSF
LWNTEAACPIQTTTDTDQACSIRDPNSGFVFNLNPLNSSQGYNVSGIGKIFMFNVCGT
MPVCGTILGKPASGCEAETQTEELKNWKPARPVGIEKSLQLSTEGFITLTYKGPLSAK
GTADAFIVRFVCNDDVYSGPLKFLHQDIDSGQGIRNTYFEFETALACVPSPVDCQVTD
LAGNEYDLTGLSTVRKPWTAVDTSVDGRKRTFYLSVCNPLPYIPGCQGSAVGSCLVSE
GNSWNLGVVQMSPQAAANGSLSIMYVNGDKCGNQRFSTRITFECAQISGSPAFQLQDG
CEYVFIWRTVEACPVVRVEGDNCEVKDPRHGNLYDLKPLGLNDTIVSAGEYTYYFRVC
GKLSSDVCPTSDKSKVVSSCQEKREPQGFHKVAGLLTQKLTYENGLLKMNFTGGDTCH
KVYQRSTAIFFYCDRGTQRPVFLKETSDCSYLFEWRTQYACPPFDLTECSFKDGAGNS
FDLSSLSRYSDNWEAITGTGDPEHYLINVCKSLAPQAGTEPCPPEAAACLLGGSKPVN
LGRVRDGPQWRDGIIVLKYVDGDLCPDGIRKKSTTIRFTCSESQVNSRPMFINAVEDC
EYTFAWPTATACPMKSNEHDDCQVTNPSTGHLFDLSSLSGRAGFTAAYSEKGLVYMSI
CGENENCPPGVGACFGQTRISVGKANKRLRYVDQVLQLVYKDGSPCPSKSGLSYKSVI
SFVCRPEAGPTNRPMLISLDKQTCTLFFSWHTPLACEQATECSVRNGSSIVDLSPLIH
RTGGYEAYDESEDDASDTNPDFYINICQPLNPMHGVPCPAGAAVCKVPIDGPPIDIGR
VAGPPILNPIANEIYLNFESSTPCLADKHFNYTSLIAFHCKRGVSMGTPKLLRTSECD
FVFEWETPVVCPDEVRMDGCTLTDEQLLYSFNLSSLSTSTFKVTRDSRTYSVGVCTFA
VGPEQGGCKDGGVCLLSGTKGASFGRLQSMKLDYRHQDEAVVLSYVNGDRCPPETDDG
VPCVFPFIFNGKSYEECIIESRAKLWCSTTADYDRDHEWGFCRHSNSYRTSSIIFKCD
EDEDIGRPQVFSEVRGCDVTFEWKTKVVCPPKKLECKFVQKHKTYDLRLLSSLTGSWS
LVHNGVSYYMNLCQKIYKGPLGCSERASICRRTTTGDVQVLGLVHTQKLGVIGDKVVV
MYSKGYPCGGNKTASSVIELTCTKTVGRPAFKRFDIDSCTYYFSWDSRAACAVKPQEV
QMVNGTITNPINGKSFSLGDIYFNLFRESGDMRTNGDNYLYEILLSSITSSRNPACSG
ANICQVKPNDQHFSRKVGTSDKTKYYLQDGDLDVVFASSSKCGKDKTKSVSSTIFFHC
DPLVEDGIPEFSHETADCQYLFSWYTSAVCPLGVGFDSENPGDDGQMHKGLSERSQAV
GAVLSLLLVALTCCLLALLLYKKKRRETMISKLTSCCRRSSNVSYKYSKVNKEEETDE
NETEWLMEEIQLPPPRQGKEGQENGHITTKSVKALSSLHGDDQDSTDEVLTIPEVKVH
SGRGAGAESSHPVRNAQSNALQEREDDRVGLVRGEKARKGKSSSAQQKTVSSTKLVSF
HDDSDEDLLHI"
sig_peptide 148..267
/gene="M6PR"
/note="G00-120-162"
mat_peptide 268..7620
/gene="M6PR"
/product="mannose 6-phosphate receptor"
/note="G00-120-162"
BASE COUNT 2243 a 2233 c 2476 g 2129 t
ORIGIN Chromosome 12; 475 bp upstream of EcoRI site.
1 gagcccagtc gagccgcgct cacctcgggc tcccgctccg tctccacctc cgcctttgcc
61 ctggcggcgc gaccccgtcc cgggcgcggc cccagcagtc gcgcgccgtt agcctcgcgc
121 ccgccgcgca gctccgggcc cggcgcgatg ggggccgccg ccggccggag cccccacctg
181 gggcccgcgc ccgcccgccg cccgcagcgc tctctgctcc tgctgcagct gctgctgctc
241 gtcgctgccc cggggtccac gcaggcccag gccgccccgt tccccgagct gtgcagttat
301 acatgggaag ctgttgatac caaaaataat gtactttata aaatcaacat ctgtggaagt
361 gtggatattg tccagtgcgg gccatcaagt gctgtttgta tgcacgactt gaagacacgc
421 acttatcatt cagtgggtga ctctgttttg agaagtgcaa ccagatctct cctggaattc
481 aacacaacag tgagctgtga ccagcaaggc acaaatcaca gagtccagag cagcattgcc
541 ttcctgtgtg ggaaaaccct gggaactcct gaatttgtaa ctgcaacaga atgtgtgcac
601 tactttgagt ggaggaccac tgcagcctgc aagaaagaca tatttaaagc aaataaggag
661 gtgccatgct atgtgtttga tgaagagttg aggaagcatg atctcaatcc tctgatcaag
721 cttagtggtg cctacttggt ggatgactcc gatccggaca cttctctatt catcaatgtt
781 tgtagagaca tagacacact acgagaccca ggttcacagc tgcgggcctg tccccccggc
841 actgccgcct gcctggtaag aggacaccag gcgtttgatg ttggccagcc ccgggacgga
901 ctgaaggtgg tgcgcaagga caggcttgtc ctgagttacg tgagggaaga ggcaggaaag
961 ctagactttt gtgatggtca cagccctgcg gtgactatta catttgtttg cccgtcggag
1021 cggagagagg gcaccattcc caaactcaca gctaaatcca actgccgcta tgaaattgag
1081 tggattactg agtatgcctg ccacagagat tacctggaaa gtaaaacttg ttctctgagc
1141 ggcgagcagc aggatgtctc catagacctc acaccacttg cccagagcgg aggttcatcc
1201 tatatttcag atggaaaaga atatttgttt tatttgaatg tctgtggaga aactgaaata
1261 cagttctgta ataaaaaaca agctgcagtt tgccaagtga aaaagagcga tacctctcaa
1321 gtcaaagcag caggaagata ccacaatcag accctccgat attcggatgg agacctcacc
1381 ttgatatatt ttggaggtga tgaatgcagc tcagggtttc agcggatgag cgtcataaac
1441 tttgagtgca ataaaaccgc aggtaacgat gggaaaggaa ctcctgtatt cacaggggag
1501 gttgactgca cctacttctt cacatgggac acggaatacg cctgtgttaa ggagaaggaa
1561 gacctcctct gcggtgccac cgacgggaag aagcgctatg acctgtccgc gctggtccgc
1621 catgcagaac cagagcagaa ttgggaagct gtggatggca gtcagacgga aacaaagaag
1681 aagcattttt tcattaatat ttgtcacaga gtgctgcagg aaggcaaggc acgagggtgt
1741 cccgaggacg cggcagtgtg tgcagtggat aaaaatggaa gtaaaaatct gggaaaattt
1801 atttcctctc ccatgaaaga gaaaggaaac attcaactct cttattcaga tggtgatgat
1861 tgtggtcatg gcaagaaaat taaaactaat atcacacttg tatgcaagcc aggtgatctg
1921 gaaagtgcac cagtgttgag aacttctggg gaaggcggtt gcttttatga gtttgagtgg
1981 cacacagctg cggcctgtgt gctgtctaag acagaagggg agaactgcac ggtctttgac
2041 tcccaggcag ggttttcttt tgacttatca cctctcacaa agaaaaatgg tgcctataaa
2101 gttgagacaa agaagtatga cttttatata aatgtgtgtg gcccggtgtc tgtgagcccc
2161 tgtcagccag actcaggagc ctgccaggtg gcaaaaagtg atgagaagac ttggaacttg
2221 ggtctgagta atgcgaagct ttcatattat gatgggatga tccaactgaa ctacagaggc
2281 ggcacgccct ataacaatga aagacacaca ccgagagcta cgctcatcac ctttctctgt
2341 gatcgagacg cgggagtggg cttccctgaa tatcaggaag aggataactc cacctacaac
2401 ttccggtggt acaccagcta tgcctgcccg gaggagcccc tggaatgcgt agtgaccgac
2461 ccctccacgc tggagcagta cgacctctcc agtctggcaa aatctgaagg tggccttgga
2521 ggaaactggt atgccatgga caactcaggg gaacatgtca cgtggaggaa atactacatt
2581 aacgtgtgtc ggcctctgaa tccagtgccg ggctgcaacc gatatgcatc ggcttgccag
2641 atgaagtatg aaaaagatca gggctccttc actgaagtgg cttccatcag taacttggga
2701 atggcaaaga ccggcccggt ggttgaggac agcggcagcc tccttctgga atacgtgaat
2761 gggtcggcct gcaccaccag cgatggcaga cagaccacat ataccacgag gatccatctc
2821 gtctgctcca ggggcaggct gaacagccac cccatctttt ctctcaactg ggagtgtgtg
2881 gtcagtttcc tgtggaacac agaggctgcc tgtcccattc agacaacgac ggatacagac
2941 caggcttgct ctataaggga tcccaacagt ggatttgtgt ttaatcttaa tccgctaaac
3001 agttcgcaag gatataacgt ctctggcatt ggtaagattt ttatgtttaa tgtctgcggc
3061 acaatgcctg tctgtgggac catcctggga aaacctgctt ctggctgtga ggcagaaacc
3121 caaactgaag agctcaagaa ttggaagcca gcaaggccag tcggaattga gaaaagcctc
3181 cagctgtcca cagagggctt catcactctg acctacaaag ggcctctctc tgccaaaggt
3241 accgctgatg cttttatcgt ccgctttgtt tgcaatgatg atgtttactc agggcccctc
3301 aaattcctgc atcaagatat cgactctggg caagggatcc gaaacactta ctttgagttt
3361 gaaaccgcgt tggcctgtgt tccttctcca gtggactgcc aagtcaccga cctggctgga
3421 aatgagtacg acctgactgg cctaagcaca gtcaggaaac cttggacggc tgttgacacc
3481 tctgtcgatg ggagaaagag gactttctat ttgagcgttt gcaatcctct cccttacatt
3541 cctggatgcc agggcagcgc agtggggtct tgcttagtgt cagaaggcaa tagctggaat
3601 ctgggtgtgg tgcagatgag tccccaagcc gcggcgaatg gatctttgag catcatgtat
3661 gtcaacggtg acaagtgtgg gaaccagcgc ttctccacca ggatcacgtt tgagtgtgct
3721 cagatatcgg gctcaccagc atttcagctt caggatggtt gtgagtacgt gtttatctgg
3781 agaactgtgg aagcctgtcc cgttgtcaga gtggaagggg acaactgtga ggtgaaagac
3841 ccaaggcatg gcaacttgta tgacctgaag cccctgggcc tcaacgacac catcgtgagc
3901 gctggcgaat acacttatta cttccgggtc tgtgggaagc tttcctcaga cgtctgcccc
3961 acaagtgaca agtccaaggt ggtctcctca tgtcaggaaa agcgggaacc gcagggattt
4021 cacaaagtgg caggtctcct gactcagaag ctaacttatg aaaatggctt gttaaaaatg
4081 aacttcacgg ggggggacac ttgccataag gtttatcagc gctccacagc catcttcttc
4141 tactgtgacc gcggcaccca gcggccagta tttctaaagg agacttcaga ttgttcctac
4201 ttgtttgagt ggcgaacgca gtatgcctgc ccacctttcg atctgactga atgttcattc
4261 aaagatgggg ctggcaactc cttcgacctc tcgtccctgt caaggtacag tgacaactgg
4321 gaagccatca ctgggacggg ggacccggag cactacctca tcaatgtctg caagtctctg
4381 gccccgcagg ctggcactga gccgtgccct ccagaagcag ccgcgtgtct gctgggtggc
4441 tccaagcccg tgaacctcgg cagggtaagg gacggacctc agtggagaga tggcataatt
4501 gtcctgaaat acgttgatgg cgacttatgt ccagatggga ttcggaaaaa gtcaaccacc
4561 atccgattca cctgcagcga gagccaagtg aactccaggc ccatgttcat caacgccgtg
4621 gaggactgtg agtacacctt tgcctggccc acagccacag cctgtcccat gaagagcaac
4681 gagcatgatg actgccaggt caccaaccca agcacaggac acctgtttga tctgagctcc
4741 ttaagtggca gggcgggatt cacagctgct tacagcgaga aggggttggt ttacatgagc
4801 atctgtgggg agaatgaaaa ctgccctcct ggcgtggggg cctgctttgg acagaccagg
4861 attagcgtgg gcaaggccaa caagaggctg agatacgtgg accaggtcct gcagctggtg
4921 tacaaggatg ggtccccttg tccctccaaa tccggcctga gctataagag tgtgatcagt
4981 ttcgtgtgca ggcctgaggc cgggccaacc aataggccca tgctcatctc cctggacaag
5041 cagacatgca ctctcttctt ctcctggcac acgccgctgg cctgcgagca agcgaccgaa
5101 tgttccgtga ggaatggaag ctctattgtt gacttgtctc cccttattca tcgcactggt
5161 ggttatgagg cttatgatga gagtgaggat gatgcctccg ataccaaccc tgatttctac
5221 atcaatattt gtcagccact aaatcccatg cacggagtgc cctgtcctgc cggagccgct
5281 gtgtgcaaag ttcctattga tggtcccccc atagatatcg gccgggtagc aggaccacca
5341 atactcaatc caatagcaaa tgagatttac ttgaattttg aaagcagtac tccttgctta
5401 gcggacaagc atttcaacta cacctcgctc atcgcgtttc actgtaagag aggtgtgagc
5461 atgggaacgc ctaagctgtt aaggaccagc gagtgcgact ttgtgttcga atgggagact
5521 cctgtcgtct gtcctgatga agtgaggatg gatggctgta ccctgacaga tgagcagctc
5581 ctctacagct tcaacttgtc cagcctttcc acgagcacct ttaaggtgac tcgcgactcg
5641 cgcacctaca gcgttggggt gtgcaccttt gcagtcgggc cagaacaagg aggctgtaag
5701 gacggaggag tctgtctgct ctcaggcacc aagggggcat cctttggacg gctgcaatca
5761 atgaaactgg attacaggca ccaggatgaa gcggtcgttt taagttacgt gaatggtgat
5821 cgttgccctc cagaaaccga tgacggcgtc ccctgtgtct tccccttcat attcaatggg
5881 aagagctacg aggagtgcat catagagagc agggcgaagc tgtggtgtag cacaactgcg
5941 gactacgaca gagaccacga gtggggcttc tgcagacact caaacagcta ccggacatcc
6001 agcatcatat ttaagtgtga tgaagatgag gacattggga ggccacaagt cttcagtgaa
6061 gtgcgtgggt gtgatgtgac atttgagtgg aaaacaaaag ttgtctgccc tccaaagaag
6121 ttggagtgca aattcgtcca gaaacacaaa acctacgacc tgcggctgct ctcctctctc
6181 accgggtcct ggtccctggt ccacaacgga gtctcgtact atatgaatct gtgccagaaa
6241 atatataaag ggcccctggg ctgctctgaa agggccagca tttgcagaag gaccacaact
6301 ggagacgtcc aggtcctggg actcgttcac acgcagaagc tgggtgtcat aggtgacaaa
6361 gttgttgtca tgtactccaa aggttatccg tgtggtggaa ataagaccgc atcctccgtg
6421 atagaattga cctgtacaaa gacggtgggc agacctgcat tcaagaggtt tgatatcgac
6481 agctgcactt actacttcag ctgggactcc cgggctgcct gcgccgtgaa gcctcaggag
6541 gtgcagatgg tgaatgggac catcaccaac cctataaatg gcaagagctt cagcctcgga
6601 gatatttatt ttaacctgtt cagagaatct ggggacatga ggaccaatgg ggacaactac
6661 ctgtatgaga tcctactttc ctccatcaca agctccagaa acccggcgtg ctctggagcc
6721 aacatatgcc aggtgaagcc caacgatcag cacttcagtc ggaaagttgg aacctctgac
6781 aagaccaagt actaccttca agacggcgat ctcgatgtcg tgtttgcctc ttcctctaag
6841 tgcggaaagg ataagaccaa gtctgtttct tccaccatct tcttccactg tgaccctctg
6901 gtggaggacg ggatccccga gttcagtcac gagactgccg actgccagta cctcttctct
6961 tggtacacct cagccgtgtg tcctctgggg gtgggctttg acagcgagaa tcccggggac
7021 gacgggcaga tgcacaaggg gctgtcagaa cggagccagg cagtcggcgc ggtgctcagc
7081 ctgctgctgg tggcgctcac ctgctgcctg ctggccctgt tgctctacaa gaagaagagg
7141 agggaaacaa tgataagtaa gctgacctct tgctgtagga gaagttccaa cgtgtcctac
7201 aaatactcaa aggtgaataa ggaagaagag acagatgaga atgaaacaga gtggctgatg
7261 gaagagatcc agctgcctcc tccacggcag ggaaaggaag ggcaggagaa cggccatatt
7321 accaccaagt cagtgaaagc cctcagctcc ctgcatgggg atgaccagga cagtacggat
7381 gaggttctga ccatcccaga ggtgaaagtt cactcgggca ggggagctgg ggcagagagc
7441 tcccacccag tgagaaacgc acagagcaat gcccttcagg agcgtgagga cgatagggtg
7501 gggctggtca ggggtgagaa ggcgaggaaa gggaagtcca gctctgcaca gcagaagaca
7561 gtgagctcca ccaagctggt gtccttccat gacgacagcg acgaggacct cttacacatc
7621 tgactccgca gtgcctgcag gggagcacgg agccgcggga cagccaagca cctccaacca
7681 aataagactt ccactcgatg atgcttctat aattttgcct ttaacagaaa ctttcaaaag
7741 ggaagagttt ttgtgatggg ggagagggtg aaggaggtca ggccccactc cttcctgatt
7801 gtttacagtc attggaataa ggcatggctc agatcggcca cagggcggta ccttgtgccc
7861 agggttttgc cccaagtcct catttaaaag cataaggccg gacgcatctc aaaacagagg
7921 gctgcattcg aagaaaccct tgctgcttta gtcccgatag gtatttgacc ccgatatatt
7981 ttagcatttt aattctctcc ccctatttat tgactttgac aattactcag gtttgagaaa
8041 aaggaaaaaa aaacagccac cgtttcttcc tgccagcagg ggtgtgatgt accagtttgt
8101 ccatcttgag atggtgaggc tgtcagtgta tggggcagct tccggcggga tgttgaactg
8161 gtcattaatg tgtcccctga gttggagctc attctgtctc ttttctcttt tgctttctgt
8221 ttcttaaggg cacacacacg tgcgtgcgag cacacacaca tacgtgcaca gggtccccga
8281 gtgcctaggt tttggagagt ttgcctgttc tatgccttta gtcaggaatg gctgcacctt
8341 tttgcatgat atcttcaagc ctgggcgtac agagcacatt tgtcagtatt tttgccggct
8401 ggtgaattca acctgcccaa agattgattt gtgtgtttgt gtgtgtgtgt gtgtgtgtgt
8461 gtgtgtgtgt gagtggagtt gaggtgtcag agaaaatgaa ttttttccag atttggggta
8521 taggtctcat ctcttcaggt tctcatgata ccacctttac tgtgcttatt tttttaagaa
8581 aaaagtgttg atcaaccatt cgacctataa gaagccttaa tttgcacagt gtgtgactta
8641 cagaaactgc atgaaaaatc atgggccaga gcctcggccc tagcattgca cttggcctca
8701 tgctggaggg aggctgggcg ggtacagcgc ggaggaggag ggaggccagg cgggcatggc
8761 gtggaggagg tgggaggccg ggcggtcaca gcatggagga ggagggaggc gctgctggtg
8821 ttcttattct ggcggcagcg cctttcctgc catgtttagt gaatgacttt tctcgcattg
8881 tagaattgta tatagactct ggtgttctat tgctgagaag caaaccgccc tgcagcatcc
8941 ctcagcctgt accggtttgg ctggcttgtt tgatttcaac atgagtgtat tttttaaaat
9001 tgatttttct cttcattttt ttttcaatca actttactgt aatataaagt attcaacaat
9061 ttcaataaaa gataaattat t
//