LOCUS HUMXEH 1742 bp mRNA linear HUM 14-JAN-1995
DEFINITION Human epoxide hydrolase mRNA, complete cds.
ACCESSION J03518
VERSION J03518.1
KEYWORDS epoxide hydrolase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1742)
AUTHORS Skoda,R.C., Demierre,A., McBride,O.W., Gonzalez,F.J. and Meyer,U.A.
TITLE Human microsomal xenobiotic epoxide hydrolase. Complementary DNA
sequence, complementary DNA-directed expression in COS-1 cells, and
chromosomal localization
JOURNAL J. Biol. Chem. 263 (3), 1549-1554 (1988)
PUBMED 2891713
COMMENT Original source text: Human liver, cDNA to mRNA, clone pheh32.
Printed copy of sequence for [1] kindly provided by U.A.Meyer,
04-DEC-1987.
There appears to be one copy only of the epoxide hydrolase gene in
the human genome.
FEATURES Location/Qualifiers
source 1..1742
/db_xref="H-InvDB:HIT000191165"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="1p11-qter"
gene 1..1742
/gene="EPHX"
mRNA <1..1742
/gene="EPHX"
/product="epoxide hydrolase mRNA"
CDS 163..1530
/gene="EPHX"
/note="epoxide hydrolase"
/codon_start=1
/protein_id="AAA61305.1"
/db_xref="GDB:G00-119-876"
/translation="MWLEILLTSVLGFAIYWFISRDKEETLPLEDGWWGPGTRSAARE
DDSIRPFKVETSDEEIHDLHQRIDKFRFTPPLEDSCFHYGFNSNYLKKVISYWRNEFD
WKKQVEILNRYPHFKTKIEGLDIHFIHVKPPQLPAGHTPKPLLMVHGWPGSFYEFYKI
IPLLTDPKNHGLSDEHVFEVICPSIPGYGFSEASSKKGFNSVATARIFYKLMLRLGFQ
EFYIQGGDWGSLICTNMAQLVPSHVKGLHLNMALVLSNFSTLTLLLGQRFGRFLGLTE
RDVELLYPVKEKVFYSLMRESGYMHIQCTKPDTVGSALNDSPVGLAAYILEKFSTWTN
TEFRYLEDGGLERKFSLDDLLTNVMLYWTTGTIISSQRFYKENLGQGWMTQKHERMKV
YVPTGFSAFPFELLHTPEKWVRFKYPKLISYSYMVRGGHFAAFEEPELLAQDIRKFLS
VLERQ"
BASE COUNT 387 a 513 c 449 g 393 t
ORIGIN 153 bp upstream of RsaI site; chromosome 1.
1 cacagctctc tttcccaagg agtaatcaga gggtgagaac gtggagcctg gtggacaggt
61 gaaagcactg ggatctttct gcccagaaag gggaaagttg cacatttata tcctagaggg
121 aagcgacagc agtgcttctc cctgtgctga ggtacaggag ccatgtggct agaaatcctc
181 ctcacttcag tgctgggctt tgccatctac tggttcatct cccgggacaa agaggaaact
241 ttgccacttg aagatgggtg gtgggggcca ggcacgaggt ccgcagccag ggaggacgac
301 agcatccgcc ctttcaaggt ggaaacgtca gatgaggaga tccacgactt acaccagagg
361 atcgataagt tccgtttcac cccacctttg gaggacagct gcttccacta tggcttcaac
421 tccaactacc tgaagaaagt catctcctac tggcggaatg aatttgactg gaagaagcag
481 gtggagattc tcaacagata ccctcacttc aagactaaga ttgaagggct ggacatccac
541 ttcatccacg tgaagccccc ccagctgccc gcaggccata ccccgaagcc cttgctgatg
601 gtgcacggct ggcccggctc tttctacgag ttttataaga tcatcccact cctgactgac
661 cccaagaacc atggcctgag cgatgagcac gtttttgaag tcatctgccc ttccatccct
721 ggctatggct tctcagaggc atcctccaag aaggggttca actcggtggc caccgccagg
781 atcttttaca agctgatgct gcggctgggc ttccaggaat tctacattca aggaggggac
841 tgggggtccc tgatctgcac taatatggcc cagctggtgc ccagccacgt gaaaggcctg
901 cacttgaaca tggctttggt tttaagcaac ttctctaccc tgaccctcct cctgggacag
961 cgtttcggga ggtttcttgg cctcactgag agggatgtgg agctgctgta ccccgtcaag
1021 gagaaggtat tctacagcct gatgagggag agcggctaca tgcacatcca gtgcaccaag
1081 cctgacaccg taggctctgc tctgaatgac tctcctgtgg gtctggctgc ctatattcta
1141 gagaagtttt ccacctggac caatacggaa ttccgatacc tggaggatgg aggcctggaa
1201 aggaagttct ccctggacga cctgctgacc aacgtcatgc tctactggac aacaggcacc
1261 atcatctcct cccagcgctt ctacaaggag aacctgggac agggctggat gacccagaag
1321 catgagcgga tgaaggtcta tgtgcccact ggcttctctg ccttcccttt tgagctattg
1381 cacacgcctg aaaagtgggt gaggttcaag tacccaaagc tcatctccta ttcctacatg
1441 gttcgtgggg gccactttgc ggcctttgag gagccggagc tgctcgccca ggacatccgc
1501 aagttcctgt cggtgctgga gcggcaatga cccacccctc tccccccgcc tgccacctcc
1561 ccccacaagt gccctccagg cttttcttgg ggaagatacc ccttttctga ggaatgagtt
1621 tgcctccgtc ccctgcccat gctgggagcc cacgctcacc ccctcacccc tccaagctca
1681 ctccccaacc cccaactccg tgtggtaagc aacatggctt tgatgataaa cgactttact
1741 ct
//