LOCUS       HUMRISDAD               3795 bp    mRNA    linear   HUM 09-JAN-1995
DEFINITION  Human poly(ADP-ribose) synthetase mRNA, complete cds.
ACCESSION   J03473
VERSION     J03473.1
KEYWORDS    poly(ADP-ribose) synthetase.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3795)
  AUTHORS   Kurosaki,T., Ushiro,H., Mitsuuchi,Y., Suzuki,S., Matsuda,M.,
            Matsuda,Y., Katunuma,N., Kangawa,K., Matsuo,H., Hirose,T.,
            Inayama,S. and Shizuta,Y.
  TITLE     Primary structure of human poly(ADP-ribose) synthetase as deduced
            from cDNA sequence
  JOURNAL   J. Biol. Chem. 262 (33), 15990-15997 (1987)
   PUBMED   2824474
COMMENT     Original source text: Human placenta, cDNA to mRNA (library of
            H.Okayama), clones pPARS[1,11,21,32,32,41,-F].
            Draft entry and printed copy of sequence for [1] kindly provided by
            Y.Shizuta, 23-NOV-1987.
FEATURES             Location/Qualifiers
     source          1..3795
                     /db_xref="H-InvDB:HIT000191159"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /map="1q41-q42"
     gene            1..3795
                     /gene="PPOL"
     mRNA            <1..3795
                     /gene="PPOL"
                     /product="poly(ADP-ribose) synthetase mRNA"
     CDS             96..3140
                     /gene="PPOL"
                     /note="poly(ADP-ribose) synthetase"
                     /codon_start=1
                     /protein_id="AAB59447.1"
                     /db_xref="GDB:G00-119-508"
                     /translation="MAESSDKLYRVEYAKSERASCKKCSESIPKDSLRMAIMVQSPMF
                     DGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGI
                     GSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHP
                     GCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDKVDGVDE
                     VAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGE
                     SAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWV
                     TPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSN
                     MKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEAN
                     IRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSK
                     GQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGT
                     NSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGN
                     AWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESM
                     KKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLI
                     PHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLK
                     TDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHN
                     RRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGD
                     PIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLG
                     TGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW"
     old_sequence    804..805
                     /gene="PPOL"
                     /note="cg"
                     /citation=[1]
                     /replace=""
     old_sequence    1193..1199
                     /gene="PPOL"
                     /note="ccac"
                     /citation=[1]
                     /replace=""
BASE COUNT         1048 a          847 c         1037 g          863 t
ORIGIN      73 bp upstream of AluI site.
        1 tgcggctggg tgagcgcacg cgaggcggcg aggcggcagc gtgtttctag gtcgtggcgt
       61 cgggcttccg gagctttggc ggcagctagg ggaggatggc ggagtcttcg gataagctct
      121 atcgagtcga gtacgccaag agcgagcgcg cctcttgcaa gaaatgcagc gagagcatcc
      181 ccaaggactc gctccggatg gccatcatgg tgcagtcgcc catgtttgat ggaaaagtcc
      241 cacactggta ccacttctcc tgcttctgga aggtgggcca ctccatccgg caccctgacg
      301 ttgaggtgga tgggttctct gagcttcggt gggatgacca gcagaaagtc aagaagacag
      361 cggaagctgg aggagtgaca ggcaaaggcc aggatggaat tggtagcaag gcagagaaga
      421 ctctgggtga ctttgcagca gagtatgcca agtccaacag aagtacgtgc aaggggtgta
      481 tggagaagat agaaaagggc caggtgcgcc tgtccaagaa gatggtggac ccggagaagc
      541 cacagctagg catgattgac cgctggtacc atccaggctg ctttgtcaag aacagggagg
      601 agctgggttt ccggcccgag tacagtgcga gtcagctcaa gggcttcagc ctccttgcta
      661 cagaggataa agaagccctg aagaagcagc tcccaggagt caagagtgaa ggaaagagaa
      721 aaggcgataa ggtggatgga gtggatgaag tggcgaagaa gaaatctaaa aaagaaaaag
      781 acaaggatag taagcttgaa aaagccctaa aggctcagaa cgacctgatc tggaacatca
      841 aggacgagct aaagaaagtg tgttcaacta atgacctgaa ggagctactc atcttcaaca
      901 agcagcaagt gccttctggg gagtcggcga tcttggaccg agtagctgat ggcatggtgt
      961 tcggtgccct ccttccctgc gaggaatgct cgggtcagct ggtcttcaag agcgatgcct
     1021 attactgcac tggggacgtc actgcctgga ccaagtgtat ggtcaagaca cagacaccca
     1081 accggaagga gtgggtaacc ccaaaggaat tccgagaaat ctcttacctc aagaaattga
     1141 aggttaaaaa gcaggaccgt atattccccc cagaaaccag cgcctccgtg gcggccacgc
     1201 ctccgccctc cacagcctcg gctcctgctg ctgtgaactc ctctgcttca gcagataagc
     1261 cattatccaa catgaagatc ctgactctcg ggaagctgtc ccggaacaag gatgaagtga
     1321 aggccatgat tgagaaactc ggggggaagt taacggggac ggccaacaag gcttccctgt
     1381 gcatcagcac caaaaaggag gtggaaaaga tgaataagaa gatggaggaa gtaaaggaag
     1441 ccaacatccg agttgtgtct gaggacttcc tccaggacgt ctccgcctcc accaagagcc
     1501 ttcaggagtt gttcttagcg cacatcttgt ccccttgggg ggcagaggtg aaggcagagc
     1561 ctgttgaagt tgtggcccca agagggaagt caggggctgc gctctccaaa aaaagcaagg
     1621 gccaggtcaa ggaggaaggt atcaacaaat ctgaaaagag aatgaaatta actcttaaag
     1681 gaggagcagc tgtggatcct gattctggac tggaacactc tgcgcatgtc ctggagaaag
     1741 gtgggaaggt cttcagtgcc acccttggcc tggtggacat cgttaaagga accaactcct
     1801 actacaagct gcagcttctg gaggacgaca aggaaaacag gtattggata ttcaggtcct
     1861 ggggccgtgt gggtacggtg atcggtagca acaaactgga acagatgccg tccaaggagg
     1921 atgccattga gcacttcatg aaattatatg aagaaaaaac cgggaacgct tggcactcca
     1981 aaaatttcac gaagtatccc aaaaagttct accccctgga gattgactat ggccaggatg
     2041 aagaggcagt gaagaagctg acagtaaatc ctggcaccaa gtccaagctc cccaagccag
     2101 ttcaggacct catcaagatg atctttgatg tggaaagtat gaagaaagcc atggtggagt
     2161 atgagatcga ccttcagaag atgcccttgg ggaagctgag caaaaggcag atccaggccg
     2221 catactccat cctcagtgag gtccagcagg cggtgtctca gggcagcagc gactctcaga
     2281 tcctggatct ctcaaatcgc ttttacaccc tgatccccca cgactttggg atgaagaagc
     2341 ctccgctcct gaacaatgca gacagtgtgc aggccaaggt ggaaatgctt gacaacctgc
     2401 tggacatcga ggtggcctac agtctgctca ggggagggtc tgatgatagc agcaaggatc
     2461 ccatcgatgt caactatgag aagctcaaaa ctgacattaa ggtggttgac agagattctg
     2521 aagaagccga gatcatcagg aagtatgtta agaacactca tgcaaccaca cacaatgcgt
     2581 atgacttgga agtcatcgat atctttaaga tagagcgtga aggcgaatgc cagcgttaca
     2641 agccctttaa gcagcttcat aaccgaagat tgctgtggca cgggtccagg accaccaact
     2701 ttgctgggat cctgtcccag ggtcttcgga tagccccgcc tgaagcgccc gtgacaggct
     2761 acatgtttgg taaagggatc tatttcgctg acatggtctc caagagtgcc aactactgcc
     2821 atacgtctca gggagaccca ataggcttaa tcctgttggg agaagttgcc cttggaaaca
     2881 tgtatgaact gaagcacgct tcacatatca gcaagttacc caagggcaag cacagtgtca
     2941 aaggtttggg caaaactacc cctgatcctt cagctaacat tagtctggat ggtgtagacg
     3001 ttcctcttgg gaccgggatt tcatctggtg tgaatgacac ctctctacta tataacgagt
     3061 acattgtcta tgatattgct caggtaaatc tgaagtatct gctgaaactg aaattcaatt
     3121 ttaagacctc cctgtggtaa ttgggagagg tagccgagtc acacccggtg gctctggtat
     3181 gaattcaccc gaagcgcttc tgcaccaact cacctggccg ctaagttgct gatgggtagt
     3241 acctgtacta aaccacctca gaaaggattt tacagaaacg tgttaaaggt tttctctaac
     3301 ttctcaagtc ccttgttttg tgttgtgtct gtggggaggg gttgttttgg ggttgttttt
     3361 gttttttctt gccaggtaga taaaactgac atagagaaaa ggctggagag agattctgtt
     3421 gcatagacta gtcctatgga aaaaaccaag cttcgttaga atgtctgcct tactggtttc
     3481 cccagggaag gaaaaataca cttccaccct tttttctaag tgttcgtctt tagttttgat
     3541 tttggaaaga tgttaagcat ttatttttag ttaaaaataa aaactaattt catactattt
     3601 agattttctt ttttatcttg cacttattgt ccccttttta gttttttttg tttgcctctt
     3661 gtggtgaggg gtgtgggaag accaaaggaa ggaacgctaa caatttctca tacttagaaa
     3721 caaaaagagc tttccttctc caggaatact gaacatggga gctcttgaaa tatgtagtat
     3781 taaaagttgc atttg
//